Severe hyperlipemia-induced pseudoerythrocytosis - Implication for misdiagnosis and blood transfusion: A case report and literature review
作者机构：Department of HematologyThe Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Clinical LaboratoryThe Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of HematologyThe Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2020年第8卷第19期
页 面：4595-4602页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Department Gastroenterology The Affiliated Hospital of Qingdao University
主 题：Case report Hyperlipemia Fat droplet Pancreatitis Pseudoerythrocytosis Blood transfusion indication
摘 要：BACKGROUND Severe hyperlipemia(SHLE)has an impact on the results of many kinds of laboratory *** blood count(CBC)examination by automated blood cell counter(ABCC)is a quick and convenient measurement for screening abnormalities of blood cells that are triggered by various pathogenic insults in disease diagnosis and for monitoring changes in the treatment of existing hematological ***,CBC results are frequently affected by many intrinsic and extrinsic factors from blood samples,such as in the setting of hypergammaglobulinemia and certain *** could also affect CBC *** SUMMARY A 33-year-old Chinese male presented with painful foot numbness and abdominal *** was initially misdiagnosed as having a myeloproliferative neoplasm(MPN)because of the marked abnormalities in CBC examination by the *** evaluation of the bone marrow smears and biopsy showed no evidence of *** mutations in Breakpoint cluster regions-Abelson murine leukemia viral oncogene homologue 1(BCR-ABL1),Janus kinase 2(JAK2),calreticulin(CALR),myeloproliferative leukemia virus(MPL),and colony-stimulating factor 3 receptor(CSF3R)were *** noticed the thick chylomicron layer on blood samples and the dramatically fluctuating CBC results,we speculated that the fat droplets formed by shaking the blood samples in the setting of SHLE were mistakenly identified as blood cells due to the limited parameters of ***,we removed a large part of the chylomicron layer and then reexamined the CBC,and the CBC results,as we expected,differed significantly from that of the sample before the chylomicron layer was *** significant differences had been validated by the subsequently repeated laboratory tests by measuring dual blood samples that the chylomicron layer was removed in one sample and was not in another,and comparing the CBC *** tomography reexamination of the upper abdomen revealed an exudative lesion
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