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Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

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Infectious Diseases of Poverty 2017年第1期6卷 1074-1078页

作者： Lei Ji Yong-liang Lou Zhong-Xiu Wu Jin-Qin Jiang xing-li fan li-fang Wang Xiao-Xiang liu Peng Du Jie Yan Ai-Hua Sun Department of Basic Medicine Hangzhou Medical CollegeHangzhou 310053ZhejiangPeople’s Republic of China School of Laboratory Medical Science and life Science Wenzhou Medical UniversityWenzhou 325035ZhejiangPeople’s Republic of China Zhejiang Blood Center Hangzhou 310006ZhejiangPeople’s Republic of China Division of Basic Medical Microbiology State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesFirst Affiliated Hospital of Zhejiang UniversityHangzhou 310003ZhejiangPeople’s Republic of China Department of Medical Microbiology and Parasitology College of MedicineZhejiang UniversityHangzhou 310058ZhejiangPeople’s Republic of China

Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical *** research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary ***:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy *** samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s ***:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),*** was no statistically significant difference of its performance between these two sample sets(P>0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P>0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis.

关键词： Interferon-gamma release assay Smear-negative pulmonary TB Extra-pulmonary TB

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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以短肽组装体为模板仿生矿化二氧化硅纳米管

生物化学与生物物理进展 2022年第9期49卷 1785-1794页

作者：赵玉荣王丽李幸凡张黎民王栋陈翠霞中国石油大学(华东)化学化工学院青岛266580

目的二氧化硅纳米管由于具有生物相容性好、光学性质优异等特殊性能在不同领域展现出良好的应用前景,其尺寸和形貌可显著影响材料性质。为制备尺寸较大的纳米管并拓展其在不同领域的应用,本研究选择尺寸较大的多肽组装体为模板,进行二... 详细信息

目的二氧化硅纳米管由于具有生物相容性好、光学性质优异等特殊性能在不同领域展现出良好的应用前景,其尺寸和形貌可显著影响材料性质。为制备尺寸较大的纳米管并拓展其在不同领域的应用,本研究选择尺寸较大的多肽组装体为模板,进行二氧化硅的仿生矿化。方法以Bola型多肽Ac-KI3VK-CONH2自组装形成的尺寸较大(直径约40 nm)的纳米管为模板,通过仿生矿化的方法制备二氧化硅纳米材料。首先考察了多肽纳米管的稳定性,发现在稀释、加入有机溶剂和改变溶液pH值时,纳米管的形貌均被破坏,展示出较差的稳定性。在此基础上,以该多肽纳米管为模板,选择反应速率较快的正硅酸甲酯(TMOS)为前驱体仿生矿化二氧化硅纳米材料,探索了不同矿化条件对二氧化硅纳米管尺寸和形貌的影响。结果以反应速率较快的TMOS为硅源、体积百分比浓度为1.11%~3.33%、溶液为中性或者弱碱性时能够矿化形成形貌和尺寸较大且分布均匀的二氧化硅纳米管。结论通过选择合适的多肽组装体模板和反应速率快的TMOS为硅源,成功制备出了尺寸较大的二氧化硅纳米管,这为拓展其在不同领域的应用奠定了基础,具有重要意义。

关键词：肽纳米管二氧化硅仿生矿化

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我国金属矿产成矿区带地球化学普查发展历史

矿产与地质 2005年第6期19卷 592-598页

作者：李幸凡有色金属矿产地质调查中心北京100012

二十世纪60～70年代是我国金属矿产成矿区带地球化学普查发展的初期阶段.1976年,成矿区带地球化学普查规划制订,我国金属矿产成矿区带地球化学普查进入大规模普查实施的第一阶段;随着一系列新技术规定的颁布执行,1992年开始进入第二阶... 详细信息

二十世纪60～70年代是我国金属矿产成矿区带地球化学普查发展的初期阶段.1976年,成矿区带地球化学普查规划制订,我国金属矿产成矿区带地球化学普查进入大规模普查实施的第一阶段;随着一系列新技术规定的颁布执行,1992年开始进入第二阶段的成矿区带地球化学异常详细检查评价与综合研究;1993年以后,成矿区带地球化学普查与详查仍然以寻找金属矿产为主要任务,同时,成矿区带地球化学普查成果开始向应用地球化学方向发展,这标志着第三个阶段的开始,即应用成矿区带地球化学普查成果进行生态环境地球化学与人类健康、综合农林业地球化学研究和开发.

关键词：成矿区带地球化学普查发展史综述应用地球化学金属矿产

染料掺杂手性向列相液晶器件中实现随机激光辐射

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液晶与显示 2018年第6期33卷 464-468页

作者：乌日娜王兴杨帆李业秋岱钦沈阳理工大学理学院辽宁沈阳110159

设计制作了染料掺杂手性向列相液晶器件,研究了其随机激光辐射行为。均匀混合激光染料DCM和PM597、手性剂S-811、向列相液晶TEB30A,注入无摩擦取向的40μm液晶盒,制成焦锥织构态的手性向列相液晶激光器件。采用固体Nd:YAG倍频532nm波长... 详细信息

设计制作了染料掺杂手性向列相液晶器件,研究了其随机激光辐射行为。均匀混合激光染料DCM和PM597、手性剂S-811、向列相液晶TEB30A,注入无摩擦取向的40μm液晶盒,制成焦锥织构态的手性向列相液晶激光器件。采用固体Nd:YAG倍频532nm波长的脉冲激光作为抽运光泵浦样品。掺杂激光染料PM597和DCM的液晶器件分别在575～588nm和600～620nm范围显示了尖锐、分立的随机激光辐射峰,线宽约为0.3nm。探测了器件在不同方向上的激光辐射谱,在与样品表面夹角约为45°～150°的范围内均能探测到随机激光。在器件中,手性向列相液晶焦锥织构态对光的强散射作用是随机激光产生的主要原因。

关键词：手性向列相液晶随机激光焦锥织构态

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin li Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying fang Xiao-Rui Pan Xin-xing Zeng Zheng-Zheng li Bo-fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

教育游戏家园共育模式下幼儿能力培养实验研究——以“幼小衔接”阶段幼儿加减运算能力培养为例

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数字教育 2016年第4期2卷 14-22页

作者：逯行李芒喻凡李营北京市昌平区教师进修学校教育网络和信息中心北京昌平102200 北京师范大学教育学部北京海淀100875 云南财经大学实验管理中心云南昆明650221

教育游戏近年来快速发展,逐渐渗透到幼儿培养中,且在家庭培养和学校教学中得到了应用。本研究在一所县级幼儿园大班中开展,以解决"幼小衔接"阶段出现的"小学化倾向"等问题为出发点,以学龄前儿童数学加减运算能力培养为例,探讨将教育游... 详细信息

教育游戏近年来快速发展,逐渐渗透到幼儿培养中,且在家庭培养和学校教学中得到了应用。本研究在一所县级幼儿园大班中开展,以解决"幼小衔接"阶段出现的"小学化倾向"等问题为出发点,以学龄前儿童数学加减运算能力培养为例,探讨将教育游戏与家园共育的幼儿培养方式相结合,试图创建一种切实有效的幼儿培养模式,并观察该模式在学龄前儿童培养中的效果。经过16周实验干预和前后测对比,结果表明:采取基于教育游戏的家园共育模式培养的实验组幼儿,其加减运算能力和学习兴趣显著高于采用传统训练方式的对照组幼儿,肯定了基于教育游戏的家园共育模式在培养幼儿数学能力方面的有效性。

关键词：幼儿教育游戏家园共育加减运算能力实验研究

Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior