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Development and validation of a nomogram to predict allograft survival after pediatric liver transplantation

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World Journal of Pediatrics 2024年第3期20卷 239-249页

作者： guang-xiang Gu shu-Ting Pan Yi-Chen Fan Chen Chen Qiang Xia Department of Liver Surgery Renji HospitalShanghai Jiaotong University School of MedicineNo.160 Pujian RoadPudong New DistrictShanghai 200128China Department of Liver Transplantation Sun Yet-Sen Memorial HospitalSun Yat-Sen UniversityNo.107 Yanjiang West RoadGuangzhou 510080China Clinical Center for Investigation Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Background Liver transplantation is the main treatment for cholestatic liver disease and some metabolic liver diseases in ***,no accurate prediction model to determine the survival probability of grafts prior to surgery *** study aimed to develop an effective prognostic model for allograft survival after pediatric liver *** This retrospective cohort study included 2032 patients who underwent pediatric liver transplantation between January 1,2006,and January 1,2020.A nomogram was developed using Cox regression and validated based on bootstrap *** and discriminatory accuracies were determined using the concordance index and visualized using calibration curves;net benefits were calculated for model *** online Shiny application was developed for easy access to the *** Multivariable analysis demonstrated that preoperative diagnosis,recipient age,body weight,graft type,preoperative total bilirubin,interleukin-1β,portal venous blood flow direction,spleen thickness,and the presence of heart disease and cholangitis were independent factors for survival,all of which were selected in the *** of the nomogram indicated that the 1-,3-,and 5-year predicted survival rates agreed with the actual survival *** concordance indices for graft survival at 1,3,and 5 years were 0.776,0.757,and 0.753,respectively,which were significantly higher than those of the Pediatric End-Stage Liver Disease and Child-Pugh scoring *** allograft dysfunction risk of a recipient could be easily predicted using the following URL:https://***/ASPELT/l Conclusion The allograft survival after pediatric liver transplantation(ASPELT)score model can effectively predict the graft survival rate after liver transplantation in children,providing a simple and convenient evaluation method for clinicians and patients.

关键词： Allograft survival Nomogram Pediatric liver transplantation

High-Order Fully Actuated System Models for Strict-Feedback Systems With Increasing Dimensions

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IEEE/CAA Journal of Automatica Sinica 2024年第12期11卷 2451-2462页

作者： xiang Xu guang-Ren Duan Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and Technology the School of System Design and Intelligent Manufacturing Southern University of Science and Technology

This paper mainly addresses control problems of strict-feedback systems(SFSs) with increasing dimensions. Compared with the commonly-considered SFSs where the subsystems have the same dimension, we aim to handle more complex cases,i.e., the subsystems in the considered SFSs are assumed to have increasing dimensions. By transforming the systems into highorder fully-actuated system(HOFAS) models, the stabilizing controllers can be directly given. Besides first-order SFSs, secondorder and high-order SFSs are also considered.

关键词： Increasing dimensions high-order fully-actuated system nonlinear systems strict-feedback systems

A Cheeger-Mller theorem for symmetric bilinear torsions on manifolds with boundary

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Science China Mathematics 2015年第2期58卷 423-446页

作者： SU guang xiang Chern Institute of Mathematics and LPMC Nankai University

In this paper,we extend Su-Zhang’s Cheeger-Mller type theorem for symmetric bilinear torsions to manifolds with boundary in the case that the Riemannian metric and the non-degenerate symmetric bilinear form are of product structure near the *** result also extends Brning-Ma’s Cheeger-Mller type theorem for Ray-Singer metric on manifolds with boundary to symmetric bilinear torsions in product *** also compare it with the Ray-Singer analytic torsion on manifolds with boundary.

关键词： analytic torsion heat kernel symmetric bilinear torsion

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针刺麻醉术前预测指标之研究

针刺研究 1981年第3期 175-180页

作者：杨蓁朱凤仙项立敏上海中医学院中医实验研究室上海中医学院附属曙光医院

针刺麻醉术前预测对了解个体差异与针麻效果的临床规律、寻找提高针麻有效方法、选择针麻适应症和阐明针麻原理均具有重要意义.目前采用预测指标繁多、方法各异,且易受主观成份及客观因素影响,因而结论往往不一,所以在条件相对稳定,方... 详细信息

针刺麻醉术前预测对了解个体差异与针麻效果的临床规律、寻找提高针麻有效方法、选择针麻适应症和阐明针麻原理均具有重要意义.目前采用预测指标繁多、方法各异,且易受主观成份及客观因素影响,因而结论往往不一,所以在条件相对稳定,方法相对统一的情况下研究一些方法简易、符合率高,受主、客观因素干扰小的预测指标仍是当前

关键词：脉率术前针刺麻醉针麻预测指标符合率

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

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World Journal of Gastroenterology 2020年第38期26卷 5812-5821页

作者： Ying Cao xiang-Bing shu Zemin Yao guang Ji Li Zhang Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Geratology Baoshan Branch of Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201999China Department of Biochemistry Microbiology and ImmunologyUniversity of OttawaOttawa K1H8M5OntarioCanada

Nonalcoholic steatohepatitis(NASH)is a progressed stage of non-alcoholic fatty liver disease,and available therapeutic strategies for NASH are *** D receptor(VDR)is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH *** date,vitamin D supplementation has not consistently conferred expected therapeutic benefits,raising the question of whether VDR can serve as a proper drug target for *** is known that VDR can interact with other ligands such as bile acids in addition to vitamin D,and its expression can be induced by fatty acids,and *** has also been shown that while activation of VDR in hepatic macrophages and hepatic stellate cells resulted in attenuation of hepatic inflammation and fibrosis,activation of VDR in hepatocytes could accelerate lipid ***,the multiplicity of VDR ligands,together with the cell type-specificity of VDR activation,must be taken into consideration in assessing the validity of VDR being a potential druggable target for NASH *** this end,we have evaluated the relationship between VDR activation and various contributing factors,such as gut microbiota,bile acid,fatty acids,and insulin,in addition to vitamin D,with an expectation that a potential drug might be identified that can elicit VDR activation in a tissue-and/or cell type-specific manner and therefore achieving therapeutic benefits in NASH.

关键词： Vitamin D receptor Non-alcoholic steatohepatitis Vitamin D Bile acids Inflammation Lipid metabolism

Liobagrus chengduensis,a new species of torrent catfish(Teleostei:Siluriformes:Amblycipitidae)from the upper Changjiang River basin in southwest China

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Zoological Research 2022年第4期43卷 679-682页

作者： Zhong-guang Chen Yan-shu Guo Jia-Yun Wu An-xiang Wen College of Life Sciences Sichuan Agricultural UniversityYa’anSichuan 625014China Ecological Restoration and Conservation on Forest and Wetland Key Laboratory of Sichuan Province Sichuan Academy of Forestry SciencesChengduSichuan 610081China

DEAR EDITOR,A new torrent catfish species,Liobagrus chengduensis ***.,is described from the Xihe River,a tributary of the Minjiang River,Qionglai City,Chengdu City,Sichuan Province,*** can be distinguished from all other congeneric species by a unique combination of the following characters:3-4 serrations on posterior edge of pectoral-fin spine;anal fin with 15-16 rays;upper jaw obviously shorter than lower jaw;caudal fin rounded,with 42-44 rays;vertebral column with 36-37 post-Weberian elements;anus close to pelvic-fin insertion;adipose fin posteriorly continuous with caudal fin,with marked incision at confluence;body generally brownish yellow;all fins lacking well-defined light-colored margins,with color fading towards edge.

关键词： southwest colored insertion

Experimental Investigation and Prediction Model of the Loads Exerted by Oblique Internal Solitary Waves on FPSO

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China Ocean Engineering 2022年第2期36卷 179-190页

作者： ZHANG Rui-rui WANG Hong-wei CHEN Ke YOU Yun-xiang ZHANG shu-guang XIONG Xiao-hu Jiangsu University of Science and Technology Zhenjiang 212003China State Key Laboratory of Ocean Engineering Shanghai Jiaotong UniversityShanghai 200240China China Ship Development and Design Center(Shanghai) Shanghai 201108China SJTU Yazhou Bay Institute of Deep-sea Technology Sanya 572000China Dayang Offshore Equipment Co. LtdNanjing 210032China

By using a 30-meter-long wave flume equipped with a double-plate wave maker,a series of depression ISWs were generated in a density stratified two-layer fluid and the forces exerted by oblique internal solitary waves(ISWs)on fixed FPSO model had been *** to the laboratory experiments,a numerical flume taken the applicability of KdV,eKdV and MCC ISWs theories in consideration was adopted to study the force *** on the experimental data and the force composition,the simplified prediction model was *** was shown that the horizontal and transversal loads consisted of two parts:the Froude−Krylov force that could be calculated by integrating the dynamic pressure induced by ISW along the FPSO wetted surface,as well as the viscous force that could be obtained by multiplying the friction coefficient Cfx(C_(fy)),correction factor K_(x)(K_(y))and the integration of particle tangential velocity along the FPSO wetted *** vertical load was mainly the vertical Froude−Krylov *** on the experimental results,a conclusion can be drawn that the friction coefficient Cf and correction factor K were regressed as a relationship of Reynolds number Re,Keulegan-Carpenter number KC,upper layer depth h1/h and ISW accident angleα.Moreover,the horizontal friction coefficient Cfx yielded the logarithmic function with Re,and transversal friction coefficient C_(fy)obeyed the exponent function with Re,while the correction factors K_(x)and K_(y)followed power function with *** force prediction was also performed based on the regression formulae and pressure *** predicted results agreed well with the experimental *** maximum forces increase linearly with the ISWs ***,the upper layer thickness had an obvious influence on the extreme value of the horizontal and transversal forces.

关键词： internal solitary wave(ISW) FPSO wave forces friction coefficient and correction factor accident angle

Development of new ductile iron with super-high thermal conductivity and elongation

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Journal of Iron and Steel Research International 2022年第3期29卷 462-473页

作者： guang-hua Wang Yan-xiang Li School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing100084China

The effects of Si content,graphite volume fraction and pearlite volume fraction on the thermal conductivity of ductile iron were studied based on theoretical model *** results showed that the thermal conductivity of ductile iron was more sensitive to Si content compared with the volume fractions of pearlite and *** key method to design and develop high thermal conductivity ductile iron was to control the Si *** 0.9-2.2 wt.%Si content,experimental results showed that with the increase in Si content,the thermal conductivity of ductile iron decreased dramatically,and the yield strength and tensile strength of ductile iron almost linearly increased,but the elongation remained almost *** dependence of thermal conductivity of ductile iron on temperature changed from monotonic decreasing to increasing first and then ***,we broke the common composition range of ductile iron and designed a new high C(≥3.9 wt.%)and low Si(1.0-1.4 wt.%)ductile iron with super-high thermal conductivity and *** thermal conductivity exceeded 40 W/(m K)within 27-300℃,and maintained at 35-40 W/(m K)at 500℃.The elongation was over 25%,and the tensile strength was more than 300 MPa.

关键词： Thermal conductivity Ductile iron Elongation Tensile strength Silicon alloying

Carbon Sequestration in Soil Humic Substances Under Long-Term Fertilization in a Wheat-Maize System from North China

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Journal of Integrative Agriculture 2014年第3期13卷 562-569页

作者： SONG xiang-yun LIU shu-tang LIU Qing-hua ZHANG Wen-ju HU Chun-guang College of Resources and Environment Qingdao Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

The changes in humic substances （HS） is fundamental in detecting soil carbon sequestration mechanisms in natural and cultivated environments. Based on a long-term trial, the amounts of water dissolved substances （WSS）, humic acid （HA）, fulvic acid （FA） and humin （HU） were determined to explore the impact of long-term fertilization on HS. Increases in the amounts of WSS, HA, FA and HU were significant different among the treatments with manure. A significant correlation was found between the increased soil organic carbon （SOC） and HS （R^2=0.98, P〈0.01）. The change in the E4/E6 ratio was significantly correlated with the increased SOC （R2=0.88, P〈0.01）, HA （R^2=0.91, P〈0.01）, FA （R^2=0.91, P〈0.01） and HU （R^2=0.88, P〈0.01）. The cluster was mainly divided into two parts as manure fertilization and inorganic fertilization, based on the increases in HA, FA and HU. These results suggest that long term fertilization with manure favours carbon sequestration in HS and is mainly stabilized as HU, while the HA becomes more aliphatic. We conclude that increases in SOC can be linked to changes in the molecular characteristics of HS fractions under long term fertilization.

关键词： carbon sequestration humic acid humin long term fertilization E4/E6 ratio