检索结果-南通市图书馆

Thermoelectric performance enhancement by manipulation of Sr/Ti doping in two sublayers of Ca_(3)Co_(4)O_(9)

Journal of Advanced Ceramics 2020年第6期9卷 769-781页

作者： Li ZHANG Yichen LIU Thiam Teck TAN Yi LIU Jian zheng Yanling YANG xiaojiang HOU Lei FENG Guoquan SUO Xiaohui YE Sean LI Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic Materials School of Materials Science and EngineeringShaanxi University of Science&TechnologyXi’an 710021China UNSW Materials and Manufacturing Futures Institute School of Material Science and EngineeringThe University of New South WalesKensingtonNew South Wales2052Australia

Thermoelectric(TE)performance of Ca_(3)Co_(4)O_(9)(CCO)has been investigated extensively via a doping strategy in the past ***,the doping sites of different sublayers in CCO and their contributions to the TE performance remain unrevealed because of its strong correlated electronic *** this work,Sr and Ti are chosen to realize doping at the[Ca_(2)CoO_(3)]and[CoO_(2)]sublayers in *** was found that figure of merit(ZT)at 957 K of Ti-doped CCO was improved 30% than that of undoped CCO whereas 1 at% Sr doping brought about a 150% increase in ZT as compared to undoped *** significant increase in electronic conductivity and the Seebeck coefficient are attributed to the enhanced carrier concentration and spin-entropy of Co^(4+) originating from the Sr doping effects in[Ca_(2)CoO_(3)]sublayer,which are evidenced by the scanning electron microscope(SEM),Raman,Hall,and X-ray photoelectron spectroscopy(XPS)***,the reduced thermal conductivity is attributed to the improved phonon scattering from heavier Sr doped Ca site in[Ca_(2)CoO_(3)]*** findings demonstrate that doping at Ca sites of[Ca_(2)CoO_(3)]layer is a feasible pathway to boost TE performance of CCO material through promoting the electronic conductivity and the Seebeck coefficient,and reducing the thermal conductivity *** work provides a deep understanding of the current limited ZT enhancement on CCO material and provides an approach to enhance the TE performance of other layered structure materials.

关键词： layered structures manipulation doping sites Ca_(3)Co_(4)O_(9)(CCO) spin-entropy thermoelectric performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TGF-β-induced CD4+FoxP3+regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model

引用

Cellular & Molecular Immunology 2021年第11期18卷 2516-2529页

作者： Jingrong Chen Feng Huang Yuluan Hou Xiaorong Lin Rongzhen Liang xiaojiang Hu Jun Zhao Julie Wang Nancy Olsen Song Guo zheng Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Internal Medicine Division of RheumatologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Division of Rheumatology Department of MedicinePenn State University Hershey Medical CenterHersheyPAUSA

CD4^(+)FOXP3^(+)Treg cells are central to the maintenance of self-tolerance and can be defective in *** autoimmune rheumatic diseases,dysfunctional self-tolerance,is to a large extent,caused by insufficient Treg-cell *** nTregs have therapeutic effects in vivo,their relative scarcity and slow rate of in vitro expansion hinder the application of nTreg *** was previously reported that EVs contribute significantly to the suppressive function of FOXP3^(+)Treg *** that the stability and plasticity of nTregs remain major challenges in vivo,we established EVs derived from in vitro TGF-β-induced Treg cells(iTreg-EVs)and assessed their functions in a murine model of autoimmune *** results demonstrated that iTreg-EVs preferentially homed to the pathological joint and efficiently prevented the imbalance in Th17/Treg cells in arthritic ***,we found that miR-449a-5p mediated Notch1 expression modulation and that miR-449a-5p knockdown abolished the effects of iTreg-EVs on effector T cells and regulatory T cells in vitro and in *** together,our results show that iTreg-EVs control the inflammatory responses of recipient T cells through miR-449a-5p-dependent modulation of Notch1 and ameliorate the development and severity of arthritis,which may provide a potential cell-free strategy based on manipulating iTreg-EVs to prevent autoimmune arthritis.

关键词： EVs iTreg Arthritis Th17 MicroRNA Notch1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance

引用

Cellular & Molecular Immunology 2021年第10期18卷 2410-2421页

作者： Bing Wu Ge Zhang Zengli Guo Gang Wang xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian zheng Yisong Y.Wan Lineberger Comprehensive Cancer Center School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Immunology College of Basic Medical ScienceDalian Medical UniversityDalianLiaoning 116044China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhouJiangsu221002China Integrative Bioinformatics National Institute of Environmental Health SciencesResearch Triangle ParkChapel HillNC 27709USA Department of Genetics School of MedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Acute viral infection causes illness and *** addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly *** its initial identification as a marker for resident memory CD8^(+)T cells in barrier tissues,the function and regulation of CD103 integrin(encoded by ITGAE gene)have been extensively ***,the function and regulation of the resident CD103^(+)CD8^(+)T cell response to acute viral infection remain *** TGFβsignaling is essential for CD103 expression,the precise molecular mechanism behind this regulation is ***,we reveal a TGFβ–SKI–Smad4 pathway that critically and specifically directs resident CD103^(+)CD8^(+)T cell generation for protective immunity against primary and secondary viral *** found that resident CD103^(+)CD8^(+)T cells are abundant in both lymphoid and nonlymphoid tissues from uninfected ***103 acts as a costimulation signal to produce an optimal antigenic CD8^(+)T cell response to acute viral *** is a reduction in resident CD103^(+)CD8^(+)T cells following primary infection that results in increased susceptibility of the host to secondary ***,CD103 expression inversely and specifically correlates with SKI proto-oncogene(SKI)expression but not R-Smad2/3 *** expression of SKI restricts CD103 expression in CD8^(+)T cells in vitro and in vivo to hamper viral ***,SKI is recruited to the Itgae loci to directly suppress CD103 transcription by regulating histone acetylation in a Smad4-dependent *** study therefore reveals that resident CD103^(+)CD8^(+)T cells dictate protective immunity during primary and secondary *** with SKI function may amplify the resident CD103^(+)CD8^(+)T cell response to promote protective immunity.

关键词： CD103 TGFβ SKI Smad4 LCMV infection Histone acetylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 2082-2094页

作者： Ze Xiu Xiao xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo zheng Department of Clinical Immunology The Third Affiliated Hospital at Sun Yat-sen University510630 GuangzhouChina Department of Internal Medicine Ohio State University College of Medicine and Wexner Medical CenterColumbusOH 43210USA Department of Medicine Penn State College of MedicineHersheyPA 17033USA Laboratory of Human Diseases and Immunotherapy West China HospitalSichuan UniversityChengduChina Department of Internal Medicine The First Hospital of Harbin Medical UniversityHarbinChina Department of Allergy and Clinical Immunology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Pediatrics and Microbiology-Immunology Georgetown University Medical CenterWashingtonDCUSA

The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary *** sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including *** the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE *** used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient *** observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC *** treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in *** of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced *** mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal *** p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune *** together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of ***,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.

关键词： STAT1 lupus prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications

引用

Chinese Journal of Cancer Research 2014年第1期26卷 104-111页

作者： Zhixue zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Central Laboratory Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Clinical Gastric Cancer Translational Research Laboratory Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Biological Tissue BankPeking University Cancer Hospital&Institute

Objective：The programmed cell death-1 receptor/programmed cell death-1 ligand （PD-1/PD-L1） pathway plays a crucial role in tumor evasion from host *** study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric ***：Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present *** PD-L1 expression was tested by enzymelinked immunosorbent assay （ELISA）.The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed ***：Expression of PD-L1 in advanced gastric cancer patients was significandy up-regulated compared with health people （P=0.006）.The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis （P=0.026 and P=0.041,respectively）.Although we didn＇t find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients （65.6％ vs.44.7％,P=0.028）.Conclusions：PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis.

关键词： Programmed cell death-1 ligands (PD-L1) tumor immunity advanced gastric cancer enzyme-linked immunosorbent assay (ELISA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Face Detection Detection, Alignment Alignment, Quality Assessment and Attribute Analysis with Multi-Task Hybrid Convolutional Neural Networks

引用

ZTE Communications 2019年第3期17卷 15-22,49页

作者： GUO Da zheng Qingfang PENG xiaojiang LIU Ming Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China ZTE Corporation ShenzhenGuangdong 518057China State Key Laboratory of Mobile Network and Mobile Multimedia Technology ShenzhenGuangdong 518057China

This paper proposes a universal framework,termed as Multi-Task Hybrid Convolutional Neural Network(MHCNN),for joint face detection,facial landmark detection,facial quality,and facial attribute *** consists of a high-accuracy single stage detector(SSD)and an efficient tiny convolutional neural network(T-CNN)for joint face detection refinement,alignment and attribute *** the SSD face detectors achieve promising results,we find that applying a tiny CNN on detections further boosts the detected face scores and bounding *** multi-task training,our T-CNN aims to provide five facial landmarks,facial quality scores,and facial attributes like wearing sunglasses and wearing *** there is no public facial quality data and facial attribute data as we need,we contribute two datasets,namely FaceQ and FaceA,which are collected from the *** show that our MHCNN achieves face detection performance comparable to the state of the art in face detection data set and benchmark(FDDB),and gets reasonable results on AFLW,FaceQ and FaceA.

关键词： face detection face alignment facial attribute CNN multi-task training

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer

引用

Chinese Journal of Cancer Research 2013年第1期25卷 79-89页

作者： Zhaode Bu Zhixue zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Pathology Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Clinical Gastric Cancer Research Laboratory Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Tissue Bank Peking University Cancer Hospital & Institute

Objective： To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 （LGR5） expressions in gastric cancer and to evaluate its clinical significance. Methods： LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results： The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues （P〈0.001）, and more frequently in patients with intestinal type, well-moderate differentiation and stage I and II （P〈0.05）. Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn＇t meet statistical significance （P〉0.05）. LGR5 negative expression was significantly related to the favorable overall survival in stage I and II gastric cancer patients （P〈0.05）. Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival （P〈0.05）. Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage I and II gastric cancer （P〈0.05）. Conclusions： Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage I and II gastric cancer.

关键词： Leucine-rich repeat-containing G protein-coupled receptor 5 (LGRS) gastric cancer cancer stemcell biomarker prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Disaster Investigation for August 20^th,2019 Sanya M4.2 Earthquake in Hainan,China

引用

Earthquake Research in China 2020年第2期34卷 285-295页

作者： JIA Wei WU Tiesheng zheng Kexian WANG Zhicheng LIN Zhen HU Jinqiao XU Xiaofeng LI Zhixiong WU xiaojiang Hainan Earthquake Agency Haikou 570203China

On August 20th,2019,a M4.2 earthquake occurred near Zhanan and Lixin Village,Tianya District,Sanya City,Hainan Province. We conduct field investigations in the vicinity of the epicenter which includes 25 natural villages based on the data provided by local government and finally complete the map of the earthquake *** the analysis of the houses and cracks in the earthquake area,the structure types and crack characteristics of the houses are basically unveiled. Furthermore,suggestions for earthquake disaster reduction in study area are obtained from the investigation.

关键词： M4.2 earthquake 25 natural villages Field investigation Seismic intensity map

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

聚酰亚胺的冷风微量润滑辅助切削工艺

引用

上海交通大学学报 2022年第6期56卷 784-793页

作者：曹拯雷学林张航蔡晓江华东理工大学机械与动力工程学院上海200237 上海航天控制技术研究所上海201109

研究了冷风微量润滑辅助的多孔聚酰亚胺材料切削加工性能,并探讨了切削加工工艺参数对多孔材料切削加工效果(切削力、表面加工质量及含油率)的影响规律.结果表明,相较于干切削和低温冷风切削,冷风微量润滑切削的切削温度及已加工表面粗... 详细信息

研究了冷风微量润滑辅助的多孔聚酰亚胺材料切削加工性能,并探讨了切削加工工艺参数对多孔材料切削加工效果(切削力、表面加工质量及含油率)的影响规律.结果表明,相较于干切削和低温冷风切削,冷风微量润滑切削的切削温度及已加工表面粗糙度最低,多孔流道损伤最小.切削深度和进给量分别是对铣削力和表面粗糙度影响最大的因素.切屑毛边、撕裂等缺陷是导致表面粗糙度增大的主要因素.工件表面存在的拉丝、微裂纹、堆叠及微小碎屑附着等缺陷是材料含油率及输油率降低的根本原因.正交实验获得冷风微量润滑辅助条件下多孔聚酰亚胺材料最优加工参数:切削速度v_(c)=(85±5)mm/min,进给量f_(z)=(0.28±0.02)mm/r,切削深度a_(p)=(0.8±0.1)mm.冷风微量润滑切削技术可以实现多孔聚酰亚胺材料的低损伤加工,获得高含油率及高输油率的保持架产品.

关键词：聚酰亚胺冷风微量润滑铣削低损伤加工工艺含油率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Present status and prospective on the seismic hazard studies of major seismic gaps in the Sichuan-Yunnan region

引用

Science China Earth Sciences 2024年第11期67卷 3339-3366页

作者： Yong zheng Rumeng GUO Dechuan LIU State Key Laboratory of Geological Processes and Mineral Resources School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan 430077China Hubei Subsurface Multi-scale Imaging Key Laboratory Wuhan 430074China Luojia Laboratory Wuhan 430072China National Precise Gravity Measurement Facility Huazhong University of Science and TechnologyWuhan 430074China

Several seismic gaps have been identified along the Xianshuihe-xiaojiang fault zone and the Longmenshan fault zone in the Sichuan-Yunnan region, including the Daofu-Shimian gap on the Xianshuihe Fault, the Anninghe-Zemuhe gap, parts of the xiaojiang Fault, and the Dayi gap between the Wenchuan and Lushan earthquakes. The seismic hazards of the Daofu-Shimian and Dayi gaps have aroused great concern and caused considerable debate. This paper reviews the recent geophysical observations and multidisciplinary studies conducted by domestic and international researchers in these areas, focusing on seismogenic structures, seismic activity, fault locking, stress fields, as well as earthquake triggering, and further analyzes the current controversial viewpoints about the seismic hazards in these regions. Based on the comprehensive analysis, we argue that the kinematic status along the Daofu-Shimian segment may vary significantly along the fault strike. Due to limitations in data and models, there is no consensus on the seismogenic potential of this area. Conversely, the Dayi seismic gap presents a high seismic potential. Furthermore, we delve into the scientific problems associated with major seismic gaps in the Sichuan-Yunnan region and make prospects for the strategy of future work. We propose a research framework that combines dense array and distributed acoustic sensing, artificial intelligence and big data technologies, joint inversion of multiple geophysical fields, as well as numerical simulation techniques for comprehensive seismic hazard analysis in seismic gaps.

关键词： Sichuan-yunnan region Seismic gap Seismic hazard Present status Prospective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：