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Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer

World Journal of Gastroenterology 2018年第31期24卷 3538-3546页

作者： Ting Zhang Fang Wang Jing-Yi Wu Zhi-Chao Qiu Yan Wang Fen Liu xiao-song ge xiao-Wei Qi Yong Mao Dong Hua Institute of Cancer Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

AIM To investigate the expression and clinical significance of B7 homolog 3(B7-H3) and β-1,3-galactosyltransferase-4(B3 GALT4) in colorectal cancer(CRC) *** Using tissue microarray, we identified the expression of B7-H3 and B3 GALT4 in 223 CRC patient samples by immunohistochemistry and evaluated the possible correlation between B7-H3 and B3 GALT4 and clinicaloutcomes. Further, the m RNA and protein expression were identified to establish the regulatory relationship of B7-H3 with B3 GALT4 in *** A significant positive correlation between B7-H3 and B3 GALT4 was observed in CRC specimens(r = 0.219, P = 0.001). High expression of B7-H3 was identified as a significant independent predictor of poor overall survival(OS) [hazard ratio(HR) = 1.781; 95%CI: 1.027-3.089; P = 0.040]. Moreover, high expression of B3 GALT4 was also recognized as an independent predictor of inferior OS(HR = 1.597; 95%CI: 1.007-2.533; P = 0.047). Additionally, CRC patients expressing both high B7-H3 and high B3 GALT4 contributed to a significant decrease in OS(HR = 2.283; 95%CI: 1.289-4.042; P = 0.005). In CRC cell lines with stable expression of high B7-H3, the m RNA and protein expressions of B3 GALT4 were significantly upregulated. Similarly, the expression of B3 GALT4 was significantly reduced when expression of B7-H3 was knocked *** The expression of B3 GALT4 in CRC is positively correlated with B7-H3 expression in vitro. B7-H3/B3 GLAT4 may be used as dual prognostic biomarkers for CRC.

关键词： B7 homolog 3 β-1,3-galactosyltransferase-4 Colorectal cancer Prognosis Correlation

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Mechanism of acupuncture on anti-neuronal apoptosis and the regulation of PI3K/AKT signaling pathway in heroin relapse rats

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 285-289页

作者： xiao-Rong Hou Xing-Hui Cai Sheng-Bing Wu Rong-Jun Zhang Li-Da Zhang xiao-ge song College of Integrated Chinese and Western Medicine Anhui University of Traditional Chinese MedicineHefei 230012China Institute of Acupuncture-Moxibustion and Meridian Anhui University of Traditional Chinese MedicineHefei 230038China Scientific Research Experiment Center Anhui University of Traditional Chinese MedicineHefei 230038China College of Graduate Anhui University of Traditional Chinese MedicineHefei 230038China

Objective:To explore the mechanism of acupuncture intervention on anti-neuronal apoptosis in heroindependent rats based on the PI3K/AKT signaling ***:A total of 30 SD rats were randomly divided into a normal group,a model group and an acupuncture group,10 rats in each *** the model group and the acupuncture group,the heroin relapse rat model was established by intramuscular incremental injection of *** the model group,no any intervention was *** the acupuncture group,after modeling,acupuncture was applied at"Bǎihuì(百会GV20)"and"Dàzhuī(大椎GV14)".Transmission electron microscope(TEM)was adopted to observe neuronal apoptosis in the *** effect of acupuncture on anti-neuronal apoptosis was *** reverse transcription-polymerase chain reaction(RT-PCR)and western blot methods,the mRNA and protein expressions of PI3 K and AKT were detected in ventral tegmental area(VTA).Results:It was found that edema was presented in VTA neuronal cytoplasm and organelles basically disappeared in the heroin relapse rats,nuclear chromatin aggregation,condensation and increased neuronal apoptosis were presented as *** acupuncture at"Bǎihuì(百会GV20)"and"Dàzhuī(大椎GV14)",a small amount of mitochondria,rough endoiplasmic reticulum and glycogen granules were visible in the cytoplasm of VTA *** nuclear membrane structure was clear and the chromatin in the nucleus was basically *** fluorescence quantitative polymerase chain reaction(PCR)and western blot methods were adopted to detect mRNA and protein expressions of PI3K and *** was found that the mRNA and protein expressions of PI3K and AKT in the brain of the rats in the model group were lower than those in the normal group(all P<0.05).Compared with the model group,the mRNA and protein expressions of PI3K and AKT in the acupuncture group were increased(all P<0.05),tending to the levels as the normal ***:The effect of acupuncture on anti-brain cell apoptosis in heroin relap

关键词： Acupuncture Heroin relapse rats Neuronal apoptosis PI3K/AKT signaling pathway

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Recent Advances in Fibrous Materials for Hydroelectricity generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can ge Duo Xu xiao Feng Xing Yang Zheheng song Yuhang song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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针灸对海洛因复吸大鼠条件性位置偏爱及脑前额叶皮质超微结构的影响

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针刺研究 2009年第2期34卷 97-100页

作者：张荣军宋小鸽蔡兴慧安徽中医学院解剖教研室合肥230038 安徽中医学院针灸经络研究所合肥230038

目的:观察针灸对海洛因复吸大鼠条件性位置偏爱的行为学改变及脑神经元超微结构变化的影响,探讨针灸的作用机制。方法:Wistar大鼠32只随机分为正常组、模型组、药物组和针灸组,每组8只。递增量肌肉注射海洛因,按染毒(成瘾)→脱毒的方法... 详细信息

目的:观察针灸对海洛因复吸大鼠条件性位置偏爱的行为学改变及脑神经元超微结构变化的影响,探讨针灸的作用机制。方法:Wistar大鼠32只随机分为正常组、模型组、药物组和针灸组,每组8只。递增量肌肉注射海洛因,按染毒(成瘾)→脱毒的方法,反复3个阶段,建立海洛因复吸大鼠模型。药物组在染毒期给予大鼠连续递增量肌肉注射海洛因,在脱毒期给予美沙酮灌胃治疗;针灸组在染毒期处理与药物组相同,在脱毒期给予针灸治疗(针刺"百会"穴,艾灸"肾俞"穴)。记录造模前、后及治疗后各组大鼠在暗箱内的停留时间,于实验第39天取材并运用透射电镜观察脑前额叶皮质(PFC)神经元超微结构。结果:造模后与造模前相比,模型组、药物组、针灸组大鼠在暗箱停留时间明显缩短(P<0.01);治疗后与模型组、药物组相比,针灸组大鼠在暗箱停留时间明显延长(P<0.01)。与正常组相比,模型组、药物组大鼠脑PFC在电镜视野下可见不同程度的胞质空泡、水肿,粗面内质网扩张,线粒体空泡、消失,核糖体数目减少,核膜间隙增宽;与模型组和药物组相比,针灸组大鼠脑PFC线粒体、核糖体数目略有增多,线粒体嵴比较清楚,粗面内质网数量相对增多,但有轻度扩张,核膜间隙正常。结论:针灸可干预海洛因复吸大鼠条件性位置偏爱的行为学改变,对海洛因复吸大鼠脑组织的损伤具有一定的保护作用。

关键词：海洛因复吸针灸超微结构大脑皮层条件性位置偏爱

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Effect of electroacupuncture on the learning and memory abilities in type 2 diabetic model rats with cognitive impairment

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Journal of Acupuncture and Tuina Science 2020年第1期18卷 1-9页

作者： Cao Jiang-peng Yuan Ai-hong Yang Jun song xiao-ge Zha Bi-xiang Liu Zhen Yang Yan-ping Graduate School Anhui University of Chinese MedicineHefei 230012China The First Aftlliated Hospital Anhui University of Chinese MedicineHefei 230031China Institute of Acupuncture and Meridian of Anhui University of Chinese Medicine Hefei 230012China 不详

Objective:To observe the effects of electroacupuncture(EA)on the protein and gene expressions of Bax,Caspase-3 and Bcl-2 in cerebral cortex of type 2 diabetic rats with cognitive impairment(CI),and to explore the mechanism of EA in improving the learning and memory ***:A total of 100 Sprague-Dawley(SD)rats were divided into a normal group(n=10)and a model group(n=90)by random number table *** in the model group were intraperitoneally injected with a small dose of streptozotocin(STZ)to establish the type 2 diabetic models,after being fed with high-fat and high-sugar diet for 1 *** CI rats were selected from the 50 successful model rats by the Morris water maze(MWM)test and randomly divided into a model group and an EA group according to the blood glucose level and MWM data(n=10).Rats in the EA group received acupuncture at Zusanli(ST 36),Neiting(ST 44)and Yishu(Extra),of which Zusanli(ST 36)and Neiting(ST 44)were stimulated by EA apparatus,20 min/time,once a day for 6 d a week and 4 consecutive *** rats in the model and the normal groups were fixed without *** 4-week treatment,the random blood glucose level of the rats was measured;the learning and memory abilities of rats were measured by MWM;terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL)assay was used to detect apoptotic cells;Western blot(WB)and real-time quantitative polymerase chain reaction(RT-qPCR)were used to detect the protein and gene expressions of Bax,Caspase-3 and Bcl-2 in cerebral ***:After modeling,the random blood glucose level and the escape latency tested by MWM were significantly increased,and the number of crossing the platform tested by the MWM was decreased in the EA and model groups,and were significantly different from those in the normal group(P0.05).After 4-week treatment,the random g

关键词： Acupuncture Therapy Electroacupuncture Diabetes Mellitus,Type 2 Cognitive Disorders Maze Learning Apoptosis Caspases Rats

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Effect of acupuncture in intervening heroin-induced brain damage via regulating ubiquitin-proteasome pathway

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Journal of Acupuncture and Tuina Science 2018年第2期16卷 80-88页

作者： Zhang Li-da Cao Jiang-peng Cai Xing-hui WU Sheng-bing Hou xiao-rong Gao Yong-long Zhang Rong-jun song xiao-ge School of Graduate Anhui University of Chinese MedicineHefei 230038China School of Acupuncture Moxibustion and TuinaAnhui University of Chinese MedicineHefei 230038China Key Laboratory of Xin＇ an Medicine Constructed by Anhui Province and Chinese Ministry of Education Anhui University of Chinese MedicineHefei 230038China School of Integrated Traditional Chinese and Western Medicine Anhui University of Chinese MedicineHefei 230038China Institute of Acupuncture and Meridian Anhui University of Chinese MedicineHefei 230038China

Objective：To observe the effect of acupuncture in regulating ubiquitin-proteasome pathway （UPP）,and discuss the action of acupuncture in intervening heroin-induced brain ***：Thirty male Sprague-Dawley （SD） rats were divided into a control group,a model group and an acupuncture group by using the random number *** in the model and acupuncture groups received intramuscular heroin injection for successive 8 d at a progressively increased ***,the injection was suspended for 5 d for *** heroin relapse rat model was established by repeating the drug addiction and withdrawal process for 3 *** control group followed the step of the model establishment,but was given intramuscular injection of normal saline at the stage of addiction and no intervention at the stage of withdrawal;the model group was given intramuscular heroin injection at a progressively increased dose at the addiction stage and no intervention at the withdrawal stage;the acupuncture group was dealt in the same way as the model group at the addiction stage,but received acupuncture at Baihui （GV 20） and Dazhui （GV 14） at the withdrawal stage,with the needles retained for 30 min each time,1 session a day,for successive 5 *** the 39th day,brain tissues were extracted from the hippocampus and ventral tegmental area （VTA） of the three groups of *** apoptosis of brain nerve cells was detected by using terminal deoxynucleotidyl transferase-mediated nick and labeling （TUNEL）.The mRNA and protein expressions of ubiquitin （Ub）,ubiquitin protein ligase （E3） and 26S were examined by immunohistochemistry and quantitative real-time polymerase chain reaction （RT-qPCR）.Results：Compared with the model group,rat＇s hippocampus and VTA in the acupuncture group showed significantly fewer cells positively stained by TUNEL staining （P〈0.01）,and its mRNA and protein expressions of Ub,E3,26S were significantly lower （P〈0.01）.Conclusion：Reducing nerve cell apoptosis and regulating th

关键词： Acupuncture Therapy Ubiqutins Proteasome Substance Withdrawal Syndrome Heroin Dependence BrainInjuries Rats

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Effect of Moxibustion Therapy on the Serumal Intercellular Cell Adhesion Molecule and the Histopathology of Experimental Arthritis in Rats

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Journal of Acupuncture and Tuina Science 2010年第4期8卷 210-213页

作者：何璐 Lars Dirckinck-Holmfeld 蔡荣林宋小鸽胡玲余爽张道琴 Research Institute of Acupuncture and Meridian Anhui College of Traditional Chinese Medicine Hefei 230038 E R. China

Objective： To observe the effects of moxibustion therapy at Shenshu （BL 23） and Zusanli （ST 36） of rats with induced rheumatoid arthritis （RA） on the serumal intercellular cell adhesion molecule-1 （ICMA-1） and the pathological tissue, to discuss the mechanism of the warming and activating effect of moxibustion. Methods： After establishing the RA rats model, the induced rats were treated with moxibustion therapy on the acupoint Shenshu （BL 23） and Zusanli （ST 36）, followed by analyzing the pathological section of the ankle of the hind limb and testing the ICAM-1 content with ELISA. Results： The plantar circumferences of the induced rat increased significantly compared with the rats in the control group （P〈0.01）, accompanying with the increase of the synovial layer, the erosion of phlogocytes to chondrocytes and the specific increase of ICAM- 1 content. After the moxibustion therapy, the plantar circumferences decreased significantly （P〈0.01） while the synovial layer tended to reduce. In addition, there was no pathological damage of the articular cartilage and the ICAM content decreased with significant deviation （P〈0.01）, compared to the model group. Conclusion： It was concluded that moxibustion therapy could inhibit the arthrosynovitis and hyperplasia, ameliorate the erosion of phlogocyte to cartilage, prevent articular periosteal lesions and delay the pathological course. The warming and activating effect of moxibustion therapy may involve the inhibition of the formation of ICAM- 1 and pannus.

关键词： Moxibustion Therapy Arthritis, Rheumatoid Intercellular Adhesion Molecule-l Rats

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近10年针灸戒毒研究概况

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中国针灸 2012年第7期32卷 669-672页

作者：宋小鸽吕航蔡兴慧张荣军安徽中医学院针灸经络研究所合肥230038

回顾近10年针灸改善戒断症状、干预心理渴求防复吸以及针灸戒毒作用机制的研究,在此基础上分析总结针灸戒毒康复的疗效及其可能机制。围绕针灸抗稽延性戒断症状、防复吸、针刺戒毒机制的切入点3个方面,思考展望今后针灸戒毒康复研究的... 详细信息

回顾近10年针灸改善戒断症状、干预心理渴求防复吸以及针灸戒毒作用机制的研究,在此基础上分析总结针灸戒毒康复的疗效及其可能机制。围绕针灸抗稽延性戒断症状、防复吸、针刺戒毒机制的切入点3个方面,思考展望今后针灸戒毒康复研究的发展趋势和应用前景,提出今后要努力探索针灸干预心理渴求的临床观察及针刺影响认知行为,阻断与药物成瘾有关的学习和记忆过程的机制,进一步发挥针灸在抗药物成瘾方面的优势。

关键词：针灸戒毒综述文献

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Effect of Moxibustion on IL-1β and IL-2 in Rat Models of Rheumatoid Arthritis

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Journal of Acupuncture and Tuina Science 2010年第3期8卷 149-153页

作者：胡玲 Dirckinck-Holmfeld Lars 宋小鸽唐照亮蔡荣林何璐罗磊 Research Institute of Acupuncture and Meridian Anhui College of Traditional Chinese Medicine Hefei 230038 R R. China

Objective： To observe the influence on IL-1β and IL-2 in rat models with rheumatoid arthritis after moxibustion on Shenshu （BL 23） and Zusanli （ST 36） points, and to discuss the mechanism of moxibustion. Methods： Fifty male Wistar rats were divided randomly into 5 groups, control group, model group, drug group, moxibustion group, and laser group, 10 for each. Four groups except the normal group were built on the model of rheumatoid arthritis. The changes of body weight and plantar circumference were measured and the level of IL-1β, IL-2 in sera were examined by ELISA. Results： Compared with the model group, the weight and plantar circumference of rats in the moxibustion group were improved significantly after treatment （P〈0.01）, and the improvement of plantar circumference also had significant differences compared with the drug group and the laser group （P〈0.05）. The level of IL-1β, IL-2 in sera were down regulated in the moxibustion group and the laser group, which had statistical differences compared with the model group （P〈0.05）, but no statistical differences were found when comparing with the drug group. Conclusion： Moxibustion obviously improves the toe tumefaction of the rats with rheumatoid arthritis, which is better than CO2 laser of 10.6μm. On the aspect of decreasing the amount of IL-1β, IL-2, CO2 laser of 10.6μm is similar with moxibustion.

关键词： Moxibustion Therapy Arthritis, Rheumatoid Interleukin-1 beta Interleukin-2 Rats [CLC Number] R2-03

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艾灸对实验性关节炎影响的研究概况

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上海针灸杂志 2009年第4期28卷 187-190页

作者：余爽宋小鸽胡玲安徽中医学院合肥230038

综述近年来实验性关节炎在模型制作、病理改变、艾灸治疗方法以及对各项指标影响的实验研究。这些研究为临床应用艾灸治疗关节炎提供了一定的依据。

关键词：灸法艾炷灸实验性关节炎综述

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