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Enzyme-directed pH-responsive exfoliation and dispersion of graphene and its decoration by gold nanoparticles for use as a hybrid catalyst

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Nano Research 2013年第9期6卷 693-702页

作者： Konggang qu Li Wu Jinsong Ren xiaogang qu Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences ChangchunJilin 130022 China

A non-destructive, safe and practical strategy to produce high quality graphene in high yield is urgently required, since this would pave the way for a wide range of applications of graphene in the future. Here we present a pH-responsive water-dispersible method for the exfoliation and functionalization of graphene by using lysozyme. The pH-responsive dispersion of graphene may be useful for the reversible assembly of multicomponent/multifunctional nanohybrid materials and nanoscale electronic devices. More importantly, composites can be easily constructed through the interactions between disulphide groups in lysozyme and gold nanoparticles （AuNPs）. The resulting graphene-AuNPs composites show excellent catalytic activity towards reduction of o-nitroaniline by NaBH4. Since lysozyme is low cost and has antibacterial properties, and has been widely used in food preservation, medicine and the pharmaceutical industry, our approach may open a new scalable route for the manufacture of high-quality, nondestructive graphene for practical applications.

关键词： grapheme exfoliation lysozyme pH-responsive catalysis protein

Intelligent Optimization Methods for the Design of an Overhead Travelling Crane

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Chinese Journal of Mechanical Engineering 2015年第1期28卷 187-196页

作者： qu xiaogang XU Gening FAN Xiaoning BI Xiaoheng School of Mechanical & Electronical Engineering Lanzhou University of Technology School of Mechanical Engineering Taiyuan University of Science and Technology

In design optimization of crane metal structures, present approaches are based on simple models and mixed variables, which are difficult to use in practice and usually lead to failure of optimized results for rounding variables. Crane metal structure optimal design（CMSOD） belongs to a constrained nonlinear optimization problem with discrete variables. A novel algorithm combining ant colony algorithm with a mutation-based local search（ACAM） is developed and used for a real CMSOD for the first time. In the algorithm model, the encoded mode of continuous array elements is introduced. This not only avoids the need to round optimization design variables during mixed variable optimization, but also facilitates the construction of heuristic information, and the storage and update of the ant colony pheromone. Together with the proposed ACAM, a genetic algorithm（GA） and particle swarm optimization（PSO） are used to optimize the metal structure of a crane. The optimization results show that the convergence speed of ACAM is approximately 20% of that of the GA and around 11% of that of the PSO. The objective function value given by ACAM is 22.23% less than the practical design value, a reduction of 16.42% over the GA and 3.27% over the PSO. The developed ACAM is an effective intelligent method for CMSOD and superior to other methods.

关键词： crane metal structure design optimization continuous array element encoded model ant colony optimization particle swarm optimization genetic algorithm

Multicolor Luminescent Carbon Nanoparticles： Synthesis, Supramolecular Assembly with Porphyrin, Intrinsic Peroxidase-Like Catalytic Activity and Applications

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Nano Research 2011年第9期4卷 908-920页

作者： Xiaohui Wang Konggang qu Bailu Xu Jinsong Ren xiaogang qu Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Laboratory of Chemical Biology Changchun Institute Of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China Graduate School of the Chinese Academy of Sciences Changchun Jilin 130022 China

Luminescent carbon nanoparticles （CNPs） are newcomers to the world of nanomaterials and have shown great impact in health and environmental applications as well as being promising building blocks for future nanodevices because of their fascinating photoluminescence and potential to serve as nontoxic replacements for traditional heavy-metals-based quantum dots. Herein, fluorescent CNPs have been prepared from candle soot by re fluxing with HNO3 and subsequently separated by a single centrifugation. The CNPs can be represented by the empirical formula C1Ho.677Oo.586No.o15Nao.069, and have a size of 20-100 nm, height of 3.0 nm, lifetime of 7.31 ns ＋ 0.06 ns and quantum yield of -1.7%. Further studies demonstrate that：（1）the as-prepared CNPs exhibit excellent stability in biological media and their luminescence intensity does not change with ionic strength or pH in the physiological and pathological range of pH 4.5-8.8; （2） CNPs can act as electron donors and transporters and porphyrin can assemble onto CNPs through electrostatic and ^-stacking interactions to form porphyrin-CNPs supramolecular composites; （3）CNPs have strong intrinsic peroxidase-like activity. Based on this intrinsic peroxidase activity, a simple, cheap, and highly selective and sensitive colorimetric and quantitative assay has been developed for the detection of glucose levels. This assay has been used to analyze real samples, such as diluted blood and fruit juice.

关键词： Carbon nanoparticles luminescence supramolecular assembly peroxidase biosensing

Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dual- functionalized graphene substrate

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Nano Research 2015年第3期8卷 887-899页

作者： Lingyan Feng Wen Li Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China University of Chinese Academy of Sciences Beijing 100039 P. R. China

Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin （β-CD） and Fc on clinical trial II aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA （cDNA） also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.

关键词： cell release ferrocene/β-cyclodextrin AS1411 graphene

A pH-switched mesoporous nanoreactor for synergetic therapy

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Nano Research 2017年第5期10卷 1651-1661页

作者： Zhengqing Yan Andong Zhao Xinping Liu Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

Zinc oxide nanoparticles （ZnO NPs）, as a new type of pH-sensitive drug carrier, have received much attention. ZnO NPs are stable at physiological pH, but can dissolve quickly in the acidic tumor environment （pH 〈 6） to generate cytotoxic zinc ions and reactive oxygen species （ROS）. However, the protein corona usually causes the non-specific degradation of ZnO NPs, which has limited their application considerably. Herein, a new type of pH-sensitive nanoreactor （ZnO-DOX@F-mSiO2-FA）, aimed at reducing the non-specific degradation of ZnO NPs, is presented. In the acidic tumor environment （pH 〈 6）, it can release cytotoxic zinc ions, ROS, and anticancer drugs to kill cancer cells effectively. In addition, the fluorescence emitted from fluorescein isothiocyanate （FITC）-labeled mesoporous silica （F-mSiO2） and doxorubicin （DOX） can be used to monitor the release behavior of the anticancer drug. This report provides a new method to avoid the non-specific degradation of ZnO NPs, resulting in synergetic therapy by taking advantage of ZnO NPs-induced oxidative stress and targeted drug release.

关键词： zinc oxide mesoporous nanoreactor non-specific degradation controllable release fluorescent imaging

Cross-fibrillation of insulin and amyloid β on chiral surfaces： Chirality affects aggregation kinetics and cytotoxicity

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Nano Research 2018年第8期11卷 4102-4110页

作者： Zhi Du Yijia Guan Nan Gao Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of AppliedChemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

Recent clinical and epidemiological research has shown that insulin is associated with the pathological mechanisms of Alzheimer＇s disease （AD） and can protect against the oxidative stress triggered by amyloidq3 peptide （Aβ3）. Herein, we present a systematic study on how the cross-fibrillation of insulin and Aβ is influenced by the surface chirality of an interface designed to mimic their aggregation on the cytomembrane. Intriguingly, the surface chirality strongly affected the aggregation kinetics, structure, morphologβ and cellular responses of the cross-aggregates of insulin and Aβ. On a D-phenylalanine- modified surface, Aβ induced insulin to co-aggregate into β-sheet-rich fibrils and cross-fibrils that showed a pronounced cellular toxicity. However, on an L-phenylalanine-modified surface, insulin and Aβ3 formed non-toxic amorphous aggregates. Our work indicates that surface chirality can influence the cross- fibrillation of Aβ and insulin as well as the cytotoxicity of their aggregates.

关键词： Alzheimer's disease insulin,amyloid β-peptides artificial biointerfaces chirality

Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy

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Nano Research 2022年第6期15卷 5273-5278页

作者： Mengyu Sun Yanjuan Sang Qingqing Deng Zhengwei Liu Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100039China

Nitric oxide(NO)gas therapy,especially,L-arginine(L-Arg)-based NO treatment strategies have attracted extensive attention in the field of ***,current strategies are unable to differentiate well between normal cells and cancer cells,which may lead to unpredictable *** by the fact that mitochondria of cancer cells can express excessive nitric oxide synthetase(NOS),herein,a nanozyme-based NO generator,cerium oxide(CeO_(2))-AT,is fabricated to specifically catalyze the production of NO in cancer cells for selective tumor *** this system,after being endocytosed into cancer cells,the generator can produce a number of NO under the catalysis of NOS in mitochondria of cancer cells,which can disrupt the mitochondrial respiratory chain of tumor cells and further induce cell *** addition,the generator with catalase(CAT)-like activity can catalyze H_(2)O_(2)to produce O_(2),which can promote the generation of NO and improve the performance of NO gas *** is more,our system has no obvious impact on the viability of normal cells owing to the less production of *** work paves a new way for the development of highly selective NO-based treatment particularly useful for the safe and specific cancer therapy.

关键词： nitric oxide nitric oxide synthetase nanozyme mitochondria specific cancer therapy

Biomolecule-templated photochemical synthesis of silver nanoparticles： Multiple readouts of localized surface plasmon resonance for pattern recognition

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Nano Research 2018年第6期11卷 3213-3221页

作者： Fang Pu Xiang Ran Meng Guan Yanyan Huang Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Cancer Center FirstAffiliated Hospital Jilin University Changchun 130061 China University of Chinese Academy of Sciences Beijing 100039 China

Silver nanoparticles （AgNPs） with distinct localized surface plasmon resonance （LSPR） absorption spectra can be synthesized using different proteins as templates upon irradiation by light. We utilized the multiple readouts of LSPR signals of AgNPs to construct sensor arrays for pattern recognition of proteins. Room temperature, aqueous solutions, and lack of harsh reducing reagents make the whole process inherently ＂green＂. Meanwhile, the strategy efficiently simplified the process of array-receptor preparation and data acquisition, leading to lower time consumption, sample use, and cost. Furthermore, the system can differentiate proteins using flexible and alterable sensor elements by choosing different combinations of LSPR signals at different wavelengths. The principle of the sensor design can also be further extended to differentiate other biomolecules. The study provides a new method to construct feasible, economical, and general nanoparficle-based sensing arrays for pattern recognition.

关键词： localized surface plasmon resonance silver nanoparticles pattern recognition biomolecule photochemical synthesis

A cytotoxic amyloid oligomer self-triggered and NIR- enhanced amyloidosis therapeutic system

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Nano Research 2015年第7期8卷 2431-2444页

作者： Can Xu Peng Shi Meng Li Jinsong Ren xiaogang qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

We report a new strategy for improving the efficiency of non-specific amyloidosis therapeutic drugs by coating amyloid-responsive lipid bilayers. The approach had drawn inspiration from amyloid oligomer-mediated cell membrane disruption in the pathogenesis of amyloidosis. A graphene-mesoporous silica hybrid （GMS）-supported lipid bilayer （GMS-Lip） system was used as a drug carrier, Drugs were well confined inside the nanocarrier until encountering amyloid oligomers, which could pierce the lipid bilayer coat and cause drug release. To ensure release efficiency, use of a near-infrared （NIR） laser was also introduced to facilitate drug release, taking advantage of the photothermal effect of GMS and thermal sensitivity of lipid bilayers. To facilitate tracking, fluorescent dyes were co-loaded with drugs within GMS-Lip and the NIR laser was used once the oligomer-triggered release had been signaled. Because of the spatially and temporally controllable property of light, the NIR-assisted release could be easily and selectively activated locally by tracking the fluorescence signal. Our design is based on arnyloidosis pathogenesis, the cytotoxic amyloid oligomer self-triggered release via cell membrane disruption, for the controlled release of drug molecules. The results may shed light on the development of pathogenesis- inspired drug delivery systems,

关键词： amyloid disease,near-infrared (NIR) grapheme,mesoporous silica,lipid bilayer, drug delivery