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Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla

Science China(Life Sciences) 2023年第5期66卷 1170-1182页

作者： Datian Lang xiaoping wang Chunbing Liu Weihang Geng David M.Irwin Shanyuan Chen Chunqing Li Li Yu Heng Xiao School of Life Sciences Yunnan UniversityKunming 650500China School of Ecology and Environmental Science Yunnan UniversityKunming 650091China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan UniversityKunming 650091China Biodiversity Research Center of Wumeng Mountain Department of Agronomy and Life ScienceZhaotong UniversityZhaotong 657000China Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada

RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease(RNase)A superfamily,a gene family that is widely used as a model for molecular evolutionary ***,we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this ***,RNase9experienced an evolutionary scenario of“birth and death”in Ruminantia,and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues(epididymis,vas deferens or prostate).This expression pattern combined with the estimate that these genes duplicated during the middle Eocene,a time when Ruminantia become a successful lineage,suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this *** contrast,all RNase9 genes were lost in the Cetacean lineage,which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean *** study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla,providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment.

关键词： RNase9 gene duplication gene loss Cetartiodactyla

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An Iterative Thresholding Method for the Heat Transfer Problem

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Annals of Applied Mathematics 2023年第3期39卷 264-280页

作者： Luyu Cen xiaoping wang Department of Mathematics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of Science and Engineering The Chinese University of Hong KongShenzhenGuangdong 518172China Shenzhen International Center for Industrial and Applied Mathematics Shenzhen Research Institute of Big DataShenzhenGuangdong 518172China

In this paper,we propose a simple energy decaying iterative thresholding algorithm to solve the heat transfer *** material domain is implicitly represented by its characteristic function,and the problem is formulated into a minimum-minimum *** prove that the energy is decreasing in each *** experiments for two types the heat transfer problems(volume to point and volume to sides)are performed to demonstrate the effectiveness of the proposed methods.

关键词： Optimization in heat transfer convolution thresholding

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Efficacy of Williams LifeSkills Training in improving psychological health of Chinese male juvenile violent offenders:a randomized controlled study

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Neuroscience Bulletin 2015年第1期31卷 53-60页

作者： Simei Zhang Hong wang Chen Chen Jiansong Zhou xiaoping wang Mental Health Institute of the Second Xiangya Hospital Central South University

This randomized controlled study was conducted to evaluate the efficacy of Williams Life Skills Training（WLST） as a means ofimproving the psychological health of Chinese male juvenile violent ***-six participants were assigned randomly to receive the usual intervention plus 8 weeks of WLST（study group,n = 33） or only the usual intervention（control group,n = 33）. We found that the study group exhibited significantly decreased State-Trait Anxiety Inventory（STAI X-1,X-2） STAX2 scores and Trait Coping Style Questionnaire（TCSQ） negative scores,and increased Interpersonal Support Evaluation List（ISEL） tangible scores from baseline to 9 weeks later（P 〈0.01）. In addition,a between-group difference in changes of TCSQ negative score was observed at the end of week 9（P 〈0.05）. These fi ndings suggest that WLST can improve trait anxiety,coping style,and interpersonal support in male Chinese juvenile violent offenders.

关键词： violent offenders juvenile Williams Life Skills Training psychological health

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Involuntary admission and treatment of patients with mental disorder

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Neuroscience Bulletin 2015年第1期31卷 99-112页

作者： Simei Zhang Graham Mellsop Johann Brink xiaoping wang Mental Health Institute of The Second Xiangya Hospital Hunan Province Technology Institute of PsychiatryKey Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South University Waikato Clinical School University of Auckland University of British Columbia VancouverBritish ColumbiaCanada

Despite the efforts of the World Health Organization to internationally standardize strategies for mental-health care delivery,the rules and regulations for involuntary admission and treatment of patients with mental disorder still differ markedly across countries. This review was undertaken to describe the regulations and mental-health laws from diverse countries and districts of Europe（UK,Austria,Denmark,France,Germany,Italy,Ireland,and Norway）,the Americas（Canada,USA,and Brazil）,Australasia（Australia and New Zealand）,and Asia（Japan and China）. We outline the criteria and procedures for involuntary admission to psychiatric hospitals and to community services,illustrate the key features oflaws related to these issues,and discuss their implications for contemporary psychiatric practice. This review may help to standardize the introduction oflegislation that allows involuntary admission and treatment of patients with mental disorders in the mainland of China,and contribute to improved mental-health care. In this review,involuntary admission or treatment does not include the placement of mentally-ill offenders,or any other aspect of forensic psychiatry.

关键词： involuntary admission involuntary treatment mental-health legislation compulsory admission commitment criteria

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Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury

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Neural Regeneration Research 2013年第1期8卷 64-69页

作者： Xiaodan wang Jinming Xu Jieqin Gong Hui Shen xiaoping wang Department of Neurology Shanghai First People's Hospital Shanghai Jiao Tong University School of Medicine Department of Neurology Suzhou Kowloon Hospital Shanghai Jiao Tong University School of Medicine

Netrin-1 is currently one of the most highly studied axon guidance factors. Netrin-1 is widely expressed in the embryonic central nervous system, and together with the deleted in colorectal cancer and uncoordinated locomotion-5 homolog B receptors, netrin-1 plays a guiding role in the construction of neural conduction pathways and the directional migration of neuronal cells. In this study, we established a rat middle cerebral artery ischemia reperfusion model using the intraluminal thread technique. Immunofluorescence microscopy showed that the expression of netrin-1 and deleted in colorectal cancer in the ischemic penumbra was upregulated at 1 day after reperfusion, reached a peak at 14 days, and decreased at 21 days. There was no obvious change in the expression of uncoordinated locomotion-5 homolog B during this time period. Double immunofluorescence labeling revealed that netrin-1 was expressed in neuronal cells and around small vessels, but not in astrocytes and microglia, while deleted in colorectal cancer was localized in the cell membranes and protrusions of neurons and astrocytes. Our experimental findings indicate that netrin-1 may be involved in post-ischemic repair and neuronal protection via deleted in colorectal cancer receptors.

关键词： neural regeneration brain injury cerebral ischemia and reperfusion netrin-1 uncoordinatedlocomotion-5 homolog B deleted in colorectal cancer neuron brain injury grant-supported paper photographs-containing paper neuroregeneration

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Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution

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Science Bulletin 2018年第20期63卷 1358-1363页

作者： Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li xiaoping wang Yi wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma College of Chemistry and Molecular Engineering Peking University Beijing 100871China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Syncat@Beijing Synfuels China Technology Co. LtdBeijing 101407China State Key Laboratory of Separation Membranes and Membrane Processes Department of Chemical Engineering Tianjin Polytechnic UniversityTianjin 300387China

Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts.

关键词： Wet-chemistry synthesis Bimetallic transition metal carbide Iron Cobalt Hydrogenation evolution reaction

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OSCILLATION CRITERIA FOR ODD-ORDER DELAYED DIFFERENCE EQUATIONS

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Annals of Differential Equations 2007年第4期23卷 505-510页

作者： wang xiaoping Dept. of Math. Xiangnan University Chenzhou 423000 Hunan

In this paper,we obtain some oscillation criteria to an odd-order delayed difference equation.

关键词： oscillation nonoscillation delay difference equation

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Engineering human seleno-glutaredoxin containing consecutive rarecodons as an artificial glutathione peroxidase

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Chinese Science Bulletin 2012年第1期57卷 25-32页

作者： ZHANG Wei LUO Quan wang xiaoping ZHANG DongMei MIAO Lu XU JiaYun LUO GuiMin SHEN JiaCong LIU JunQiu State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin UniversityChangchun 130012China

The active center of human glutaredoxin(hGrx1)shares a common thioredoxin fold and specific affinity for substrate glutathione (GSH)with natural glutathione peroxidase(GPx).hGrx1 was redesigned to introduce the catalytic selenocysteine residue to imi- tate the function of antioxidant selenoenzyme GPx in *** human hGrx1 scaffold is a good candidate for potential medical application compared with other animal-originated protein *** consecutive rare codons(AGG-AGG)in the open reading frame of hGrx1 mRNA encoding Arg26-Arg27 residues can reduce seleno-hGrx1 expression level significantly in the Cys auxotrophic Escherichia coli strain ***,we optimized the rare codons,which resulted in a remarkable in- crease of the expression level in the Cys auxotrophic cells,which may be sufficient for future medical *** engineered artificial selenoenzyme displays high GPx catalytic activity,rivaling that of some natural GPx *** analysis of the engineered seleno-hGrx1 showed a typical ping-pong kinetic mechanism;its catalytic properties are similar to those of some nat- urally occurring GPx proteins.

关键词：谷胱甘肽过氧化酶稀有密码子氧工程硒硫氧还蛋白营养缺陷型动力学机制人造

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EmotionIC: emotional inertia and contagion-driven dependency modeling for emotion recognition in conversation

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Science China(Information Sciences) 2024年第8期67卷 130-146页

作者： Yingjian LIU Jiang LI xiaoping wang Zhigang ZENG School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Key Laboratory of Brain-inspired Intelligent Systems Huazhong University of Science and Technology Key Laboratory of Image Processing and Intelligent Control (Huazhong University of Science and Technology) Ministry of Education Institute of Artificial Intelligence Huazhong University of Science and Technology

Emotion recognition in conversation(ERC) has attracted growing attention in recent years as a result of the advancement and implementation of human-computer interface technologies. In this paper,we propose an emotional inertia and contagion-driven dependency modeling approach(EmotionIC) for ERC tasks. Our EmotionIC consists of three main components, i.e., identity masked multi-head attention(IMMHA), dialogue-based gated recurrent unit(DiaGRU), and skip-chain conditional random field(SkipCRF).Compared to previous ERC models, EmotionIC can model a conversation more thoroughly at both the feature-extraction and classification levels. The proposed model attempts to integrate the advantages of attention-and recurrence-based methods at the feature-extraction level. Specifically, IMMHA is applied to capture identity-based global contextual dependencies, while Dia GRU is utilized to extract speaker-and temporal-aware local contextual information. At the classification level, SkipCRF can explicitly mine complex emotional flows from higher-order neighboring utterances in the conversation. Experimental results show that our method can significantly outperform the state-of-the-art models on four benchmark *** ablation studies confirm that our modules can effectively model emotional inertia and contagion.

关键词： emotion recognition in conversation emotional inertia and contagion multi-head attention gated recurrent unit conditional random field

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Procedural learning changes in patients with Wilson's disease

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Neural Regeneration Research 2011年第18期6卷 1410-1414页

作者： Yumei Jiang Xiang Shen xiaoping wang Wenjie Li Department of Neurology First People's Hospital of Shanghai Jiao Tong University Shanghai 200080 China

In the present study, we compared explicit memory performance, using the Wechsler Memory Scale and implicit memory performance, using the Nissen software version of the serial reaction time task, in patients with Wilson＇s disease to normal controls. The Wilson＇s disease patients exhibited deficits in explicit memory tasks, such as figure recall and understanding memory. Moreover, the Wilson＇s disease patients exhibited deficits in implicit memory tasks, including significantly prolonged response times. These findings indicate that Wilson＇s disease patients have explicit and implicit partial memory impairments.

关键词： Wilson's disease basal ganglia procedural learning Wechsler Memory Scale sedal reaction time task cognitive neuroscience neural regeneration

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