High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways
作者机构：Department of Clinical ImmunologyThe Third Affiliated Hospital at Sun Yat-sen University510630 GuangzhouChina Department of Internal MedicineOhio State University College of Medicine and Wexner Medical CenterColumbusOH 43210USA Department of MedicinePenn State College of MedicineHersheyPA 17033USA Laboratory of Human Diseases and ImmunotherapyWest China HospitalSichuan UniversityChengduChina Department of Internal MedicineThe First Hospital of Harbin Medical UniversityHarbinChina Department of Allergy and Clinical ImmunologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Pediatrics and Microbiology-ImmunologyGeorgetown University Medical CenterWashingtonDCUSA
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：2082-2094页
核心收录：
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：supported by the National Key R&D Program of China[2017YFA0105801] the Zhujiang Innovative and Entrepreneurial Talent Team Award of Guangdong Province[2016ZT06S252] the National Natural Science Foundation of China[Nos.81871224,81671611,81901657] the Natural Science Foundation of Guangdong Province[grant no.2014A030308005](all to Z.X.X.),NIH R01 AR059103,and the NIH STAR award(to S.G.Z.)
主 题：STAT1 lupus prevention
摘 要：The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary *** sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including *** the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE *** used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient *** observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC *** treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in *** of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced *** mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal *** p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune *** together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of ***,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.
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