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Nicotine-induced upregulation of antioxidant protein Prx 1 in oral squamous cell carcinoma

Chinese Science Bulletin 2013年第16期58卷 1912-1918页

作者： ZHAO YanHua ZHANG Min YAN Fei CASTO Bruce C tang xiaofei Division of Oral Pathology Beijing Institute of Dental Research School of Stomatology Capital Medical University Division of Medical Oncology Department of Internal Medicine Ohio State University College of Medicine and Comprehensive Cancer Center Division of Environmental Health Sciences Ohio State University College of Public Health

Nicotine is a source of exogenous oxidative stress, which is associated with the pathogenesis of numerous diseases including oral squamous cell carcinoma (OSCC), whereas an antioxidant protein, peroxiredoxin 1 (Prx 1), plays an important role in the modulation of this condition. This study was to investigate the association between Prx 1 and tobacco-induced oxidative stress. The expression of Prx 1 and GST in OSCC Tca8113 cells, which were pre-treated with nicotine, was determined. In the present study, MTT assay, reactive oxygen species (ROS) assay, RT-PCR and Western blot analyses, respectively, were conducted to assess cell viability, ROS level, and expression level of Prx 1 and GST in nicotine-treated Tca8113 cells. Nuclear factor kappa B (NF- B) expression was detected by immuno-fluorescence. Our results showed the growth of Tca8113 cells was increased in a dose-dependent manner when cells were treated with nicotine at concentrations from 0.1 to 10 mol/L, but the proliferation of the cells decreased at 100 mol/L. ROS levels increased in all groups treated with nicotine at concentrations of 0.1, 1, 10, or 100 mol/L for 24h. Prx 1 and GST mRNA and protein expression were up-regulated in cells treated with nicotine for the same time at different concentrations or at the same concentration for different times (P<0.05). NF-B was translocated from cytoplasm to nucleus, the expression of NF- B was increased in nucleus. These results suggest that up-regulation of Prx1 expression appears to be associated with tobacco-induced oxidative stress, which may play an important role in the pathogenesis of OSCC.

关键词：鳞状细胞癌蛋白表达抗氧化剂尼古丁口腔诱导氧化应激 RT-PCR

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Merkle Tree Digital Signature and Trusted Computing Platform

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Wuhan University Journal of Natural Sciences 2006年第6期11卷 1467-1472页

作者： WANG xiaofei HONG Fan tang Xueming CUI Guohua College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei China

Lack of efficiency in the initial key generation process is a serious shortcoming of Merkle tree signature scheme with a large number of possible signatures. Based on two kinds of Merkle trees, a new tree type signature scheme is constructed, and it is provably existentially unforgeable under adaptive chosen message attack. By decentralizing the initial key generation process of the original scheme within the signature process, a large Merkle tree with 6.87×10^10 possible signatures can be initialized in 590 milliseconds. Storing some small Merkle trees in hard disk and memory can speed up Merkle tree signature scheme. Mekle tree signature schemes are fit for trusted computing platform in most scenarios.

关键词： digital signature one-time signature Merkle tree trusted computing platform

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Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1a response

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Cellular & Molecular Immunology 2010年第5期7卷 355-360页

作者： Naihong Zhang Zhaoe Wang xiaofei tang Haiping Wang Hongzhao Li Huanjun Huang Hong Bai Xi Yang Department of Immunology Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyKey Laboratory of Educational Ministry of ChinaTianjinChina Laboratory for Infection and Immunity Departments of Medical Microbiology and ImmunologyFaculty of MedicineUniversity of ManitobaWinnipegManitobaCanada

Chemokines and their receptors are important mediators of leukocyte trafficking and recruitment and sometimes work as modulators of T-cell responses during infections and *** the biological activity of chemokines has been found to influence the course of ***,little is known about the role of chemokine responses during chlamydial lung *** therefore analyzed the dynamics of multiple chemokines,which are frequently associated with type 1(Th1)T cell immune responses,and their receptors for their expression in the lungs during Chlamydia muridarum(Cm)*** also examined the relationship between chemokine responses and the development of Th1 responses as well as the clearance of *** results showed that in parallel with the high levels of gamma interferon(IFN-c)and IL-12 production in the lungs and draining lymph nodes,and the expansion of IFN-c-producing CD4 and CD81 T cells,the production of the cell-related chemokines RANTES,IFN-c-inducible protein-10(IP-10)and macrophage inflammatory protein-1a(MIP-1a)and their receptor CCR1 was elevated in the lung tissues after ***,in a later phase of infection,the expression of RANTES and IP-10 remained elevated but the expression of MIP-1a and CCR1 decreased to a low level,which suggests a closer association with the pattern of Th1 cytokine responses in the process of *** results suggest a close association between the MIP-1a response and the Th1-type T-cell responses in chlamydial lung infections .

关键词： Chlamydial pneumonia MIP-1a RANTES Th1 response

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Learnability of Grammatical Sequencing: A Processability Perspective of Textbook Evaluation in EFL Settings

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Chinese Journal of Applied Linguistics 2019年第2期42卷 236-257,264页

作者： xiaofei tang Wuhan University of Technology

This study conducts an acquisition-based evaluation of four primary-school English textbook series used in China. The evaluation aims to determine whether the sequencing of grammatical structures in the series is compatible with the L2 learning sequence stipulated in Processability Theory (PT). The results show a partial agreement between the sequencing of structures as teaching objectives in the series and the PT-based processability hierarchy. The sequencing of structures in the initial stages is consistent with the learning sequence of L2 English stated in PT. However, several structures in the intermediate or high stages are taught in a deviant way against their sequencing in PT. The deviant grading of those structures is possibly associated with the theme-based guidelines adopted in the textbooks. It appears that concerns with the utility of grammatical structures in a given context take precedence over concerns for L2 development. A number of suggestions are offered to textbook writers in terms of the role of input, the learners, developmental readiness, and the issue of heterogeneity in L2 classrooms.

关键词： textbook evaluation L2 learning sequence Processability Theory TESOL EFL settings

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Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation during the Late Stage of Infection

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Cellular & Molecular Immunology 2009年第4期6卷 253-260页

作者： xiaofei tang Xiaokun Bu Naihong Zhang Xiaoxia Li Huanjun Huang Hong Bai Xi Yang Department of Immunology Tianjin Medical University Tianjin Key Laboratory of Cellular and Molecular Immunology Key Laboratory of Educational Ministry of China Tianjin China Laboratory fur Infection and Immunity Departments of Medical Microbiology and Immunology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada These authors contributed equally to this work Department of Immunology Tianjin Medical University 22 Qixiangtai Road Heping Distinct Tianjin 300070 China

We previously reported that massive infiltration of neutrophils in C3H/HeN （C3H） mice could not efficiently control Chlamydia muridarum （Cm） infection and might contribute to the high susceptibility of these mice to lung infection. To further define the nature of neutrophil responses in C3H mice during chlamydial infection, we examine the expression of adhesion molecules and CDllb related to neutrophils infiltration and activation, respectively, following intranasal Cm infection. The results showed that the expression of selectins （E-selectin, P-selectin and L-selectin）, and intercellular cell adhesion molecule-1 （ICAM-1） in the lung of C3H mice increased more significantly than in C57BL/6 （B6） mice, the more resistant strain. These results correlated well with the massive neutrophils infiltration in C3H mice. In contrast, CDllb expression on peripheral blood and lung neutrophils in C3H mice exhibited a significant reduction compared with B6 mice during the late phage of infection （day 14）. These findings suggest that the high-level expression of adhesion molecules in C3H mice may enhance neutrophils recruitment to the lung, but the decline of CDllb expression on neutrophils may attenuate neutrophil function. Therefore, CDllb down-regulation on neutrophils may contribute to the failure of C3H mice to control chlamydial lung infection.

关键词： Chlamydia trachomatis neutrophils selectins ICAM-1 CD11b

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不同裁判模式对第三方公众赛事公平性感知的影响研究:基于理解错觉的中介和道德理解的调节

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体育科学 2022年第9期42卷 90-96,F0003页

作者：邬红丽唐小飞成都体育学院四川成都610041 西南财经大学工商管理学院四川成都610030

随着人工智能技术的发展,以及国际体育赛事中裁判员不公平的裁判事件被媒体不断曝光,越来越多的媒体和公众呼吁采纳人工智能裁判取代传统裁判员。选取2018—2022年国际体育赛事中涉及人工智能裁判模式与传统裁判员模式中有争论的媒体材... 详细信息

随着人工智能技术的发展,以及国际体育赛事中裁判员不公平的裁判事件被媒体不断曝光,越来越多的媒体和公众呼吁采纳人工智能裁判取代传统裁判员。选取2018—2022年国际体育赛事中涉及人工智能裁判模式与传统裁判员模式中有争论的媒体材料,通过三组实验验证有关假设。研究结果表明:人工智能裁判模式对第三方公众赛事公平性感知的影响要显著大于传统裁判员模式;理解错觉在不同裁判模式与第三方公众赛事公平性感知之间起部分中介作用;道德理解对主效应之间的关系有显著的调节作用,即道德理解抑制了人工智能裁判模式对第三方公众赛事公平性感知的影响,而增强了传统裁判员模式对第三方公众赛事公平性感知的影响。

关键词：人工智能体育裁判赛事公平感知理解错觉

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Current Situation and Countermeasures of Antibiotic Pollu-tion in the Surface Water of the Yangtze River Basin in a Province of Central China

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Meteorological and Environmental Research 2023年第1期14卷 63-67页

作者： Zhao WANG Bin ZHAO Chao ZHU xiaofei tang Bangben YAO Min ZHANG Anhui Institute of Product Quality Supervision and Inspection Hefei 230051China Anhui Ecological Environment Monitoring Center Hefei 230071China

Antibiotics are widely used in the process of human medical treatment,livestock and poultry breeding,and *** the excretion of urine and feces,they enter the water environment of human life and become an important source of water environment *** residues in the environment have high ecological and health *** the pilot monitoring of antibiotics in the main stream of the Yangtze River,Chaohu Lake and the drinking water source of Hefei City,the current situation and impact of antibiotic pollution were *** results show that 32 kinds of antibiotics and their derivatives of the six major categories involved were detected to varying degrees,and the concentrations at some points reached 1.26μg/***,the prevention and control of antibiotic pollution in the surface water of the Yangtze River basin in a province of central China were summarized,and relevant suggestions were given.

关键词： Antibiotics Surface water Pollution status Countermeasures

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2型糖尿病患者发生低血糖的原因及护理对策

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重庆医科大学学报 2012年第9期37卷 838-840页

作者：唐小飞赵锡丽重庆医科大学附属第二医院内分泌科重庆400010

目的:分析2型糖尿病患者发生低血糖的原因,提出有效的护理对策,指导临床及社区的糖尿病教育工作。方法:收集2006年2月-2010年2月我院内分泌科住院2型糖尿病患者发生低血糖症病例共100例,进行回顾性分析,对其发作时的临床表现、应用的治... 详细信息

目的:分析2型糖尿病患者发生低血糖的原因,提出有效的护理对策,指导临床及社区的糖尿病教育工作。方法:收集2006年2月-2010年2月我院内分泌科住院2型糖尿病患者发生低血糖症病例共100例,进行回顾性分析,对其发作时的临床表现、应用的治疗方案、发生低血糖的时间段、年龄、糖尿病患者对疾病的认知度及其他原因进行分析。结果:糖尿病患者发生低血糖的原因与采用的治疗方案、患者的年龄、对疾病的认知度等密切相关。结论:糖尿病患者发生低血糖的原因多,需要医护人员、患者及家属的重视及多方面配合。临床及社区应加强低血糖的护理干预及患者教育。

关键词：糖尿病低血糖原因分析护理干预

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深入理解营销渠道研究的过去和未来

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科研管理 2015年第1期36卷 159-166页

作者：鲁平俊唐小飞西南财经大学工商管理学院四川成都611130

为了洞悉营销渠道研究中过去和未来最有价值的文献和研究议题,挖掘渠道研究未来可能的研究方向和研究机会,本文借用引证研究法定量分析了营销渠道研究的发展趋势和演化轨迹。研究结果显示,在营销渠道研究的过去63年中学者们主要提出了1... 详细信息

为了洞悉营销渠道研究中过去和未来最有价值的文献和研究议题,挖掘渠道研究未来可能的研究方向和研究机会,本文借用引证研究法定量分析了营销渠道研究的发展趋势和演化轨迹。研究结果显示,在营销渠道研究的过去63年中学者们主要提出了18个具有重要价值的研究议题,同时,通过定量分析探寻出该研究领域中最具影响力的20篇文献,并揭示出在未来相当一段时间内渠道关系、线上渠道和渠道治理等议题将会成为研究的新热点。研究结果有助于帮助相关学者从理论上厘清关于营销渠道我们知道些什么、过去做了些什么和未来还需要探索些什么。

关键词：营销渠道引证研究研究议题文献

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补救时机和人格特质对补救绩效影响研究

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管理世界 2011年第4期27卷 178-179页

作者：唐小飞钟帅郑杰西南财经大学工商管理学院

本文首次在服务补救领域提出相对性延迟补救的概念,打破了长期以来把"即时补救"作为一种规范来执行的垄断局面。作者将相对性延迟补救这一重要变量引入研究,构建了基于补救时机、人格特特对补救绩效影响的概念模型,以情景实验法对模型... 详细信息

本文首次在服务补救领域提出相对性延迟补救的概念,打破了长期以来把"即时补救"作为一种规范来执行的垄断局面。作者将相对性延迟补救这一重要变量引入研究,构建了基于补救时机、人格特特对补救绩效影响的概念模型,以情景实验法对模型进行了验证。研究对丰富市场营销理论和提高企业经营管理水平均有重要意义。

关键词：补救时机人格特质补救绩效

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