A pH-switched mesoporous nanoreactor for synergetic therapy
A pH-switched mesoporous nanoreactor for synergetic therapy作者机构：Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2017年第10卷第5期
页 面：1651-1661页
核心收录：
学科分类：07[理学]
主 题：zinc oxide mesoporous nanoreactor non-specific degradation controllable release fluorescent imaging
摘 要：Zinc oxide nanoparticles （ZnO NPs）, as a new type of pH-sensitive drug carrier, have received much attention. ZnO NPs are stable at physiological pH, but can dissolve quickly in the acidic tumor environment （pH 〈 6） to generate cytotoxic zinc ions and reactive oxygen species （ROS）. However, the protein corona usually causes the non-specific degradation of ZnO NPs, which has limited their application considerably. Herein, a new type of pH-sensitive nanoreactor （ZnO-DOX@F-mSiO2-FA）, aimed at reducing the non-specific degradation of ZnO NPs, is presented. In the acidic tumor environment （pH 〈 6）, it can release cytotoxic zinc ions, ROS, and anticancer drugs to kill cancer cells effectively. In addition, the fluorescence emitted from fluorescein isothiocyanate （FITC）-labeled mesoporous silica （F-mSiO2） and doxorubicin （DOX） can be used to monitor the release behavior of the anticancer drug. This report provides a new method to avoid the non-specific degradation of ZnO NPs, resulting in synergetic therapy by taking advantage of ZnO NPs-induced oxidative stress and targeted drug release.
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