检索结果-南通市图书馆

Asian Journal of Andrology 2018年第6期20卷 608-614页

作者： qing-qing Yin Lin-Hui xu Mi Zhang Chen xu Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China.

The autonomic nervous system contributes to prostate cancer proliferation and metastasis. However, the exact molecular mechanism remains unclear. In this study, muscarinic acetylcholine receptor M1 （CHRM1） expression was measured via immunohistochemical analysis in human prostate cancer tissue array slides. PC-3, LNCaP, and A549 cells were treated with pirenzepine or carbachol, and the cell migration and invasion abilities were evaluated. Western blotting and quantitative real-time PCR were performed to measure GLI family zinc finger 1 （GLI1）, patched 1 （PTCH1）, and sonic hedgehog （SHH） expression levels. High expression of CHRM1 was found in early-stage human prostate cancer tissues. In addition, the selective CHRM1 antagonist pirenzepine inhibited PC-3, LNCaP, and A549 cell migration and invasion, but the agonist carbachol promoted the migration and invasion of these three cell lines. Muscarinic signaling can be relayed by hedgehog signaling. These data show that CHRM1 is involved in the regulation of prostate cancer migration and invasion through the hed^eho~ si^nalin~ ~athwav.

关键词： hedgehog signaling muscarinic acetylcholine receptor M1 (CHRM1) metastasis prostate cancer

Study on the Interaction between Strychnine and Bovine Serum Albumin by Capillary Electrophoretic Frontal Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第9期16卷 1233-1236页

作者： Shao Ping FU Xiao Zhe ZHANG Feng ZHANG qing xu Hong Bin XIAO Xin miao LIANG Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023

The protein binding constant, binding sites of the Strychnos alkaloid-strychnine and bovine serum albumin （BSA） was determined by capillary electrophoretic frontal analysis （CE-FA） for the first time. The experiment was carried out in a polyacrylamide-coated fused silica capillary （48.4 cm×50 μm i.d., 38.1 cm effective length） with 20 mmol/L citrate/MES buffer （pH 6.0, ionic strength 0.17）. The applied voltage was 12 kV and detection wavelength was set at 257 nm. The plateau height of the peak was employed to determine the unbound concentration of drug in BSA equilibrated sample solution based on the external drug standard in the absence of protein. The present method provides a convenient, accurate technique for the early stage of drug screening.

关键词： Strychnine binding constant capillary electrophoretic frontal analysis bovine serumalbumin

On GF(p)-linear complexities of binary sequences

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2009年第4期16卷 112-115,124页

作者： xu Li-qing Software Engineering Institute East China Normal University Shanghai 200062 China

Several geometric sequences have very low linear complexities when considered as sequences over GF（p）, such as the binary sequences of period q^n - 1 constructed by Chan and Games [1-2] （q is a prime power p^m, p is an odd prime） with the maximal possible linear complexity q^n-1 when considered as sequences over GF（2）. This indicates that binary sequences with high GF（2） linear complexities LC2 and low GF（p）-linear complexities LCp are not secure for use in stream ciphers. In this article, several lower bounds on the GF（p）-linear complexities of binary sequences is proved and the results are applied to the GF（p）-linear complexities of Blum-Blum-Shub, self-shrinking, and de Bruijn sequences. A lower bound on the number of the binary sequences with LC2 〉 LCD is also presented.

关键词： cryptography stream cipher binary sequences GF(2) linear complexity GF(p)-linear complexity

Color routing at the nanoscale

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 663-664页

作者： qing-Hua xu Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore

Two types of color routing effects were observed in silver nanorods on the single particle level as a result of distinct far-field behaviors of different multipolar plasmon modes,which enables tunable color sorting wi... 详细信息

关键词： routing nanorods silver

Ultra-deep carbonate basement reservoirs formed by polyphase fracture-related karstification in the Offshore Bohai Bay Basin, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2023年第4期20卷 2009-2025页

作者： Jian Luo Hai-Yang Cao Domenico Chiarell Ru-Lin miao Tao Ye Yun-Long xu An-qing Chen Xiao-Ping Luo State Key Laboratory of Oil&Gas Reservoir Geology and Exploration(Chengdu University of Technology) ChengduSichuan610059China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications MNR&Institute of Sedimentary GeologyChengdu University of TechnologyChengduSichuan610059China Department of Earth Sciences Royal Holloway University of LondonSurreyTW200EXUnited Kingdom Tianjin Branch of China National Offshore Oil Company Ltd. Tianjin300452China Exploration and Development Research Institute Zhongyuan Oilfield CompanySINOPECPuyangHenan457001China

The Palaeozoic carbonate basement of the Offshore Bohai Bay Basin (OBBB) presents considerable potential for hydrocarbon exploration. However, the multistage tectonism and complex superimposed palaeo-karstification in the area are unclear, which leads to a lack of understanding on the formation mechanism and distribution of the deep carbonate basement reservoirs. In this study, the occurrence of a fracture-vug network and its fillings in carbonate reservoirs were investigated based on borehole cores, thin sections, and image logs from the southwestern slope of the OBBB's Bozhong Sag. Then the diagenetic fluid properties of the carbonate matrix and fillings were analysed via the data of carbon, oxygen, and strontium isotopes, and major, rare elements from coring intervals. The results revealed that fracture-related karst reservoirs have lithologic selectivity inclined toward dolomite strata. The intersecting relationships, widths, and strikes of the fractures and the regional tectonic background indicate three structural fracture families: NW-, NNE-, and NNW- trending, related to the Indosinian, middle Yanshanian, and late Yanshanian orogeny, respectively. The Indosinian NW- and end-Mesozoic NNE-trending fractures produced by compressional tectonic stress mainly contributed to the formation of the basement reservoirs. The geochemistry of the calcite veins filling these fractures suggests two main types of diagenetic fluids. The fluid of autogenic recharge related to the earlier fills is karstification diffuse flow dominated by internal runoff from rainfall in the highland setting of the Indosinian thrusting orogenic belt. The other fluid of allogenic recharge related to the later fills is the main lateral freshwater flow dominated by external runoff from the catchment in the setting of the horst-lowland within the rifting basin, induced by the Yanshanian destruction of the North China Craton. Finally, the relationship between the three fracture families and two kinds

关键词： Carbonate basement reservoirs Buried hill Diagenetic fluid Fracture system Karstification Bohai bay basin

Using hydrochemical signatures to characterize the long-period evolution of groundwater information in the Dagu River Basin,China

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2021年第5期15卷 311-323页

作者： Ziyue Yin qing Lin Shaohui xu School of Environmental Science and Engineering Qingdao UniversityQingdao266071China

The evolution of hydrochemical compositions influenced by long-period interactions between groundwater and the geo-environment is a fundamental issue for exploring groundwater quality and *** study systematically investigated the hydrochemical processes and anthropogenic interference occurring in the river basin by bivariate plots,Gibbs diagrams,saturation index,and the major ions *** changes in groundwater hydrochemistry have been observed in the study area,illustrating the origins of major ions are affected by various internal and external *** highlighted that TDS varied from freshwater to brackish water,ranging between 187.90 and 2294.81 mg/***^(2+)and HCO_(3)^(−)are the dominant ions in the studied *** results gained by Gibbs diagrams,bivariate plots,saturation index,and the major ions ratios demonstrated that minerals dissolution/precipitation,cation exchange,and human inputs play crucial roles in the unconfined ***,the overuse of nitrogen fertilizer,livestock manure,and industrial/domestic sewage led to nitrate and nitrite contamination and brought significant challenges to the surrounding *** present study could make an unambiguous identification of natural processes and anthropogenic interventions influencing groundwater hydrochemistry’s long-period evolution and create a preliminary strategy for groundwater resources management.

关键词： Groundwater quality Hydrochemical signatures Spatial-temporal variations Water-rock interactions Anthropogenic interventions

Multi-Attribute Preferences Mining Method for Group Users with the Process of Noise Reduction

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2021年第4期36卷 944-960页

作者： qing-Mei Tan xu-Na Wang College of Economic and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China Research Base for Civilian-Military Integration Development in Jiangsu Province Nanjing 211106China

Traditional researches on user preferences mining mainly explore the user’s overall preferences on the project,but ignore that the fundamental motivation of user preferences comes from their attitudes on some attributes of the *** addition,traditional researches seldom consider the typical preferences combination of group users,which may have influence on the personalized service for group *** solve this problem,a method with noise reduction for group user preferences mining is proposed,which focuses on mining the multi-attribute preference tendency of group ***,both the availability of data and the noise interference on preferences mining are considered in the algorithm *** the process of generating group user preferences,a new path is used to generate preference keywords so as to reduce the noise ***,the Gibbs sampling algorithm is used to estimate the parameters of the ***,using the user comment data of several online shopping websites as experimental objects,the method is used to mine the multi-attribute preferences of different *** proposed method is compared with other methods from three aspects of predictive ability,preference mining ability and preference topic *** results show that the method is significantly better thap other existing methods.

关键词： preferences mining group user multi-attribute noise reduction noise interference

Molecular identification of the key starch branching enzyme-encoding gene SBE2.3 and its interacting transcription factors in banana fruits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1354-1368页

作者： Hongxia miao Peiguang Sun qing Liu Juhua Liu Caihong Jia Dongfang Zhao Biyu xu Zhiqiang Jin Key Laboratory of Tropical Crop Biotechnology Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences571101 HaikouPeople’s Republic of China Key Laboratory of Genetic Improvement of Bananas Haikou Experimental StationChinese Academy of Tropical Agricultural Sciences571101 HaikouHainan ProvincePeople’s Republic of China Commonwealth Scientific and Industrial Research Organization Agriculture and Food CanberraACT 2601Australia College of Horticulture Nanjing Agricultural University210095 NanjingPeople’s Republic of China

Starch branching enzyme(SBE)has rarely been studied in common starchy banana *** the first time,we report here the molecular characterization of seven SBE(MaSBE)and six SBE(MbSBE)genes in the banana A-and B-genomes,respectively,which could be classified into three distinct subfamilies according to genome-wide *** transcriptomic analysis revealed that six MaSBEs and six MbSBEs were expressed in the developing banana fruits of two different genotypes,BaXi Jiao(BX,AAA)and Fen Jiao(FJ,AAB),among which MaSBE2.3 and MbSBE2.3 were highly *** silencing of MaSBE2.3 expression in banana fruit discs led to a significant decrease in its transcription,which coincides with significant reductions in total starch and amylopectin contents compared to those of empty vector *** suggested functional role of MaSBE2.3 in banana fruit development was corroborated by its transient overexpression in banana fruit discs,which led to significant enhancements in total starch and amylopectin contents.A number of transcription factors,including three auxin response factors(ARF2/12/24)and two MYBs(MYB3/308),that interact with the MaSBE2.3 promoter were identified by yeast one-hybrid library *** these ARFs and MYBs,MaARF2/MaMYB308 and MaARF12/MaARF24/MaMYB3 were demonstrated via a luciferase reporter system to upregulate and downregulate the expression of MaSBE2.3,respectively.

关键词： branching starch fruits

Analysis of torque transmitting behavior and wheel slip prevention control during regenerative braking for high speed EMU trains

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2016年第2期32卷 244-251页

作者： Kun xu Guo-qing xu Chun-Hua Zheng Shenzhen Institutes of Advanced Technology Chinese Academy of Sciencesand The Chinese University of Hong Kong Shenzhen College of Advanced Technology University of Chinese Academy of Sciences School of Electronics and Information Tongji University

The wheel-rail adhesion control for regenerative braking systems of high speed electric multiple unit trains is crucial to maintaining the stability,improving the adhesion utilization,and achieving deep energy *** remain technical challenges mainly because of the nonlinear,uncertain,and varying features of wheel-rail contact *** research analyzes the torque transmitting behavior during regenerative braking,and proposes a novel methodology to detect the wheel-rail adhesion ***,applications to the wheel slip prevention during braking are investigated,and the optimal slip ratio control scheme is proposed,which is based on a novel optimal reference generation of the slip ratio and a robust sliding mode *** proposed methodology achieves the optimal braking *** simulation results for uncertain slippery rails verify the effectiveness of the proposed methodology.

关键词： High speed electric multiple unit(EMU) train Regenerative braking Wheel-rail adhesion Optimal slip ratio

A new formula on the Fresnel reflectance and its application in microwave remote sensing

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2004年第11期47卷 1045-1052页

作者： xu qing LIU Yuguang Key Laboratory of Physical Oceanography of the Ministry of Education Ocean University of China Qingdao 266003 China Key Laboratory of Physical Oceanography of the Ministry of Education Ocean University of China Qingdao 266003 China

A new formula on the Fresnel reflectance is derived based on our understanding of the complex index of refraction and continuity condition of the E-M waves across the interface between two media. The imaginary component of the complex index of refraction is related to the attenuation of the E-M waves propagating in a medium. It does not denote the phase of the E-M waves. The traditional derivation confuses the physical meaning of the imaginary component of the complex index of refraction. The derived formula on the Fresnel reflectance can be used to obtain the emissivity of sea surface, which is useful to retrieve sea surface temperature and sea surface salinity in the microwave remote sensing.

关键词： reflectance, refraction, microwaves, optics, remote sensing.