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A computational model to identify fertility-related proteins using sequence information

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Frontiers of Computer Science 2024年第1期18卷 229-237页

作者： Yan LIN Jiashu WANG xiaowei LIU Xueqin XIE De WU Junjie ZHANG Hui DING Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengdu 610054China

Fertility is the most crucial step in the development process,which is controlled by many fertility-related proteins,including spermatogenesis-,oogenesis-and embryogenesis-related *** identification of fertility-related proteins can provide important clues for studying the role of these proteins in ***,in this study,we constructed a two-layer classifier to identify fertility-related *** this classifier,we first used the composition of amino acids(AA)and their physical and chemical properties to code these three fertility-related ***,the feature set is optimized by analysis of variance(ANOVA)and incremental feature selection(IFS)to obtain the optimal feature *** five-fold cross-validation(CV)and independent data tests,the performance of models constructed by different machine learning(ML)methods is evaluated and ***,based on support vector machine(SVM),we obtained a two-layer model to classify three fertility-related *** the independent test data set,the accuracy(ACC)and the area under the receiver operating characteristic curve(AUC)of the first layer classifier are 81.95%and 0.89,respectively,and them of the second layer classifier are 84.74%and 0.90,*** results show that the proposed model has stable performance and satisfactory prediction accuracy,and can become a powerful model to identify more fertility related proteins.

关键词： sfertility-related proteins machine1 learning sequence information feature selection

A Structural Measurement of the Valuation Effect of China's External Assets:Method and Application

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China & World Economy 2024年第2期32卷 97-124页

作者： Guowei Cai xiaowei Chen Xun Wang Lingnan College Sun Yat-sen UniversityChina China Center for Economic Research National School of DevelopmentPeking UniversityChina

Existing research on the measurement of the valuation effect mainly follows the residual method proposed by Lane and Milesi-Ferretti(2001).This cannot be used to perform structural *** propose an aggregation approach rather than the residual method to measure structurally the investment flow and valuation effect of China's external *** results indicate that the valuation effect of China's external assets has been highly volatile and it was negative during the pandemic *** structural decomposition shows that portfolio investment and direct investment made the main contributions to the valuation *** impact of exchange rates on the valuation effect has generally been higher than that of asset price in terms of direct investment and total external assets but the opposite has been true for portfolio ***'s outward investments are currently more inclined to Asian countries and a few European countries but inflows to China still mainly come from developed countries.

关键词： external asset investment direction structural measurement valuation effect

Virus-Host Interactions Drive Contrasting Bacterial Diel Dynamics in the Ocean

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Research 2024年第2期6卷 389-399页

作者： xiaowei Chen Chen Hu Wei Wei Yunlan Yang Markus G.Weinbauer Hongbo Li Shiying Ren Ruije Ma YVibin huang Tingwei Luo Nianzhi Jiao Rui Zhang State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102PR China College of the Environment and Ecology Xiamen UniversityXiamen 361102PR China Research Center for Environmental Ecology and Engineering School of Environmental Ecology and Biological EngineeringWuhan Institute of TechnologyWuhan 430205PR China Sorbonne Universités UPMCUniversitéParis 06CNRSLaboratoire d'Oceanographie de Villefranche(LOV)Villefranche-sur-Mer 06230France National Marine Environmental Monitoring Center Ministry of Ecological EnvironmentDalian 116023PR China Department of Ocean Sciences University of CaliforniaSanta CruzCAUSA NOAA/OAR Pacific Marine Environmental Laboratory SeattleWAUSA Institute for Advanced Study Shenzhen UniversityShenzhen 518055PR China

Marine organisms perform a sea of diel *** diel dynamics have been shown to be driven by light,energy resources,circadian rhythms,and the coordinated coupling of photoautotrophs and heterotrophic ***,we explore the diel fluctuation of viral production and decay and their impact on the total and active bacterial community in the coastal and open seawaters of the South China *** results showed that the night-production diel pattern of lytic viral production was concurrent with the lower viral decay at night,contributing to the accumulation of the viral population size during the night for surface *** diel variations in bacterial activity,community composition,and diversity were found highly affected by viral *** was revealed by the finding that bacterial community diversity was positively correlated to lytic viral production in the euphotic zone of the open ocean but was negatively related to lysogenic viral production in the coastal *** distinct but contrasting correlations suggest that viral life strategies can not only contribute to diversifying bacterial community but also potentially piggyback their host to dominate bacterial community,suggesting the tightly synchronized depth-dependent and habitat-specific diel patterns of virus-host *** further implies that viruses serve as an ecologically important driver of bacterial diel dynamics across the ocean,highlighting the viral roles in bacterial ecological and biogeochemical processes in the ocean.

关键词： coastal ocean Marine

Influence of multi-stage volcanic events on the Late Cretaceous-Paleogene reservoirs and its geological significance in the northern Central Myanmar Basin

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Journal of Oceanology and Limnology 2024年第4期42卷 1074-1086页

作者： Zengyuan ZHOU Weilin ZHU Wenxu PENG Hefeng SUN Shijie ZHAO xiaowei FU State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China CNOOC International Ltd. Beijing 100027China

The northward subduction of the Neo-Tethys oceanic crust triggered multiple magmatic activities in the West Myanmar Arc,which in turn influenced the deposition of sedimentary pyroclastic rocks from the Cretaceous to Eocene strata in the Central Myanmar Basin(CMB).The pore structure of these lithologic reservoirs is complex and rich in tuffaceous sandstone,which plays an adverse role in reservoir development in this *** understand the development characteristics and genetic mechanism of the pyroclastic rocks within three sets of reservoirs in this area,a comprehensive analysis was conducted through borehole core observations,thin section identification,scanning electron microscope analysis,and mercury injection *** tuffaceous sandstone from the upper Cretaceous to the Eocene is dominated by intermediate-acid volcanic rock *** pyroclastic rocks exhibit evident chloritization and ironization,with residual intergranular pores being the principal type accompanied by a smaller amount of intergranular dissolved pores and intragranular dissolved *** highest porosity is observed in the Eocene tuffaceous sandstone,ranging from 8%to 12%.The Late Cretaceous to Paleocene sandstones exhibit lower porosity levels of only 4%-6%.These reservoirs are characterized by their low porosity and *** the presence of a good source rock in this area,the volcanic debris particles filling the pores,as well as their subsequent devitrification,chloritization,and limonite mineralization,result in pore throat blockage and *** reservoirs in this area are small in size,exhibit poor reservoir connectivity and lateral continuity,and fail to meet the necessary conditions for commercial-scale hydrocarbon accumulation and migration.

关键词： Central Myanmar Basin back-arc basin reservoir characteristic volcanic debris

Design of high-temperature superconductors at moderate pressures by alloying AlH3 or GaH3

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Matter and Radiation at Extremes 2024年第1期9卷 94-103页

作者： xiaowei Liang Xudong Wei Eva Zurek Aitor Bergara Peifang Li Guoying Gao Yongjun Tian Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry State University of New York at BuffaloBuffaloNew York 14260-3000USA Physics Department and EHU Quantum Center University of the Basque CountryUPV/EHU48080 BilbaoSpain Donostia International Physics Center(DIPC) 20018 DonostiaSpain Centro de Física de Materiales CFM Centro Mixto CSIC-UPV/EHU20018 DonostiaSpain Extreme Conditions Physics Research Team College of Physics and Electronic InformationInner Mongolia Minzu UniversityTongliao 028043China

Since the discovery of hydride superconductors,a significant challenge has been to reduce the pressure required for their *** this context,we propose that alloying could be an effective strategy to achieve *** focus on a series of alloyed hydrides with the AMH_(6)composition,which can be made via alloying A15 AH_(3)(A=Al or Ga)with M(M=a group IIIB or IVB metal),and study their behavior under *** of them are predicted to maintain the A15-type structure,similar to AH_(3)under pressure,providing a platform for studying the effects of alloying on the stability and superconductivity of AH_(3).Among these,the A15-type phases of AlZrH_(6)and AlHfH_(6)are found to be thermodynamically stable in the pressure ranges of 40–150 and 30–181 GPa,***,they remain dynamically stable at even lower pressures,as low as 13 GPa for AlZrH_(6)and 6 GPa for AlHfH_(6).These pressures are significantly lower than that required for stabilizing A15 ***,the introduction of Zr or Hf increases the electronic density of states at the Fermi level compared with *** enhancement leads to higher critical temperatures(Tc)of 75 and 76 K for AlZrH_(6)and AlHfH_(6)at 20 and 10 GPa,*** the case of GaMH_(6)alloys,where M represents Sc,Ti,Zr,or Hf,these metals reinforce the stability of the A15-type structure and reduce the lowest thermodynamically stable pressure for GaH_(3) from 160 GPa to 116,95,80,and 85 GPa,*** noteworthy are the A15-type GaMH_(6)alloys,which remain dynamically stable at low pressures of 97,28,5,and 6 GPa,simultaneously exhibiting high Tc of 88,39,70,and 49 K at 100,35,10,and 10 GPa,***,these findings enrich the family of A15-type superconductors and provide insights for the future exploration of high-temperature hydride superconductors that can be stabilized at lower pressures.

关键词： alloying alloys superconductors

The risk of mpox importation and subsequent outbreak potential in Chinese mainland: a retrospective statistical modelling study

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Infectious Diseases of Poverty 2024年第1期13卷 63-73页

作者： xiaowei Deng Yuyang Tian Junyi Zoul Juan Yang Kaiyuan Sun Hongjie Yu School of Public Health Key Laboratory of Public Health SafetyMinistry of EducationFudan UniversityShanghai 200032China Division of International Epidemiology and Population Studies Fogarty International CenterNational Institutes of HealthBethesdaMDUSA

Background The 2022-2023 mpox(monkeypox)outbreak has spread rapidly across multiple countries in the non-endemic region,mainly among men who have sex with men(MSM).In this study,we aimed to evaluate mpox's importation risk,border screening effectiveness and the risk of local outbreak in Chinese *** We estimated the risk of mpox importation in Chinese mainland from April 14 to September 11,2022 using the number of reported mpox cases during this multi-country outbreak from *** and the international air-travel data from Official Aviation *** constructed a probabilistic model to simulate the effectiveness of a border screening scenario during the mpox outbreak and a hypothetical scenario with less stringent quarantine *** we further evaluated the mpox outbreak potential given that undetected mpox infections were introduced into men who have sex with men,considering different transmissibility,population immunity and population *** We found that the reduced international air-travel volume and stringent border entry policy decreased about 94% and 69% mpox importations *** the quarantine policy,15-19% of imported infections would remain *** a case of mpox is introduced into active MSM population with almost no population immunity,the risk of triggering local transmission is estimated at 42%,and would rise to>95% with over six *** Our study demonstrates that the reduced international air-travel volume and stringent border entry policy during the COvID-19 pandemic reduced mpox importations ***,the risk could be sub-stantially higher with the recovery of air-travel volume to pre-pandemic *** could emerge as a public health threat for Chinese mainland given its large MSM community.

关键词： Mpox(Monkeypox) Importation risk International air travel Statistical modelling Men who have sex with men

Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen Zhao xiaowei Liu Yujie Ouyang Chuan Xu Ying Shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune *** of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely ***,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule *** structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical *** way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic *** ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle *** this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

High-precision X-ray characterization for basic materials in modern high-end integrated circuit

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Journal of Semiconductors 2024年第7期45卷 12-24页

作者： Weiran Zhao Qiuqi Mo Li Zheng Zhongliang Li xiaowei Zhang Yuehui Yu National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China

Semiconductor materials exemplify humanity's unwavering pursuit of enhanced performance,efficiency,and functionality in electronic *** its early iterations to the advanced variants of today,this field has undergone an extraordinary *** the reliability requirements of integrated circuits continue to increase,the industry is placing greater emphasis on the crystal ***,conducting a range of characterization tests on the crystals has become *** paper will examine the correlation between crystal quality,device performance,and production yield,emphasizing the significance of crystal characterization tests and the important role of high-precision synchrotron radiation X-ray topography characterization in semiconductor ***,we will cover the specific applications of synchrotron radiation characterization in the development of semiconductor materials.

关键词： X-ray topography synchrotron radiation semiconductor materials crystal defects

Cloning and expression of a novel human HCUTA cDNA

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Chinese Science Bulletin 2000年第14期45卷 1301-1304页

作者： LUO Wenqin CHEN Jianhe ZHOU Haijun huang xiaowei ZHOU Van YUAN Jiangang QIANG Boqin Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Center of Human Genome ResearchBeijing 100005China

Copper is one of the most important trace elements to life. Human HCUTA is a novel cDNA encoding a 156aa protein, which may participate in human copper tolerance system. The HCUTA protein is highly similar to protein CUT A1 of E. coli. The whole opening reading frame of HCUTA cDNA was amplified by PCR and cloned into pET28a + express vector, and the HCUTA protein was effectively expressed in E. co/i BL21 (DE3).

关键词： copper tolerance system HCUTA cDNA prokaryotic expression.