Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation during the Late Stage of Infection

作     者：Xiaofei Tang Xiaokun Bu Naihong Zhang Xiaoxia Li Huanjun Huang Hong Bai Xi Yang 

作者机构：Department of Immunology Tianjin Medical University Tianjin Key Laboratory of Cellular and Molecular Immunology Key Laboratory of Educational Ministry of China Tianjin China Laboratory fur Infection and Immunity Departments of Medical Microbiology and Immunology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada These authors contributed equally to this work Department of Immunology Tianjin Medical University 22 Qixiangtai Road Heping Distinct Tianjin 300070 China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2009年第6卷第4期

页      面：253-260页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 071005[理学-微生物学] 090102[农学-作物遗传育种] 10[医学] 

基　　金：Tianjin Science and Technology Committee  (07JCYBJC10600) 

主　　题：Chlamydia trachomatis neutrophils selectins ICAM-1 CD11b 

摘      要：We previously reported that massive infiltration of neutrophils in C3H/HeN （C3H） mice could not efficiently control Chlamydia muridarum （Cm） infection and might contribute to the high susceptibility of these mice to lung infection. To further define the nature of neutrophil responses in C3H mice during chlamydial infection, we examine the expression of adhesion molecules and CDllb related to neutrophils infiltration and activation, respectively, following intranasal Cm infection. The results showed that the expression of selectins （E-selectin, P-selectin and L-selectin）, and intercellular cell adhesion molecule-1 （ICAM-1） in the lung of C3H mice increased more significantly than in C57BL/6 （B6） mice, the more resistant strain. These results correlated well with the massive neutrophils infiltration in C3H mice. In contrast, CDllb expression on peripheral blood and lung neutrophils in C3H mice exhibited a significant reduction compared with B6 mice during the late phage of infection （day 14）. These findings suggest that the high-level expression of adhesion molecules in C3H mice may enhance neutrophils recruitment to the lung, but the decline of CDllb expression on neutrophils may attenuate neutrophil function. Therefore, CDllb down-regulation on neutrophils may contribute to the failure of C3H mice to control chlamydial lung infection.