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Tetraamido-oxacalix[4]arene Derivatives： Synthesis, Structures and Supramolecular Assemblies

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Chinese Journal of Chemistry 2013年第5期31卷 684-688页

作者： Lingwei Kong mingliang Ma Xiaoli Zhao Yahua Liu xianqiang mi Biao Jiang Ke Wen ~hanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Nor- mal University Shanghai 200062 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes and Department of Chemistry East China Normal University Shanghai 200062 China Medicinal Chemistry ChemBridge Research Laboratories Inc. San Diego CA 92127 USA Sustainable Technology Research Center Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201203 China

Tetraamido-oxacalix[4]arene derivatives have been synthesized via the reactions of tetraamino-oxacalix[4]arene with excess butyryl chloride, octanoyl chloride, benzoyl chloride and p-toluenesulfonyl chloride, respectively. JH NMR results suggest that these oxacalix[4]arene derivatives preferentially adopt the 1,3-alternate （saddle-like） con- formation in solution, which were also the case in the solid state as demonstrated by single crystal X-ray analysis. A dimerized slipped capsule could be formed by tetra-butyramido-oxacalix[4]arene in the solid state via intermolecu- lar hydrogen bond interactions under the assistance of two encapsulated methanol molecules. On the other hand, a molecular cavity was formed by tetra-p-toluenesulfonamido-oxacalix[4]arene which can encapsulate a solvent molecule of ethyl acetate.

关键词： oxacalixarene synthesis assembly macrocycle

microfluidic magnetic detection system combined with a DNA framework-mediated immune-sandwich assay for rapid and sensitive detection of tumor-derived exosomes

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microsystems & Nanoengineering 2023年第6期9卷 195-204页

作者： Qiuling Qian Yutong Wei Yi Xu Mengmeng Zheng Chenguang Wang Shulin Zhang Xiaoming Xie Chaofeng Ye xianqiang mi National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and information TechnologyChinese Academy of Sciences865 Changning RoadShanghai 200050China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Bejing 100049China school of Information Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Sciences Shanghai UniversityShanghai 20044China School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China

Tumor-derived circulating exosomes(TDEs)are being pursued as informative and noninvasive ***,quantitatively detecting TDEs is still ***,we constructed a DNA tetrahedral-structured probe(TSP)-mediated microfluidic magnetic detection system(μFMS)to provide a rapid and sensitive platform for analyzing ***63 aptamer-modified Fe_(3)O_(4)magnetic nanoparticles(MNPs)were constructed to form magnetic nano-report probes(MNRs).The microfluidic chips were fabricated from glass functionalized with DNA TSP-modified aldehyde groups and a PDMS layer designed with serpentine *** induction coil-based magnetic detector was used to measure the magnetic *** linear dynamic range of theμFMS system for TDE assays was 1.98×10^(3)-1.98×10^(7)particles/mL with a limit of detection of 1.98×10^(3)particles/mL in *** was no significant difference in TDE detection between the simulated serum and PBS,which indicated the feasibility of the constructedμFMS system for TDE analysis in complex biological *** terms of cost,reaction time and operation procedure,thisμFMS has the potential to be developed as a clinical point-of-care testing tool for cancer diagnosis and therapeutics.

关键词： fluid diagnosis magnetic

DNA tetrahedron-mediated immune-sandwich assay for rapid and sensitive detection of PSA through a microfluidic electrochemical detection system

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microsystems & Nanoengineering 2021年第2期7卷 221-230页

作者： Dezhi Feng Jing Su Yi Xu Guifang He Chenguang Wang Xiao Wang Tingrui Pan Xianting Ding xianqiang mi Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050ShanghaiChina Shanghai Advanced Research Institute Chinese Academy of Sciences201210ShanghaiChina University of Chinese Academy of Sciences 100049BeijingChina State Key Laboratory of Oncogenes and Related Genes Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong University200030ShanghaiChina School of Life Sciences Shanghai University200444ShanghaiChina Shenzhen Institutes of Advanced Technology Chinese Academy of Science518055ShenzhenChina CAS Center for Excellence in Superconducting Electronics (CENSE)200050ShanghaiChina Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of Sciences310024HangzhouChina

Prostate-specific antigen(PSA)is the most widely used biomarker for the early diagnosis of prostate *** methods for PSA detection are burdened with some limitations and require ***,we developed a novel microfluidic–electrochemical(μFEC)detection system for PSA ***,we constructed an electrochemical biosensor based on screen-printed electrodes(SPEs)with modification of gold nanoflowers(Au NFs)and DNA tetrahedron structural probes(TSPs),which showed great detection ***,we fabricated microfluidic chips by DNA TSP-Au NF-modified SPEs and a PDMS layer with designed dense meandering ***,theμFEC detection system was achieved based on microfluidic chips integrated with the liquid automatic conveying unit and electrochemical detection ***μFEC system we developed acquired great detection performance for PSA detection in PBS *** PSA assays in spiked serum samples of theμFEC system,we obtained a linear dynamic range of 1–100 ng/mL with a limit of detection of 0.2 ng/mL and a total reaction timemiluminescence assays and theμFEC *** terms of operation procedure,cost,and reaction time,our method was superior to the current methods for PSA detection and shows great potential for practical clinical application in the future.

关键词： fluid diagnosis system

Multi-wavelength nanowire micro-LEDs for future high speed optical communication

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Opto-Electronic Advances 2024年第3期7卷 1-3页

作者： Ayush Pandey Zetian mi Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA

The future of optoelectronics is directed towards small-area light sources,foremost being ***,their use has been inhibited so far primarily due to fabrication and integration challenges,which impair efficiency and ***,bottom-up nanostructures grown using selective area epitaxy have garnered attention as a solution to the aforementioned *** Fu *** used this technique to demonstrate uniform p-i-n core-shell InGaAs/InP nanowire array light emitting *** devices are capable of voltage and geometry-controlled multi-wavelength and high-speed *** publication accentuates the wide capabilities of bottom-up nanostructures to resolve the difficulties of nanoscale optoelectronics.

关键词： communication high operations

电沉积纳米金修饰的16通道电流型PSA免疫传感器的制备

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中国生物医学工程学报 2015年第1期34卷 55-61页

作者：王泽华曾冬冬张欢宓现强上海理工大学医疗器械与食品学院上海200093 中国科学院上海高等研究院上海201210

近年来有关电化学免疫传感器的研究报道虽然很多,但普遍存在如预处理操作繁琐、灵敏度低、特异性差和成本昂贵等不足.本研究通过电沉积纳米金修饰16通道丝网印刷电极,以提高免疫传感器的性能.采用恒电位沉积法将氯金酸（HAuCl4）直接还... 详细信息

近年来有关电化学免疫传感器的研究报道虽然很多,但普遍存在如预处理操作繁琐、灵敏度低、特异性差和成本昂贵等不足.本研究通过电沉积纳米金修饰16通道丝网印刷电极,以提高免疫传感器的性能.采用恒电位沉积法将氯金酸（HAuCl4）直接还原成纳米金,并修饰于16通道丝网印刷碳电极（16-SPCE）表面;以浓度为0.05mg/mL的HAuC14溶液和150 s电沉积时间为电沉积纳米金修饰16-SPCE的最优条件.利用静电吸附原理将前列腺抗原（PSA）抗体固定在电极表面,结合双抗夹心法制备免疫电极.通过循环伏安法和稳态时间电流曲线法表征免疫电极的性能.对30份前列腺癌患者和3份正常人血清进行PSA检测,与标准ELISA方法对照.结果表明：获得的免疫电极线性检测范围为0.2 ～ 100 ng/mL,其线性回归方程为y=134.558X＋72.705,线性相关系数为1,检测限为0.14 ng/mL.采用免疫传感器检测到的前列腺癌患者血清PSA水平与标准ELISA方法检测结果具有良好的线性相关性（R =0.944,P ＜0.001）,正常人的检测值符合正常人血清中PSA的含量.所研制的免疫传感器具有灵敏度高、特异性强、成本低和反应时间短等特点,具有应用前景.

关键词：纳米金电沉积 16通道丝网印刷电极电化学免疫传感器前列腺特异性抗原

一种双单片机激光功率控制系统的软件抗干扰方法

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应用激光 2011年第6期31卷 494-496页

作者：陆兆丹宓现强李铁军上海理工大学医疗器械与食品学院上海200093 中国科学院上海高等研究院纳米医学中心上海201203

以软件设计为主,将信号在单片机内部可能受到干扰的情况分为两个阶段,并创新性的提出通过双单片机结构自检识别受干扰信号的方式,有效的阻断错误信号的输出,大大降低了信号干扰所造成的不良事件发生率,提高了激光医疗产品功率输出的可... 详细信息

以软件设计为主,将信号在单片机内部可能受到干扰的情况分为两个阶段,并创新性的提出通过双单片机结构自检识别受干扰信号的方式,有效的阻断错误信号的输出,大大降低了信号干扰所造成的不良事件发生率,提高了激光医疗产品功率输出的可靠性。

关键词：激光软件信号干扰 ATmega16 功率控制

16通道无标记型糖化血红蛋白检测免疫传感器的构建

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检验医学 2019年第9期34卷 835-840页

作者：王潇宓现强上海大学生命科学学院上海200444 中国科学院上海高等研究院上海201210

目的构建1种检测糖化血红蛋白(HbA1c)的无标记电化学免疫传感器。方法通过HbA1c抗体修饰16通道丝网印刷碳电极(16-SPCE),制备特异检测HbA1c的无标记电化学免疫传感器。采用循环伏安法测定16-SPCE电化学免疫传感器检测HbA1c的电信号,优... 详细信息

目的构建1种检测糖化血红蛋白(HbA1c)的无标记电化学免疫传感器。方法通过HbA1c抗体修饰16通道丝网印刷碳电极(16-SPCE),制备特异检测HbA1c的无标记电化学免疫传感器。采用循环伏安法测定16-SPCE电化学免疫传感器检测HbA1c的电信号,优化检测条件(HbA1c抗体最佳包被浓度、HbA1c抗原最佳孵育时间、电极的电化学特性、不同修饰电极的性能),同时进行初步方法学评价。结果HbA1c抗体最佳包被浓度为50μg/mL,HbA1c抗原最佳孵育时间为60 min。构建的16-SPCE电化学免疫传感器检测HbA1c的线性范围为1~50μg/mL,线性方程为Y=0.199X+10.468(r=0.955),检测限为0.88μg/mL。50μg/mL牛血清白蛋白(BSA)、50μg/mL前列腺特异性抗原(PSA)和50μg/mL葡萄糖对16-SPCE电化学免疫传感器检测HbA1c无干扰。制备的免疫电极在4℃能稳定放置5 d。采用16-SPCE电化学免疫传感器检测模拟血清样本中的HbA1c,各浓度的电流响应值能明显区分,且检测结果的重复性较好。结论构建的16-SPCE电化学免疫传感器具有良好的电化学响应能力、线性范围、抗干扰能力等。

关键词：糖化血红蛋白 16通道丝网印刷碳电极电化学免疫传感器

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miRNA应用于胰腺癌早期检测研究进展

检验医学 2014年第4期29卷 395-399页

作者：练宓宓现强上海理工大学医疗器械与食品学院上海200093 中国科学院上海高等研究院上海201210

胰腺癌恶性度高、预后差、死亡率高,临床通常依靠影像检测,所用诊断试剂盒特异性、准确性低,使其早期发现、鉴别诊断困难。分子诊断学是近年来新发展的临床诊断手段之一。由于miRNA在胰腺癌中的特异性表达使其可以作为胰腺癌的新型诊断... 详细信息

胰腺癌恶性度高、预后差、死亡率高,临床通常依靠影像检测,所用诊断试剂盒特异性、准确性低,使其早期发现、鉴别诊断困难。分子诊断学是近年来新发展的临床诊断手段之一。由于miRNA在胰腺癌中的特异性表达使其可以作为胰腺癌的新型诊断标志物,其相关的检测技术也因此得到不断发展。本文综述了胰腺癌当前临床诊断方法及诊断标志物,并对用于胰腺癌miRNA早期检测方法进行了探究。

关键词：胰腺癌 miRNA 分子诊断学

Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： Sheng mi Chaofeng Hou Wei Ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid was investigated theoretically and the critical bubble size was derived from macroscale thermodynamic equations,below which the system destabilizes with sharp drop in *** critical size was quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,where stronger attraction between the molecules at lower density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems where reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size