Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

作     者：Ying Cao Xiang-Bing Shu Zemin Yao Guang Ji Li Zhang 

作者机构：Institute of Digestive DiseasesLonghua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Department of GeratologyBaoshan Branch of Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201999China Department of BiochemistryMicrobiology and ImmunologyUniversity of OttawaOttawa K1H8M5OntarioCanada 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第38期

页      面：5812-5821页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China,No.81774084 and 81804020 and Young Talent Promotion Project of Chinese Medicine Association,No.2019-QNRC2-C04 

主　　题：Vitamin D receptor Non-alcoholic steatohepatitis Vitamin D Bile acids Inflammation Lipid metabolism 

摘      要：Nonalcoholic steatohepatitis(NASH)is a progressed stage of non-alcoholic fatty liver disease,and available therapeutic strategies for NASH are *** D receptor(VDR)is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH *** date,vitamin D supplementation has not consistently conferred expected therapeutic benefits,raising the question of whether VDR can serve as a proper drug target for *** is known that VDR can interact with other ligands such as bile acids in addition to vitamin D,and its expression can be induced by fatty acids,and *** has also been shown that while activation of VDR in hepatic macrophages and hepatic stellate cells resulted in attenuation of hepatic inflammation and fibrosis,activation of VDR in hepatocytes could accelerate lipid ***,the multiplicity of VDR ligands,together with the cell type-specificity of VDR activation,must be taken into consideration in assessing the validity of VDR being a potential druggable target for NASH *** this end,we have evaluated the relationship between VDR activation and various contributing factors,such as gut microbiota,bile acid,fatty acids,and insulin,in addition to vitamin D,with an expectation that a potential drug might be identified that can elicit VDR activation in a tissue-and/or cell type-specific manner and therefore achieving therapeutic benefits in NASH.