A cytotoxic amyloid oligomer self-triggered and NIR- enhanced amyloidosis therapeutic system
作者机构：Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2015年第8卷第7期
页 面：2431-2444页
核心收录：
学科分类：07[理学]
基 金：This work was supported by the National Basic Research Program of China (Nos. 2011CB936004 and 2012CB720602) and the National Natural Science Foundation of China (Nos. 21210002 21431007 91413111 and 21401187)
主 题：amyloid disease,near-infrared (NIR) grapheme,mesoporous silica,lipid bilayer, drug delivery
摘 要：We report a new strategy for improving the efficiency of non-specific amyloidosis therapeutic drugs by coating amyloid-responsive lipid bilayers. The approach had drawn inspiration from amyloid oligomer-mediated cell membrane disruption in the pathogenesis of amyloidosis. A graphene-mesoporous silica hybrid （GMS）-supported lipid bilayer （GMS-Lip） system was used as a drug carrier, Drugs were well confined inside the nanocarrier until encountering amyloid oligomers, which could pierce the lipid bilayer coat and cause drug release. To ensure release efficiency, use of a near-infrared （NIR） laser was also introduced to facilitate drug release, taking advantage of the photothermal effect of GMS and thermal sensitivity of lipid bilayers. To facilitate tracking, fluorescent dyes were co-loaded with drugs within GMS-Lip and the NIR laser was used once the oligomer-triggered release had been signaled. Because of the spatially and temporally controllable property of light, the NIR-assisted release could be easily and selectively activated locally by tracking the fluorescence signal. Our design is based on arnyloidosis pathogenesis, the cytotoxic amyloid oligomer self-triggered release via cell membrane disruption, for the controlled release of drug molecules. The results may shed light on the development of pathogenesis- inspired drug delivery systems,
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