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Effect of Liuweidihuang pill and Jinkuishenqi pill on inhibition of spontaneous breast carcinoma growth in mice

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Journal of Traditional Chinese Medicine 2015年第4期35卷 453-459页

作者： Zheng Lixiang Liu Hongning Gong Yan Meng Xianming Jiang Runde wang xiaomin wang Qiaofeng wang Yue School of Basic Medicine Jiangxi University of Traditional Chinese Medicine

OBJECTIVE: To investigate the preventing and treating action of Liuweidihuang pill(LP) and Jinkuishenqi pill(JP) on spontaneous breast carcinoma in ***: A model of spontaneous breast carcinoma was derived from 11.5-month-old female Kunming breeding mice following the delivery of several litters. The mice were randomly divided into five groups: model control group(C),Liuweidihuang pill high-dose group(LH; 4.6 g·kg1·d1),Liuweidihuang pill low-dose group(LL;2.3 g·kg1·d﹣1),Jinkuishenqi pill high-dose group(JH; 4.6 g·kg﹣1·d1) and Jinkuishenqi pill low-dose group(JL;2.3 g·kg﹣1·d﹣1). Cancer tissue volume was measured by water immersion. Histopathology was analyzed by hematoxylin and eosin staining. Vascular endothelial growth factor(VEGF),extracellular signal-regulated kinase(ERK) and cyclin D1 protein expression in cancer tissue was assayed by western ***: Compared with the control group,cancer tissue volume and weight were lower in the LP and JP groups,and survival time was longer. The expression of VEGF,ERK and Cyclin D1 were inhibited in the LP and JP groups(P < 0.05),and cell differentiation was increased. Tumor weights and volumes and VEGF,ERK and Cyclin D1 expression in LL or LH were significantly lower than in JL and JH(P < 0.01).CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation;moreover,LP was more effective than JP The likely mechanism of action was via inhibition of VEGF,ERK and cyclin D1.

关键词： Breast neoplasms Pathology Vascular endothelial growth factors Extracellular signal-reg-ulated MAP kinases Cyclin D1 Liuweidihuang pill Jinkuishenqi pill

Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer

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Journal of Genetics and Genomics 2018年第1期45卷 47-50页

作者： Chong Feng xiaomin wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai Beijing SINOGENE Biotechnology Co. Ltd Beijing 102200 China Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China University of Chinese Academy of Sciences Beijing 100049 China College of Veterinary Medicine China Agricultural University Beijing 100193 China Jilin Provincial Key Laboratory of Animal Embryo Engineering College of Veterinary Medicine Jilin University Changchun 130062 China

Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors （WHO）. Athero- sclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall （Gofman and Lindgren, 1950）. Tremendous clinical and experimental efforts have been made to reveal the pathogenesis of the disease. Nevertheless, the mechanism of atherosclerosis is still unclear. A suitable animal model to study metabolic disorders and subsequent atherosclerosis is a necessity. The traditional method by feeding high fat diet to establish animal models of atherosclerosis disease is time- consuming and laborious, and in many circumstances, the pheno- types are not consistent among the individual models.

关键词： Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer

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基于粒子群优化的ATO控制策略

铁道学报 2017年第3期39卷 53-58页

作者：李诚王小敏西南交通大学信息科学与技术学院四川成都611756

传统列车自动驾驶(ATO)控制策略通过提高对目标速度的追踪精度来精确控制工况切换频繁,能耗较大且无法进行全局优化。直接控制列车驾驶的全局ATO控制策略能较好解决传统控制策略的缺陷。列车在自动运行过程中依据不同的全局控制策略,能... 详细信息

传统列车自动驾驶(ATO)控制策略通过提高对目标速度的追踪精度来精确控制工况切换频繁,能耗较大且无法进行全局优化。直接控制列车驾驶的全局ATO控制策略能较好解决传统控制策略的缺陷。列车在自动运行过程中依据不同的全局控制策略,能耗、运行时间误差、停站误差等评价指标均产生变化。由于评价指标存在内部矛盾,不存在所有指标均最优的控制策略。本文提出1种基于动态邻居和广义学习策略的粒子群(ADPSO)优化全局控制策略的算法。该算法通过挖掘线路信息和列车运行信息指导优化过程,以获得在列车安全运行的前提下,满足一定能耗、运行时间误差和停站误差要求的全局ATO控制策略。仿真研究结果表明与其他两种优化算法相比,该算法具有更好的性能。

关键词：列车自动控制全局ATO控制策略 ADPSO算法

Endogenous auxin and its manipulation influence in vitro shoot organogenesis of citrus epicotyl explants

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Horticulture Research 2017年第1期4卷 26-31页

作者： Wei Hu Sabrina Fagundez Lorenzo Katin-Grazzini Yanjun Li Wei Li Yingnan Chen xiaomin wang Ziniu Deng Shenxi Xie Richard J McAvoy Yi Li National Center for Citrus Improvement Horticulture and Landscape CollegeHunan Agricultural UniversityChangsha410128People’s Republic of China Department of Plant Science and Landscape Architecture University of ConnecticutStorrs06269CTUSA Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing210014People’s Republic of China

Endogenous auxin is an important regulator of in vivo organ development,but its role in in vitro organogenesis is *** has been observed that the basal end of epicotyl cuttings of juvenile citrus seedlings produces fewer shoots than the apical ***,we report that elevated endogenous auxin levels in the basal end of citrus epicotyl cuttings are inhibitory for in vitro shoot *** transgenic citrus plants expressing an auxin-inducible GUS reporter gene,we have observed elevated levels of auxin at the basal end of stem cuttings that are mediated by polar auxin *** endogenous auxin or blocking polar auxin transport enhances shoot *** auxin transport inhibitor,N-1-naphthylphthalamic acid(NPA),can also enhance shoot organogenesis independent of its action on polar auxin ***,we demonstrate that the promotional effects of depleting endogenous auxin or blocking polar auxin transport on shoot organogenesis are *** study thus provides meaningful insights into possible roles of endogenous auxin and polar auxin transport,as well as auxin–cytokinin interactions,in in vitro shoot ***,our results may also provide practical strategies for improving in vitro shoot organogenesis for citrus and many other plant species.

关键词： organogenesis citrus endogenous

Feasibility Verification of Train Operations Using Petri Nets

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Feasibility Verification of Train Operations Using Petri Net...

双重化PWM整流器自抗扰模型预测直接功率控制

第32届中国控制与决策会议

作者： Luxi wang Yin Tong xiaomin wang School of Information Science and Technology Southwest Jiaotong University

Train punctuality and safe operation are two of the most basic requirements for rail transport. As train speeds and operating densities continue to increase, trains cannot operate in accordance with operational plans sometimes. Feasibility verification of train operation plans is particularly important. In this paper, Petri nets are used as a formalization tool. The basic Petri net models of the trains in the different situations: overtaking, following and station avoidance are established. Based on the idea of modularly modeling and the evolution law of Petri nets, the algorithm of constructing the Petri net model for the potential operation plan is proposed. Then according to the time constraints of the train operation, the time factors are assigned to the corresponding transitions in the Petri net model. Finally, the time Petri net simulation software TINA is used to calculate the reachability graph of the Petri net model and to determine whether the given train operations scheduling meets the station requirements.

关键词： Railway transportation system Discrete event system Formal verification Petri nets

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电力系统保护与控制 2024年第7期52卷 45-56页

作者：王新菊王小敏西南交通大学信息科学与技术学院四川成都611756

针对车载双重化脉宽调制(pulse width modulation,PWM)整流器控制性能易受到模型不确定性和列车运行条件(输入电压、功率等级、电路参数等)变化影响的问题,提出一种基于自抗扰控制(active disturbance rejection control,ADRC)和模型预... 详细信息

针对车载双重化脉宽调制(pulse width modulation,PWM)整流器控制性能易受到模型不确定性和列车运行条件(输入电压、功率等级、电路参数等)变化影响的问题,提出一种基于自抗扰控制(active disturbance rejection control,ADRC)和模型预测直接功率控制(model predictive direct power control,MPDPC)的双闭环控制算法。其中,外环基于自抗扰控制理论,构建了基于误差驱动的ADRC(error-based ADRC,EADRC)控制器调节直流侧电压;内环结合基于内模原理的功率补偿方案使用两步MPDPC算法实现电流信号的控制。仿真和实验将所提自抗扰模型预测直接功率控制(ADRC-MPDPC)算法与传统基于比例积分的直接功率控制(proportional integral-based direct power control,PI-DPC)算法和PI-MPDPC方法进行对比,结果表明所提策略在系统启动、负载变化及工况切换等场景表现出更优的动态特性和鲁棒性能。

关键词：双重化PWM整流器自抗扰控制模型预测控制直接功率控制

Two inverse methods for characterization of an inaccessible thin film under a plate by low-frequency ultrasound

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Chinese Journal of Acoustics 2010年第3期29卷 230-241页

作者： wang Yang MAO Jie LI Mingxuan wang xiaomin National Laboratory of Acoustics Institute of AcousticsChinese Academy of Sciences Beijing 100190

Two ultrasonic methods were studied for determining the parameters of a composite consisting of a soft thin film attached beneath a hard plate substrate from resonant frequencies and amplitude spectra in low frequency region,*** of the sensitivity function, the objective function and the error transfer function were presented for discussing the effects of the two methods for both single parameter and two-parameter *** techniques were employed in experiment to characterize a composite consisting of a film attached beneath an aluminum plate substrate with a 7 MHz center frequency broadband *** was observed that the results were similar for single parameter inversion and the method based on resonant frequencies got better result for two-parameter inversion under the same condition. The relative errors of the method based on resonant frequencies for inversing acoustic impedance and time-of-flight were 3.4%and 4.7%,respectively,and the method based on amplitude spectra got no results.

关键词： Two inverse methods for characterization of an inaccessible thin film under a plate by low-frequency ultrasound

A Microarray Analysis of Parkinson’s Disease: New Clues and Evaluation

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Journal of Biosciences and Medicines 2015年第9期3卷 55-60页

作者： Lirong Huo Xibin Liang Yi He xiaomin wang Department of Neurology Fu Xing Hospital Capital Medical University Beijing China Department of Physiology Key Laboratory for Neurodegenerative Disorders of the Ministry of Education Captal Medical University Beijing China Department of Neurology Stanford University Stanford USA

Parkinson’s disease (PD) is complex and most likely results from an unknown combination of genetic and environmental factors. Here, we defined discrete genes (DGs) in a microarray analysis and found that the percentage of DGs versus all analyzable genes correlated with PD progression. Furthermore, this new parameter was also easily used to evaluate the therapeutic effect of high- frequency electro-acupuncture (EA), thus improving symptoms of PD model rats.

关键词： Parkinson’s Disease 6-OHDA Microarray Discrete Genes Cortex Striatum

Ultrasonic field radiated by a normal shear wave probe

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Chinese Journal of Acoustics 2007年第1期26卷 85-96页

作者： WU Di LI Mingxuan wang xiaomin CHENG Yue WU DiChinese Academy of Sciences Beijing 100080

The field of horizontally polarized ultrasonic shear wave radiated by a 2/2 piezoelectric composite normal probe was studied. The strictly analytic field solutions for two different surface forces were deduced and the field distribution and directivity patterns were given by numerical calculations. The vertical radiated field of shear wave was obtained theoretically and compared with experiment. The experimental result of directivity pattern conformed the theoretical prediction, which provided the theoretical basis for the engineering application of the transducer.

关键词： piezoelectric composite engineering application theoretical prediction numerical calculations field distribution theoretical basis different surface