Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases

作     者：Hui Wang Jing-Shi Liu Shao-Hua Peng Xi-Yun Deng De-Mao Zhu Sara Javidiparsijani Gui-Rong Wang Dai-Qiang Li Long-Xuan Li Yi-Chun Wang Jun-Ming Luo 

作者机构：Department of Radiation Oncologythe Affiliated Hunan Provincial Tumor HospitalXiangya Medical SchoolCentral South University Department of Anesthesiologythe Affiliated Hunan Provincial Tumor Hospital at Central South University Department of PathologyMedical College of Hunan Normal University Department of PathologyChangsha Central Hospital Department of SurgerySUNY Upstate Medical University Department of Pathologythe Second Affiliated HospitalXiangya Medical SchoolCentral South University Department of NeurologyGuangdong Medical College Affiliated Hospital Department of PathologyQinghai Provincial People's Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第40期

页      面：6794-6804页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Inflammatory bowel disease Pulmonary symptoms Gut-lung crosstalk Biao-Li relationship Social manner 

摘      要：Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously *** evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the *** there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.