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Analytic approximations of Von Krmn plate under arbitrary uniform pressure—equations in integral form

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Science China(Physics,Mechanics & Astronomy) 2018年第1期61卷 57-67页

作者： xiaoxu zhong ShiJun Liao School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Collaborative Innovative Center for Advanced Ship and Deep-Sea Exploration State Key Laboratory of Ocean Engineering Ministry-of-Education Key Laboratory of Scientific and Engineering Computing

Analytic approximations of the Von Karman＇s plate equations in integral form for a circular plate under external uniform pressure to arbitrary magnitude are successfully obtained by means of the homotopy analysis method （HAM）, an analytic approximation technique for highly nonlinear problems. Two HAM-based approaches are proposed for either a given external uniform pressure Q or a given central deflection, respectively. Both of them are valid for uniform pressure to arbitrary magnitude by choosing proper values of the so-called convergence-control parameters c1 and c2 in the frame of the HAM. Besides, it is found that the HAM- based iteration approaches generally converge much faster than the interpolation iterative method. Furthermore, we prove that the interpolation iterative method is a special case of the first-order HAM iteration approach for a given external uniform pressure Q when c1= -0 and c2 = -1, where 0 denotes the interpolation iterative parameter. Therefore, according to the convergence theorem of Zheng and Zhou about the interpolation iterative method, the HAM-based approaches are valid for uniform pressure to arbitrary magnitude at least in the special case c1 = -0 and c2= -1. In addition, we prove that the HAM approach for the Von karman＇s plate equations in differential form is just a special case of the HAM for the Von karman＇s plate equations in integral form mentioned in this paper. All of these illustrate the validity and great potential of the HAM for highly nonlinear problems, and its superiority over perturbation techniques.

关键词： circular plate high nonlinearity homotopy analysis method

Identifying Qingkailing(清开灵)ingredients-dependent mesenchymal-epithelial transition factor-axiation“π”structuring module with angiogenesis and neurogenesis effects

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Journal of Traditional Chinese Medicine 2024年第1期44卷 35-43页

作者： CHENG Kunming YUAN Jianan LIU Jun ZHANG Shengpeng XU Qixiang XIE Yong ZHAO Jingfeng ZHANG xiaoxu TANG Xudong ZHENG Yongqiu WANG zhong Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui Teaching and Research Section of Traditional Chinese MedicineSchool of PharmacyWannan Medical CollegeWuhu 241000China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationDepartment of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE:To explore the functional role of the drugdependent mesenchymal-epithelial transition(Met)-axiation"π"structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ***:We used a Glutathione S-transferase(GST)-pull down assay,isothermal titration calorimetry assay,and other related methods to identify the relationships among Met,inositol polyphosphate phosphatase like 1(Inppl1),and death associated protein kinase 3(Dapk3)in this allosteric *** biological effects of the modules of neurons generation composed of Met,Inppl1,and Dapk3 were measured through Western blot,apoptosis analysis,and double immunofluorescence ***:The GST-pull down assay revealed that proline-serine-threonine rich domain of Met binds to the Src homology domain of Inppl1 to form a protein-protein complex;Dapk3 with a C-terminal domain interacts weakly with the protein kinase C domain of Met in the intracellular ***,we obtained a“π”structuring module considered a neural regeneration *** biological effects of angiogenesis and neurogenesis modules composed of Met,Inppl1,and Dapk3 were also ***:The study suggested that understanding the functional modules that contribute to pharmaceutics might provide novel signatures that can be used as endpoints to define disease processes under stroke or cerebral ischemia conditions.

关键词： brain ischemia stroke neurogenesis angiogenesis modular pharmacology Met-axiation allosteric module

HIV社交网络与分子传播网络融合研究的进展

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中国艾滋病性病 2024年第2期30卷 200-204页

作者：尹晓伊赵彬钟平韩晓旭传染病重症诊治全国重点实验室、国家卫生健康委艾滋病防治重点实验室、国家医学检验临床医学研究中心、中国医科大学附属第一医院沈阳110001

构建社交网络已成为HIV感染诊断和提供预防服务中的重要依据。同时,随着基因组测序技术的快速进展以及HIV耐药数据大量积累,基于病毒序列分析的HIV分子传播网络在监测HIV传播增长簇、识别HIV感染的高风险个体以及确定HIV传播风险因素上... 详细信息

构建社交网络已成为HIV感染诊断和提供预防服务中的重要依据。同时,随着基因组测序技术的快速进展以及HIV耐药数据大量积累,基于病毒序列分析的HIV分子传播网络在监测HIV传播增长簇、识别HIV感染的高风险个体以及确定HIV传播风险因素上的优势也引起了专家学者们的关注。当分子传播网络与传统的社交网络进行融合应用时,可以为基于分子簇的靶向干预提供关键信息,可将有限的干预资源引至“HIV传播热点”指导靶向干预。本文综述了HIV社交网络和分子传播网络两种方法各自的优势和局限性、目前二者融合的主要方式及效果,为更高效地利用公共卫生资源开展艾滋病精准防控、遏制HIV传播提供新的思路。

关键词：艾滋病病毒社交网络分子传播网络融合靶向干预

DNA条形码技术在医学媒介生物鉴定中的应用

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中国热带医学 2017年第8期17卷 831-837页

作者：张瑞玲王晓旭张忠泰山医学院基础医学院病原生物学教研室山东泰安271016 泰山医学院新发传染病溯源及防控协同创新中心山东泰安271016

DNA条形码(DNA barcode)基于一段相对较短的线粒体细胞色素c氧化酶I基因(COI),根据遗传距离的差异进行物种鉴定,具有不受发育状态和标本保存情况的限制、简便易行、快速准确等优势,在多种生物中得到广泛应用。医学媒介生物的准确鉴定是... 详细信息

DNA条形码(DNA barcode)基于一段相对较短的线粒体细胞色素c氧化酶I基因(COI),根据遗传距离的差异进行物种鉴定,具有不受发育状态和标本保存情况的限制、简便易行、快速准确等优势,在多种生物中得到广泛应用。医学媒介生物的准确鉴定是虫媒病防控的基础和关键。基于形态特征的传统鉴定方法对技术人员有着极高的要求,除了受分类专家主观认识的影响外,也易受标本保存情况、样品的发育阶段等多种客观因素的限制。DNA条形码技术的出现弥补了形态学鉴定方法的不足,为媒介生物的鉴定提供了的途径,在虫媒病的防控、口岸检验检疫等方面发挥了重要作用。本文基于目前的研究综述了DNA条形码技术在主要医学媒介生物蚊、蝇、蜱、蟑螂、蠓、白蛉、鼠鉴定中的应用,以期为该技术在其它医学媒介生物种类鉴定中的应用和推广提供参考。

关键词： DNA条形码物种鉴定医学媒介生物虫媒病

Research on Calculation Method of Aerodynamic Parameters of Supersonic Probe Based on Gas Compressibility Factor

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Journal of Thermal Science 2022年第1期31卷 111-119页

作者： zhong Jingjun HUANG Gangfeng WU Wanyang KAN xiaoxu Merchant Marine College Shanghai Maritime University1550 Haigang AvenuePudong DistrictShanghai 201306

The supersonic multi-hole probe is an essential test tool for wind tunnel experiments, which is necessary to develop the basic research of improving the measurement accuracy and expanding the application of the probes.

关键词： supersonic flow probe gas compressible factor aerodynamic parameter error analyses

Effect of tip geometry and tip clearance on aerodynamic performance of a linear compressor cascade

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Chinese Journal of Aeronautics 2013年第3期26卷 583-593页

作者： zhong Jingjun Han Shaobing Lu Huawei Kan xiaoxu Marine Engineering College Dalian Maritime University

The tip leakage flow between a blade and a casing wall has a strong impact on compressor pressure rise capability, efficiency, and stability. Consequently, there is a strong motivation to look for means to minimize its impact on performance. This paper presents the potential of passive tip leakage flow control to increase the aerodynamic performance of highly loaded compressor blades. Experimental investigations on a linear compressor cascade equipped with blade winglets mounted to the blade tips have been carried out. Results for a variation of the tip clearance and the winglet geometry are presented. Current results indicate that the use of proper tip winglets in a compressor cascade can positively affect the local aerodynamic field by weakening the tip leakage vortex. Results also show that the suction-side winglets are aerodynamically superior to the pressure-side or combined winglets. The suction-side winglets are capable of reducing the exit total pressure loss associated with the tip leakage flow and the passage secondary flow to a significant degree.

关键词： Compressor cascade Experimental investigation Tip clearance Tip geometry Tip leakage vortex

Effects of End-Bend and Curved Blades on the Flow Field and Loss of a Compressor Linear Cascade in the Design Condition

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Journal of Thermal Science 2019年第4期28卷 801-810页

作者： KAN xiaoxu WU Wanyang YANG Ling zhong Jingjun Merchant Marine College Shanghai Maritime University

Curved blade and end-bend blade are considered as effective passive control methods for improving the aerodynamic performance of a compressor cascade,and their applicability also needs to be further studied.A highly-loaded compressor linear cascade in the design condition was taken as the research objective in this *** simulation was used to study the positive and negative effects of these methods on the flow loss of the cascade by redistributing the vortex *** show that:the curved blade could reduce the flow loss to 2.55%,while the end-bend blade and the end-bend+curved blade increase it to 10.58%and 2.19%,*** positive effect of the curved blade weakens the strength and scale of Concentrated Shedding Vortex(CSV),which accounts for 59.2%of the total flow *** negative effect of the end-bend blade exacerbates the low-energy fluid clusters from the end wall and wake into ***,the end-bend+curved blade can take their own strengths,but it enhances the twisting motion of Passage Vortex(PV)and CSV,which makes it fail to reduce the flow ***,the positive and negative effects of these methods on the flow loss of a compressor cascade are much *** addition,we also predict the potential danger of the end-bend blade in the negative incidence conditions and provides some suggestion for future study.

关键词： compressor linear cascade flow loss vortex structure curved blade end-bend blade design condition

调查研究融入思政课社会大课堂的价值意蕴和实践进路

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江西开放大学学报 2024年第3期26卷 1-5页

作者：王晓旭钟庚秀南昌大学马克思主义学院江西南昌330031

社会大课堂是新时代落实立德树人根本任务的重要载体,为思政课教学内容的丰富、教学空间的延伸等诸多方面提供新思路和新抓手,是青年学生树立马克思主义实践观,强本领、长才干的重要课堂。调查研究是马克思主义认识世界、改造世界的重... 详细信息

社会大课堂是新时代落实立德树人根本任务的重要载体,为思政课教学内容的丰富、教学空间的延伸等诸多方面提供新思路和新抓手,是青年学生树立马克思主义实践观,强本领、长才干的重要课堂。调查研究是马克思主义认识世界、改造世界的重要方法,是理论联系实际的重要中介,将调查研究融入社会大课堂是思政课坚持理论性与实践性相统一的应有之义。本研究着眼于回应新时代新征程重大关切,探索调查研究融入思政课社会大课堂的价值意蕴,探究融入过程中的难点阻点,以期构建“三位一体”的协同育人机制,提高学生的“五项能力”,厚植学生的软实力;将教师的指导贯穿调查研究的“三个过程”,提高教师的驾驭力;搭建起“四种平台”,强化社会的保障力,汇聚起协同育人合力。

关键词：调查研究社会大课堂大思政课实践教学

Effect of Winglet Geometry Arrangement and Incidence on Tip Clearance Control in a Compressor Cascade

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Journal of Thermal Science 2014年第4期23卷 381-390页

作者： HAN Shaobing zhong Jingjun LU Huawei KAN xiaoxu YANG Ling Marine Engineering College Dalian Maritime University

An experimental study is conducted to investigate the influences of blade tip winglet on the flow field of a compressor cascade. The tests are performed in a low speed linear cascade with stationary endwall, with three blade tip configurations, including the baseline tip, the suction-side winglet tip and the pressure-side winglet tip. The fiowfield downstream of the cascade is measured using five-hole probe, from which the three-dimensional velocity field, vorticity field and pressure field are obtained. Static pressure measurements are made on the endwall above the blade row using pressure taps embedded in the plywood endwall. All measurements are made at both design and off-design conditions for tip clearance level of about 2 percent of the blade chord. The results revealed the incidence variation significantly affects the secondary flow and the associated loss field downstream of the cascade, where the tip leakage vortex and passage vortex exist as the major contributors on the field. The winglet geometry arrangements can change the trajectory of the tip leakage vortex. The suction-side winglet tip blade provides a lower overall total pressure loss coefficient when compared to the baseline tip blade and pressure-side winglet tip blade at all incidence angles.

关键词： blade tip winglet compressor cascade incidence tip clearance flow