Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China
作者机构：Department of Basic MedicineHangzhou Medical CollegeHangzhou 310053ZhejiangPeople’s Republic of China School of Laboratory Medical Science and Life ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangPeople’s Republic of China Zhejiang Blood CenterHangzhou 310006ZhejiangPeople’s Republic of China Division of Basic Medical MicrobiologyState Key Laboratory for Diagnosis and Treatment of Infectious DiseasesFirst Affiliated Hospital of Zhejiang UniversityHangzhou 310003ZhejiangPeople’s Republic of China Department of Medical Microbiology and ParasitologyCollege of MedicineZhejiang UniversityHangzhou 310058ZhejiangPeople’s Republic of China
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2017年第6卷第1期
页 面：1074-1078页
核心收录：
学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学]
基 金：This work was supported by Grants from the National Natural Sciences Foundation of China(81271893) the Natural Science Foundation of Zhejiang Province(LY12H19002) Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents,the Scientific Research Foundation of the Education Department of Zhejiang Province(Y201534356) the Natural Science Foundation of Zhejiang Medical College(2014B01) Visiting Engineer Program of the Education Department of Zhejiang Province(FG2014011)
主 题：Interferon-gamma release assay Smear-negative pulmonary TB Extra-pulmonary TB
摘 要：Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical *** research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary ***:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy *** samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s ***:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),*** was no statistically significant difference of its performance between these two sample sets(P0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis.
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