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Synthesis of （S） - 2 - Ethoxy - 3 - Phenylpropanoic Acid Derivatives and Their Insulin- Sensitizing Activity

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怀化医专学报 2006年第2期5卷 1-5页

作者： CAI xiao - hua wu Ying- hua Department of pharmaceuticals Huaihua Medical College Huaihua 418000

血清及卵泡液中抑制素B动态变化及其与促排卵结局的相关性研究

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生殖与避孕 2016年第11期36卷 897-903页

作者：刘小惠吴小华河北医科大学石家庄050017 白求恩国际和平医院石家庄050082

目的:探讨不同控制性超促排卵(controlled ovarian hyperstimulation,COH)方案中血清及卵泡液(follicular fluid,FF)中抑制素B(inhibin B,INHB)的动态变化及其与COH结局的相关性。方法:收集因输卵管因素和/或男方因素首次接受体外受精/... 详细信息

目的:探讨不同控制性超促排卵(controlled ovarian hyperstimulation,COH)方案中血清及卵泡液(follicular fluid,FF)中抑制素B(inhibin B,INHB)的动态变化及其与COH结局的相关性。方法:收集因输卵管因素和/或男方因素首次接受体外受精/卵细胞质内单精子注射-胚胎移植(IVF/ICSI-ET)助孕患者COH过程各时间节点的血清及取卵(ovum pick up,OPU)日不同大小卵泡的FF,按筛选要求选取长方案组(A组,n=38)及非降调节方案组(B组,n=38)患者,对其血清及FF中INHB水平进行检测并行相关性分析。结果:①降调节过程中,血清INHB水平显著下降(P0.05)。③ Gn第5日血清INHB水平与COH结局相关性最强,且Gn启动日血清INHB水平与Gn用量呈高度负相关(P0.05),但A组中小卵泡的FF中INHB水平显著高于B组(P<0.01);且大卵泡的FF中INHB水平与COH结局相关性最好。结论:①降调节后血清INHB水平预示降调节对卵泡同步化作用较好;②COH过程中血清及大中卵泡的FF中INHB水平能很好地预测卵巢反应性及COH结局。

关键词：抑制素B(INHB) 体外受精/卵细胞质内单精子注射-胚胎移植(IVF/ICSI—ET) 控制性超促排卵(COH)

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抑制素B在两性生殖生理和病理中的研究进展

生殖与避孕 2016年第9期36卷 737-744页

作者：刘小惠吴小华河北医科大学石家庄050017 中国人民解放军白求恩国际和平医院石家庄050082

抑制素B(inhibin B,INHB)是由α及β(B型)亚单位构成的异源二聚体糖蛋白激素,属于转化生长因子β(transforming growth factor-β,TGFβ)超家族的一员。INHB在男性主要由睾丸支持细胞合成,在女性主要由卵巢的中、小窦卵泡颗粒细胞产生,... 详细信息

抑制素B(inhibin B,INHB)是由α及β(B型)亚单位构成的异源二聚体糖蛋白激素,属于转化生长因子β(transforming growth factor-β,TGFβ)超家族的一员。INHB在男性主要由睾丸支持细胞合成,在女性主要由卵巢的中、小窦卵泡颗粒细胞产生,其主要作用是通过负反馈机制抑制垂体促卵泡生成激素(follicular stimulation hormone,FSH)分泌,进而调节配子发生、发育,与雌雄两性生命活动密切相关。

关键词：抑制素B(INHB) 转化生长因子β(TGFβ) 体外受精-胚胎移植(IVF-ET)

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia

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Neuroscience Bulletin 2022年第9期38卷 992-1006页

作者： Kang-Wei Qian Yun-Yun Li xiao-hua wu Xue Gong Ai-Lin Liu Wen-Hao Chen Zhe Yang Ling-Jie Cui Yun-Feng Liu Yuan-Yuan Ma Chen-Xi Yu Furong huang Qiongsi Wang Xiangtian Zhou Jia Qu Yong-Mei Zhong Xiong-Li Yang Shi-Jun Weng State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai200032China Discipline of Neuroscience and Department of Anatomy and Physiology College of Basic Medical SciencesShanghai Jiao Tong University School of MedicineShanghai200025China School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhou325027China Department of Immunology School of Basic Medical SciencesAnhui Medical UniversityHefei230032China

Reduced levels of retinal dopamine,a key regulator of eye development,are associated with experimental myopia in various species,but are not seen in the myopic eyes of C57BL/6 mice,which are deficient in melatonin,a neurohormone having extensive interactions with ***,we examined the relationship between form-deprivation myopia(FDM)and retinal dopamine levels in melatonin-proficient CBA/CaJ *** found that these mice exhibited a myopic refractive shift in form-deprived eyes,which was accompanied by altered retinal dopamine *** melatonin receptors were pharmacologically blocked,FDM could still be induced,but its magnitude was reduced,and retinal dopamine levels were no longer altered in FDM animals,indicating that melatonin-related changes in retinal dopamine levels contribute to ***,FDM is mediated by both dopamine level-independent and melatonin-related dopamine level-dependent mechanisms in CBA/CaJ *** previously reported unaltered retinal dopamine levels in myopic C57BL/6 mice may be attributed to melatonin deficiency.

关键词： Myopia Refractive development Dopamine Melatonin Mouse Retina

磁性壳聚糖-5-氟尿嘧啶纳米粒的制备及体外释药性能

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高分子材料科学与工程 2007年第1期23卷 189-191,195页

作者：李和平肖华伍肖子丹阮建明长沙理工大学化学与环境工程学院湖南长沙410076 中南大学湘雅医院湖南长沙410083 中南大学粉末冶金国家重点实验室湖南长沙410083

采用交联-聚合法在超声波的作用下,制备了磁性壳聚糖-5-氟尿嘧啶纳米粒(M CN-Fu)。透射电子显微镜(TEM)和红外光谱(IR)等分析结果表明,M CN-Fu粒子外形规整,分散性好,粒径主要在50 nm^60 nm之间。紫外-可见光谱分析结果表明,M CN-Fu的... 详细信息

采用交联-聚合法在超声波的作用下,制备了磁性壳聚糖-5-氟尿嘧啶纳米粒(M CN-Fu)。透射电子显微镜(TEM)和红外光谱(IR)等分析结果表明,M CN-Fu粒子外形规整,分散性好,粒径主要在50 nm^60 nm之间。紫外-可见光谱分析结果表明,M CN-Fu的载药量为21.3%,在磷酸盐缓冲溶液(pH=7.2)中,30 h的累积释药率为67.6%,具有良好缓释性能,并具有良好磁响应性能。

关键词：磁性壳聚糖氟尿嘧啶纳米粒药物缓释剂

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茶树茶氨酸的代谢及其育种研究进展

园艺学报 2016年第9期43卷 1791-1802页

作者：方开星姜晓辉吴华玲广东省农业科学院茶叶研究所广东省茶树资源创新利用重点实验室广州510640

茶氨酸是茶树特征性生化物质,不仅能调节茶树氮代谢及转运,影响茶叶品质,同时对人体还具有镇静、安神等保健功能。茶氨酸含量是数量性状,在茶树体内合成不仅受基因调控且易受环境影响。对茶氨酸的分布及变化规律、代谢途径及相关基因、... 详细信息

茶氨酸是茶树特征性生化物质,不仅能调节茶树氮代谢及转运,影响茶叶品质,同时对人体还具有镇静、安神等保健功能。茶氨酸含量是数量性状,在茶树体内合成不仅受基因调控且易受环境影响。对茶氨酸的分布及变化规律、代谢途径及相关基因、外界影响因子及高茶氨酸品种选育等研究现状进行了综述,旨在为高茶氨酸茶树种质筛选及其高含量形成的机制研究提供参考。

关键词：茶树茶氨酸育种基因

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Retinal dopamine levels in both eyes are equally reduced in CBA/Ca J mice treated with monocular form deprivation

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Deprivation of form vision induces myopia in mice with optic nerve crush

中国神经科学学会第十二届全国学术会议

作者： Kang-Wei QIAN Yun-Yun LI xiao-hua wu Yong-Mei ZHONG Xiong-Li YANG Shi-Jun WENG Institutes of Brain Science State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science Fudan University

Objective Unlike observed in most other species, retinal dopamine（DA） levels are unaltered in C57 BL/6 mice with form-deprivation myopia（FDM）. Although implying a novel, DA-independent mechanism for FDM, this discrepancy might be attributed to the fact that the C57 BL/6 strain is deficient in melatonin, a hormone that interplays with DA. Here we explored whether and how form deprivation changed refractive development and retinal DA levels in a mouse strain proficient in melatonin. Methods CBA/Ca J mice were used in this study. Normal refractive development was measured every 5-10 days from P21 to P106. FDM was induced by wearing monocular occluder, starting at P21, for 5 weeks. Refractions were measured with an eccentric infrared photorefractor. Ocular biometry was performed with A-scan ultrasonography, optical coherence tomography and photokeratometry. Retinal DA, DOPAC and vitreal DOPAC（an indicator of DA release） levels were assessed by HPLC analysis. Retinal tyrosine hydroxylase（TH） levels were examined by quantitative Western blotting. Results Under normal visual conditions, the refraction at P21 was 4.544 ± 0.147 D. It increased continuously in hyperopic direction, reaching a peak（18.262 ± 0.378 D） at P86, and then leveled off. FDM was successfully induced with the refractive status of deprived eyes（8.489 ± 0.877 D） being significantly different（P = 0.00000003） from fellow eyes（13.048 ± 0.870 D）. As expected, axial length in deprived eyes（2.698 ± 0.007 mm） is significantly longer（P = 0.0011） than that in fellow eyes（2.675 ± 0.008 mm）;but unexpectedly, both values were significantly smaller（P = 0.0012, 0.000001） than that of normal eyes（2.736 ± 0.006 mm） in intact animals. Consistent with previous results in C57 BL/6 mice, either retinal DA（P = 0.234）, DOPAC（P = 0.643） or TH（P = 0.653） levels were similar between deprived and fellow eyes. But surprisingly, both deprived and fellow eyes exhibited significantly lower retinal DA（P = 0.006, 0.0004）, DOPAC（P = 0.000

关键词： form-deprivation myopia melatonin dopamine refraction CBA/CaJ mouse

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Deprivation of form vision induces myopia in mice with optic...