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基于力链变化的直剪试验数值分析

科学技术与工程 2024年第25期24卷 10874-10883页

作者：张志伟左银辉常晁瑜徐久欢李佩茹贾唯龙成都理工大学油气藏地质及开发工程国家重点实验室成都610059 成都理工大学能源学院成都610059 防灾科技学院地质工程学院三河065201 河北省地震灾害防御与风险评价重点实验室三河065201 中国地质大学工程技术学院北京100083

构造宏观力学与细观力学的联结,一直是岩土力学领域研究课题的热点。从宏、细观两个角度出发,利用颗粒流软件PFC 2D模拟直剪试验,对直剪试验各阶段进行分析,利用风玫瑰图描述力链的方向,综合试验、离散元颗粒流模拟和细观理论对直剪试... 详细信息

构造宏观力学与细观力学的联结,一直是岩土力学领域研究课题的热点。从宏、细观两个角度出发,利用颗粒流软件PFC 2D模拟直剪试验,对直剪试验各阶段进行分析,利用风玫瑰图描述力链的方向,综合试验、离散元颗粒流模拟和细观理论对直剪试验的力链分布变化及演化规律进行研究。结果表明,室内试验、数值模拟试验二者结果基本一致;剪切应力达到峰值前内部力链结构有规律地重构,强力链逐渐靠向角平分线;剪切应力达到峰值与水平方向呈接近45°夹角,在卸荷失稳阶段,弱力链重新分布,部分强力链转化而消散,绝大多数保留在剪切带周边。该研究可以更好地理解土体的细观力学机理,为相关数值模拟试验提供参考依据。

关键词：离散元宏细观力学力链直剪试验 PFC

Association of Urinary Strontium Levels with Pregnancy-induced Hypertension

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Current Medical Science 2021年第3期41卷 535-541页

作者： Yi TANG Wei XIA Shun-qing xu Hong-xiu LIU Yuan-yuan LI Key Laboratory of Environment and Health(HUST) Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubation)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Pregnancy-induced hypertension(PIH),including gestational hypertension and preeclampsia,accounts for the majority of maternal and perinatal morbidity and ***(Sr)has been recently associated with preeclampsia in a small group of women;however,the role of Sr in PIH is not fully understood and warrants further *** this study,we examined the association between urinary Sr levels and PIH,and assessed the effect of maternal age on the *** Sr concentrations were measured in 5423 pregnant women before delivery by inductively coupled plasma mass spectrometry(ICP-MS).Logistic regression analysis adjusting for potential confounders was applied to explore the association between Sr and PIH,and to evaluate the Sr-PIH relationship stratified by maternal *** the participants,200(3.83%)women were diagnosed with *** with non-PIH women,women who developed PIH had lower urinary Sr concentrations(131.26 us.174.98μg/L creatinine,P<0.01).With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing,the risk of PIH decreased significantly[adjusted OR=0.60(95%CI:0.51,0.72)].Furthermore,the significant association of Sr with PIH was found among women under 35 years(P<0.01).Our finding suggested that Sr may play a potential protective role in the pathogenesis of PIH,especially among young pregnant women under 35 years old.

关键词： strontium pregnancy hypertension maternal age trace elements

Species richness patterns and the determinants of larch forests in China

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Plant Diversity 2022年第5期44卷 436-444页

作者： Wen-Jing Fang Qiong Cai qing Zhao Cheng-Jun Ji Jiang-Ling Zhu zhi-Yao Tang Jing-Yun Fang School of Ecology and Environmental Science Yunnan UniversityKunming 650091China Department of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China

Larch forests are important for species diversity,as well as soil and water conservation in mountain *** this study,we determined large-scale patterns of species richness in larch forests and identified the factors that drive these *** found that larch forest species richness was high in southern China and low in northern China,and that patterns of species richness along an elevational gradient depend on larch forest *** addition,we found that patterns of species richness in larch forests are best explained by contemporary climatic ***,mean annual temperature and annual potential evapotranspiration were the most important factors for species richness of tree and shrub layers,while mean temperature of the coldest quarter and anomaly of annual precipitation from the Last Glacial Maximum to the present were the most important for that of herb layer and the whole *** structural factors,especially stand density,are also associated with the species richness of larch *** findings that species richness in China's larch forests is mainly affected by energy availability and cold conditions support the ambient energy hypothesis and the freezing tolerance hypothesis.

关键词： Biodiversity Community structure Determinants Geographic pattern Larch forest Species richness

一种无源干扰试验中烟幕遮蔽面积的测量计算方法

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光学与光电技术 2024年第3期22卷 57-62页

作者：梁建兴陈庆良刘虎张旭唐昌建 63895部队河南焦作454750

在烟幕无源干扰试验中,烟幕对红外辐射源的有效遮蔽面积是评估和鉴定成烟装备综合性能的重要指标,由于烟幕的流动扩散性特点,其遮蔽面积的计算方法和标准已成为业界研究的难点和热点。通过对烟幕遮蔽面积和红外辐射点源衰减率的测量原... 详细信息

在烟幕无源干扰试验中,烟幕对红外辐射源的有效遮蔽面积是评估和鉴定成烟装备综合性能的重要指标,由于烟幕的流动扩散性特点,其遮蔽面积的计算方法和标准已成为业界研究的难点和热点。通过对烟幕遮蔽面积和红外辐射点源衰减率的测量原理分析,推导出利用红外辐射点源的衰减率插值得到焦平面内衰减率空间分布的函数关系,列出了具体方法步骤,用红外辐射图像的插值效果进行了验证,当采样间隔大于20倍像元间距时无法恢复红外烟幕轮廓,并根据插值效果推导了红外辐射点源阵列布设的最大有效距离。该方法可作为光电外场试验中红外辐射点源阵列布设的参考,具有较高的实用价值。

关键词：烟幕衰减率辐射源遮蔽面积插值

Using oligonucleotide suspension arrays for laboratory identification of bacteria responsible for bacteremia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 291-298页

作者： Xiao-li HOU Han-liang JIANG qing-yi CAO Li-ying ZHAO Barbara J. CHANG zhi CHEN Institute of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Microbiology and Immunology School of Biomedical Biomolecular and Chemical Sciences University of Western Australia Nedlands WA 6009 Australia

The aim of this study was to develop and validate an oligonucleotide suspension array for rapid identification of 15 bacterial species responsible for bacteremia, particularly prevalent in Chinese hospitals. The multiplexed array, based on the QIAGEN LiquiChip Workstation, included 15 oligonucleotide probes which were covalently bound to different bead sets. PCR amplicons of a variable region of the bacterial 23S rRNA genes were hybridized to the bead-bound probes. Thirty-eight strains belonging to 15 species were correctly identified on the basis of their corresponding species-specific hybridization profiles. The results show that the suspension array, in a single assay, can differentiate isolates over a wide range of strains and species, and suggest the potential utility of suspension array system to clinical laboratory diagnosis.

关键词： Oligonucleotide array Bacteremia 23S rRNA Multiplexed detection

Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3730-3739页

作者： Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng qing xu Qian xu qing Wei Huanlong Qin Department of Pathology Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of Oncology Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina

Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic *** evidence suggests that microbes influence the efficacy of cancer *** nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)***,we investigated the effect of *** on anti-PD-L1 therapy in *** found that high *** levels correlate with improved therapeutic responses to PD-1 blockade in patients with ***,*** enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged *** *** supplementation with immunotherapy rescued the therapeutic effects of PD-L1 ***,*** induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 ***,patient-derived organoid models demonstrated that increased *** levels correlated with an improved therapeutic response to PD-L1 *** findings suggest that *** may modulate immune checkpoint therapy for CRC.

关键词： colorectal cancer interferon

复方活脑舒胶囊联合多奈哌齐对帕金森病轻度认知功能障碍患者认知功能和血清脑神经递质的影响

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现代生物医学进展 2024年第8期24卷 1482-1485,1529页

作者：曹玲闫卫红丁智斌徐心田宋艳丽沈志丽山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院)神经内科山西太原030032 山西盈康一生总医院老年医学科山西运城044000 河北省卢龙县医院神经内科河北秦皇岛066400

目的:观察复方活脑舒胶囊联合多奈哌齐对帕金森病(PD)轻度认知功能障碍(PD-MCI)患者认知功能和血清脑神经递质的影响。方法:选择2021年3月~2022年12月期间在我院接受治疗的PD-MCI患者128例。按照随机数字表法将患者分为对照组(多奈哌齐... 详细信息

目的:观察复方活脑舒胶囊联合多奈哌齐对帕金森病(PD)轻度认知功能障碍(PD-MCI)患者认知功能和血清脑神经递质的影响。方法:选择2021年3月~2022年12月期间在我院接受治疗的PD-MCI患者128例。按照随机数字表法将患者分为对照组(多奈哌齐治疗)和研究组(复方活脑舒胶囊联合多奈哌齐治疗),各为64例。对比两组疗效、简易智能精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、日常生活能力量表(ADL)评分和血清脑神经递质[5-羟色胺(5-HT)、乙酰胆碱(Ach)、多巴胺(DA)]。同时统计两组治疗期间不良反应发生率。结果:与对照组相比,研究组的临床总有效率明显升高(P0.05)。结论:复方活脑舒胶囊联合多奈哌齐治疗PD-MCI患者,可有效改善患者的认知功能,改善血清脑神经递质水平,提高患者的日常生活自理能力。

关键词：复方活脑舒胶囊多奈哌齐帕金森认知功能障碍脑神经递质

Effect of Martensite Morphology on Impact Toughness of Ultra-High Strength 25CrMo48V Steel Seamless Tube Quenched at Different Temperatures

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Journal of Iron and Steel Research International 2013年第2期20卷 62-67页

作者： ZHANG Chuan-you WANG qing-feng KONG Jin-li XIE Guo-zhu WANG Ming-zhi ZHANG Fu-cheng State Key Laboratory of Metastable Materials Science and Technology Yanshan University National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University

A 25CrMo48V steel for ultra-deep oil/gas well casings was quenched at 900-1 200 ℃ and tempered at 650 ℃. The lath martensitic structures were characterized by optical microscope （OM）, field emission scanning electron microscopy （FESEM）, electron backscattering diffraction （EBSD） and transmission electron microscopy （TEM）, and the transverse impact energy at 0 ℃ was measured from the as-quenched and tempered specimens. The results show that with the quenching temperature decreased, the prior austenite grain, martensitic packet and block are refined, while the lath width seems to remain unchanged. The enhancement of impact toughness with the decreasing quenching temperature can be attributed to refinement of the martensitic structure with high-angle boundaries, and the block is the minimum structure unit controlling impact toughness. The transverse impact energy [ECVN （0 ℃） ≥100 J] required for seamless casings with ultra-high strength （Rp0.2≥932 MPa） has been finally achieved with the experimental steel quenched at 900-1 000 ℃ and tempered at 650 ℃.

关键词： seamless steel tube lath martensitic morphology toughness

《环境化学污染物参考剂量推导技术指南》(WS/T 10006-2023)解读

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环境卫生学杂志 2024年第8期14卷 681-686页

作者：李晓君夏玮瞿静瑜徐顺清华中科技大学同济医学院公共卫生学院/环境与健康教育部重点实验室/生态环境部环境污染健康效应重点实验室武汉430030 江门市市场监督管理局江门529000 张家港市卫生监督所海南大学环境科学与工程学院

环境化学污染物的参考剂量是制定环境基准及环境质量标准的基础,也是环境健康风险评估、化学品风险管理和环境健康管理的重要依据。《环境化学污染物参考剂量推导技术指南》(WS/T 10006-2023)提供了以保护人体健康为目标的环境化学污染... 详细信息

环境化学污染物的参考剂量是制定环境基准及环境质量标准的基础,也是环境健康风险评估、化学品风险管理和环境健康管理的重要依据。《环境化学污染物参考剂量推导技术指南》(WS/T 10006-2023)提供了以保护人体健康为目标的环境化学污染物参考剂量推导的程序、方法步骤和技术内容的指导。本文对该技术指南的制定背景、编制原则、主要内容及使用注意事项进行解读和说明。

关键词：参考剂量环境化学污染物技术指南标准解读