Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics
作者机构：Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Zhejiang Key Laboratory of PathophysiologyHealth Science CenterNingbo UniversityNingboZhejiangChina West China Biomedical Big Data CenterWest China HospitalSichuan UniversityChengduSichuanChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗(英文))
年 卷 期：2023年第8卷第9期
页 面：3920-3922页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(81970481 to Y.Yuan,31970630 to Q.Liao,82000514 to Y.Yang) key projects of Sichuan Provincial Department of science and technology(2022YFS0048 to Y.Yuan,2021YFS0222 to Y.Yang) 1·3·5 project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(2020HXFH047 and 2020HXJS005 to Y.Yuan,ZYJC18010 to X.Zeng) Zhejiang Provincial Natural Science Foundation of China(LY21C060002) the Fundamental Research Funds for the Provincial Universities of Zhejiang(SJLZ2021001)
主 题：neoadjuvant squamous esophageal
摘 要：Dear Editor,Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esopha-geal squamous cell carcinoma(ESCC).However,more than half of patients having a partial response to neoadjuvant therapy,which is considered as a therapy-resistant phenotype and the mechan-ism is still *** heterogeneity of the ESCC with surgery alone therapy were characterized by single-cell RNA sequencing(scRNA-seq)previously,but few report was about ESCC patients with neoadjuvant therapy.1 It is emergent to illustrate the comprehensive hallmarks of neoadjuvant therapy-resistance in ESCC at single cell level.
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