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Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin

Insect Science 2024年第2期31卷 435-447页

作者： Jie Hao Chang liu Ning Zhang Jing li Tong Ni Mingbo Qu xiang-dong li State Key Laboratory oflntegrated Management of lnsect Pests and Rodents Insttute of ZoologyChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BejingChina School of Bioengeering Dalian University of TechnologyDalianChina

Locust(Locusta migratoria)has a single striated muscle myosin heavy chain(Mhc)gene,which contains 5 clusters of alternative exclusive exons and 1 differently included penultimate *** alternative exons of Mhc gene encode 4 distinct regions in the myosin motor domain,that is,the N-terminal SH3-like domain,one lip of the nucleotide-binding pocket,the relay,and the ***,we investigated the role of the alternative regions on the motor function of locust muscle *** Sf9-baculovirus protein expression system,we expressed and purified 5 isoforms of the locust muscle myosin heavy meromyosin(HMM),including the major isoform in the thorax dorsal longitudinal flight muscle(FL1)and 4 isoforms expressed in the abdominal intersegmental muscle(AB1 to AB4).Among these 5 HMMs,FL1-HMM displayed the highest level of actin-activated adenosine triphosphatase(ATPase)activity(hereafter referred as ATPase activity).To identify the alternative region(s)responsible for the elevated ATPase activity of FL1-HMM,we produced a number of chimeras of FL1-HMM and *** with the relay of AB4-HMM(encoded by exon-14c)substantially decreased the ATPase activity of FL1-HMM,and conversely,the relay of FL1-HMM(encoded by exon-14a)enhanced the ATPase activity of *** showed that the exon-14a-encoded residues Gly474 and Asn509 are responsible for the elevated ATPase activity of *** results indicate that the alternative relay encoded by exon-14a/c play a key role in regulating the ATPase activity of FL1-HMM and AB4-HMM.

关键词： alternative splicing ATPase Locusta migratoria molecular motor muscle myosin

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A Study on White Dwarf Masses in Cataclysmic Variables Based on XMM-Newton and Suzaku Observations

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Research in Astronomy and Astrophysics 2022年第4期22卷 21-35页

作者： Zhuo-li Yu Xiao-Jie Xu xiang-dong li School of Astronomy and Space Science and Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing210093China

The distribution of the mass of white dwarfs(WDs)is one of the fundamental questions in the field of cataclysmic variables(CVs).In this work,we make a systematical investigation on the WD masses in two subclass of CVs:intermediate polars(IPs)and non-magnetic CVs in the solar vicinity based on the fiux ratios of Fe XXVI-Lyαto Fe XXV-Heαemission lines(I_(7.0)/I_(6.7))from archival XMM-Newton and Suzaku *** first verify the(semi-empirical)relations between I_(7.0)/I_(6.7),the maximum emission temperature(T_(max))and the WD mass(M_(WD))with the mkcfiow model based on the apec description and the latest Atom *** then introduce a new spectral model to measure M_(WD)directly based on the above relations.A comparison shows that the derived M_(WD)is consistent with dynamically measured ***,we obtain the average WD masses of 58 CVs(including 36IPs and 22 non-magnetic CVs),which is the largest X-ray selected *** average WD masses are=0.81±0.21 M☉and=0.81±0.21M☉ for IPs and non-magnetic CVs,*** results are consistent with previous works.

关键词： (stars:)binaries(including multiple):close (stars:)novae cataclysmic variables X-rays:binaries

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急性缺血性脑卒中伴发下肢深静脉血栓应用低分子肝素钙治疗的效果评估

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中国实用医药 2024年第11期19卷 100-103页

作者：席富强常昕董向力包头医学院第一附属医院神经内一科 014010 包头医学院第一附属医院蒙医骨伤科 014010 包头医学院 014010

目的讨论在急性缺血性脑卒中伴发下肢深静脉血栓患者中使用低分子肝素钙治疗的效果,并评估其安全性。方法选取50例急性缺血性脑卒中伴发下肢深静脉血栓患者,按随机数字表法分为对照组与治疗组,每组25例。对照组给予脑卒中常规治疗,治... 详细信息

目的讨论在急性缺血性脑卒中伴发下肢深静脉血栓患者中使用低分子肝素钙治疗的效果,并评估其安全性。方法选取50例急性缺血性脑卒中伴发下肢深静脉血栓患者,按随机数字表法分为对照组与治疗组,每组25例。对照组给予脑卒中常规治疗,治疗组给予脑卒中常规治疗联合低分子肝素钙治疗。比较两组临床疗效、临床预后[美国国立卫生研究院卒中量表(NIHSS)评分]、静脉血栓栓塞(VTE)风险[无手术患者静脉血栓栓塞风险评分表(Padua)评分]、不良反应(血小板减少、注射部位皮肤变化、肝肾功能异常、出血)发生率。结果治疗组总有效率为80%,对照组总有效率为52%,治疗组高于对照组,差异有统计学意义(P0.05)。结论低分子肝素钙可以促进急性缺血性脑卒中伴发下肢深静脉血栓患者肢体功能恢复,减少不良反应发生,在急性缺血性脑卒中伴发下肢深静脉血栓的治疗中取得理想效果。

关键词：急性缺血性脑卒中下肢深静脉血栓低分子肝素钙

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Are There Magnetars in High-mass X-Ray Binaries?

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Research in Astronomy and Astrophysics 2022年第1期22卷 46-59页

作者： Kun Xu xiang-dong li Zhe Cui Qiao-Chu li Yong Shao Xilong liang Jifeng liu School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Astronomy Nanjing UniversityNanjing 210023China Key Laboratory of Modem Astronomy and Astrophysics Nanjing UniversityMinistry of EducationNanjing 210023China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhanChina

Magnetars form a special population of neutron stars with strong magnetic fields and long spin periods. About 30 magnetars and magnetar candidates known currently are probably isolated, but the possibility that magnetars are in binaries has not been excluded. In this work, we perform spin evolution of neutron stars with different magnetic fields in wind-fed high-mass X-ray binaries and compare the spin period distribution with observations, aiming to find magnetars in binaries. Our simulation shows that some of the neutron stars, which have long spin periods or are in widely-separated systems, need strong magnetic fields to explain their spin evolution. This implies that there are probably magnetars in high-mass X-ray binaries. Moreover, this can further provide a theoretical basis for some unclear astronomical phenomena, such as the possible origin of periodic fast radio bursts from magnetars in binary systems.

关键词： stars:magnetars stars:neutron stars:rotation (stars:)supergiants accretion accretion disks X-rays:binaries

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Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie dong Han xiang li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

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Weighted Composition Operators That Preserve Frames On Weighted Hardy Spaces

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1645-1654页

作者： Ya li dong Rui liu Guo xiang Lu School of Mathematical Sciences and LPMC Nankai UniversityTianjin300071P.R.China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan430073P.R.China

In this paper, we characterize weighted composition operators that preserve frames on the weighted Hardy spaces in the unit disk. In particular, we obtain the symbol properties of the bounded invertible weighted composition operators. Moreover, we establish the equivalence between bounded invertible operators and frame-preserving operators. Furthermore, we show that weighted composition operator preserves frames if and only if it preserves the Riesz bases property. Additionally,we investigate the weighted composition operators that preserve tight or normalized tight frames on the Dirichlet space.

关键词： Weighted composition operators Weighted Hardy spaces frames invertible

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The youngest X-ray binaries

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Research in Astronomy and Astrophysics 2020年第10期20卷 221-228页

作者： xiang-dong li School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China

Several X-ray binaries(XRBs)have been identified to be associated with supernova remnants(SNRs).Because of the short lifetimes of SNRs,this leaves them to be the youngest known *** small group of binaries provides valuable information on the formation of compact stars under the framework of massive binary *** this paper we review the observational characteristics of these youngest XRBs and discuss their possible implications on the initial conditions of compact stars and their interaction with the companion stars.

关键词： accretion,accretion disks stars:black holes stars:neutron,evolution

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Cost-effective fabrication of liquid metals via a laser induced graphene stamp for highly-stretchable integrated optoelectronics

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Nano Research 2024年第8期17卷 7603-7613页

作者： Weiqi Sun li xiang Zebang Luo Hui Wang dong li Anlian Pan College of Materials Science and Engineering Hunan UniversityChangsha 410082China

Stretchable electronics have found widespread applications in various fields such as wearable electronics,soft robots,and *** an important promising alternative of traditional rigid conductors,liquid metals have demonstrated immense potential to provide high conductivity and stretchability for the stretchable electronic ***,limited by their fluidity and high surface tension,challenges remain in achieving liquid metal patterns with low-cost,high-precision,large-scale,and complex ***,a fabrication technique was proposed based on laser-induced graphene(liG)stamps to enable liquid metal self-selectively adhere to *** metal patterns could thus be achieved in different designed geometries and could be transferred onto stretchable *** liquid metal patterns exhibit exceptional electrical conductivity(3.24×10^(6)S/m even under 1000%strain),high stretchability(1000%strain,maximum of 2500%),small resistance changes under significant deformations(with a quality factor of 62.5 under 1000%strain),and high resolution(down to 50μm).Utilizing the patterned liquid metals,a stretchable integrated multifunctional optoelectronic system was demonstrated,encompassing a stretchable display matrix,a pressure sensor array,a wireless powering coil,and cardiovascular sensors,which further highlight the remarkable application potential of liquid metals in optoelectronic user-interaction and advanced physiological monitoring.

关键词： liquid metal wettability selective adhesion transfer printing stretchable electronics

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ResNeSt-biGRU: An Intrusion Detection Model Based on Internet of Things

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Computers, Materials & Continua 2024年第4期79卷 1005-1023页

作者： Yan xiang Daofeng li Xinyi Meng Chengfeng dong Guanglin Qin School of Computer and Electronics Information Guangxi UniversityNanning530004China Guangxi Colleges and Universities Key Laboratory of Multimedia Communications and Information Processing Guangxi UniversityNanning530004China

The rapid expansion of Internet of Things (IoT) devices across various sectors is driven by steadily increasingdemands for interconnected and smart technologies. Nevertheless, the surge in the number of IoT device hascaught the attention of cyber hackers, as it provides them with expanded avenues to access valuable data. Thishas resulted in a myriad of security challenges, including information leakage, malware propagation, and financialloss, among others. Consequently, developing an intrusion detection system to identify both active and potentialintrusion traffic in IoT networks is of paramount importance. In this paper, we propose ResNeSt-biGRU, a practicalintrusion detection model that combines the strengths of ResNeSt, a variant of Residual Neural Network, andbidirectionalGated RecurrentUnitNetwork (biGRU).Our ResNeSt-biGRUframework diverges fromconventionalintrusion detection systems (IDS) by employing this dual-layeredmechanism that exploits the temporal continuityand spatial feature within network data streams, a methodological innovation that enhances detection *** conjunction with this, we introduce the PreIoT dataset, a compilation of prevalent IoT network behaviors, totrain and evaluate IDSmodels with a focus on identifying potential intrusion traffics. The effectiveness of proposedscheme is demonstrated through testing, wherein it achieved an average accuracy of 99.90% on theN-BaIoT datasetas well as on the PreIoT dataset and 94.45% on UNSW-NB15 dataset. The outcomes of this research reveal thepotential of ResNeSt-biGRU to bolster security measures, diminish intrusion-related vulnerabilities, and preservethe overall security of IoT ecosystems.

关键词： Internet of Things cyberattack intrusion detection internet security

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W-entropy formulas on super Ricci flows and Langevin deformation on Wasserstein space over Riemannian manifolds Dedicated to Professor Zhiming Ma on His Seventieth Birthday

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Science China Mathematics 2018年第8期61卷 1385-1406页

作者： Songzi li xiang-dong li School of Mathematical Sciences Beijing Normal University Beijing 100875 China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 China

In this survey paper, we give an overview of our recent works on the study of the W-entropy for the heat equation associated with the Witten Laplacian on super-Ricci flows and the Langevin deformation on the Wasserstein space over Riemannian manifolds. Inspired by Perelman's seminal work on the entropy formula for the Ricci flow, we prove the W-entropy formula for the heat equation associated with the Witten Laplacian on n-dimensional complete Riemannian manifolds with the CD(K, m)-condition, and the W-entropy formula for the heat equation associated with the time-dependent Witten Laplacian on n-dimensional compact manifolds equipped with a(K, m)-super Ricci flow, where K ∈ R and m ∈ [n, ∞]. Furthermore, we prove an analogue of the W-entropy formula for the geodesic flow on the Wasserstein space over Riemannian *** result improves an important result due to Lott and Villani(2009) on the displacement convexity of the Boltzmann-Shannon entropy on Riemannian manifolds with non-negative Ricci curvature. To better understand the similarity between above two W-entropy formulas, we introduce the Langevin deformation of geometric flows on the tangent bundle over the Wasserstein space and prove an extension of the W-entropy formula for the Langevin deformation. We also make a discussion on the W-entropy for the Ricci flow from the point of view of statistical mechanics and probability theory. Finally, to make this survey more helpful for the further development of the study of the W-entropy, we give a list of problems and comments on possible progresses for future study on the topic discussed in this survey.

关键词：黎曼流形热方程计算方法数学

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