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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu xian qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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Synthesis and Characterization of Novel Sulfonylurea Derivatives

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Chemical Research in Chinese Universities 2005年第4期21卷 439-443页

作者： ZHANGGuang-liang LIYao-xian ZHANGSuo-qin GAOFei-fei CollegeofChemistry JilinUniversityChangchun130021P.R.China

On the basis of study on the mechanism of action of sulfonylurea herbicides, nine sulfonylurea derivatives of iso-{xazolidinone} were designed and synthesized. The structures of these compounds were confirmed by means of IR, MS, NMR and elemental analysis. The results of preliminary active tests indicate that the compounds have some herbicidal activity. The structure-activity relationship was also studied.

关键词： 4,4-Dimethyl-3-isoxazolidinone Sulfonylurea Acetohydroxyacid synthase Herbicidal activity

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Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

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Bone Research 2021年第2期9卷 223-232页

作者： Guangdao Zhang Xiaofei Li Lin Wu Yi-xian qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Prosthodontics School of StomatologyChina Medical UniversityShenyangChina

Mechanobiological stimuli,such as low-intensity pulsed ultrasound(LIPUS),have been shown to promote bone regeneration and fresh fracture repair,but the fundamental biophysical mechanisms involved remain ***,we propose that a mechanosensitive ion channel of Piezo1 plays a pivotal role in the noninvasive ultrasound-induced mechanical transduction pathway to trigger downstream cellular signal *** study aims to investigate the expression and role of Piezo1 in MC3T3-E1 cells after LIPUS *** analysis shows that Piezo1 was present on MC3T3-E1 cells and could be ablated by shRNA ***3T3-E1 cell migration and proliferation were significantly increased by LIPUS stimulation,and knockdown of Piezo1 restricted the increase in cell migration and *** labeling with Fluo-8,MC3T3-E1 cells exhibited fluorescence intensity traces with several high peaks compared with the baseline during LIPUS *** obvious change in the fluorescence intensity tendency was observed after LIPUS stimulation in shRNA-Piezo1 cells,which was similar to the results in the GsMTx4-treated *** phosphorylation ratio of ERK1/2 in MC3T3-E1 cells was significantly increased(P<0.01)after LIPUS *** addition,Phalloidin-iFluor-labeled F-actin filaments immediately accumulated in the perinuclear region after LIPUS stimulation,continued for 5 min,and then returned to their initial levels at 30 *** results suggest that Piezo1 can transduce LIPUS-induced mechanical signals into intracellular *** influx of Ca2+serves as a second messenger to activate ERK1/2 phosphorylation and perinuclear F-actin filament polymerization,which regulate the proliferation of MC3T3-E1 cells.

关键词： stimulation Piezo1 activation

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Geometric Phase in a Time-Dependent A-Type Jaynes-Cummings Model

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Communications in Theoretical Physics 2009年第3期51卷 407-410页

作者： qin xian-Ming YU Zbao-xian JIAO Zhi-Yong XIE Bing-Hao Department of Mathematics and Physics Chongqing University of Science and Technology Chongqing 400042 China Department of Physics Beijing Information Science and Technology University Beijing 100192 China Department of Physics China University of Petroleum （East China） Dongying 257061 China

By using the Lewis-Riesenfeld invariant theory, we have studied the dynamical and the geometric phases in a generalized time-dependent A-type Jaynes Cummings model. We lind that, compared with the dynamical phases, the geometric phases in a cycle case are independent of the frequency of the photon field, the coupling coefficient between photons and atoms, and the atom transition frequency. It is pointed out that the geometric phases in a cycle ease can be measured under the case of a stronger time-dependent photon field and a stronger coupling photon-atom system. On the other hand, the geometric phases of the model may be measured in the composition of cold atoms.

关键词： geometric phase generalized Jaynes-Cummings model

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Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy:Correlating in vitro and in vivo studies

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Bioactive Materials 2021年第5期6卷 1223-1229页

作者： Julia Gao Yingchao Su Yi-xian qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY11794United States

Magnesium(Mg)and its alloys are promising biodegradable materials for orthopedic ***,one of the major problems is their rapid degradation rate with quick evolution of hydrogen *** overcome this problem,calcium phosphate(CaP)coatings have been used to improve the degradation resistance and the biocompatibility of Mg *** study focuses on the comparison and correlation of the in vitro and in vivo degradation and biocompatibility behaviors of these materials.A CaP coating consisting of dicalcium phosphate dihydrate(DCPD)was deposited on an AZ60 Mg alloy by the chemical conversion ***,the in vitro degradation testing including electrochemical and immersion tests,and in vivo implantation of the CaP coated Mg alloy were conducted to compare the degradation ***,the in vitro cell behavior and in vivo bone tissue response were also compared on both uncoated and CaP-coated Mg *** showed that the CaP coating provided the Mg alloy with significantly better biodegradation behavior and *** in vitro and in vivo biocompatibility tests exhibited good consistency while not the case for *** showed that the in vitro electrochemical test could be a quick screening tool for the biodegradation rate,while the in vitro immersion degradation rate was often 2-4 folds faster than the in vivo degradation rate.

关键词： Magnesium implants Calcium phosphate Biodegradation Cytocompatibility Bone regeneration

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Stabilized seventh-order dissipative compact scheme for two-dimensional Euler equations

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Chinese Physics B 2019年第10期28卷 408-416页

作者： Jia-xian qin Ya-Ming Chen Xiao-Gang Deng College of Aerospace Science and Engineering National University of Defense Technology

We derive in this paper a time stable seventh-order dissipative compact finite difference scheme with simultaneous approximation terms(SATs) for solving two-dimensional Euler equations. To stabilize the scheme, the choice of penalty coefficients for SATs is studied in detail. It is demonstrated that the derived scheme is quite suitable for multi-block problems with different spacial steps. The implementation of the scheme for the case with curvilinear grids is also *** experiments show that the proposed scheme is stable and achieves the design seventh-order convergence rate.

关键词： compact scheme time stability simultaneous approximation term interface treatment

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A hypothesis study on a four-period prevention model for high altitude disease

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Military Medical Research 2018年第2期5卷 183-188页

作者： xian-Sheng Liu xiang-Rong Yang Lu Liu xian-Kui qin Yu-Qi Gao Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Medical Affairs The 5th Hospital of the Chinese PLANo.893 Shengli StreetXingqing DistrictYinchuanNingxia 750003China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Key Laboratory of High Altitude Medicine of PLA No.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Health Service Training Base of Health ServiceThird Military Medical UniversityNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China Department of Outpatient PLA No.96819 UnitNo.2 Heping RoadChaoyang DistrictBeijing 100085China

Background:High altitude disease(HAD)can reduce combat effectiveness and damage the health of soldiers at high *** objective of this hypothesis study is to build a four-period prevention model for high altitude disease that can be applied at high altitudes of over 3000 *** of the hypothesis:We divided the time at high altitude into nine periods,with three stages from the ascent preparation to the descent to the plain,and applied a continuous dynamic and systematic four-period prevention model across the nine *** period of three stages has its own different measures and targets high altitude health care services for the prevention of high altitude disease.A standard four-period prevention model for high altitude disease was constructed for the high altitude health services at the population *** the hypothesis:Our hypothesized HAD prevention model represents a continuous dynamic and systematic four-period prevention model across the nine *** hypothesis can be tested from three *** first one is assessment of soldiers’operating *** second is comparison of the long-term high altitude population health basic data and development and utilization of big *** third is descent population health status comparative study and historical retrospective study on ***:As we know,it is necessary to protect soldiers’health through the ascent and *** the standard four-period model,we can protect soldiers’health by preventing high altitude diseases,screening the susceptible population,securely tracking their location and maintaining soldiers’health statuses;we also maintain their operational capabilities,eliminate their psychological fears and ease their family troubles.

关键词： High altitude disease High altitude health service Prevention model

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Bioactive superparamagnetic iron oxide-gold nanoparticles regulated by a dynamic magnetic field induce neuronal Ca^(2+)influx and differentiation

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Bioactive Materials 2023年第8期26卷 478-489页

作者： Elias Georgas Muzhaozi Yuan Jingfan Chen Ya Wang Yi-xian qin Department of Biomedical Engineering The State University of New York at Stony BrookStony BrookNYUnited States J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege StationTXUnited States Department of Biomedical Engineering Texas A&M UniversityCollege StationTXUnited States Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTXUnited States

Treating neurodegenerative diseases,e.g.,Alzheimer’s Disease,remains a significant challenge due to the limited neuroregeneration rate in the *** objective of this study is to evaluate the hypothesis that external magnetic field(MF)stimulation of nerve growth factor functionalized superparamagnetic iron oxide-gold(NGF-SPIO-Au)nanoparticles(NPs)can induce Ca^(2+)influx,membrane depolarization,and enhance neuron differentiation with dynamic MF(DMF)outperforming static MF(SMF)*** showed the that total intracellular Ca^(2+)influx of PC-12 cells was improved by 300%and 535%by the stimulation of DMF(1 Hz,0.5 T,30min)with NGF-SPIO-Au NPs compared to DMF alone and SMF with NGF-SPIO-Au NPs,respectively,which was attributed to successive membrane *** uptake performed with the application of sodium azide proved that DMF enhanced cellular uptake of NGF-SPIO-Au NPs via *** addition,DMF upregulated both the neural differentiation marker(β3-tubulin)and the cell adhesive molecule(integrin-β1)with the existence of NGF-SPIO-Au NPs,while SMF did not show these *** results imply that noninvasive DMF-stimulated NPs can regulate intracellular Ca^(2+)influx and enhance neuron differentiation and neuroregeneration rate.

关键词： Calcium influx Membrane potential Dynamic magnetic fields Neuroregeneration SPIO-Au Core-shell nanoparticles

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Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors

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Chemical Research in Chinese Universities 2006年第5期22卷 593-597页

作者： GAO Fei-fei LI Yao-xian ZHANG Suo-qin ZHANG Guang-liang College of Chemistry Jilin University Changchun 130021 P. R. China

A novel kind of acetohydroxyacid synthase（AHAS） inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5- methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.

关键词： Sulfonylaminocarbonyl-2-thiohydantoin Sulfonylurea Acetohydroxyacid synthase, Herbicidal activity

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Pd nanoparticles immobilized on MIL-53(Al)as highly e ective bifunctional catalysts for oxidation of liquid methanol to methyl formate

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Petroleum Science 2019年第4期16卷 901-911页

作者： Jian-Fang Liu Jin-Cheng Mu Rong-xian qin Sheng-Fu Ji State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

A series of Pd/MIL-53(Al) heterogeneous bifunctional catalysts with di erent Pd contents were prepared by an impregnation method. The prepared metal–organic frameworks MIL-53(Al) and catalysts were characterized by XRD, SEM, HRTEM,FT-IR and N2 adsorption/desorption techniques. The results showed that MIL-53(Al) was synthesized successfully, and the structure was unchanged during and after the preparation of the catalysts. The Pd nanoparticles(NPs) with an average particle size of 4.6 nm were uniformly dispersed on the MIL-53(Al). The catalyst exhibited good catalytic activity in the selective oxidation of liquid methanol to methyl formate. Under the conditions of 150 °C, 2 MPa O2 and solvent-free for5 h, the conversion of methanol could reach 60.3%, and the selectivity of methyl formate was up to 62.2%. In addition, the Pd/MIL-53(Al) bifunctional catalyst exhibited excellent stability and maintained high catalytic activity after five cycles.

关键词： MIL-53(Al) Pd Bifunctional catalyst Methanol Methyl formate

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