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Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2065-2072页

作者： Yu-Juan Li Yong-Yan Chen xia-lan lin Wei-Zhi Zhang Department of Anesthesiology Shanxi Provincial Children’s HospitalTaiyuan 030013Shanxi ProvinceChina

BACKGROUND Acute appendicitis(AA)is the most common cause of acute abdomen in *** significantly influences the surgical treatment of AA in children,making the scientific and effective selection of anesthetics *** To assess the clinical effect of atropine(ATR)in combination with remifentanil(REMI)in children undergoing surgery for *** In total,108 cases of pediatric AA treated between May 2020 and May 2023 were selected,58 of which received ATR+REMI[research group(RG)]and 50 who received REMI[control group(CG)].Comparative analyses were conducted on the time to loss of eyelash reflex,pain resolution time,recovery time from anesthesia,incidence of adverse events(AEs;respiratory depression,hypoxemia,bradycardia,nausea and vomiting,and hypotension),intraoperative responses(head shaking,limb activity,orientation recovery,safe departure time from the operating room),hemodynamic parameters[oxygen saturation(SPO2),mean arterial pressure,heart rate,and respiratory rate],postoperative sedation score(Ramsay score),and pain level[the Face,Legs,Activity,Cry,Consolability(FLACC)Behavioral Scale].RESULTS Compared with the CG,the RG showed significantly shorter time to loss of eyelash reflex,pain resolution,recovery from anesthesia,and safe departure from the operating ***,the incidence rates of overall AEs(head shaking,limb activity,etc.)were lower,and influences on intraoperative hemodynamic parameters and stress response indexes were *** Ramsay score at 30 min after extubation and the FLACC score at 60 min after extubation were significantly lower in the RG than in the *** ATR+REMI is superior to REMI alone in children undergoing AA surgery,with a lower incidence of AEs,fewer influences on hemodynamics and stress responses,and better post-anesthesia recovery.

关键词： Atropine Remifentanil Pediatric acute appendicitis Surgery Clinical efficacy

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Cognitive impairment in cerebral small vessel disease induced by hypertension

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Neural Regeneration Research 2024年第7期19卷 1454-1462页

作者： Weipeng Wei Denglei Ma lin Li lan Zhang Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center Beijing Engineering Research Center for Nervous System DrugsNational Center for Neurological DisordersNational Clinical Research Center for Geriatric DiseasesBeijingChina

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular *** r,the causal relationship between hypertension and cerebral small vessel disease remains *** has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular *** hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and *** is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of *** review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive *** also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

关键词： blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter high signal intensity

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Aerodynamic optimization of an adaptive flap for next-generation green aircraft

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Chinese Journal of Aeronautics 2024年第2期37卷 100-122页

作者： Tianlong lin Rosario PECORA Danilo CILIBERTI Wei xia Shuling HU State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Deparment of Industrial Engineering Aerospace DivisionUniversity of Naples"FEDERICO II"Napoli 80125Italy

Adaptive,morphing flaps are taking ever-increasing attention in civil aviation thanks to the expected benefits this technology can bring at the aircraft level in terms of high-lift performance improvement and related fuel burnt reduction per *** upon morphing capabilities,it is possible to fix a unique setting for the flap and adapt the flap shape to match the aerodynamic requirements for take-off or *** proper morphed shapes can assure better high-lift performances than those achievable by referring to a conventional ***,standing the unique flap setting for take-off and landing,a dramatic simplification of the flap deployment systems may be *** a consequence of this simplification,the deployment system can be fully hosted in the wing,thus avoiding under-wing nacelles with significantly better aerodynamics and fuel *** first step for a rational design of an adaptive flap consists in defining the target morphed shapes and the unique optimal flap setting in the take-off and landing *** this work,aerodynamic optimization analyses are carried out to determine the best flap setting and related morphed shapes in compliance with the take-off and landing requirements of a reference civil transport *** different initial conditions are adopted to avoid the optimization falling into local optima,thus obtaining four groups of optimal candidate *** comparing each candidate’s performance through 2D and 3D simulations,the optimal configuration has been selected.2D simulations show that the optimal configuration is characterized by a maximum lift increase of 31.92%in take-off and 9.04%in *** to 3D simulations,the rise in maximum lift equals 22.26%in take-off and 3.50%in *** results are finally verified through wind tunnel tests,and the aerodynamic mechanism behind the obtained improvements is explained by carefully analyzing the flow field around the flap.

关键词： Morphing wings High-lift system Adaptive flap Computational Fluid Dynamics(CFD) Wind tunnel tests

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Targeted DNA N^(6)-methyladenine editing by dCas9 fused to METTL4 in the lepidopteran model insect Bombyx mori

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Insect Science 2024年第2期31卷 646-650页

作者： Feng Chen Hao Guo Weiqun lan Mingyi Zhou Wenjng Geng Guanwang Shen Ping lin Qingyou xia Ping Zhao Zhiqing Li Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City Biological Science Research CenterSouthwest UniversityChongqingChina Chongqing Key Laboratory of Sericultural Science Chongqing Engineering and Technology Research Center for Novel Silk MaterialsSouthwest UniversityChongqingChina

Dear Editor,N^(6)-Methyladenine(6mA)DNA modification is an important epigenetic mechanism with roles in regulating gene expression,nucleosome positioning,DNA damage repair,and cell cycle progression(Heyn&Esteller,2015;Luo et al.,2015;Boulias&Greer,2022).Despite progress in understanding the biological functions of 6mA,the contribution of individual 6mA installations on site-specific target genes is largely unknown,and therefore deciphering the molecular mechanism of 6mA in target gene expression has been difficult.

关键词： adenine fused Bombyx

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Three dimensional discrete element modelling of the conventional compression behavior of gas hydrate bearing coal

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International Journal of Coal Science & Technology 2024年第1期11卷 61-77页

作者： xia Gao Nannan Wang Baoyong Zhang Qiqi lin Qiang Wu Wei Meng xia Liu Department of Architecture and Civil Engineering Heilongjiang University of Science and TechnologyHarbin150022China School of Qilu Transportation Shandong UniversityJinan250061China Department of Safety Engineering Heilongjiang University of Science and TechnologyHarbin150022China Jining Hongxiang Highway Survey Design and Research Institute Co.Ltd Jining272000China

To analyze the relationship between macro and meso parameters of the gas hydrate bearing coal(GHBC)and to calibrate the meso-parameters,the numerical tests were conducted to simulate the laboratory triaxial compression tests by PFC3D,with the parallel bond model employed as the particle contact constitutive ***,twenty simulation tests were conducted to quantify the relationship between the macro–meso ***,nine orthogonal simulation tests were performed using four meso-mechanical parameters in a three-level to evaluate the sensitivity of the meso-mechanical ***,the calibration method of the meso-parameters were then ***,the contact force chain,the contact force and the contact number were examined to investigate the saturation effect on the meso-mechanical behavior of *** results show that:(1)The elastic modulus linearly increases with the bonding stiffness ratio and the friction coefficient while exponentially increasing with the normal bonding strength and the bonding radius *** failure strength increases exponentially with the increase of the friction coefficient,the normal bonding strength and the bonding radius coefficient,and remains constant with the increase of bond stiffness ratio;(2)The friction coefficient and the bond radius coefficient are most sensitive to the elastic modulus and the failure strength;(3)The number of the force chains,the contact force,and the bond strength between particles will increase with the increase of the hydrate saturation,which leads to the larger failure strength.

关键词： Gas hydrate bearing coal Discrete element method Triaxial compression test Macro-meso mechanical propertie

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Chronic stress as an emerging risk factor for the development and progression of glioma

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Chinese Medical Journal 2024年第4期137卷 394-407页

作者： lan Yi xiang lin xiaoling She Wei Gao Minghua Wu Institute of Cytology and Genetics The Hengyang Key Laboratory of Cellular Stress BiologyHunan Province Cooperative Innovation Center for Molecular Target New Drug StudyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pathology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research InstituteCentral South UniversityChangshaHunan 410008China NHC Key Laboratory of Carcinogenesis Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous *** with patients with other cancers,glioma patients often suffer from increased levels of psychological stress,such as anxiety and *** stress(CS)is thought to impact glioma ***,because of the complex mechanisms underlying CS and variability in individual tolerance,the role of CS in glioma remains *** review suggests a new proposal to redivide the stress system into two *** activity is dominant ***-signaling molecules produced by the neuroendocrine system are dominant *** discuss the underlying molecular mechanisms by which CS impacts *** pharmacological treatments are also summarized from the therapeutic perspective of CS.

关键词： Chronic stress Glioma Microbiota-gut-brain axis Neuroendocrine system Stress system Neural circuit

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Defect detection and repair algorithm for structures generated by topology optimization based on 3D hierarchical fully convolutional network

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Biomimetic Intelligence & Robotics 2024年第2期4卷 24-31页

作者： Zhiyu Wan Hai lan Sichao lin Houde Dai School of Advanced Manufacturing Fuzhou UniversityJinjiang 362251China Quanzhou Institute of Equipment Manufacturing Haixi InstitutesChinese Academy of SciencesJinjiang 362216China Fujian Key Laboratory of Special Intelligent Equipment Safety Measurement and Control Fujian Special Equipment Inspection and Research InstituteFuzhou 350008China

Customized 3D-printed structural parts are widely used in surgical *** satisfy the mechanical properties and kinematic functions of these structural parts,a topology optimization technique is adopted to obtain the optimal structural layout while meeting the constraints and ***,topology optimization currently faces some practical challenges that must be addressed,such as ensuring that structures do not have significant defects when converted to additive manufacturing *** address this problem,we designed a 3D hierarchical fully convolutional network(FCN)to predict the precise position of the defective *** on the prediction results,an effective repair strategy is adopted to repair the defective structure.A series of experiments is conducted to demonstrate the effectiveness of our *** to the 2D fully convolutional network and the rule-based detection method,our approach can accurately capture most defect structures and achieve 89.88%precision and 95.59%***,we investigate the impact of different ways to increase the receptive field of our model,as well as the trade-off between different defect-repairing *** results of the experiment demonstrate that the hierarchical structure,which increases the receptive field,can substantially improve the defect detection *** the best of our knowledge,this paper is the first to investigate 3D defect prediction and repair for topology optimization in conjunction with deep learning algorithms,providing practical tools and new perspectives for the subsequent development of topology optimization techniques.

关键词： Topology optimization Additive manufacturing Deep learning 3D semantic segmentation Defect detection

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Fabrication of Molecularly Imprinted Electrospun Nanofibers with Mono-amidoxime Functional Ligand for Efficient Decontamination of Toxic Organophosphates

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Chinese Journal of Polymer Science 2024年第4期42卷 446-456页

作者： lan Wang Peng Jiang Ya-lin Niu Jun-Peng Cao Tian-Ying Guo Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of Chemistry and Frontier Science Center for the Creation of New Organic SubstancesNankai UniversityTianjin300071China

There is an urgent imperative to discover practical and efficacious artificial catalysts for the expeditious decontamination of toxic organophosphates. Herein, we propose a novel molecularly imprinted approach utilizing electrospun fiber scaffolds. Specifically, an amidoxime-based functional polymer (PMAOX) has been synthesized, which contains amidoxime groups that can act as nucleophiles and ligands for the formation of catalytic active sites. This polymer was blended with polyacrylonitrile (PAN), a well-processable material, to prepare a nanofiber mat using electrospinning techniques. Then, the amidoxime side groups on fiber surface were further cross-linked after the molecular coordination of templates to complete the molecularly imprinting process. This approach can not only enhance the content of functional molecularly imprinted polymers without affecting structural stability, but also combines surface MI technology to fully expose and leverage the advantages of active sites. The as prepared molecularly imprinted electrospun nanofibers MIF-Zn-PMAOX/PAN-6/4 catalyzes the degradation of paraoxon with a half-life of 32 min, and MIF-Ag-PMAOX/PAN catalyzes the degradation of parathion with a half-life of 18 min. The maximum catalytic rate evidence rate enhancements nearly 3700-fold of the self-hydrolysis. Thus, the mono-amidoxime based molecularly imprinted fibers demonstrate the versatility and superiority as self-detoxifying for organophosphates.

关键词： Organophosphateshydrolysis Electrospinning Molecular imprinting

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Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying xia Ming Sun Hai Huang Wei-lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

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Parameter Estimation of a Valve-Controlled Cylinder System Model Based on Bench Test and Operating Data Fusion

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 247-263页

作者： Deying Su Shaojie Wang Haojing lin xiaosong xia Yubing Xu Liang Hou Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Xuzhou XCMG Excavation Machinery Co. LtdXuzhou 221000China

The accurate estimation of parameters is the premise for establishing a high-fidelity simulation model of a valve-controlled cylinder *** test data are easily obtained,but it is challenging to emulate actual loads in the research on parameter estimation of valve-controlled cylinder *** the actual load information contained in the operating data of the control valve,its acquisition remains *** paper proposes a method that fuses bench test and operating data for parameter estimation to address the aforementioned *** proposed method is based on Bayesian theory,and its core is a pool fusion of prior information from bench test and operating ***,a system model is established,and the parameters in the model are ***,the bench and operating data of the system are ***,the model parameters and weight coefficients are estimated using the data fusion ***,the estimated effects of the data fusion method,Bayesian method,and particle swarm optimisation(PSO)algorithm on system model parameters are *** research shows that the weight coefficient represents the contribution of different prior information to the parameter estimation *** effect of parameter estimation based on the data fusion method is better than that of the Bayesian method and the PSO *** load complexity leads to a decrease in model accuracy,highlighting the crucial role of the data fusion method in parameter estimation studies.

关键词： Valve-controlled cylinder system Parameter estimation The Bayesian theory Data fusion method Weight coefficients

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