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Recent Advances on Chiral Mobile Phase Additives: A Critical Review

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Journal of Analysis and Testing 2022年第2期6卷 129-162页

作者： Yuan Li xiao-Ning Jin Yue Cheng xiao-fei ma Yong Wang Department of Chemistry School of ScienceTianjin UniversityTianjin 300075China

Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic,toxicological and pharmacological properties in organisms. Consequently, obtaining enantiomerically pure drugs or optically active intermediates is highly desired in many fields like medicine, food and biochemistry. Thereby, it also promoted the development of various enantiomer selective separation techniques. Among the many chiral separation methods, chiral mobile phase additives(CMPAs) are widely used in various chromatographic techniques due to their simple operation,good versatility and low price. There have been a number of reviews on the research progress of CMPAs in last 2 decades,but they only reviewed the application of CMPAs in one specific chromatographic technique. Therefore, to provide a more comprehensive illustration of CMPAs in separation technology, their applications in high-performance liquid chromatography, capillary electrophoresis, countercurrent chromatography, nano-liquid chromatography were summarized and their advantages and disadvantages were briefly introduced in this critical review. The application of molecular simulation in the study of chiral separation mechanism was briefly summarized. We expect that it will provide researchers with the latest developments in this field and potential inspirations.

关键词： Chiral mobile phase additives High-performance liquid chromatography(HPLC) Capillary electrophoresis(CE) Countercurrent chromatography(CCC) Nano-liquid chromatography(Nano-LC)

An efficient and facile procedure for synthesis of octyl polyglucoside

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Chinese Chemical Letters 2007年第10期18卷 1173-1175页

作者： Ying Wu Jiu Gao Yu xiao fei ma Jian She Zhang Department of Chemistry School of Science Tianjin University Tianjin 300072 China

Nonionic surfactant alkyl polyglucoside （APG） was prepared by direct glycosidation of alkyl alcohol with glucose in the presence of sulfate acid-silica gel （H2SO4/SiO2） as solid acidic catalyst. The quantity of catalyst was only of 1 wt%, based on the glucose, and the conversion of glucose was close to 100% at 110 ℃ in 1.5 h. The product was characterized by FT-IR, mass and ^1H NMR spectra. The degree of polymerization （DP） of the glucose in the product was 1.37, and critical micelle concentration （CMC） of product was only 0.0104 wt%.

关键词： Alkyl polyglucoside Sulfate acid-silica gel Solid acidic Catalyst

Synthesis of aliphatic amidediol and used as a novel mixed plasticizer for thermoplastic starch

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Chinese Chemical Letters 2008年第4期19卷 395-398页

作者： Jian She Zhang Jiu Gao Yu Ying Wu xiao fei ma School of Science Tianjin UniversityTianjin 300072PR China

In this paper,aliphatic amidediol was synthesized and mixed with glycerol used as a plasticizer for preparing thermoplastic starch（AGPTPS）.The yield of aliphatic amidediol was 91%.FF-IR expressed that the mixture of aliphatic amidediol and glycerol formed stronger and stable hydrogen bond with starch molecules compared to the native *** scanning electron microscope（SEM）native cornstarch granules were proved to transfer to a homogeneous continuous *** being stored for a period time at room temperature,the mechanical properties of AGPTPS were also *** a mixed plasticizer,aliphatic amidediol and glycerol would be practical to extend TPS application scopes.

关键词： Thermoplastic starch Aliphatic amidediol Glycerol Plasticizer

Rectifying characteristics and solar-blind photoresponse in β-Ga2O3/ZnO heterojunctions

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Chinese Physics B 2019年第8期28卷 403-407页

作者： xiao-fei ma Yuan-Qi Huang Yu-Song Zhi Xia Wang Pei-Gang Li Zhen-Ping Wu Wei-Hua Tang State Key Laboratory of Information Photonics and Optical Communications & School of Science Beijing University of Posts and Telecommunications

Heterojunctions composed ofβ-Ga2 O3 and ZnO films are fabricated on sapphire substrates by using the laser molecular beam epitaxy *** heterojunction possesses excellent rectifying characteristics with an asymmetry ratio over *** solar-blind photoresponse effect is also observed in the formed *** photodetector exhibits a self-powered behavior with a fast response speed(rise time and decay time are 0.035 s and 0.032 s respectively)at zero *** obtained high performance can be related to the built-in field driven photogenerated electron-hole separation.

关键词： Ga2O3 solar blind photodetector heterojunction self-powered

The evolutionary history of Reaumuriasoongaricainferring from population genetic analysis based onnuclear multilocus

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The evolutionary history of Reaumuriasoongaricainferring fro...

A retrospective monocenter review of simultaneous pancreaskidney transplantation with bladder drainage in China

遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛

作者： Yong Shi XiaYan Hengxia Yin xiao-fei ma Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions Gansu ProvinceDepartment of Ecology and Agriculture ResearchCold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Key Laboratory of Eco-hydrology and of Inland River Basin Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences

Reaumuriasoongarica(Tamaricaceae)is aTertiary relic species widely distributed in northwestern China as one of constructive and dominant species in desert *** spatial and temporal patterns of genetic diversity *** populations and the relationship between their demographic historiesand aridification of northwestern Chinaare not fully understood *** test the hypothesis that its evolutionary history was influenced by Quaternary climatic oscillations and aridification of northwestern China,14 unlinked random nuclear loci with length ranged from 381 to 1734bp,were sequenced in 328 individuals from 41 ***,to estimate the genetic diversity within/among populations which sampled from all the desert regions of northwestern *** of all,standard neutrality tests and MDFM test wereconducted to test the likelihood of adaptiveevolution of *** on the loci nearly neutral,Isolation-with-Migration model(IM model)was then applied to determine the divergent time andpotential gene flowbetween different *** furtherprofile the historical change of effective population sizes from different geological regions andto simulate the most reasonable evolutionary scenarios which shapedthe current patterns of genetic variation,Approximate Bayesian Computation(ABC),Bayesian skyline plot and αaαianalysis were used for the populations from each local *** with the help of ecological niche modeling(ENM)to summarize the range shift in the history,we are able tounderstandthe most parsimonious evolutionary scenario of this desert shrub *** willalso support molecular phylogeographic evidences to understand theasynchronous aridificationprocesses ofthe local regions of northwestern China.

关键词： Reamuriasoongarica IM model ABC demographic history aridification of northwestern China

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Chinese Medical Journal 2011年第2期124卷 205-209页

作者： BI Hai HOU xiao-fei ma Lu-lin LUO Kang-ping WANG Guo-liang ZHAO Lei LIU Ya-li Department of Urology Third Hospital of Peking University Beijing 100191 China

Background Simultaneous pancreas-kidney transplantation （SPKT） frees the diabetic patient with end-stage nephropathy from dialysis and daily insulin ***,we review consecutive cases of SPKT with bladder drainage performed at our institution over an 8-year *** The study population included 21 patients （16 males and 5 females） who underwent SPKT between September 2001 and September *** patients had type-1 diabetes and 14 had type-2 *** patients were on dialysis at the time of *** after cardiac death donors were selected for *** mean human leukocyte antigen match was 2 （range 0-4）.SPKT was always performed using bladder drainage and vascular anastomoses to the systemic *** treatment consisted of anti-lymphocyte globulin induction followed by tacrolimus,mycophenolate mofetil,and *** The mean hospital stay was 45.43 *** a mean follow-up of 39.4 months,survival rates for patient,kidney,and pancreas were 76.2%,76.2%,and 66.7% at 1 year;76.2%,59.3%,and 55.6% at 5 years;and 57.1%,39.5%,and 41.7% at 8 years,*** complications included anastomotic leaks,reflux pancreatitis,and *** patients died from septic shock （n=3）,duodenal stump leak （1）,cardiac arrest （1）,or renal failure （1）.Eight kidney grafts were lost due to acute rejection （n=2）,chronic rejection （3）,and death with a functioning graft （3）.Pancreatic graft failure （9） was caused by thrombosis （n=1）,rejection （2）,duodenal stump leak （1）,and death with a functioning graft （5）.Concluslons SPKT is a valid therapeutic option for uremic diabetics although few hospitals in China can undertake SPKT.

关键词： pancreas transplantation kidney transplantation survival rate postoperative complications

The mechanism of adaptive evolution of the early flowering in wild barley to mitigate global climate change

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The mechanism of adaptive evolution of the early flowering i...

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛

作者：钱朝菊 Xia Yan Jiecai Zhao Guoxiong Chen Eviatar Nevo xiao-fei ma 于黎 Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions Gansu ProvinceDepartment of Ecology and Agriculture ResearchCold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Heihe Key Laboratory of Ecohydrology and Integrated River Basin Science Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Institute of Evolution University of HaifaMount Carmel

In the recent decades,there found overwhelming evidences showed that the climate is changing rapidly,which has been the research hotspot in the area of evolution and *** climate change is one of themajor environmental stressesthat threating biodiversity and the living of organisms,as a result,plant always get some phenotypic variation to adapt to the environment,however,for plants,the successful reproduction requires exact timing of flowering,and the time of flowering during the year is an important adaptive *** studies witnessed that the time of flowering in wild species have been earlier than before,showed that the change of flowering time is an effective strategy to adapt to the climate *** 2012,a research examined 10 wild barley sampled in 1980 and again in 2008 detected profound adaptive changes in flowering time(Nevo et al.,2012 PNAS),the results found that the average flowering time of the all ten populations of wild barleyin 2008 have been distinct earlier than that in 1980,and SSR analysis showed that the frequencies of genotypes have been changed to mitigate the global climate ***,thegenetic mechanism of the phenomena has not been *** examined the phenotypeof 10wild barley populations sampled in 1980 and again in 2008,then took advantage of the genome of barley to investigate the nucleotide diversity and linkage disequilibriumof the flowering time networks based on the Sanger sequencing and Next-generation *** the frequency and the co-contribution to the phenotypes ofthe regulatory network of flowering time genes,we used the clinal variation and candidate gene association study approaches to map the mutationswhich contribute to the complex adaptive *** study will address the genetic basis underline early flowering in natural populations of wild barley,to provide an genetic example how annual plantmitigate in a short generations to adaptthe global climate change by regulating flowering

关键词： global climate change adaptive evolution wild barley genetic basis association study

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun ma Taiwei Dong fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

基于双马来酰亚胺树脂的高耐热电子封装模塑料制备

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热固性树脂 2023年第4期38卷 7-13,20页

作者：包颖黄家腾朱飞宇费小马魏玮江南大学化学与材料工程学院江苏无锡214122 无锡创达新材料股份有限公司江苏无锡214028

采用双马来酰亚胺树脂(BMI70)、2,2′-二烯丙基双酚A(DBA)、多官环氧树脂(EPPN501H)和芳烷基型酚醛树脂(MEH78004S)制备了BDEP四元树脂共混物,研究了不同BMI含量对共混物固化行为和热稳定性的影响。以BDEP四元树脂为基体制备了电子封装... 详细信息

采用双马来酰亚胺树脂(BMI70)、2,2′-二烯丙基双酚A(DBA)、多官环氧树脂(EPPN501H)和芳烷基型酚醛树脂(MEH78004S)制备了BDEP四元树脂共混物,研究了不同BMI含量对共混物固化行为和热稳定性的影响。以BDEP四元树脂为基体制备了电子封装模塑料,测试了所得模塑料的热性能、力学性能、耐老化性及介电性能,并与商用环氧模塑料(EMC)进行对比。结果表明,选用质量分数1%的2-乙基-4-甲基咪唑作固化促进剂时,BDEP四元树脂的固化放热峰温约为150℃,可在较低温度下成型。通过优化配方,BDEP模塑料固化物的玻璃化转变温度可达242℃,与商用EMC相比提高了约60℃,最大热分解温度可达455℃,同时具有良好的力学强度和介电性能,在高功率电子元器件封装领域具有良好的应用前景。

关键词：双马来酰亚胺环氧树脂模塑料耐热高功率电子封装