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8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin

World Journal of Gastroenterology 2013年第43期19卷 7680-7695页

作者： Mei-Fang Quan Li-Hong xiao Zhi-Hong Liu Hui Guo Kai-Qun Ren Fei Liu Jian-Guo Cao xi-yun deng Medical College Hunan Normal University Department of pathology Hunan Provincial Tumor Hospital

AIM:To evaluate whether 8-bromo-7-methoxychrysin(BrMC),a synthetic analogue of chrysin,inhibits the properties of cancer stem cells derived from the human liver cancer MHCC97 cell line and to determine the potential ***:CD133+cells were sorted from the MHCC97 cell line by magnetic activated cell sorting,and amplified in stem cell-conditioned medium to obtain the enriched CD133+sphere forming cells(SFCs).The stem cell properties of CD133+SFCs were validated by the tumorsphere formation assay in vitro and the xenograft nude mouse model in vivo,and termed liver cancer stem cells(LCSCs).The effects of BrMC on LCSCs in vitro were evaluated by MTT assay,tumorsphere formation assay and transwell chamber *** effects of BrMC on LCSCs in vivo were determined using a primary and secondary xenograft model in Balb/c-nu *** of the stem cell markers,epithelialmesenchymal transition(EMT)markers andβ-catenin protein were analyzed by western blotting or immunohistochemical ***:CD133+SFCs exhibited stem-like cell properties of tumorsphere formation and tumorigenesis capacity in contrast to the parental MHCC97 *** found that BrMC preferentially inhibited proliferation and self-renewal of LCSCs(P<0.05).Furthermore,BrMC significantly suppressed EMT and invasion of ***,BrMC could efficaciously eliminate LCSCs in ***,we showed that BrMC decreased the expression ofβ-catenin in *** ofβ-catenin by small interfering RNA could synergize the inhibition of self-renewal of LCSCs induced by BrMC,while Wnt3a treatment antagonized the inhibitory effects of ***:BrMC can inhibit the functions and characteristics of LCSCs derived from the liver cancer MHCC97 cell line through downregulation ofβ-catenin expression.

关键词： Liver cancer Cancer stem cell 8-bromo7-methoxychrysin Self-renewal β-catenin

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Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-кB and AP-1

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Cell Research 2003年第3期13卷 187-194页

作者： LIN deng,JING YANG,xiAO RONG ZHAO,xi yun deng,LIANG ZENG,HUAN HUA GU,MIN TANG,YA CAOCancer Research Institute,xiangya School of Medicine,Central South University,xiangya Road 88,Chang-sha,Hunan 410078,China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China 1Cancer Research Institute Xiangya School of Medicine Central South University Xiangya Road 88 Changsha Hunan 410078 China

Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latentmembrane protein 1 （LMP1） 5 could induce the nasopharyngeal carcinoma cells in G2/M phase increased, littleis known about the target molecules and mechanisms. The present study demonstrated that LMP1 couldinduce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, whichresulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phasethrough the activation of NF-κB and AP-1 signaling pathways, and the effect of NF-κB was more obviousthan that of AP-1. This study provided some significant evidence for further elucidating the molecularmechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survivalof transformed cells and tumorigenesis.

关键词： LMP1 nasopharyngeal carcinoma p53 G2/M

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Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases

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World Journal of Gastroenterology 2013年第40期19卷 6794-6804页

作者： Hui Wang Jing-Shi Liu Shao-Hua Peng xi-yun deng De-Mao Zhu Sara Javidiparsijani Gui-Rong Wang Dai-Qiang Li Long-Xuan Li Yi-Chun Wang Jun-Ming Luo Department of Radiation Oncology the Affiliated Hunan Provincial Tumor HospitalXiangya Medical SchoolCentral South University Department of Anesthesiology the Affiliated Hunan Provincial Tumor Hospital at Central South University Department of Pathology Medical College of Hunan Normal University Department of Pathology Changsha Central Hospital Department of Surgery SUNY Upstate Medical University Department of Pathology the Second Affiliated HospitalXiangya Medical SchoolCentral South University Department of Neurology Guangdong Medical College Affiliated Hospital Department of Pathology Qinghai Provincial People's Hospital

Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously *** evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the *** there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.

关键词： Inflammatory bowel disease Pulmonary symptoms Gut-lung crosstalk Biao-Li relationship Social manner

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Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng xi Yanling Lou Liucheng Meng Chao deng Youlu Chu Zhaoyang Xu Huining xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

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拉萨河下游水温变化特征及其影响因子分析

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人民黄河 2016年第6期38卷 99-103页

作者：魏希邓云脱友才梁瑞峰四川大学水力学与山区河流开发保护国家重点实验室四川成都610065

以拉萨河下游1956—1982年水温、气温及流量资料为基础,利用累计距平和滑动平均法分析了水温变化特性及变化趋势,并分析了水温对气温及流量变化的响应关系。结果表明：1拉萨河下游河段水温沿程升温率为1.0～2.8℃/100 km,研究河段的下... 详细信息

以拉萨河下游1956—1982年水温、气温及流量资料为基础,利用累计距平和滑动平均法分析了水温变化特性及变化趋势,并分析了水温对气温及流量变化的响应关系。结果表明：1拉萨河下游河段水温沿程升温率为1.0～2.8℃/100 km,研究河段的下游段因气温升高,且多为分汊型河道,故水温显著升高,研究站点间春季水温温差较大,冬季水温温差较小;2研究河段年均水温为7.3～8.4℃,夏季水温变幅大于冬季的;320世纪50年代中期到60年代中期水温降温率为-0.74℃/10 a,60年代中期到70年代初期水温升温率为0.47℃/10 a,70年代初期到80年代初期水温倾向率为0.005℃/10 a;4多年平均水温高于多年平均气温,同时期内水温的变化趋势与气温的相同,与流量的相反。

关键词：累计距平滑动平均水温气温流量拉萨河下游

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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Robust asymptotic stability for BAM neural networks with time-varying delays via LMI approach

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Applied Mathematics(A Journal of Chinese Universities) 2009年第3期24卷 282-290页

作者： LIU Jia ZONG Guang-deng ZHANG yun-xi Research Institute of Automation Qufu Normal University Qufu 273165 China School of Automation Nanjing University of Science & Technology Nanjing 210064 China

Several novel stability conditions for BAM neural networks with time-varying delays are *** on Lyapunov-Krasovskii functional combined with linear matrix inequality approach,the delay-dependent linear matrix inequality（LMI） conditions are established to guarantee robust asymptotic stability for given delayed BAM neural *** criteria can be easily verified by utilizing the recently developed algorithms for solving LMIs.A numerical example is provided to demonstrate the effectiveness and less conservatism of the main results.

关键词： robust asymptotic stability bidirectional associative memory (BAM) neural networks timevarying delays linear matrix inequality(LMI) Lyapunov-Krasovskii functional

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A unified Minorization-Maximization approach for estimation of general mixture models

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 343-362页

作者： HUANG xi-fen LIU deng-ge ZHOU yun-peng ZHU Fei School of Mathematics Yunnan Normal UniversityKunming 650092China Department of Statistics and Actuarial Science The University of Hong KongHong KongChina

The mixed distribution model is often used to extract information from heteroge-neous data and perform modeling *** the density function of mixed distribution is complicated or the variable dimension is high,it usually brings challenges to the parameter es-timation of the mixed distribution *** application of MM algorithm can avoid complex expectation calculations,and can also solve the problem of high-dimensional optimization by decomposing the objective *** this paper,MM algorithm is applied to the parameter estimation problem of mixed distribution *** method of assembly and decomposition is used to construct the substitute function with separable parameters,which avoids the problems of complex expectation calculations and the inversion of high-dimensional matrices.

关键词： MM algorithm mixed distribution model parameter estimation assembly decomposition tech-nology parameter separation

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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