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高脂血症性胰腺炎患者外周血C肽、IL-6及HBP与肺损伤的相关性探讨

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世界华人消化杂志 2024年第8期32卷 584-590页

作者：陈园汤武亨曹春宇徐乾超舟山市第三人民医院(舟山市妇女儿童医院)消化内科浙江省舟山市316000

背景外周血C肽、白细胞介素-6(interleutin-6,IL-6)及肝素结合蛋白(heparin-binding protein,HBP)可能与肺损伤发生有关,对预测高脂血症性胰腺炎(hyperlipidemia acute pancreatitis,HLAP)患者肺损伤可能具有重要价值.目的探究HLAP患者外周血C肽、IL-6、HBP与肺损伤的相关性.方法选取2019-04/2023-03舟山市第三人民医院150例HLAP患者,根据患者住院期间是否发生肺损伤分为肺损伤组(n=56)与非肺损伤组(n=94).比较两组基线资料、外周血C肽、IL-6及HBP水平,Pearson相关性分析外周血C肽、IL-6及HBP水平与病情评分的相关性;Logistic回归分析HLAP患者肺损伤的影响因素;受试者工作特征(receiver operating characteristic,ROC)曲线评价外周血C肽、IL-6及HBP水平对HLAP患者肺损伤的预测价值.结果肺损伤组年龄、胸腔积液所占比例、甘油三酯、慢性健康评价系统Ⅱ(Acute Physiological and Chronic Health Evaluation SystemⅡ,APACHEⅡ)评分、BMI、改良CT严重指数(Modified CT Severity Index,MCTSI)评分及序贯器官衰竭评估(Sequential Organ Failure Assessment,SOFA)评分高于非肺损伤组(P<0.05);肺损伤组外周血C肽水平低于非肺损伤组,IL-6、HBP水平高于非肺损伤组(P<0.05);Pearson相关性分析可知,外周血C肽水平与急性生理与APACHEⅡ、MCTSI评分、SOFA呈负相关(P<0.05),IL-6、HBP水平与APACHEⅡ评分、MCTSI评分、SOFA评分呈正相关(P<0.05);Logistic回归显示,BMI、三酰甘油、外周血C肽、IL-6及HBP水平均为HLAP患者肺损伤的独立影响因素(P<0.05);ROC曲线显示,外周血C肽、IL-6及HBP水平联合预测HLAP患者肺损伤的曲线下面积值为0.906,明显高于各指标单独预测,且敏感度、特异度分别为89.29%、81.91%,提示联合预测效能优于各指标单独预测效能.结论HLAP患者外周血C肽、IL-6及HBP水平与肺损伤发生有关,临床检测三者水平,可为HLAP患者肺损伤预测提供参考依据.

关键词：高脂血症性胰腺炎肺损伤 C肽白细胞介素-6 肝素结合蛋白

Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences

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World Journal of Gastroenterology 2015年第3期21卷 944-952页

作者： Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao Shi wu-heng tang Xin-Jian Zhu Wei Shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of MedicineZhejiang University Zhiyuan Medical Inspection Institute Co. Ltd. Sanmen People’s Hospital The First People’s Hospital of Xiaoshan District The First People’s Hospital of Cangnan Jinhua Municipal Central Hospital The First People’s Hospital of Pingyang The First Hospital of Jiaxing Zhoushan Hospital The First People’s Hospital of Wenling Rui’an People’s Hospital Maternal and Child Health Hospital of Zhoushan City Shangyu People’s Hospital People’s Hospital of Putuo District Zhoushan Hangzhou First People’s Hospital Qingtian People’s Hospital The First People’s Hospital of Yongkang The Children’s Hospital Zhejiang University School of Medicine Lishui People’s Hospital The Affiliated Hospital of Hangzhou Normal University wuxi No.4 Hospital Affiliated to Suzhou University Jinhua Wenrong Hospital The First Affiliated Hospital of Wenzhou Medical College Yueqing People’s Hospital Tiantai People’s Hospital Lin’an people’s Hospital Rui’an City TCM Hospital Medical College of Hebei University of Engineering

AIM:To evaluate the efficacy of centralized culture and possible influencing ***:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(***) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal *** mucosal biopsies were taken from the antrum for *** biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 *** culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 *** additional 5736 biopsies from ***-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory ***:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the ***-positive quality control *** the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport *** contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter *** samples.

关键词： Centralized isolation Helicobacter pylori Influenc

褐煤水煤浆气化炉工艺烧嘴改造的模拟研究及应用

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煤化工 2017年第5期45卷 68-71页

作者：吴辉霞赵恒唐强北京航天石化技术装备工程有限公司北京100166

分析了国内首套褐煤水煤浆气化炉的运行情况,针对气化炉运行不稳定的情况,决定对工艺烧嘴进行改造,利用CFD软件进行了改造前后工艺烧嘴的冷态数值模拟。根据模拟计算结果,确定并实施了工艺烧嘴改造方案。改进后的工艺烧嘴在气化炉运行后... 详细信息

分析了国内首套褐煤水煤浆气化炉的运行情况,针对气化炉运行不稳定的情况,决定对工艺烧嘴进行改造,利用CFD软件进行了改造前后工艺烧嘴的冷态数值模拟。根据模拟计算结果,确定并实施了工艺烧嘴改造方案。改进后的工艺烧嘴在气化炉运行后,实际运行状态与数值模拟结果具有一致性,烧嘴气化燃烧火焰被拉长,轴向温度梯度减小,从而使得炉子拱顶及炉膛局部超温情况得到了改善,在同样氧煤比的情况下,渣口排渣更顺畅,但内喷嘴的使用寿命成为制约烧嘴长周期运行的重要因素。

关键词：褐煤水煤浆气化工艺烧嘴数值模拟火焰长度

重症急性胰腺炎多重耐药菌铜绿假单胞菌感染的危险因素分析

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中国现代医学杂志 2017年第12期27卷 96-100页

作者：曹春宇金海汤武亨陈园庄一渝浙江省舟山市妇幼保健院消化内科浙江舟山316000 浙江大学医学院附属邵逸夫医院ICU 浙江杭州310016

目的探讨重症急性胰腺炎(SAP)患者并发多重耐药性铜绿假单胞菌(PAE)感染的危险因素及其耐药性分析。方法回顾性纳入该院2006年1月-2016年12月收治的SAP患者102例。根据是否合并多重耐药性PAE感染分为感染组(17例)和对照组(85例),分析两... 详细信息

目的探讨重症急性胰腺炎(SAP)患者并发多重耐药性铜绿假单胞菌(PAE)感染的危险因素及其耐药性分析。方法回顾性纳入该院2006年1月-2016年12月收治的SAP患者102例。根据是否合并多重耐药性PAE感染分为感染组(17例)和对照组(85例),分析两组患者一般情况,采用Logistic回归分析患者感染多重耐药性PAE的危险因素。结果 SAP合并多重耐药性PAE感染的比例为16.67%。两组患者性别、病因及合并疾病发生率比较,差异无统计学意义(P>0.05)。感染组年龄、CT危重度评分(CTSI)及SAP危重度分级高于对照组(P<0.05);急性期急性呼吸窘迫综合征(ARDS)和休克发生率高于对照组(P<0.05);入院时急性生理功能和慢性健康状况评分Ⅱ(APACHEⅡ)评分更高;急性期重症监护病房(ICU)住院天数更长。多因素Logistic回归分析发现,PAE感染的危险因素包括CTSI、SAP危重度、急性期出现ARDS、入院APACHEⅡ评分过高及急性期过长的ICU暴露时间(P<0.05)。临床预后方面,相比于对照组,感染组感染期休克和脓毒症发生率高于对照组;ICU住院天数和总住院天数高于对照组,但两组死亡率比较差异无统计学意义。结论 SAP患者PAE感染的危险因素包括CTSI、SAP危重度、急性期ARDS、过长的ICU暴露时间及入院APACHEⅡ评分过高。

关键词：重症急性胰腺炎铜绿假单胞菌危险因素预后

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong tang Jie wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue tang Mansheng Chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis