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Chinese Journal of Natural Medicines 2018年第1期16卷 1-9页

作者： xu jing-yuan ZHU Yan YI Ze WU Gang XIE Guo-Yong QIN Min-Jian Department of Resources Science of Traditional Chinese Medicines State Key Laboratory of Natural Medicines China Pharmaceutical University

"Wu zhu yu", which is obtained from the dried unripe fruits of Tetradium ruticarpum(A. Jussieu) T. G. Hartley, has been used as a traditional Chinese medicine for treatment of headaches, abdominal colic, and hypertension for thousands of years. The present study was designed to assess the molecular genetic diversity among 25 collected accessions of T. ruticarpum(Wu zhu yu in Chinese) from different areas of China, based on inter-primer binding site(i PBS) markers and inter-simple sequence repeat(ISSR) markers. Thirteen ISSR primers generated 151 amplification bands, of which 130 were polymorphic. Out of 165 bands that were amplified using 10 iPBS primers, 152 were polymorphic. The iPBS markers displayed a higher proportion of polymorphic loci(PPL = 92.5%) than the ISSR markers(PPL = 84.9%). The results showed that T. ruticarpum possessed high loci polymorphism and genetic differentiation occurred in this plant. The combined data of iPBS and ISSR markers scored on 25 accessions produced five clusters that approximately matched the geographic distribution of the species. The results indicated that both iPBS and ISSR markers were reliable and effective tools for analyzing the genetic diversity in T. ruticarpum.

关键词： Genetic diversity Tetradium ruticarpum iPBS Retrotransposon ISSR

Gradient Gene Algorithm: a Fast Optimization Method to MST Problem

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 535-540页

作者： Zhang Jin bo, xu jing wen, Li yuan xiang State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, China State Key Laboratory of Software Engineering Wuhan University Wuhan China

The extension of Minimum Spanning Tree(MST) problem is an NP hard problem which does not exit a polynomial time algorithm. In this paper, a fast optimization method on MST problem——the Gradient Gene Algorithm is introduced. Compared with other evolutionary algorithms on MST problem, it is more advanced: firstly, very simple and easy to realize; then, efficient and accurate; finally general on other combination optimization problems.

关键词： combination optimization minimum spanning tree problem extension of minimum spanning tree problem gradient gene algorithm

Pretreatment of poly(acrylic acid) sodium by continuous diafiltration and time revolution of filtration potential

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Journal of Central South University 2019年第3期26卷 577-586页

作者： xu jing-yuan TANG Shu-yun QIU Yun-ren School of Chemistry and Chemical Engineering Central South University

The pretreatment for the removal of small molecules from poly(acrylic acid) sodium (PAAS) solution by continuous diafiltration was investigated using ultrafiltration membrane. The effects of PAAS concentration, pH, trans-membrane pressure and pretreatment time on the permeate concentration and permeate flux were studied. The results show that the necessary pretreatment time (NPT) increases with PAAS concentration, decreases with TMP. The change trend of permeate flux with time is affected by pH. The permeate fluxes rapidly decrease from the start, and then increase gradually to stable values at pH 5.0, pH 7.0 and pH 9.3. However, it decreases gradually with time till a state value at pH 3.0 (iso-electric point, IEP). The removal of small molecules is easy at pH greater than iso-electric point (IEP). The change of filtration potential with time indicates the similar trend to that of permeation concentration, but the former is more convenient for indication of NPT.

关键词： pretreatment diafiltration ultrafiltration poly(acrylic acid) sodium filtration potential

Role of immunodeficiency in Acinetobacter baumannii associated pneumonia in mice

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Chinese Medical Journal 2020年第18期133卷 2161-2169页

作者： Ai-Ran Liu Wen-jing Du Jian-Feng Xie jing-yuan xu Ying-Zi Huang Hai-Bo Qiu Yi Yang Department of Critical Care Medicine Zhong-Da HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Critical Care Medicine Xuzhou Central HospitalXuzhouJiangsu 221009China

Background:Acinetobacter baumannii(***)has become one of the most important opportunistic pathogens inducing nosocomial pneumonia and increasing mortality in critically ill patients *** interaction between *** infection and immune response can influence the prognosis of *** related *** target of the present study was to investigate the role of immunodeficiency in *** induced ***:Male BALB/c mice were randomly divided into the normal immunity control(NIC)group,normal immunity infection(NIA)group,immune compromised control(CIC)group,and immune compromised infection(CIA)group(n=15 for each group).Intraperitoneal injection of cyclophosphamide and intranasal instillation of *** solution were used to induce compromised immunity and murine pneumonia,*** mice were sacrificed at 6 and 24 h later and the specimens were collected for further ***-day mortality of mice was also ***:After *** stimulation,the recruitment of neutrophils in mice with normal immunity increased sharply(P=0.030 at 6 h),while there was no significant raise of neutrophil counts in mice with compromised immune condition(P=0.092 at 6 h,P=0.772 at 24 h).The Th cell polarization presented with pulmonary interleukin(IL)-4 and interferon(IFN)-γlevel in response to the *** in CIA group were significantly depressed in comparison with in NIA group(IFN-γ:P=0.003 at 6 h;P=0.001 at 24 h;IL-4:P<0.001 at 6 h;P<0.001 at 24 h).The pulmonary conventional dendritic cell accumulation was even found to be inhibited after *** infection in immunocompromised mice(P=0.033).Correspondingly,*** associated pneumonia in mice with compromised immunity caused more early stage death,more severe histopathological impairment in ***:*** could frustrate the immune response in immunocompromised conditions,and this reduced immune response is related to more severe lung injury and wors

关键词： Acinetobacter baumannii Compromised immunity Dendritic cells Helper T cell Neutrophilic granulocytes Pneumonia

MICROSTRUCTURE OF SILICON CARBIDE WHISKERS

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Acta Metallurgica Sinica(English Letters) 1991年第9期4卷 211-218页

作者： xu Haigang ZHU jing yuan Hong Central Iron and Steel Research Institute,Ministry of Metallurgical Industry,Beijing,ChinaNING Xiaoguang YE Hengqiang Laboratory of Atomic Imaging of Solids,Institute of Metal Research,Academia Sinica,Shenyang,China Central Iron and Steel Research Inst Beijing China

The morphology,crystal defects and chemical compositions of surfaces in two kinds of SiC whiskers related to their growth mechanism have been studied by means of electron microscopy and surface chemical *** upon the experimental results,five criteria for evaluating the whisker microstructure were suggested as:proportion of the perfect single crystals,morphology and dimensions,defects and their distribution,the bulk and surface chemistries,and crystallographic characteristics.

关键词： SiC whisker microstructure defect

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内皮祖细胞在急性肺损伤中的应用

中华结核和呼吸杂志 2010年第11期33卷 853-855页

作者：徐静媛杨毅邱海波东南大学附属中大医院危重病医学科南京210009

急性肺损伤（acute lung injury，ALl）是临床常见危承症，目前缺乏有效的治疗手段，病死率高达40％。内皮细胞的损伤和活化在ALI发病机制中占有极其重要的地位。内皮细胞异常可致毛细血管通透性增加，炎症反应扩大，进一步加重组织损... 详细信息

急性肺损伤（acute lung injury，ALl）是临床常见危承症，目前缺乏有效的治疗手段，病死率高达40％。内皮细胞的损伤和活化在ALI发病机制中占有极其重要的地位。内皮细胞异常可致毛细血管通透性增加，炎症反应扩大，进一步加重组织损伤，同时，其导致的血管舒缩功能障碍可引起肺动脉高压；细胞外基质过度增生还可导致肺纤维化。

关键词：急性肺损伤内皮祖细胞血管舒缩功能障碍应用内皮细胞血管通透性肺动脉高压细胞外基质

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非酒精性脂肪性肝病患者营养减重处方

中国实用内科杂志 2019年第3期39卷 227-230页

作者：鲁晓岚徐静远复旦大学附属浦东医院消化科上海201399 西安交通大学第二附属医院消化科陕西西安710004

肥胖是非酒精性脂肪肝(nonalcoholic fatty liver disease, NAFLD)发生最重要的危险因素,重度肥胖者NAFLD患病率高达90%以上。恰当减重治疗可不同程度地改善甚至逆转NAFLD,其中饮食疗法在减重治疗中具有更重要地位。通过控制能量摄入、... 详细信息

肥胖是非酒精性脂肪肝(nonalcoholic fatty liver disease, NAFLD)发生最重要的危险因素,重度肥胖者NAFLD患病率高达90%以上。恰当减重治疗可不同程度地改善甚至逆转NAFLD,其中饮食疗法在减重治疗中具有更重要地位。通过控制能量摄入、调节营养素比例,不仅能够有效改善肝细胞脂肪变和炎症程度,而且纤维化程度也有可能减轻,因此是NAFLD患者减重治疗最重要的手段。文章通过对普通人群、老年人、学龄儿童的热卡摄入和膳食结构分析,重点阐述NAFLD患者如何通过饮食保持合理体重。

关键词：非酒精性脂肪肝热卡饮食调控体重管理

高校国有资产管理的信息化建设探讨——以江苏省高校资产管理为例

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南京工业职业技术学院学报 2018年第4期18卷 93-95页

作者：徐晶远江苏第二师范学院资产处江苏南京210013

以江苏高校国有资产管理的现状为基础,分析目前管理中的问题,探索国有资产管理的信息化建设的途径和方法,以便提高高校国有资产管理的科学化水平。

关键词：资产管理采供平台招投标管理系统个性化升级

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减轻隧道工程施工对周边建筑物影响的措施

工程建设与设计 2013年第5期 172-175页

作者：许景源泉州市排水管理中心福建泉州362000

为了保证隧道施工的顺利进行,降低施工风险,将施工对地面建筑物的影响降低到控制范围内,必须根据结构的特征和已使用的年限,以及隧道的结构型式、地层信息、施工效应等,采取对地层变位的防治措施及建筑物的保护措施。从爆破控制、隧道... 详细信息

为了保证隧道施工的顺利进行,降低施工风险,将施工对地面建筑物的影响降低到控制范围内,必须根据结构的特征和已使用的年限,以及隧道的结构型式、地层信息、施工效应等,采取对地层变位的防治措施及建筑物的保护措施。从爆破控制、隧道自身施工、地层处理技术和建筑物自身加固等方面探讨了隧道工程对周边建筑的影响并提出了控制措施。并提出加强现场监控测量手段,及时发现有关问题,以做到对建筑物的实时跟踪保护。

关键词：隧道工程周边建筑影响爆破控制施工控制建筑物加固监测

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螺內酯聯合貝那普利在心力衰竭患者中的應用效果硏究

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系统医学 2019年第4期4卷 65-66,69页

作者：徐敬媛山东省济宁市兖州区铁路医院心内科山东济宁272100

目的探讨螺内酯联合贝那普利在心力衰竭患者中的临床效果。方法选择2017年6月—2018年8月治疗的心力衰竭患者74例作为对象,电脑抽取随机数法分为对照组(n=37)和观察组(n=37)。对照组给予贝那普利治疗,观察组在对照组基础上联合螺内酯治... 详细信息

目的探讨螺内酯联合贝那普利在心力衰竭患者中的临床效果。方法选择2017年6月—2018年8月治疗的心力衰竭患者74例作为对象,电脑抽取随机数法分为对照组(n=37)和观察组(n=37)。对照组给予贝那普利治疗,观察组在对照组基础上联合螺内酯治疗,两组均进行1个月治疗。采用超声心动图测定两组治疗前、治疗后1个月左室收缩末内径、左室舒张末径及左室射血分数;统计并记录两组治疗后恶心呕吐、腹泻、皮疹、血压升高及肝肾功能异常发生率,比较两组临床应用效果。结果观察组治疗后1个月左室收缩末内径(31.37±2.35)mm、左室舒张末径(44.57±3.41)mm水平,低于对照组,差异有统计学意义(t=12.491、9.481,P<0.05);观察组治疗后左室射血分数(57.81±5.77)%,高于对照组,差异有统计学意义(t=3.195,P<0.05);观察组与对照组治疗后并发症发生率为5.41%与对照组10.81%比较差异无统计学意义(χ~2=1.291,P=0.075)。结论将螺内酯联合贝那普利用于心力衰竭患者中有助于改善患者心功能水平,药物安全性较高,值得推广应用。

关键词：螺内酯贝那普利心力衰竭临床效果心功能水平