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Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast

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Journal of Traditional Chinese Medicine 2023年第1期43卷 105-112页

作者： xiong yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan GAO Xiaomeng QIANG Panpan WANG Zheng XU Qingyou Graduate School Hebei University of Chinese MedicineHebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineHebei University of Chinese MedicineShijiazhuang 050091China Graduate School Hebei University of Chinese Medicine Hebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineShijiazhuang 050091China Graduate School Hebei University of Chinese MedicineHebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineDepartment of Internal MedicineHebei University of Chinese MedicineShijiazhuang 050091China

OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eight male Sprague-Dawley rats weighing(200±10)g were used in this study and randomly assigned to 4 groups:a sham group,a UUO group,a UUO+eplerenone(EPL)group,and a UUO+HJHR group.The contralateral kidneys were harvested for further study 180 d after surgery.Histological analysis,immunohistochemistry and immunofluorescence were used to study the fibrosis of the contralateral kidneys obtained from UUO rats.Contralateral kidney damagerelated pathway proteins were detected by real-time polymerase chain reaction and Western blot analysis.RESULTS:HJHR significantly inhibited fibrosis of the contralateral kidney in UUO rats by attenuating the UUOinduced macrophage-to-myofibroblast transition(MMT)in the contralateral kidney.Moreover,HJHR attenuated fibrosis in the contralateral kidney of UUO rats by preventing MMT through the aldosterone/mineralocorticoid receptor/serum/glucocorticoid regulated kinase 1 pathway.CONCLUSIONS:Our findings suggest that HJHR may be a potential treatment for renal interstitial fibrosis of obstructive nephropathy.

关键词： ureteral obstruction renal fibrosis aldosterone receptors,mineralocorticoid macrophages myofibroblast Huoxue Jiedu Huayu recipe

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A Dual Yamabe Flow and Related Integral Flows

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 319-348页

作者： Jingang xiong School of Mathematical Sciences Laboratory of Mathematics and Complex SystemsMinistry of EducationBeijing Normal UniversityBeijing 100875China

The author studies a family of nonlinear integral fows that involve Riesz potentials on Riemannian manifolds.In the Hardy-Littlewood-Sobolev(HLS for short)subcritical regime,he presents a precise blow-up profile exhibited by the fows.In the HLS critical regime,by introducing a dual Q curvature he demonstrates the concentrationcompactness phenomenon.If,in addition,the integral kernel matches with the Green's function of a conformally invariant elliptic operator,this critical fow can be considered as a dual Yamabe fow.Convergence is then established on the unit spheres,which is also valid on certain locally conformally fat manifolds.

关键词： Hardy-Littlewood-Sobolev functional Dual Q curvature Integral flow

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Long non-coding RNAs with essential roles in neurodegenerative disorders

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Neural Regeneration Research 2024年第6期19卷 1212-1220页

作者： Wandi xiong Lin Lu Jiali Li Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology the Chinese Academy of Sciences Tsinghua-Peking Center for Life Sciences National Institute on Drug Dependence Peking University PKU/McGovern Institute for Brain Research Peking University Institute of Mental Health National Clinical Research Center for Mental Disorders Key Laboratory of Mental Health and Peking University Sixth Hospital Peking University

Recently, with the advent of high-resolution and high-throughput sequencing technologies, an increasing number of long non-coding RNAs(lncRNAs) have been found to be involved in the regulation of neuronal function in the central nervous system with specific spatiotemporal patterns, across different neurodegenerative diseases. However, the underlying mechanisms of lncRNAs during neurodegeneration remain poorly understood. This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, regulatory mechanisms, and research status of lncRNAs in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Finally, this review discusses the potential values of lncRNAs as diagnostic biomarkers and therapeutic targets for neurodegenerative diseases, hoping to provide broader implications for developing effective treatments.

关键词： Alzheimer's disease amyotrophic lateral sclerosis biomarker Huntington's disease long non-coding RNAs neurodegenerative diseases Parkinson's disease therapy transcriptional regulation translational regulation

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Transcatheter aortic valve replacement: A journey of two decades and beyond

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中华医学杂志(英文版) 2024年第9期137卷 1012-1015页

作者： xiong Tianyuan Chen Mao Department of Cardiology West China Hospital Sichuan University Chengdu Sichuan China Laboratory of Cardiac Structure and Function Institute of Cardiovascular Diseases West China Hospital Sichuan University Chengdu Sichuan China

The number of patients with calcific aortic stenosis (AS) is 9.4 million according to 2019 Global Disease Burden estimates,which will continue to increase as the population ages.For the treatment of symptomatic severe AS,transcatheter aortic valve replacement (TAVR) has evolved to be a well-established option across all risk spectra,with a rapid growth of procedures worldwide.The rise of TAVR initiates the revolution of the management of valvular heart diseases,from patient surveillance,the staging of disease,the use of multimodality imaging,the concept of the Heart Team,new designs and iterations of devices to technical innovations and the discovery of unmet clinical needs.As a consequence of the global adoption of TAVR,geographical differences in the epidemiology of AS and patient characteristics have also been further identified.An examination of the changing patient population,current applications and breakthroughs,and remaining challenges are crucial for the future of this technique.Herein,we discuss the temporal utilization of TAVR,the accumulation of evidence and progress of devices,the selection of patients,and some ongoing topics concerning the improvement of TAVR.

关键词： CEREBRAL EMBOLIC PROTECTION OUTCOMES TAVR

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Recent Progress in Bionic Hydrogels for Articular Cartilage:Tribological and Mechanical Characteristics

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Journal of Bionic Engineering 2024年第2期21卷 653-673页

作者： Mohammad Javan Almasi Dangsheng xiong School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Cartilage regeneration and repair are considered clinical challenges since cartilage has limited capability for reconstruction.Although tissue-engineered materials have the ability to repair cartilage,they have weak mechanical characteristics and cannot resist long-term overload.On the other hand,surgery to replace the joint is frequently done to treat significant cartilage deterioration these days.However,the materials that are being used for replacement have high friction coefficients,lack shock absorption functions,and lack cushioning.Further research on natural articular cartilage structure and function may lead to bionic hydrogels,which have suitable physicochemical and biological characteristics(e.g.,tribological and mechanical properties and the ability to support loadbearing capability),but need improvements.Based on their tribological and mechanical characteristics,the current review highlights the most recent advancements of bionic hydrogels used for articular cartilage,highlighting both the field's recent progress and its potential for future research.For this reason,firstly,some important property improvement methods of bionic hydrogels are discussed and then,the recent findings of various research on the making of those bionic materials are provided and compared.It seems that by using some modifications such as product design,surface treatments,animal tests,controlling the isoelectric point of hydrogels,and computer simulation,the intended mechanical and tribological characteristics of natural articular cartilage may be attained by the bionic hydrogels.

关键词： Bionic hydrogel Articular cartilage Mechanical property Tribological property Lubrication

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Integrated Zoology’s collection of Wildlife Diseases Research Network

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Integrative Zoology 2024年第3期19卷 348-349页

作者： Wenhua xiong Institute of Zoology Chinese Academy of Sciences Office of the International Society of Zoological Sciences

The International Society of Zoological Sciences has developed a Wildlife Diseases Research Network(WDRN)in the world,with the collaboration of its partners such as the Working Group on Zoonotic Disease of the International Union of Biological Sciences(IUBS)(https://***/).WDRN is composed of a steering committee,a scientific committee,a research expert network,and collaborative partners.

关键词： partner committee IUB

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A Generalized Blow up Criteria with One Component of Velocity for 3D Incompressible MHD System

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 253-264页

作者： Bin HAN Xi xiong Department of Mathematics Hangzhou Dianzi UniversityHangzhou 310018China

In this paper,the authors study the global regularity of the 3D magnetohydrodynamics system in terms of one velocity component.In particular,they establish a new Prodi-Serrin type regularity criterion in the framework... 详细信息

关键词： MHD Regularity Blow-up criterion

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Hole mobility enhancement in monolayer WSe2 p-type transistors through molecular doping

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Science China(Information Sciences) 2024年第6期67卷 207-213页

作者： Shiyuan LIU xiong xiong Xin WANG Xinhang SHI Ru HUANG Yanqing WU School of Integrated Circuits and Beijing Advanced Innovation Center for Integrated Circuits Peking University Wuhan National High Magnetic Field Center and School of Integrated Circuits Huazhong University of Science and Technology

Two-dimensional （2D） transition metal dichalcogenide （TMDC） semiconductor materials exhibit extraordinary electrical properties,holding promise for the realization of next-generation complementary metal-oxide-semiconductor （CMOS） devices at ultimate scaling.However,constrained by effective device doping strategies,the hole mobility and device performance of tungsten diselenide （WSe2） p-type transistors,especially monolayer chemical vapor deposition （CVD）-grown WSe2,have not met expectations.In this paper,an effective performance enhancement of monolayer WSe2p-type transistor was achieved through a molecular doping strategy.Synthesizing monolayer WSe2directly on SiO2back-gated substrates and leveraging energy band alignment design,4-nitrobenzenediazonium tetrafluoroborate （4-NBD） molecular dopant with a concentration of 10 m M was utilized to modulate the Fermi level position of monolayer WSe2for hole doping.The devices demonstrated a more than 98%increase in hole mobility,reaching up to 97 cm2·V-1·s-1while maintaining the current on/off ratio of 108.Monolayer p-type WSe2transistors with 1μm channel length exhibit a high drive current surpassing 176μA·μm-1,exceeding previous CVD-WSe2devices with similar channel length.This straightforward and effective approach to improving the electrical performance of WSe2transistors paves the way for advanced logic technologies based on transition metal dichalcogenide semiconductors.

关键词： CVD-grown WSe$_2$ molecular doping 4-NBD p-type transistors hole mobility

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Equivariant Chern Classes of Orientable Toric Origami Manifolds

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 221-234页

作者： Yueshan xiong Haozhi ZENG School of Mathematics and StatisticsHuazhong University of Science and Technology Wuhan 430074China

A toric origami manifold,introduced by Cannas da Silva,Guillemin and Pires,is a generalization of a toric symplectic manifold.For a toric symplectic manifold,its equivariant Chern classes can be described in terms of the corresponding Delzant polytope and the stabilization of its tangent bundle splits as a direct sum of complex line bundles.But in general a toric origami manifold is not simply connected,so the algebraic topology of a toric origami manifold is more difficult than a toric symplectic manifold.In this paper they give an explicit formula of the equivariant Chern classes of an oriented toric origami manifold in terms of the corresponding origami template.Furthermore,they prove the stabilization of the tangent bundle of an oriented toric origami manifold also splits as a direct sum of complex line bundles.

关键词： Equivariant Chern classes Toric origami manifolds Unitary structures Spin structures

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Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

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Neural Regeneration Research 2024年第1期19卷 49-54页

作者： Ye xiong Asim Mahmood Michael Chopp Department of Neurosurgery Henry Ford HospitalDetroitMIUSA Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA

Traumatic brain injury is a serious and complex neurological condition that affects millions of people worldwide.Despite significant advancements in the field of medicine,effective treatments for traumatic brain injury remain limited.Recently,extracellular vesicles released from mesenchymal stem/stromal cells have emerged as a promising novel therapy for traumatic brain injury.Extracellular vesicles are small membrane-bound vesicles that are naturally released by cells,including those in the brain,and can be engineered to contain therapeutic cargo,such as anti-inflammatory molecules,growth factors,and microRNAs.When administered intravenously,extra cellular vesicles can cross the blood-brain barrier and deliver their cargos to the site of injury,where they can be taken up by recipient cells and modulate the inflammatory response,promote neuroregeneration,and improve functional outcomes.In preclinical studies,extracellular vesicle-based therapies have shown promising results in promoting recove ry after traumatic brain injury,including reducing neuronal damage,improving cognitive function,and enhancing motor recovery.While further research is needed to establish the safety and efficacy of extra cellular vesicle-based therapies in humans,extra cellular vesicles represent a promising novel approach for the treatment of traumatic brain injury.In this review,we summarize mesenchymal ste m/stromal cell-de rived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration and brainderived extracellular vesicles as potential biofluid biomarkers in small and large animal models of traumatic brain injury.

关键词： biomarkers extracellular vesicles functional outcome mesenchymal stem/stromal cells neuroinflammation neuroplasticity neuroprotection traumatic brain injury

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