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Alterations of sleep deprivation on brain function:A coordinatebased resting-state functional magnetic resonance imaging metaanalysis

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World Journal of Psychiatry 2024年第2期14卷 315-329页

作者： Qin Zhang Yong-Zhe Hou Hui Ding Yan-Ping Shu Jing Li xi-zhao chen Jia-Lin Li Qin Lou Dai-xing Wang Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Sleep deprivation is a prevalent issue that impacts cognitive *** numerous neuroimaging studies have explored the neural correlates of sleep loss,inconsistencies persist in the reported results,necessitating an investigation into the consistent brain functional changes resulting from sleep *** To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging *** metaanalytic methods,signed differential mapping(SDM)and activation likelihood estimation(ALE),were employed to analyze functional magnetic resonance imaging(fMRI)*** A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29,*** that met specific inclusion criteria,focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered.A total of 21 studies were selected for SDM and ALE *** Twenty-one studies,including 23 experiments and 498 subjects,were *** to pre-sleep deprivation,post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal *** revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus,left middle frontal gyrus,corpus callosum,and right *** This meta-analysis consistently identified brain regions affected by sleep deprivation,notably the left medial frontal gyrus and corpus callosum,shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.

关键词： Sleep deprivation Resting-state-functional magnetic resonance imaging Activation likelihood estimation-meta Signed differential mapping-meta

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Gut inflammation in the pathogenesis of acquired aplastic anemia

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Chinese Medical Journal 2020年第15期133卷 1878-1881页

作者： xi-chen zhao xiao-Yun Sun Li zhao Fan-Jun Meng Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdaoShandong 266555China Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China

Acquired aplastic anemia(AAA)is an auto-immune disease(AID)resulting from aberrant T-cell-mediated and antigen-driven immune responses to hematopoietic stem and progenitor cells(HSPCs)in genetically susceptible individuals,leading to the significantly enhanced suppression and apoptosis of *** systemic and local inflammation is responsible for the overall pathophysiology.

关键词： inflammation anemia aplastic

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Acquired aplastic anemia:Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?

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World Journal of Stem Cells 2020年第11期12卷 1429-1438页

作者： xi-chen zhao xiao-Yun Sun Bo Ju Fan-Jun Meng Hong-Guo zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

We previously reported a serendipitous finding from a patient with refractory severe aplastic anemia who had gotten an unexpected hematological response to treatment with gut-cleansing preparations(GCPs).This patient experienced three recurrences over the ensuing one year of intermittent GCP treatments,with each recurrence occurring 7-8 wk from a *** his third recurrence,he was prescribed successive treatment with rifampicin,berberine,and monthly administered GCP for 4 mo,and he developed an erythroid proliferative neoplasma and an overwhelming enteropathy,and eventually died of septic *** investigations had validated the resolution of myelosuppression and the appearance of malignant clonal *** the treatment process and laboratory investigations,it is reasonably inferred that the engagement of gut inflammation is critically required in sustaining the overall pathophysiology of acquired aplastic anemia probably by creating a chronic inflammatory *** of rifampicin,berberine,and monthly GCP into cyclosporine can enhance the immunosuppressive *** a subgroup of acquired aplastic anemia patients whose pathogenesis is associated with genotoxic exposure,the suppressed normal hematopoiesis may result from the bystander insult that is mediated by the soluble inflammatory cytokines generated in response to the immunogenic products of damaged hematopoietic cells in the context of chronic inflammatory state and may offer a protective antineoplastic mechanism against malignant proliferation.

关键词： Acquired aplastic anemia Bystander insult Malignant clonal hematopoiesis Immune surveillance Antineoplastic Gut inflammation

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Severe hyperlipemia-induced pseudoerythrocytosis - Implication for misdiagnosis and blood transfusion: A case report and literature review

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World Journal of Clinical Cases 2020年第19期8卷 4595-4602页

作者： xi-chen zhao Bo Ju Na Wei Jian Ding Fan-Jun Meng Hong-Guo zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Clinical Laboratory The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Severe hyperlipemia(SHLE)has an impact on the results of many kinds of laboratory *** blood count(CBC)examination by automated blood cell counter(ABCC)is a quick and convenient measurement for screening abnormalities of blood cells that are triggered by various pathogenic insults in disease diagnosis and for monitoring changes in the treatment of existing hematological ***,CBC results are frequently affected by many intrinsic and extrinsic factors from blood samples,such as in the setting of hypergammaglobulinemia and certain *** could also affect CBC *** SUMMARY A 33-year-old Chinese male presented with painful foot numbness and abdominal *** was initially misdiagnosed as having a myeloproliferative neoplasm(MPN)because of the marked abnormalities in CBC examination by the *** evaluation of the bone marrow smears and biopsy showed no evidence of *** mutations in Breakpoint cluster regions-Abelson murine leukemia viral oncogene homologue 1(BCR-ABL1),Janus kinase 2(JAK2),calreticulin(CALR),myeloproliferative leukemia virus(MPL),and colony-stimulating factor 3 receptor(CSF3R)were *** noticed the thick chylomicron layer on blood samples and the dramatically fluctuating CBC results,we speculated that the fat droplets formed by shaking the blood samples in the setting of SHLE were mistakenly identified as blood cells due to the limited parameters of ***,we removed a large part of the chylomicron layer and then reexamined the CBC,and the CBC results,as we expected,differed significantly from that of the sample before the chylomicron layer was *** significant differences had been validated by the subsequently repeated laboratory tests by measuring dual blood samples that the chylomicron layer was removed in one sample and was not in another,and comparing the CBC *** tomography reexamination of the upper abdomen revealed an exudative lesion

关键词： Case report Hyperlipemia Fat droplet Pancreatitis Pseudoerythrocytosis Blood transfusion indication

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Excellent response of severe aplastic anemia to treatment of gut inflammation: A case report and review of the literature

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World Journal of Clinical Cases 2020年第2期8卷 425-435页

作者： xi-chen zhao Li zhao xiao-Yun Sun Zeng-Shan Xu Bo Ju Fan-Jun Meng Hong-Guo zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Cumulative evidence suggests that the aberrant immune responses in acquired aplastic anemia(AA) are sustained by active chronic infections in genetically susceptible individuals. Recently, the constant source to trigger and sustain the pathophysiology has been proposed to come from the altered gut microbiota and chronic intestinal inflammation. In this case, our serendipitous finding provides convincing evidence that the persistently dysregulated autoimmunity may be generated, at least in a significant proposition of AA patients, by the altered gut microbiota and compromised intestinal *** SUMMARY A 30-year-old Chinese male patient with refractory severe AA experienced a 3-month-long febrile episode, and his fever was refractory to many kinds of injected broad-spectrum antibiotics. When presenting with abdominal cramps, he was prescribed oral mannitol and gentamycin to get rid of the gut infection. This treatment resulted in a quick resolution of the fever. Unanticipatedly, it also produced an excellent hematological response. He had undergone three episodes of recurrence within the one-year treatment, with each recurrence occurring 7-8 wk from the gastrointestinal inflammation eliminating preparations. However,subsequent treatments were able to produce subsequent remissions and consecutive treatments were successful in achieving durative hematological improvements, strongly indicating an etiological association between chronic gut inflammation and the development of AA. Interestingly, comorbid diseases superimposed on this patient(namely, psychiatric disorders, hypertension,insulin resistance, and renal dysfunction) were ameliorated together with the hematological *** Chronic gut inflammation may be responsible for AA pathogenesis. The comorbidities and AA may share a common etiological association.

关键词： Case report Severe aplastic anemia Hematological response Chronic gut inflammation Comorbid disease Etiological association

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Decarboxylative cyanation and thiocyanation via catalytic electron donor-acceptor complex with copper catalysis

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Science China Chemistry 2024年第9期67卷 3019-3028页

作者： Hongping zhao xiaoxiang xi Tianbao Wu Zimin chen Minyan Wang Weiming Yuan Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Bioinorganic Chemistry and Materia MedicaSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518000China

A new catalytic decarboxylative cyanation and thiocyanation via a synergistic Na I/Cu catalysis is *** photoexcited electron donor-acceptor complex by assembly of Na I,R3P,and N-acyloxy-phthalimide ester(NHPI ester)triggers the generation of alkyl radical species,which then engages in Cu-catalyzed radical coupling *** to success of this dual catalytic transformation is the reliable charge transfer between I·and Cu(I).This dual catalytic platform can eliminate the use of expensive iridium-based photocatalyst or synthetically elaborate organic dyes.A series of primary,secondary,and tertiary alkyl nitriles and thiocyanates are easily ***,an asymmetric decarboxylative cyanation by applying a chiral Cu catalyst is also developed to afford chiral nitriles in high *** mechanistic details and the origin of the high enantioselectivity are further investigated by the mechanistic experiments and the density functional theory calculations.

关键词： electron donor-acceptor catalysis copper catalysis cyanation thiocyanation asymmetric synthesis

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Efficient optimization of electron transfer pathway by constructing phosphide/ceria interface boosts seawater hydrogen production

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Journal of Energy Chemistry 2024年第8期95卷 490-498,I0011页

作者： Yifan zhao Lingfeng Yang Youyu Long Min xi Anran chen Hua Zhang School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina Electron Microscopy Centre of Yunnan University Yunnan UniversityKunming 650091YunnanChina

Developing efficient and durable hydrogen evolution reaction(HER)electrocatalysts is one of the most important issues for the commercialization of seawater electrolysis,but it remains ***,we report a CeO_(2)-CoP nanoneedle array catalyst loaded on Ti mesh(CeO_(2)-CoP/TM)with workfunction-induced directional charge transport *** CeO_(2)-CoP/TM catalyst showed superior HER catalytic activity and stability,with over potentials of 41 and 60 mV to attain 10 mA cm^(-2),in 1 M KOH and 1 M KOH+seawater electrolyte,*** results and theoretical calculations reveal that the work function drives the charge transfer from CeO_(2)to CoP,which effectively balances the electronic density of CoP and CeO_(2),optimizes the d-band center,and accelerates the water activation kinetics,thus enhancing the HER *** solar-driven water electrolysis device displays a high and stable solar-to-hydrogen conversion efficiency of 19.6%.This study offers a work function-induced directional charge transport strategy to design efficient and durable catalysts for hydrogen production.

关键词： Work function Heterostructure Charge transport Seawater splitting Solar-to-hydrogen

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Bowel inflammatory presentations on computed tomography in adult patients with severe aplastic anemia during flared inflammatory episodes

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World Journal of Clinical Cases 2023年第3期11卷 576-597页

作者： xi-chen zhao cheng-Jiang Xue Hui Song Bin-Han Gao Fu-Shen Han Shu-xin xiao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Neurosurgery The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Radiology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Pneumology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Patients with severe aplastic anemia(SAA)frequently present with inflammatory episodes,and during flared inflammatory episodes,hematopoietic function is further *** gastrointestinal tract is the most common site for infectious and inflammatory diseases,and its structural and functional features confer on it the most potent capacity to affect hematopoietic and immune *** tomography(CT)is a readily accessible approach to provide highly useful information in detecting morphological changes and guiding further *** To explore CT imaging presentations of gut inflammatory damage in adult SAA patients during inflammatory *** We retrospectively evaluated the abdominal CT imaging presentations of 17hospitalized adult patients with SAA in search of the inflammatory niche when they presented with systemic inflammatory stress and exacerbated hematopoietic *** this descriptive manuscript,the characteristic images that suggested the presence of gastrointestinal inflammatory damage and related imaging presentations of individual patients were enumerated,analyzed and *** All eligible patients with SAA had CT imaging abnormalities that suggested the presence of an impaired intestinal barrier and increased epithelial *** inflammatory damages were concurrently present in the small intestine,the ileocecal region and the large *** readily identified imaging signs,such as bowel wall thickening with mural stratification(“water holo sign”,“fat holo sign”,intramural gas and subserosal pneumatosis)and mesenteric fat proliferation(fat stranding and“creeping fat sign”),fibrotic bowel wall thickening,“balloon sign”,rugged colonic configuration,heterogeneity in the bowel wall texture,and adhered and clustered small bowel loop(including various patterns of“abdominal cocoon”),occurred at a high incidence,which suggested that the damaged gastrointestinal tract is a common inflammatory niche res

关键词： Aplastic anemia Computed tomography Bowel inflammatory damage Fat holo sign Balloon sign Abdominal cocoon

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Synthesis of Anti-Pancreatic Cancer Natural Product Majusculamide D and Analogues Reveals a Preliminary Structure-Activity Relationships

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Chinese Journal of Chemistry 2024年第6期42卷 605-610页

作者： xiuhe zhao Mengxue Lv xiaonan xi Yaxin Lu Liang Wang Yue chen The State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin300350 China College of Chemistry Nankai UniversityTianjin300071 China

The total synthesis of majusculamide D(1)was achieved from commercially available *** addition,we synthesized eight analogues including three stereoisomers of majusculamide D that differ in the fatty acid *** analogues including a simplified analogue 29 exhibited significant nanomolar-level IC50 values against Panc-1 cells in MTT assays.A preliminary SAR analysis indicated that the hydroxyl group at C10 and C2−C3 unsaturated double bond of majusculamide D were essential in maintaining the high activity against Panc-1 cells and the orientation of C40-Me and C42-Me groups was tolerable.

关键词： Majusculamide D Natural products SAR Anti-pancreatic cancer Lipopentapeptide

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Enhanced red luminescence of Ca_(3)Si_(2−x)M_(x)O_(7):Eu^(3+)(M=Al,P)phosphors via partial substitution of Si^(4+) for applications in white light-emitting diodes

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Rare Metals 2024年第2期43卷 736-748页

作者： Yu-Hao Ma xi Gao Wen-Tao Zhang Zhen-Rui Yang Zhou zhao chen Qu College of Materials and Chemistry and Chemical Engineering Chengdu University of TechnologyChengdu610059China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China International Advanced Energy Science Research and Education Center Graduate School of Energy ScienceKyoto UniversityYoshida-HonmachiKyoto606-8501Japan

A red-emitting phosphor Ca_(2.91)Si_(2)O_(7):0.09Eu^(3+) with partial Al^(3+)/P^(5+) substitution on Si^(4+) was synthesized via a simple solid-state method,and the effects of the introduction of the M^(3+/5+)(M=Al,P)ions on the crystal structure and photoluminescence performance of Ca_(2.91)Si_(2−x)M_(x)O_(7):0.09Eu^(3+) phosphors were *** X-ray diffraction(XRD),energy-dispersive X-ray spectroscopy(EDS),and X-ray photoelectron spectroscopy(XPS)results revealed that the structure of Ca_(3)Si_(2)O_(7) remained the same after the introduction of Al^(3+) and P^(5+) *** characteristic emission of Eu^(3+)-doped Ca_(3)Si_(2−x)M_(x)O_(7) phosphors exhibited two main peaks at 617 nm(red)and 593 nm(orange)under excitation at 394 nm,which originated from the^(5)D_(0)→^(7)F_(2)and^(5)D_(0)→^(7)F_(1) electron transitions of Eu^(3+) *** the partial substitution of Al^(3+) and P^(5+),the red emission intensities of the Ca_(2.91)Si_(2)O_(7):0.09Eu^(3+) phosphors were significantly enhanced by 1.88-and 1.42-fold,respectively,which is attributed to the crystal-field effect around Eu^(3+).Meanwhile,the luminescence intensities of the Ca_(2.91)Si_(1.96)Al_(0.04)O_(7):0.09Eu^(3+) and Ca_(2.91)Si_(1.94)P_(0.06)O_(7):0.09Eu^(3+) phosphors at 210℃ were 79.36%and 77.53%of those at 30°C,respectively,indicating their excellent thermal ***,the as-prepared Ca_(2.91)Si_(1.96)Al_(0.04)O_(7):0.09Eu^(3+)and Ca_(2.91)Si_(1.94)P_(0.06)O_(7):0.09Eu^(3+) red-emitting phosphors were combined with a near-ultraviolet chip of 395 nm to fabricate red-light-emitting diode(LED)and white(w)-LED devices with excellent chromaticity *** summary,Al^(3+)/P^(5+)-substituted Ca_(2.91)Si_(2)O_(7):0.09Eu^(3+) can serve as red-emitting phosphors for applications in w-LEDs.

关键词： Ca_(3)Si_(2)O_(7) Red-emitting phosphor Structure substitution Luminescence enhancement Crystal-field effect White light-emitting diode

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