Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla

作     者：Datian Lang Xiaoping Wang Chunbing Liu Weihang Geng David M.Irwin Shanyuan Chen Chunqing Li Li Yu Heng Xiao 

作者机构：School of Life SciencesYunnan UniversityKunming 650500China School of Ecology and Environmental ScienceYunnan UniversityKunming 650091China State Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China Biodiversity Research Center of Wumeng MountainDepartment of Agronomy and Life ScienceZhaotong UniversityZhaotong 657000China Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoOntario M5S 1A8Canada 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第5期

页      面：1170-1182页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities(202001AO070195) the National Natural Science Foundation of China(31925006) the Applied Basic Research General Project of Yunnan Science Technology Department(202001BB050058) 

主　　题：RNase9 gene duplication gene loss Cetartiodactyla 

摘      要：RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease(RNase)A superfamily,a gene family that is widely used as a model for molecular evolutionary ***,we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this ***,RNase9experienced an evolutionary scenario of“birth and deathin Ruminantia,and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues(epididymis,vas deferens or prostate).This expression pattern combined with the estimate that these genes duplicated during the middle Eocene,a time when Ruminantia become a successful lineage,suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this *** contrast,all RNase9 genes were lost in the Cetacean lineage,which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean *** study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla,providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment.