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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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行政赔偿“先行处理”协商程序探析

广西政法管理干部学院学报 2008年第3期23卷 94-97页

作者：许林华杨林芹苏州大学法学院江苏苏州215006

"先行处理"是多数国家及地区行政赔偿普遍遵循的原则,我国《国家赔偿法》亦有相应规定,但对具体处理模式及其程序则缺少规范。协商是解决矛盾和纠纷的有效机制,借鉴和采用协商处理模式,通过加强协商程序规范与控制,由义务机关与赔偿请... 详细信息

"先行处理"是多数国家及地区行政赔偿普遍遵循的原则,我国《国家赔偿法》亦有相应规定,但对具体处理模式及其程序则缺少规范。协商是解决矛盾和纠纷的有效机制,借鉴和采用协商处理模式,通过加强协商程序规范与控制,由义务机关与赔偿请求人互相沟通、协商一致,将有利于迅速化解赔偿纠纷,切实维护和实现请求人的权益。

关键词：行政赔偿先行处理协商

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深圳湾北岸泥滩大型底栖动物次级生产力研究

台湾海峡 2007年第3期26卷 415-421页

作者：金亮蔡立哲周细平徐华林厦门大学近海海洋环境科学国家重点实验室广东内伶仃福田国家级自然保护区广东深圳518040

根据2005年3、6、9月和12月在深圳湾北岸泥滩9个取样站采集的大型底栖动物4个季度的定量样品,运用Brey(1990)的经验公式进行了大型底栖动物栖息丰度、生物量、次级生产力和P/B值的研究计算.整个研究区域大型底栖动物年次级生产力平均值... 详细信息

根据2005年3、6、9月和12月在深圳湾北岸泥滩9个取样站采集的大型底栖动物4个季度的定量样品,运用Brey(1990)的经验公式进行了大型底栖动物栖息丰度、生物量、次级生产力和P/B值的研究计算.整个研究区域大型底栖动物年次级生产力平均值(去灰干重)为54.55g/(m2.a),其中观鸟屋附近泥滩(A断面)较高,为68.85g/(m2.a),凤塘河口附近泥滩(H断面)为50.62g/(m2.a)次之,沙嘴码头附近泥滩(F断面)较低,为44.18g/(m2.a),深圳湾北岸泥滩大型底栖动物年平均P/B为2.95.可见,大型底栖动物次级生产力越靠近深圳河河口越低,这与越靠近深圳河河口,大型底栖动物个体越小、生活史更短的结果是一致的.

关键词：大型底栖动物次级生产力泥滩深圳湾

浙江省高校英语教师信息化教学设计能力之调查与分析

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湖州师范学院学报 2013年第4期35卷 132-136页

作者：许华琳顾晔浙江中医药大学外国语学院浙江杭州310053

本研究通过问卷形式,依据信息化教学设计能力一级指标体系及其细化后的二级和三级指标体系,调查浙江省高校英语教师信息化教学设计能力的实际状况。研究发现:被访教师查找教学/学习资源并进行评价的能力较好;半数被访教师未能很好利用IC... 详细信息

本研究通过问卷形式,依据信息化教学设计能力一级指标体系及其细化后的二级和三级指标体系,调查浙江省高校英语教师信息化教学设计能力的实际状况。研究发现:被访教师查找教学/学习资源并进行评价的能力较好;半数被访教师未能很好利用ICT来促进学生开展探究性学习活动;近三分之二被访教师利用ICT促进师生和生生合作交流的意识和能力处于较弱水平。我省高校英语教师信息化教学设计能力还尚待提高。

关键词：高校英语教师信息化教学设计能力结果分析

3D-QSAR Analyses of Catecholic Flavonoids as Telomerase Inhibitors

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3D-QSAR Analyses of Catecholic Flavonoids as Telomerase Inhi...

中国化学会第四届有机化学学术会议

作者： PAN, xu-lin TAN, Ning-hua HAN, Hong-Jin (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan 650204)

＜正＞Telomerase is a ribonucleoprotein responsible for maintaining telomere length by adding TTAGGG repeats to the 3’-ends of chromosomes. Human telomerase consists of two essential subunits, human telomerase RNA（hTR）, which carries the RNA template for the telomere repeats, and the human telomerase catalytic subunit （hTERT）, which has reverse transcriptase activity. Telomerase is active in 85%-90% of human tumors but not in most normal somatic cells. It has been suggested that tumor cells have unlimited proliferative potential as a consequence of

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肠易激综合征患者的心理健康状况分析

第四军医大学学报 2006年第19期27卷 1812-1814页

作者：徐维田徐志鹏许桦林郑国荣广州军区武汉总医院消化内科湖北武汉430070 广州军区武汉总医院神经内科湖北武汉430070

目的探讨肠易激综合征(IBS)与心理健康状况之间的关系.方法采用心理卫生自评量表(SCL-90)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对40例IBS患者进行了调查.结果IBS组在躯体化、强迫症状、抑郁、焦虑、恐怖、偏执因子分及总分方面均高... 详细信息

目的探讨肠易激综合征(IBS)与心理健康状况之间的关系.方法采用心理卫生自评量表(SCL-90)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对40例IBS患者进行了调查.结果IBS组在躯体化、强迫症状、抑郁、焦虑、恐怖、偏执因子分及总分方面均高于对照组和急性胃炎组(P<0.05);IBS组SDS,SAS分值均高于对照组(P<0.05).结论IBS患者存在一定程度的心理异常,心理因素可能在IBS发病过程中起重要作用.

关键词：肠易激综合征心理学心理卫生自评量表抑郁自评量表焦虑自评量表

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang Li ShiYong huang SiBo xu ZhiGang Yuan Kui Jiang QiYang Xiong RenTong lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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28例残胃癌临床分析

伤残医学杂志 2004年第4期12卷 35-37页

作者：王艳许桦林广州军区武汉总医院消化内科湖北武汉430070

目的:探讨残胃癌的临床表现、病理特点以及治疗与预后。方法:回顾性分析28例残胃癌的临床资料。结果:BillrothⅡ式术后残胃癌发生率为75％;肿瘤平均发生距胃切除时间为14.1年;1次性胃镜检查对残胃癌的捡出率为87％;肿瘤发生在吻合口14例... 详细信息

目的:探讨残胃癌的临床表现、病理特点以及治疗与预后。方法:回顾性分析28例残胃癌的临床资料。结果:BillrothⅡ式术后残胃癌发生率为75％;肿瘤平均发生距胃切除时间为14.1年;1次性胃镜检查对残胃癌的捡出率为87％;肿瘤发生在吻合口14例,胃底贲门部12例,全残胃2例;采取根治术预后好、结论:残胃癌多在Billroth Ⅱ式术后发生,定期胃镜检查可以早发现,积极的治疗可以延长患者生存时间。

关键词：残胃癌内镜检查治疗预后