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Isolation of chemical compositions as dietary antioxidant supplements and neuroprotectants from Chaga mushroom (Inonotus obliquus)

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Food Bioscience 2022年第3期47卷 211-220页

作者： Ye Chang Ming Bai xiao-Bian Xue Chun-Xin Zou xiao-xiao huang Shao-Jiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development Liaoning ProvinceChina Engineering Research Center of Natural Medicine Active Molecule Research & Development Liaoning ProvinceChina Key Laboratory of Natural Bioactive Compounds Discovery & Modification ShenyangChina School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning110016China

Excessive free radicals can cause oxidative stress (OS),which lead to neurodegenerative diseases (ND) are harmful to the human ***,it is necessary to explore dietary antioxidants and neuroprotectants from nutrient *** mushroom (Inonotus obliquus ) has been used as an important functional food in many countries for *** present study was carried out to discover active compounds from *** and investigate the in vitro antioxidant activity and neuroprotective *** natural products including two new isocoumarins (1 –2 ),a new 8-O -4′-neolignan (3 ),a new cyclic diarylheptanoid (4 ),and twelve known compounds (5 –16 ) were separated from *** .Their structures were elucidated by extensive spectroscopic analyses of high resolution electrospray mass spectrometry (HRESIMS),ultra violet (UV),and nuclear magnetic resonance (NMR).Among them,compounds 1 and 2 revealed remarkable antioxidant activities through the comprehensive analysis of DPPH,ABTS,and ferric reducing antioxidant power (FRAP) ***,compound 1 demonstrated significant neuroprotective activity by increasing SH-SY5Y cells viability and preventing mitochondrial *** from that,electronic analyses were performed using the highest occupied molecular orbital (HOMO),and the lowest unoccupied molecular orbital (LUMO) to analyze compound 1 .These results indicated that compound 1 had a significant implication for the search of natural raw material to prevent OS and nerve damage in the field of functional foods,and the isocoumarin fragment as well as an oxygenated cis double-bond might be the active sites to play prominent parts in antioxidant and neuroprotective activities of compound 1 .

关键词： Inonotus obliquus Chaga mushroom Functional food Neuroprotective activity Antioxidant activity

Low-temperature synthesis of SiC nanowires with Ni catalyst

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Rare Metals 2019年第3期38卷 206-209页

作者： Wei-Li Xie xiao-Dong Zhang Wen-Hui Liu Qi Xie Guang-Wu Wen xiao-xiao huang Jian-Dong Zhu Fei-Xiang Ma School of Material Science and Engineering Harbin Institute of Technology Department of Prosthodontics School of StomatologyHarbin Medical University School of Material Science and Engineering Harbin Institute of Technology at Weihai

SiC nano wires were fabricated on the silicon substrate dipped with a layer of Ni catalyst at 900 ℃ by gas pressure annealing processing. The morphologies and crystal structures were determined by scanning electron microscopy(SEM), transmission electron microscopy(TEM)and X-ray diffraction(XRD). The results show that the assynthesized nanowires are β-SiC single crystalline with diameter range of 50-100 nm, and length of tens of micron by directly annealing at 900 ℃. The SiC nano wires grow along the [111] direction with highly uniform morphology. And the possible growth mechanism of SiC nano wires is *** present work provides an efficient strategy for the production of high-quality SiC nano wires.

关键词： SiC nanowires Single crystalline silicon Ni catalyst Growth mechanism

Quassinoids from the Root Barks of Ailanthus altissima:Isolation,Configurational Assignment,and Cytotoxic Activities

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Chinese Journal of Chemistry 2021年第4期39卷 879-886页

作者： Ye-Qing Du Ming Bai xiao-Qi Yu Tian-Ming Lv Bin Lin xiao-xiao huang Shao-Jiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Main observation and conclusion Quassinoids,a class of highly oxygenated triterpenes,have been isolated as bitter principles from the plants of Simaroubaceae *** new quassinoids,chouchunlactone A-E(1-5),and two known ones were identified from the root barks of Ailanthus altissima Swingle(Simaroubaceae).The chemical structures of the new compounds were deduced by spectroscopic data analyses,NMR calculations and DP4+probability *** absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism(ECD)spectra data,and compounds 1-2 were further confirmed by single-crystal X-ray ***,compound 5 showed potencies equivalent to sorafenib(IC50 value,9.70μmol·L–1)against HepG2 *** Hoechst 33342 staining,JC-1 fluorescent dye and Annexin V/PI analysis studies demonstrated that 5 can induce apoptosis and attenuate mitochondrial membrane potential(MMP)in HepG2 cells.

关键词： Ailanthus altissima Simaroubaceae Quassinoids Cytotoxicity Apoptosis

Complete mitochondrial DNA sequence analysis in two southern Chinese pedigrees with Leber hereditary optic neuropathy revealed secondary mutations along with the primary mutation

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 28-31页

作者： Lei Shu Yong-Ming Zhang xiao-xiao huang Chun-Yue Chen Xian-Ning Zhang Hangzhou Red Cross Hospital Hangzhou 310003 Zhejiang Province China Department of Biochemistry and Genetics National Education Base for Basic Medical Sciences Institute of Cell Biology School of Medicine Zhejiang University Hangzhou 310058 Zhejiang Province China Department of Ophthalmology Xiangshan First People's Hospital Xiangshan County 315700 Zhejiang Province China Hangzhou No. 6 Hospital Hangzhou 310014 Zhejiang Province China

AIM: To investigate mitochondrial factors associated with Leber hereditary optic neuropathy (LHON) through complete sequencing and analysis of the mitochondrial genome of Chinese patients with this disease. METHODS: Two unrelated southern Chinese families with LHON and 10 matched healthy controls were recruited, and their entire mitochondrial DNA (mtDNA) was amplified and sequenced with the universal M13 primer. Then DNA sequence analysis and variation identification were performed by DNAssist and Chromas 2 software and compared with authoritative databases such as Mitomap. RESULTS: Mutational analysis of mtDNA in these two Chinese pedigrees revealed one common LHON-associated mutation, G11778A (Arg -> His), in the MT-ND4 gene. In addition, there were two secondary mutations in Pedigree 1: C34971 (Ala -> Val), and C3571T (Leu -> Phe) in the MT-ND1 gene, which have not been reported; and two secondary mutations occurred in Pedigree 2: A10398G (Thr -> Ala) in the MT-ND3 gene, and T14502C (Ile -> Val) in the MT-ND6 gene. Three polymorphisms, A73G, G94A and A263G in the mtDNA control region, were also found. CONCLUSION: Our study confirmed that the known MT-ND4* G11778A mutation is the most significant cause of LHON. The C3497T and C3571T mutations in Pedigree 1 were also both at hot-spots of MT-ND1; they may affect the respiratory chain in coordination with the primary mutation G11778A. In Pedigree 2, the two secondary mutations A10398G of MT-ND3 and T14502C of MT-ND6 may influence mitochondrial respiratory complex I, leading to the mitochondrial respiratory chain dysfunction which results in optic atrophy together with G11778A. Therefore, not only the common primary LHON mutation is responsible for the visual atrophy, but other secondary mtDNA mutations should also be considered when giving genetic counseling.

关键词： Leber hereditary optic neuropathy mitochondrial DNA mutation mitochondrial respiratory complex I

Brusatol:A potential anti-tumor quassinoid from Brucea javanica

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Chinese Herbal Medicines 2020年第4期12卷 359-366页

作者： xiao-qi Yu Xin-yue Shang xiao-xiao huang Guo-dong Yao Shao-jiang Song Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001China

Brusatol,a triterpene lactone compound mainly from Brucea javanica,sensitizes a broad spectrum of cancer *** is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2(Nrf2)*** this review,we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in *** review also covers pharmacokinetics studies,modification of dosages forms of *** evidences have validated the value of brusatol as a chemotherapeutic agent in cancers,which may contribute to drug development and clinical application.

关键词： antitumor Brucea javanica(L.)Merr. brusatol triterpene lactone

Outcomes of laparoscopic bile duct exploration for choledocholithiasis with small common bile duct

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World Journal of Clinical Cases 2021年第8期9卷 1803-1813页

作者： xiao-xiao huang Jia-Yi Wu Yan-Nan Bai Jun-Yi Wu Jia-Hui Lv Wei-Zhao Chen Li-Ming huang Rong-Fa huang Mao-Lin Yan Department of Hepatobiliary and Pancreatic Surgery Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Laparoscopic cholecystectomy(LC)combined with laparoscopic common bile duct(CBD)exploration(LCBDE)is one of the main treatments for choledocholithiasis with CBD diameter of larger than 10 ***,for patients with small CBD(CBD diameter≤8 mm),endoscopic sphincterotomy remains the preferred treatment at present,but it also has some drawbacks associated with a series of complications,such as pancreatitis,hemorrhage,cholangitis,and duodenal *** date,few studies have been reported that support the feasibility and safety of LCBDE for choledocholithiasis with small *** To investigate the feasibility and safety of LCBDE for choledocholithiasis with small *** A total of 257 patients without acute cholangitis who underwent LC+LCBDE for cholecystolithiasis from January 2013 to December 2018 in one institution were *** clinical data were retrospectively collected and *** to whether the diameter of CBD was larger than 8 mm,257 patients were divided into large CBD group(n=146)and small CBD group(n=111).Propensity score matching(1:1)was performed to adjust for clinical *** demographics,intraoperative data,short-term outcomes,and long-term follow-up outcomes for the patients were recorded and *** In total,257 patients who underwent successful LC+LCBDE were enrolled in the study,146 had large CBD and 111 had small *** median follow-up period was 39(14-86)*** small CBD patients,the median CBD diameter was 0.6 cm(0.2-2.0 cm),the mean operating time was 107.2±28.3 min,and the postoperative bile leak rate,rate of residual CBD stones(CBDS),CBDS recurrence rate,and CBD stenosis rate were 5.41%(6/111),3.60%(4/111),1.80%(2/111),and 0%(0/111),respectively;the mean postoperative hospital stay was 7.4±3.6 *** large CBD patients,the median common bile duct diameter was 1.0 cm(0.3-3.0 cm),the mean operating time was 115.7±32.0 min,and the postoperative bile leak rate,rate of residual CBDS,CBDS recurre

关键词： Common bile duct stones Laparoscopic common bile duct exploration Endoscopic sphincterotomy Bile leak Choledochal stenosis Recurrence

Rapid discovery of two unprecedented meroterpenoids from Daphne altaica *** molecular networking integrated with MolNetEnhancer and Network Annotation Propagation

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Chinese Chemical Letters 2024年第8期35卷 294-298页

作者： Wei-Yu Zhou Zi-Han Xi Ning-Ning Du Li Ye Ming-Hao Jiang Jin-Le Hao Bin Lin Guo-Dong Yao xiao-xiao huang Shao-Jiang Song Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia Medic1Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

Under the guidance of the approach which integrates molecular networking,MolNetEnhancer and Net-work Annotation Propagation(NAP),daphnaltaicanoids A and B(1 and 2)with unprecedented 9-oxa-tetracyclo[6.***.1.0^(2,6).0^(8,13)]pentadecane and tetracyclo[5.***.0.1^(2,5).2^(4,11)]tridecane central frameworks were iso-lated from Daphne altaica Pall.,representing two types of unparalleled meroterpenoid *** struc-tures were elucidated by extensive spectroscopic analysis,nuclear magnetic resonance(NMR)calcula-tions,DP4+analysis and electronic circular dichroism(ECD)*** plausible biosynthetic path-ways for 1 and 2 were ***,2 exerted potent neuroprotective activities which were su-perior to trolox at 12.5 and 25μmol/***,1 and 2 exhibited more noticeable acetylcholinesterase inhibitory activities than *** docking simulations were performed to explore the inter-molecular interaction of compounds 1 and 2 with *** bioactivity evaluation results highlight the prospects of 1 and 2 as a novel category of neurological agents.

关键词： Daphne altaica Pall. Molecular networking MolNetEnhancer NAP Unprecedented meroterpenoid frameworks Neuroprotective activities Acetylcholinesterase inhibitors

Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 177-184页

作者： Kang Song,Qiang Gao,Jian Zhou,Shuang-Jian Qiu,xiao-Wu huang,xiao-Ying Wang and Jia Fan Liver Cancer Institute, Zhongshan Hospitaland Institute of Biomedical Sciences , Fudan University, Shanghai 200032, China Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai 200032 China Institute of Biomedical Sciences Fudan University Shanghai 200032 China

BACKGROUND:In vitro experiments and mice models have confirmed the importance of Sprouty 2(Spry2) in inhibiting tumorigenesis and the progression of human ***,the prognostic value of Spry2 in cancer patients remains *** study is aimed to investigate the clinical relevance and prognostic significance of Spry2 expression in patients with hepatocellular carcinoma(HCC).METHODS:With samples from 240 randomly-selected HCC patients who underwent surgery,immunohistochemistry was used to investigate Spry2 expression on tissue *** correlation of Spry2 expression with survival was estimated by the Kaplan-Meier method and univariate/multivariate Cox proportional hazard regression ***2,ERK and phospho-ERK expression in HCC cell lines was detected by Western ***:Among the patients,86.3%(207 of 240) exhibited down-regulation of Spry2 *** negative for Spry2 showed poorer survival(P=0.002) and increased recurrence(P=0.003).Multivariate analysis further established Spry2 as an independent predictor of postoperative recurrence in HCC patients(HR=1.47;95% CI,1.02-2.08;P=0.037).Downregulation of Spry2 was associated with highly malignant phenotypes like vascular invasion and advanced tumor stages,and was positively correlated with the metastatic potential of HCC cell ***:In the era of molecular targeted therapy,the expression of Spry2 in HCC may have relevant clinical significance and turn out to be a key factor in prognostic assessment and in treatment planning.

关键词： hepatocellular carcinoma Sprouty 2 tumor suppressor prognosis

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding huang Yunyi Yiyu Liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel