检索结果-南通市图书馆

AlphaFold2 and its applications in the fields of biology and medicine

Signal Transduction and Targeted Therapy 2023年第4期8卷 1630-1643页

作者： Zhenyu Yang xiaoxi zeng Yi Zhao Runsheng Chen West China Biomedical Big Data Center West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Intelligent Information Processing Advanced Computer Research CenterInstitute of Computing TechnologyChinese Academy of SciencesBeijing 100190China Key Laboratory of RNA Biology Center for Big Data Research in HealthInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Pingshan Translational Medicine Center Shenzhen Bay LaboratoryShenzhen 518118China

AlphaFold2(AF2)is an artificial intelligence(AI)system developed by DeepMind that can predict three-dimensional(3D)structures of proteins from amino acid sequences with atomic-level *** structure prediction is one of the most challenging problems in computational biology and chemistry,and has puzzled scientists for 50 *** advent of AF2 presents an unprecedented progress in protein structure prediction and has attracted much *** release of structures of more than 200 million proteins predicted by AF2 further aroused great enthusiasm in the science community,especially in the fields of biology and ***2 is thought to have a significant impact on structural biology and research areas that need protein structure information,such as drug discovery,protein design,prediction of protein function,et *** the time is not long since AF2 was developed,there are already quite a few application studies of AF2 in the fields of biology and medicine,with many of them having preliminarily proved the potential of *** better understand AF2 and promote its applications,we will in this article summarize the principle and system architecture of AF2 as well as the recipe of its success,and particularly focus on reviewing its applications in the fields of biology and *** of current AF2 prediction will also be discussed.

关键词： system fields Fold

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma

引用

Acta Pharmaceutica Sinica B 2021年第5期11卷 1227-1245页

作者： Shouyue Zhang Jin Zhang Yang An xiaoxi zeng Ziyi Qin Yuqian Zhao Heng Xu Bo Liu State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China Department of Laboratory Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Division of Plastic Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115USA West China Biomedical Big Data Center West China HospitalSichuan UniversityChengdu 610041China School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhen 518060China

Autophagy is a critical cellular homeostatic mechanism,and its dysfunction is linked to invasive breast carcinoma(BRCA).Recently,several omics methods have been applied to explore autophagic regulators in BRCA;however,more reliable and robust approaches for identifying crucial regulators and druggable targets remain to be ***,we report here the results of multi-omics approaches to identify potential autophagic regulators in BRCA,including gene expression(EXP),DNA methylation(MET)and copy number alterations(CNAs)from The Cancer Genome Atlas(TCGA).Newly identified candidate genes,such as SF3 B3,TRAPPC10,SIRT3,MTERFD1,and FBXO5,were confirmed to be involved in the positive or negative regulation of autophagy in ***3 B3 was identified firstly as a negative autophagic regulator,and siRNA/shRNA-SF3 B3 were shown to induce autophagyassociated cell death in in vitro and in vivo breast cancer ***,a novel small-molecule activator of SIRT3,1-methylbenzylamino amiodarone,was discovered to induce autophagy in vitro and in ***,these results provide multi-omics approaches to identify some key candidate autophagic regulators,such as the negative regulator SF3 B3 and positive regulator SIRT3 in BRCA,and highlight SF3 B3 and SIRT3 as new druggable targets that could be used to fill the gap between autophagy and cancer drug development.

关键词： Invasive breast carcinoma Multi-omics approach SIRT3 SF3B3 Autophagic regulator Anti-proliferation Migration Druggable target

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reflection on China’s Poverty Alleviation over Four Decades of Reform and Opening Up

引用

China Economic Transition 2019年第4期2卷 1-15页

作者： WANG Sangui zeng xiaoxi of Poverty Alleviation Renmin University of China of Innovation Division Beijing Bytedance Technology Co.Ltd

China has made remarkable progress in the socioeconomic sphere since the reform and opening up in 1978;further,its success in large-scale poverty alleviation has been warmly applauded by the international *** the 18th National Congress of the Communist Party of China(CPC)in 2012,the CPC Central Committee and the State Council decided to adopt targeted poverty reduction and alleviation as the basic strategy for providing development-oriented poverty *** report delivered at the 19th National Congress of the CPC in 2017 proposed that“we must ensure that by the year 2020,all rural residents living below the current poverty line have been lifted out of poverty,and poverty is eliminated in all poor countries and regions.”

关键词： poverty alleviation eliminated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction of severe preeclampsia in machine learning

引用

Medicine in Novel Technology and Devices 2022年第3期15卷 148-153页

作者： Xinyuan Zhang Yu Chen Stephen Salerno Yi Li Libin Zhou xiaoxi zeng Huafeng Li Department of Applied Mechanics College of Architecture and EnvironmentSichuan Province Biomechanical Engineering LaboratorySichuan UniversityChengdu610065SichuanChina Department of Biostatistics University of MichiganAnn ArborMIUSA Medical Big Data Center Sichuan UniversityChengdu610065SichuanChina Department of Computer Science University of WisconsinMadisonWIUSA West China Second University Hospital Sichuan UniversityChengdu610041China Department of Applied Mechanics Sichuan UniversityChengdu610065SichuanChina

This study aimed to find out the blood data characteristics of patients and explore the correlation between severe preeclampsia and blood index *** assistance for the early attention direction of severe preeclampsia diagnosis and treatment.19,653 pregnant women presenting to the West China Second University Hospital,Sichuan University from January 2017 to April *** screening,a total of 248 patients,124 severe preeclampsia cases,and 124 controls were selected for this ***-three blood examination variables were obtained from routine blood work,hepatic,renal and coagulation function *** gradient boosting machine(light GBM),decision tree and random forest were used for date *** randomly divided 35%of the original data as a testing set to conduct internal validation of the performance of the prediction *** area under receiver operating characteristic curve(AUC)was used as the main score to compare the three ***,a binary classification light GBM model based on aspartate aminotransferase,direct bilirubin and activated partial thromboplastin time ratio can predict severe preeclampsia with sensitivity of 88.37%,specificity of 77.27%,AUC of 89.74%and positive predictive value of 65.96%.We believe relevant quantifiable indicators can establish an effective prediction model,which can provide guidance for early detection and prevention of severe preeclampsia.

关键词： Preeclampsia Screening Prediction Blood examination Data characteristics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

引用

Signal Transduction and Targeted Therapy 2023年第9期8卷 3920-3922页

作者： Yushang Yang Yanguo Li Haopeng Yu Zhenyu Ding Longqi Chen xiaoxi zeng Shunmin He Qi Liao Yi Zhao Yong Yuan Department of Thoracic Surgery West China HospitalSichuan UniversityChengduSichuanChina Zhejiang Key Laboratory of Pathophysiology Health Science CenterNingbo UniversityNingboZhejiangChina West China Biomedical Big Data Center West China HospitalSichuan UniversityChengduSichuanChina

Dear Editor,Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esopha-geal squamous cell carcinoma(ESCC).However,more than half of patients having a partial response to neoadjuvant therapy,which is considered as a therapy-resistant phenotype and the mechan-ism is still *** heterogeneity of the ESCC with surgery alone therapy were characterized by single-cell RNA sequencing(scRNA-seq)previously,but few report was about ESCC patients with neoadjuvant therapy.1 It is emergent to illustrate the comprehensive hallmarks of neoadjuvant therapy-resistance in ESCC at single cell level.

关键词： neoadjuvant squamous esophageal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comorbid conditions related to readmissions of Chinese older patients

引用

Chinese Medical Journal 2022年第6期135卷 741-743页

作者： Chunyang Li Hyokyoung GHong Zhiye Ying xiaoxi zeng Yi Li West China Biomedical Big Data Center West China HospitalSichuan UniversityChengduSichuan 610041China Medical Big Data Center Sichuan UniversityChengduSichuan 610041China Department of Statistics and Probability Michigan State UniversityEast LansingMIUSA Department of Biostatistics School of Public HealthUniversity of MichiganAnn ArborMIUSA

To the Editor:China is the most populated country,and it is aging more quickly than almost any other country in the *** to Worldometer,[1]the population size of China,as of 2020,is around 1.4 billion,with the proportion of the 60-year olds and older being 17.30%in 2017 and expected to reach 35%in *** age tended to be closely correlated with *** and Schiller[2]reported that 65%of men and 72%of women aged>65 years in the US had at least two chronic conditions in ***,older adults living with multiple chronic conditions tend to be readmitted after discharge,further leading to increased expenditure and more utilization of medical *** studies have reported higher read mission rates in elderly ***,previous studies have focused on investigating the factors that influence read mission for a single disease,rather than for the chronic comorbid conditions in the initial hospitalization and the changes in these conditions from initial hospitalization to read mission among the elderly in ***,most studies have focused on Caucasian patients and have been conducted in the *** is known about Chinese patients due to the lack of large-scale *** the common chronic comorbid conditions and the changes in these conditions from initial hospitalization to read mission among older people is important as it will help in the understanding of the chronic conditions leading to avoidable read mission and facilitate the development of efficient intervention strategies for the reduction of read missions.

关键词： conditions among admitted

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank

引用

Chinese Medical Journal 2022年第12期135卷 1414-1424页

作者： Lei Tang Lina Yang Wenwen Chen Chunyang Li Yu zeng Huazhen Yang Yao Hu Yuanyuan Qu Huan Song xiaoxi zeng Ping Fu Division of Nephrology Kidney Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China Biomedical Big Data Center of West China Hospital Med-X Center for InformaticsSichuan UniversityChengduSichuan 610041China Center of Pubic Health Sciences Faculty of MedicineUniversity of IcelandReykjavikIceland

Background:The risk for chronic kidney disease(CKD)is influenced by genetic predisposition,sex,and *** research indicates that coffee is a potentially protective factor in *** current study aims to investigate whether sex disparity exists in the coffee–CKD association,and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this ***:A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study,which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard *** scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data(n=255,343).Analyses stratified by genetic predisposition,comorbidities,and sex hormones were *** based on Bayesian model averaging were conducted to ascertain the robustness of the ***:Coffee was inversely associated with CKD in a dose-dependent *** effects of coffee did not differ across different strata of genetic risk for CKD,but were more evident among slower genetically predicted caffeine *** sex disparity was observed(P value for interaction=0.013),in that coffee drinking was only associated with the risk reduction of CKD in *** analysis revealed that testosterone and sex hormone-binding globulin(SHBG),but not estradiol,modified the coffee–CKD ***:In addition to the overall inverse coffee–CKD association that was observed in the general population,we could also establish that a sex disparity existed,in that females were more likely to experience the benefit of the *** and SHBG may partly account for the sex disparity.

关键词： Coffee Chronic kidney diseases Genotype Sex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论决胜脱贫攻坚的难点和对策

引用

河海大学学报（哲学社会科学版） 2019年第6期21卷 10-17,109页

作者：曾小溪汪三贵北京字节跳动科技有限公司北京100080 中国人民大学中国扶贫研究院北京100872

脱贫攻坚战进入深水区后,挑战与难度日益增加:一是预期维度,由于大规模扶贫下存在“逆向激励”难题,要做好贫困地区和贫困群体的期望引导,并对激励机制进行优化设计,通过设计适度的帮扶制度,减少逆向选择和道德风险。二是经济维度,由于... 详细信息

脱贫攻坚战进入深水区后,挑战与难度日益增加:一是预期维度,由于大规模扶贫下存在“逆向激励”难题,要做好贫困地区和贫困群体的期望引导,并对激励机制进行优化设计,通过设计适度的帮扶制度,减少逆向选择和道德风险。二是经济维度,由于较难兼顾扶贫成本与扶贫效益,要减少扶贫资源浪费,提高扶贫资源供给质量和使用效率,防止扶贫机会成本大幅攀升。三是时间维度,由于短期脱贫与可持续发展存在矛盾,较难处理短期出效益与长期保公平、兼顾减贫速度和脱贫质量,要从注重减贫速度向注重脱贫质量转变,并形成脱贫内生动力。四是标准维度,由于扶持对象与非扶持对象之间界限模糊容易造成“悬崖效应”,要重视临界贫困并对帮扶对象实行动态管理;创新帮扶形式,以发展式、保障式扶持为主,资金扶持为辅;注重风险防控,将风险干预前置;在公共基础设施建设、公共服务提供和集体经济发展时,照顾到边缘贫困人口。对上述问题进行理论和经验阐释,并结合精准扶贫第三方评估实践,提出相关政策建议。

关键词：精准扶贫稳定脱贫贫困退出第三方评估

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

从区域扶贫开发到精准扶贫——改革开放40年中国扶贫政策的演进及脱贫攻坚的难点和对策

引用

农业经济问题 2018年第8期39卷 40-50页

作者：汪三贵曾小溪中国人民大学中国扶贫研究院

改革开放以来中国农村扶贫开发成效显著。回顾40年中国扶贫开发历程发现,中国经历了从区域扶贫开发到精准扶贫的政策演变,并取得了巨大成就,特别是精准扶贫方略实施后的脱贫成效。针对新阶段深度贫困地区和特殊类型贫困人口特征,需要采... 详细信息

改革开放以来中国农村扶贫开发成效显著。回顾40年中国扶贫开发历程发现,中国经历了从区域扶贫开发到精准扶贫的政策演变,并取得了巨大成就,特别是精准扶贫方略实施后的脱贫成效。针对新阶段深度贫困地区和特殊类型贫困人口特征,需要采用超常规手段和创新机制,短期长期帮扶结合,短期内重点解决贫困人口生活问题,长期则需要重点解决发展动力和能力不足问题,并实施兜底政策。

关键词：农村贫困区域开发扶贫精准扶贫

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

后2020贫困问题初探

引用

河海大学学报（哲学社会科学版） 2018年第2期20卷 7-13,89页

作者：汪三贵曾小溪中国人民大学中国扶贫研究院北京100872 中国人民大学农业与农村发展学院北京100872

作为发展中大国,后2020中国仍然存在贫困问题。考虑到世界各国经验和扶贫成效,结合中国国情,应根据人的基本需求变化来确定新的贫困标准,这既符合大多数发展中国家的通常做法,又能够体现中国扶贫成效。扶持对象更加关注深度贫困地区和... 详细信息

作为发展中大国,后2020中国仍然存在贫困问题。考虑到世界各国经验和扶贫成效,结合中国国情,应根据人的基本需求变化来确定新的贫困标准,这既符合大多数发展中国家的通常做法,又能够体现中国扶贫成效。扶持对象更加关注深度贫困地区和特殊困难群体,解决难啃的硬骨头。扶贫战略应推动反贫困走向城乡一体,因为城乡住户调查一体化、低保和扶贫两项制度一体化、城乡基本公共服务均等化等能够为统筹解决城市和农村贫困问题奠定基础。后2020贫困问题的政策取向可以是区域政策解决制约深度贫困地区和贫困人口发展的外部约束,开发式扶贫政策提升一般贫困人口向上流动的能力,精准滴灌式扶贫政策解除特殊困难贫困人口的特殊困境,城乡一体化扶贫体系解决扶贫的"真空地带"。

关键词：贫困扶贫精准扶贫贫困标准城乡贫困

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：