Brusatol:A potential anti-tumor quassinoid from Brucea javanica

作     者：Xiao-qi Yu Xin-yue Shang Xiao-xiao Huang Guo-dong Yao Shao-jiang Song Xiao-qi Yu;Xin-yue Shang;Xiao-xiao Huang;Guo-dong Yao;Shao-jiang Song

作者机构：Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&DevelopmentSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Jiangsu Kanion Pharmaceutical Co.Ltd.Lianyungang 222001China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2020年第12卷第4期

页      面：359-366页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(81872767) 

主　　题：antitumor Brucea javanica(L.)Merr. brusatol triterpene lactone 

摘      要：Brusatol,a triterpene lactone compound mainly from Brucea javanica,sensitizes a broad spectrum of cancer *** is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2(Nrf2)*** this review,we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in *** review also covers pharmacokinetics studies,modification of dosages forms of *** evidences have validated the value of brusatol as a chemotherapeutic agent in cancers,which may contribute to drug development and clinical application.