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ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USIng A MOUSE MAMMARY TUMOR MODEL

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 49-55页

作者： FEIFAN zhOU xiaosong LI SHEng SOng JOSEPH T.ACQUAVIVA III ROMAN F.WOLF ERIC W.HOWARD WEI R.CHEN MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal University Guangzhou P.R.China Department of Oncology The First A±liated Hospital of Chinese PLA General Hospital Beijing 100048 P.R.China Department of Engineering and Physics University of Central Oklahoma Edmond OklahomaUSA Department of Comparative Medicine College of Medicine University of Oklahoma Health Sciences Center 940 S.L.Young Blvd.Oklahoma City OklahomaUSA Department of Cell Biology University of Oklahoma Health Sciences Center 940 S.L.Young Blvd. Oklahoma City OklahomaUSA

Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic *** immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer *** an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical *** further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were *** adoptive immunity transfer was perfomed using splenocytes as immune *** cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive ***,cytotoxicity and TNF-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was *** high level of infiltrating T cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune ***,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses.

关键词： Laser immunotherapy glycated chitosan anti-tumor immunity metastatic cancers

Bi-directional Selection in Upland Rice Leads to Its Adaptive Differentiation from Lowland Rice in Drought Resistance and Productivity

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Molecular Plant 2019年第2期12卷 170-184页

作者： Hui Xia zhi Luo Jie Xiong xiaosong Ma Qiaojun Lou Haibin Wei Jie Qiu Hua Yang Guolan Liu Longjiang Fan Liang Chen Lijun Luo Shanghai Agrobiological Gene Center Shanghai China College of Plant Sciences & Tech no logy Huazho ng Agricultural University Wuhan China lnstitute of Crop Science & Institute of Bioinformatics College of Agriculture and Biotechnology Zhejiang University Hangzhou China These authors contributed equally to this article.

Drought resistance is required in rice breeding to address the challenge of frequent droughts . However, the evolutionary mechanism of rice drought resistance is not fully understood. We investigated the genetic differentiation between upland and lowland rice domesticated in agro-ecosystems with contrasting water-soil conditions using genome-wide SNPs. We estimated morphological differences among upland and lowland rice in drought resistance and productivity through common garden experiments. Upland rice had better drought resistance but poorer productivity. The negative correlations between traits of drought resistance and productivity are attributed to the underlying genetic trade-offs through tight linkages (e.g., DCA1 and OsCesA7) or pleiotropic effects (e.g., LAX1). The genetic trade-offs are comm on and greatly shape the evolutio n of drought resista nee in upland rice . In genomic regions associated with both productivity and drought resistance, signs of balancing selection were detected in upland rice, while signs of directional selection were detected in lowland rice, potentially contributing to their adaptive differentiation. Signs of balancing selection in upland rice resulted from bi-directional selection during its domestication in drought-prone upland *** genome-wide association analysis, we ide ntified several valuable quantitative trait loci associated with drought resista nee, for which highly differentiated genes should be considered candidates. Bi-directional selection breaking tight linkages by accumulating recombination events would be applicable in breeding water-saving and droughtresistance rice.

关键词： drought resistance upland rice ecological adaptation ecotype trade-off domestication

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普洱茶中丙烯酰胺含量检测与生成机理研究

农业机械学报 2012年第3期43卷 123-129页

作者：李蕾张涛孙志健陈芳胡小松中国农业大学食品科学与营养工程学院北京100083 中国农业大学动物科技学院北京100094

对50份普洱茶样进行了检测,表明普洱茶样中丙烯酰胺(AA)含量总体较低(2.05～91.95 ng/g)。通过对渥堆茶样中AA生成量与蔗糖、葡萄糖、果糖含量进行相关性分析,得出蔗糖含量与AA生成量相关系数最大(R2=0.577 6),果糖次之(R2=0.497 7),葡... 详细信息

对50份普洱茶样进行了检测,表明普洱茶样中丙烯酰胺(AA)含量总体较低(2.05～91.95 ng/g)。通过对渥堆茶样中AA生成量与蔗糖、葡萄糖、果糖含量进行相关性分析,得出蔗糖含量与AA生成量相关系数最大(R2=0.577 6),果糖次之(R2=0.497 7),葡萄糖相关性最小(R2=0.256 7)。渥堆普洱茶样中天冬酰胺含量低于检测限,无法检出。同时结合文献推测认为普洱茶渥堆发酵过程中AA主要是通过丙烯醛途径生成,天冬酰胺途径贡献很小。

关键词：普洱茶丙烯酰胺生成机理渥堆发酵

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Clinical and economic benefits of a pharmacist in a multidisciplinary team for Chinese outpatients with gastrointestinal stromal tumors

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Journal of Chinese Pharmaceutical Sciences 2021年第7期30卷 598-605页

作者： Yi zhou Xingye Wu Juan Li Wei Cheng xiaosong Li Yifan Shen Jun zh.ng Department of Pharmacy the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Gastrointestinal Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China The Center for Clinical Molecular Medical Detection the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

The multidisciplinary approach is beneficial to the treatment of gastrointestinal stromal tumors(GISTs).However,pharmacists are seldom incorporated into a multidisciplinary team(MDT)of *** the present study,we evaluated the clinical and economic benefits of a pharmacist in an MDT of *** was a retrospective study that included 240 GIST patients receiving imatinib *** GIST MDT pharmacist developed and validated an HPLC method to monitor the trough concentrations of imatinib in GIST ***,the pharmacist also provided patient education and pharmaceutical care services and collected the data for *** 240 GIST patients received the services provided by the *** trough concentrations in 25.42%of the 240 patients were less than 1100 ng/m *** main genotypes of 121 in the 240 patients were KIT exon 11 mutations,wild type,and KIT exon 9 ***,13 GIST patients with trough concentrations less than 1100 ng/m L were confirmed to have low *** adverse reactions were primarily mild and tolerable,except that 13 GIST patients were adjusted to lower doses because of the intolerable adverse *** daily cost could be lowered by monitoring the trough concentrations and dose ***,a pharmacist included in a GIST MDT could increase the compliance of Chinese GIST patients to imatinib therapy and improve the efficacy,safety,and economy of imatinib therapy.

关键词： Pharmacist Imatinib Multidisciplinary team Gastrointestinal stromal tumor Trough concentration

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黄芪建中汤辅助中药穴位贴敷治疗对脾胃虚寒型慢性胃炎患者胃肠动力指标、炎症因子的影响

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反射疗法与康复医学 2023年第14期4卷 1-4页

作者：徐小松南通市第四人民医院内科江苏南通226000

目的探讨黄芪建中汤辅助中药穴位贴敷在脾胃虚寒型慢性胃炎(CG)患者中的应用价值。方法选择2019年1月—2021年12月该院收治的126例脾胃虚寒型CG患者为研究对象,按随机数字表法将其分为对照组与观察组。对照组(n=63)采用中药穴位贴敷治疗... 详细信息

目的探讨黄芪建中汤辅助中药穴位贴敷在脾胃虚寒型慢性胃炎(CG)患者中的应用价值。方法选择2019年1月—2021年12月该院收治的126例脾胃虚寒型CG患者为研究对象,按随机数字表法将其分为对照组与观察组。对照组(n=63)采用中药穴位贴敷治疗,观察组(n=63)采用黄芪建中汤辅助中药穴位贴敷治疗,两组均治疗14 d。对比分析两组胃肠动力指标、炎症因子、症状消失时间及不良反应发生情况。结果治疗后,观察组胃排空量为(19.54±2.78)%、基础胃酸分泌量为(3.15±0.27)mmol/h、最大胃酸分泌量为(14.98±2.14)mmol/h,均多于对照组的(16.98±3.01)%、(2.54±0.20)mmol/h、(13.69±2.10)mmol/h,白细胞介素(IL)-6水平为(14.84±2.05)pg/mL、IL-8水平为(35.26±4.19)ng/L、IL-17水平为(20.35±2.10)pg/mL、C反应蛋白水平为(7.53±1.04)mg/L,均低于对照组的(21.45±2.63)pg/mL、(47.61±5.20)ng/L、(29.67±2.48)pg/mL、(9.27±1.18)mg/L,组间差异有统计学意义(P<0.05);观察组反酸消失时间为(7.53±1.69)d、腹痛消失时间为(7.87±1.86)d、嗳气消失时间为(9.04±1.85)d,均短于对照组的(9.89±2.42)d、(8.91±1.83)d、(10.25±1.96)d,组间差异有统计学意义(P<0.05);两组治疗期间均未出现不良反应。结论黄芪建中汤辅助中药穴位贴敷可改善脾胃虚寒型CG患者胃肠动力,减轻机体炎症反应,促使嗳气、腹痛等症状缓解,且安全可靠。

关键词：慢性胃炎脾胃虚寒中药穴位贴敷黄芪建中汤胃肠动力指标炎症因子

饮用水消毒过程中溴代消毒副产物生成的研究进展

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环境科学与管理 2020年第11期45卷 106-110页

作者：查晓松厦门大学嘉庚学院环境科学与工程学院福建漳州363105

饮用水消毒过程中,消毒剂会与有机和无机前体物反应,生成消毒副产物。原水中溴离子的存在是导致消毒过程中溴代消毒副产物生成的根本原因,且溴离子浓度会影响消毒副产物的生成种类和浓度的分布。目前饮用水中已被检测出的溴代消毒副产... 详细信息

饮用水消毒过程中,消毒剂会与有机和无机前体物反应,生成消毒副产物。原水中溴离子的存在是导致消毒过程中溴代消毒副产物生成的根本原因,且溴离子浓度会影响消毒副产物的生成种类和浓度的分布。目前饮用水中已被检测出的溴代消毒副产物包括溴代三卤甲烷、溴代乙酸、溴代乙醛、溴代苯酚、溴代苯醌、溴代硝基甲烷、溴代乙酰胺、溴代乙腈、溴酸盐等。相比于氯代消毒副产物,溴代消毒副产物的浓度普遍较低,通常在n g/L~μg/L,但是却具有更高的细胞毒性和遗传毒性。溴代消毒副产物的生成机理、生物毒性评价及控制技术将是未来研究的重点。

关键词：饮用水消毒溴离子溴代消毒副产物

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离子对高效液相色谱荧光检测法测定四环素类药物

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分析化学 2000年第6期28卷 745-748页

作者：熊耀华刘轶春屈健张孝松林长山中国科学技术大学化学系!合肥230026 安徽省立医院药剂科

报道了利用Al3+作为柱前衍生试剂，高效液相色谱分离荧光检测法检测测定四环素类药物的新方法。探讨了四环素类药物-Al3+络合物的衍生条件及其色谱分离条件对荧光强度的影响，3种药物的检出限达70－150pg。

关键词：高效液相色谱法四环素类药物荧光检测铝(Ⅲ) 柱前衍生

Assessment of matrix effect in quantitative analysis of acrylamide in teas based on LC-MS/MS

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Assessment of matrix effect in quantitative analysis of acry...

中国食品科学技术学会第五届年会暨第四届东西方食品业高层论坛

作者： Jie Liu FangChen Ganghuazhao xiaosong Hu Yuan Yuan (College of Food Science & Nutritional Engineering,China Agricultural University,Beijing 100083,China)

A liquid chromatography-tandem mass spectrometry(LC-MS/MS)method was developed for the quantitative analysis of acrylamide in tea samples.13C3-labelled acrylamide was used as internal *** was extracted at 25℃ for 20 min by I0 ml water in an incubated horizontal shaker, and then 10 ml acetonitrile,4 g of magnesium sulfate and 0.5 g of sodium chloride were added into the aqueous extract and mixed *** salt combination induced separation of water and acetonitrile layers and forced the majority of acrylamide into the acetonitrile layer.9 ml acetonitrile was taken and concentrated to 0.5 *** single Oasis MCX solid-phase extraction(SPE)was carried out for clean-up. The final extract was analyzed by LC-MS/MS in positive ionization *** standard lines were prepared in different systems of standard solutions to evaluate the presence of matrix effect,assay accuracy,precision,and *** first system was prepared to evaluate the MS/MS response for neat standards of two analytes(acrylamide and 13C3-labelled acrylamide).The second system was prepared in tea extracts spiked two analytes after *** third system was prepared in tea extracts spiked two analytes before *** results showed that acrylamide and 13C3-labelled acrylamide had different matrix effect exhibiting ion suppression(92%)and ion enhancement(102%), *** recovery efficiency of the acrylamide and 13C3-labelled acrylamide agreed with each other(76%),while the overall process efficiencies containing matrix effect were different(69% and 78%,respectively).The levels of acrylamide of all tea samples were less than 100 ng/***,oolong, white and yellow tea samples had quite low acrylamide content(＜20 ng/g).High acrylamide levels occurred in baked,roasted,and one sun-dried green tea samples(46-94 ng/g).

关键词： Acrylamide Tea Liquid chromatography-mass spectrometry Quantitative anlaysis Matrix effect

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卫星式柔印机印刷套印问题的分析

包装前沿 2019年第1期 24-25页

作者：韩奎李小松陕西北人

卫星式柔版印刷机在调试过程中,出现印刷套印不准会有不同的情况。本文详细介绍了不同情况下出现套印不准的原因及处理办法。

关键词：柔印机印刷套印不准卫星式柔版印刷机调试过程