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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liU Xiao-rong li Shuo-fu mei Wen-ya liU xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Plity,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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New Iboga‑Type Indole Alkaloids from Tabernaemontana divaricata

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Natural Products and Bioprospecting 2019年第6期9卷 425-429页

作者： xiang-mei li Xian-Jun Jiang Guo-Zhu Wei li-Hua Ren li-Xia Wang Xue-lian Cheng Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China Reference Substance Branch National Engineering Research Center for Modernization of Traditional Chinese MedicineKunming 650201People’s Republic of China Department of Pharmacy The People’s Hospital of Fengjie CountyChongqing 404600People’s Republic of China

Two hitherto unknown iboga-type indole alkaloids,namely(3R)-7,19-di-epi-3-methoxytabernoxidine(1)and(3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine(2),together with eight known alkaloids(3-10),were isolated from the twigs and leaves of Tabernaemontana *** structures were established on the basis of spectroscopic data interpretation,single crystal X-ray diffraction analysis and circular dichroism spectrum.

关键词： Tabernaemontana divaricata Iboga-type indole alkaloid Single crystal X-ray diffraction

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Polysubstituted Isoflavonoids from Spatholobus suberectus,Flemingia macrophylla,and Cudrania cochinchinensis

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Natural Products and Bioprospecting 2017年第2期7卷 201-206页

作者： li-Xia Wang Hai-Rong Zheng Fu-Cai Ren Tian-Gc Chen xiang-mei li Xian-Jun Jiang Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China

Four hitherto unknown polysubstituted isofiavonoids,including three isofiavans:7,4'-dihydroxy-8,2',3'-trimethoxyisofiavan(1),7,2',4'-trihydroxy-8,3'-dimethoxyisofiavan(2),and 7,2',4'-trihydroxy-5-methoxyisofiavan(3),and one prenylated isofiavone cudraisofiavone M(4)were isolated from the ethanol extracts of Spatholobus suberectus(for 1 and 2),Flemingia macrophylla(for 3),and Cudrania cochinchinensis(for 4),*** structures were established on the basis of extensive spectroscopic *** 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines(HL-60,A-549,SMMC-7721,MCF-7,and SW-480).

关键词： Spatholobus suberect us Flemingia macrophylla Cudrania cochinchinensis Isofiavan Isofiavone Cytotoxicity

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APF-GAN:Exploring asymmetric pre-training and fine-tuning strategy for conditional generative adversarial network

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Computational Visual Media 2024年第1期10卷 187-192页

作者： Yuxuan li lingfeng Yang xiang li College of Computer Science Nankai UniversityTianjinChina School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjingChina

The use of generative adversarial network(GAN)-based models for the conditional generation of image semantic segmentation has shown promising results in recent ***,there are still some limitations,including limited diversity of image style,distortion of detailed texture,unbalanced color tone,and lengthy training *** address these issues,we propose an asymmetric pre-training and fine-tuning(APF)-GAN model.

关键词： tuning network asymmetric

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Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： Gui-quan Wang Zhuo Xu Zhong-li liu xiang Chen Yan-xiang li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

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Geographically and Temporally Weighted Regression in Assessing Dengue Fever Spread Factors in Yunnan Border Regions

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Biomedical and Environmental Sciences 2024年第5期37卷 511-520页

作者： ZHU Xiao xiang WANG Song Wang li Yan Fei ZHANG Ye Wu SU Xue mei ZHAO Xiao Tao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102211China Yunnan Institute of Parasitic Diseases Pu’er 665000YunnanChina

Objective This study employs the Geographically and Temporally Weighted Regression(GTWR)model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks,emphasizing the spatial-temporal variability of these factors in border *** We conducted a descriptive analysis of dengue fever’s temporal-spatial distribution in Yunnan border *** annual data from 2013 to 2019,with each county in the Yunnan border serving as a spatial unit,we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this *** The GTWR model,proving more effective than Ordinary Least Squares(OLS)analysis,identified significant spatial and temporal heterogeneity in factors influencing dengue fever’s spread along the Yunnan ***,the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence,meteorological variables,and imported cases across different *** In the Yunnan border areas,local dengue incidence is affected by temperature,humidity,precipitation,wind speed,and imported cases,with these factors’influence exhibiting notable spatial and temporal variation.

关键词： Dengue fever Meteorological factor Geographically and temporally weighted regression

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A review on the developments and space applications of mid- and long-wavelength infrared detection technologies

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Frontiers of Information Technology & Electronic Engineering 2024年第8期25卷 1031-1056页

作者： Yuying WANG Jindong li Hezhi SUN xiang li Beijing Institute of Spacecraft System Engineering China Academy of Space TechnologyBejing 100094China Institute of Remote Sensing Satellite China Academy of Space TechnologyBeijing 100094China

Mid-wavelength infrared(MWIR)detection and long-wavelength infrared(LWIR)detection constitute the key technologies for space-based Earth observation and astronomical *** advanced ability of infrared(IR)detection technology to penetrate the atmosphere and identify the camouflaged targets makes it excellent for space-based remote ***,such detectors play an essential role in detecting and tracking low-temperature and far-distance moving ***,due to the diverse scenarios in which space-based IR detection systems are built,the key parameters of IR technologies are subject to unique *** review the developments and features of MWIR and LWIR detectors with a particular focus on their applications in space-based *** conduct a comprehensive analysis of key performance indicators for IR detection systems,including the ground sampling distance(GSD),operation range,and noise equivalent temperature difference(NETD)among others,and their interconnections with IR detector ***,the influences of pixel distance,focal plane array size,and operation temperature of space-based IR remote sensing are *** development requirements and technical challenges of MWIR and LWIR detection systems are also identified to achieve high-quality space-based observation platforms.

关键词： Infrared detection Space application Mid-and long-wavelength infrared detection Space-based Earth observation Remote sensing

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Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19

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World Journal of Stem Cells 2024年第4期16卷 353-374页

作者： xiang-Yi Hou La-Mu Danzeng Yi-lin Wu Qian-Hui Ma Zheng Yu mei-Ying li li-Sha li The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina Department of Pharmacy Jilin UniversityChangchun 130021Jilin ProvinceChina The First Hospital of Jilin University Jilin UniversityChangchun 130021Jilin ProvinceChina

Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,which can progress to severe respiratory distress syndrome and multiple organ *** severe cases,these complications may even lead to *** of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune ***,suppressing the overactive immune response may be an effective strategy for treating *** stem cells(MSCs)and their derived exosomes(MSCs-Exo)have potent homing abilities,immunomodulatory functions,regenerative repair,and antifibrotic effects,promising an effective tool in treating *** this paper,we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating *** also summarize relevant recent clinical trials,including the source of cells,the dosage and the efficacy,and the clinical value and problems in this field,providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19.

关键词： COVID-19 Cytokine storm Immunomodulation Mesenchymal stem cell Mesenchymal stem cell-derived exosomes

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Facet-dependent transformation and toxicity of nanoscale zinc oxide in the synthetic saliva

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Journal of Environmental Sciences 2024年第5期139卷 170-181页

作者： xiang Zhang Yunpeng Huang Jikun Wang Jie Tang Yangmei Nali Zhu Zhigang li lingxiangyu li YaweiWang School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Chemistry University of PennsylvaniaPhiladelphia 19104USA

The nanoscale zinc oxide(n-ZnO)was used in food packages due to its superior antibac terial activity,resulting in potential intake of n-ZnO through the digestive system,wherein n-ZnO interacted with *** recent,facet engineering,a technique for controlling the exposed facets,was applied to n-ZnO,whereas risk of n-ZnO with specific exposed facets in saliva was *** nanoflakes(ZnO-0001)and nanoneedles(ZnO-1010)with the pri mary exposed facets of{0001}and{1010}respectively were prepared in this study,investigat ing stability and toxicity of ZnO-0001 and ZnO-1010 in synthetic *** ZnO-0001 and ZnO-1010 partially transformed into amorphous Zn_(3)(PO_(4))_(2)within 1 hr in the saliva even containing orgnaic components,forming a ZnO-Zn_(3)(PO_(4))_(2)core-shell *** less,ZnO-1010 relative to ZnO-0001 would likely transform into Zn_(3)(PO_(4))_(2),being attributed to superior dissolution of{1010}facet due to its lower vacancy formation energy(1.15 eV than{0001}facet(3.90 eV)).The toxicity of n-ZnO to Caco-2 cells was also dependent on the primary exposed facet;ZnO-0001 caused cell toxicity through oxidative stress,whereas ZnO-1010 resulted in lower cells viability than ZnO-0001 through oxidative stress and mem brane *** functional theory calculations illustrated that·O_(2)^(-)was formed and released on{1010}facet,yet O_(2)^(2-)instead of·O_(2)^(-)was generated on{0001}facet,leading to low oxidative stress from *** findings demonstrated that stability and toxicity of n-ZnO were dependent on the primary exposed facet,improving our understanding o health risk of nanomaterials.

关键词： The exposed facet Nanoscale ZnO Chemical transformation Synthetic salica Nanotoxicity

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Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie Dong Han xiang li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

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