Deprivation of form vision induces myopia in mice with optic nerve crush
作者单位：Institute of NeurobiologyInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University
会议名称：《中国神经科学学会第十届全国学术会议》
会议日期：2013年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：mouse form deprivation myopia optic nerve crush eye growt
摘 要：Objective Deprivation of form vision causes excessive axial eye growth and a myopic refractive error in juveniles of several ***,the brain may also be involved in the control of eye *** this work,we investigated whether the retina-brain link is necessary for form-deprivation myopia in mice with optic nerve crush（ONC）.Methods Eye refraction was measured by an automated eccentric infrared photorefractor and ocular components were measured by optical coherence tomography（OCT）.C57BL/6 mice（21-days-old） were monocularly deprived of form vision with white translucent occluders for 4 *** assess the role of brain in form-deprivation myopia,the right optic nerve was crushed in mice（18-days-old） 3 days before the right eyes were occluded for 4 weeks *** The occluded eyes with intact optic nerve showed a significant myopic shift（-5.55±1.83 D）,relative to the contralateral fellow eyes,after 4-week visual *** mice with ONC（but without occluders）,the injured eyes became either myopic or hyperopic,compared to the fellow *** the group with myopic-shift（-5.73±4.81D）,the injured eyes exhibited a significant decrease in both lens and retinal thickness（P 0.05）.In the group with hyperopic-shift（4.59±3.03 D）,the injured eyes showed a decrease in corneal and retinal dnckness（P 0.05）.In mice with ONC,the occluded eyes all became myopic,compared to the fellow eyes,with a myopic shift（-9.69±4.17 D） even larger than that（-5.55±1.83 D）observed in occluded eyes in mice with intact optic ***,these occluded eyes exhibited a significant increase in axial length and vitreous chamber depth（P 0.05）,and a decrease in retinal thickness（P 0.001）,lens thickness and corneal radius of curvature（P 0.05）.Conclusion Intact eye-brain link is indispensable for normal ocular growth and refractive *** centers are involved in the development of myopia due to form deprivation.