检索结果-南通市图书馆

Leveraging the potential of big genomic and phenotypic data for genome-wide association mapping in wheat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第3期12卷 803-813页

作者： moritz Lell Yusheng Zhao Jochen C.Reif Leibniz Institute of Plant Genetics and Crop Plant Research(IPK) Corrensstraße 3D-06466 SeelandGermany

Genome-wide association mapping studies(GWAS)based on Big Data are a potential approach to improve marker-assisted selection in plant *** number of available phenotypic and genomic data sets in which medium-sized populations of several hundred individuals have been studied is rapidly *** these data and using them in GWAS could increase both the power of QTL discovery and the accuracy of estimation of underlying genetic effects,but is hindered by data heterogeneity and lack of *** this study,we used genomic and phenotypic data sets,focusing on Central European winter wheat populations evaluated for heading *** explored strategies for integrating these data and subsequently the resulting potential for *** interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protocols,resulting in high quality integrated phenotypic *** this context,genomic prediction proved to be a suitable tool to study relevance of interactions between genotypes and experimental series,which was low in our *** to expectations,fewer associations between markers and traits were found in the larger combined data than in the individual experimental ***,the predictive power based on the marker-trait associations of the integrated data set was higher across data ***,the results show that the integration of medium-sized to Big Data is an approach to increase the power to detect QTL in *** results encourage further efforts to standardize and share data in the plant breeding community.

关键词： Big Data Genome-wide association study Data integration Genomic prediction Wheat

Opto-fluidically multiplexed assembly and micro-robotics

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第3期13卷 544-554页

作者： Elena Erben Weida Liao Antonio Minopoli Nicola Maghelli Eric Lauga moritz Kreysing Max Planck Institute of Molecular Cell Biology and Genetics Dresden 01307Germany Center for Systems Biology Dresden 01307Germany Institute of Biological and Chemical Systems–Biological Information Processing.Karlsruhe Institute of Technology(KIT) Eggenstein-Leopoldshafen 76344Germany Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB30WAUK

Techniques for high-definition micromanipulations,such as optical tweezers,hold substantial interest across a wide range of ***,their applicability remains constrained by material properties and laser *** while microfluidic manipulations have been suggested as an alternative,their inherent capabilities are limited and further hindered by practical challenges of implementation and *** we show that the iterative application of laser-induced,localized flow fields can be used for the relative positioning of multiple micro-particles,irrespectively of their material *** to the standing theoretical proposal,our method keeps particles mobile,and we show that their precision manipulation is non-linearly accelerated via the multiplexing of temperature stimuli below the heat diffusion *** resulting flow fields are topologically rich and mathematically *** represent unprecedented microfluidic control capabilities that are illustrated by the actuation of humanoid micro-robots with up to 30 degrees of freedom,whose motions are sufficiently well-defined to reliably communicate personal characteristics such as gender,happiness and *** results constitute high-definition micro-fluidic manipulations with transformative potential for assembly,micro-manufacturing,the life sciences,robotics and optohydraulically actuated micro-factories.

关键词： manipulation fluid assembly

Experimental and numerical investigation to elucidate the fluid flow through packed beds with structured particle packings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第6期89卷 218-237页

作者： Shirin Patil Christian Gorges Joel Lòpez Bonilla moritz Stelter Frank Beyrau Berend van Wachem Laboratory of Technical Thermodynamics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Chair of Mechanical Process Engineering Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The present paper presents an experimental and numerical investigation of the dispersion of the gaseous jet flow and co-flow for the simple unit cell(SUC)and body-centred cubic(BCC)configuration of particles in packed *** experimental setup is built in such a way that suitable and simplified boundary conditions are imposed for the corresponding numerical framework,so the simulations can be done under very similar conditions as the ***,a porous plate is used for the co-flow to achieve the uniform velocity and the fully developed flow is ensured for the jet *** SUC and BCC particle beds consist of 3D-printed spheres,and the non-isotropy near the walls is mostly eliminated by placing half-spheres at the channel *** flow velocities are analysed directly at the exit of the particle bed for both beds over 36 pores for the SUC configuration and 60 pores for the BCC configuration,for particle Reynolds numbers of 200,300,and *** particle image velocimetry is experimentally arranged in such a way that the velocities over the entire region at the exit of the packed bed are obtained *** numerical method consists of a state-of-the-art immersed boundary method with adaptive mesh *** paper presents the pore jet structure and velocity field exiting from each pore for the SUC and BCC packed particle *** numerical and experimental studies show a good agreement for the SUC configuration for all flow *** the BCC configuration,some differences can be observed in the pore jet flow structure between the simulations and the experiments,but the general flow velocity distribution shows a good overall *** axial velocity is generally higher for the pores located near the centre of the packed bed than for the pores near the *** addition,the axial velocities are observed to increase near the peripheral pores of the packed *** behaviour is predominant for the BCC configuration as compared to t

关键词： Uniform particle packing Packed bed reactor Stereo particle image velocimetry Immersed boundary method

Isoperimetry of nilpotent groups

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Mathematics in China 2016年第5期11卷 1239-1258页

作者： moritz GRUBER Karlsruhe Institute of Technology Karlsruhe Germany

This survey gives an overview of the isoperimetric properties of nilpotent groups and Lie groups. It discusses results for Dehn functions and filling functions as well as the techniques used to retrieve them. The cont... 详细信息

关键词： Nilpotent groups nilpotent Lie groups Dehn functions filling functions

Discovering plasticity models without stress data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 857-866页

作者： moritz Flaschel Siddhant Kumar Laura De Lorenzis Department of Mechanical and Process Engineering ETH Zürich8092ZürichSwitzerland Department of Materials Science and Engineering Delft University of Technology2628 CDDelftThe Netherlands

We propose an approach for data-driven automated discovery of material laws,which we call EUCLID(Efficient Unsupervised Constitutive Law Identification and Discovery),and we apply it here to the discovery of plasticity models,including arbitrarily shaped yield surfaces and isotropic and/or kinematic hardening *** approach is unsupervised,i.e.,it requires no stress data but only full-field displacement and global force data;it delivers interpretable models,i.e.,models that are embodied by parsimonious mathematical expressions discovered through sparse regression of a potentially large catalog of candidate functions;it is one-shot,i.e.,discovery only needs one *** material model library is constructed by expanding the yield function with a Fourier series,whereas isotropic and kinematic hardening is introduced by assuming a yield function dependency on internal history variables that evolve with the plastic *** selecting the most relevant Fourier modes and identifying the hardening behavior,EUCLID employs physics knowledge,i.e.,the optimization problem that governs the discovery enforces the equilibrium constraints in the bulk and at the loaded boundary of the *** promoting regularization is deployed to generate a set of solutions out of which a solution with low cost and high parsimony is automatically *** virtual experiments,we demonstrate the ability of EUCLID to accurately discover several plastic yield surfaces and hardening mechanisms of different complexity.

关键词： stress plasticity selecting

Spatial heterogeneity of flesh-cell osmotic potential in sweet cherry affects partitioning of absorbed water

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 2104-2113页

作者： Eckhard Grimm Daniel Pflugfelder Jan Hahn moritz Jonathan Schmidt Hendrik Dieckmann moritz Knoche Institut für Gartenbauliche Produktionssysteme Leibniz Universität HannoverAbteilung ObstbauHerrenhäuser Straße 2D-30419 HannoverGermany Forschungszentrum Jülich IBG-2:PflanzenwissenschaftenWilhelm-Johnen-StraßeD-52428 JülichGermany Laser Zentrum Hannover e.V. Hollerithallee 8D-30419 HannoverGermany

A fleshy fruit is commonly assumed to resemble a thin-walled pressure vessel containing a homogenous carbohydrate *** sweet cherry(Prunus avium L.)as a model system,we investigate how local differences in cell water potential affect H2O and D2O(heavy water)*** partitioning of H2O and D2O was mapped nondestructively using magnetic resonance imaging(MRI).The change in size of mesocarp cells due to water movement was monitored by optical coherence tomography(OCT,non-destructive).Osmotic potential was mapped using microosmometry(destructive).Virtual sections through the fruit revealed that the H2O distribution followed a net pattern in the outer mesocarp and a radial pattern in the inner *** patterns align with the disposition of the vascular bundles.D2O uptake through the skin paralleled the acropetal gradient in cell osmotic potential gradient(from less negative to more negative).Cells in the vicinity of a vascular bundle were of more negative osmotic potential than cells more distant from a vascular *** revealed net H2O uptake was the result of some cells loosing volume and other cells increasing volume.H2O and D2O partitioning following uptake is non-uniform and related to the spatial heterogeneity in the osmotic potential of mesocarp cells.

关键词： potential Spatial bundle

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa Danielle J.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister Jochen Kraft Rainer ALeitgeb wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbH Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

Next-Generation Imaging: New Insights from Multicolor Microscopy in Liver Biology and Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2022年第2期8卷 17-21页

作者： Felix Heymann Adrien Guillot moritz Peiseler Frank Tacke Department of Hepatology and Gastroenterology Charité–Universitätsmedizin BerlinBerlin 13353Germany

*** Our current understanding of the complex biology of solid organs,such as the liver,has been tremendously advanced by a wide variety of methodological approaches based on cell biology,biochemistry,molecular biology,and *** methods such as the morphological assessment of tissue structure by histology and immunohistochemistry have generated valuable knowledge and revealed improved treatment options for various liver ***,due to recent technological advances,it has been possible to gain deeper insights into physiological and pathological tissue organization,as well as dynamic processes taking place in *** novel methods include single-cell tar-geted transcriptome analysis,mass spectrometry-based metabolite and protein expression studies,and considerable advances in two-and three-dimensional(2D/3D)*** commentary will briefly review the recent progress that has been made in the field of imaging-based liver research,highlighting the novel possibilities of high-dimensional,multiparametric imaging in two and three dimensions,as well as those of dynamic time-lapse in vitro and in vivo imaging(Fig.1).We will also highlight some potential applications of these techniques for specific research questions in liver biology and disease.

关键词： organs dimensions advances

Climate and Forecast Mode Simulations for Antarctica:Implications for Temperature and Wind

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2010年第6期27卷 1453-1472页

作者：辛羽飞 Annette RINKE 卞林根 Klaus DETHLOFF 效存德 moritz MIELKE Chinese Academy of Meteorological Sciences Alfred Wegener Institute for Polar and Marine Research

Climate and forecast mode simulations with the regional climate model HIRlam-ECHAM（HIRHAM） are evaluated over a pan-Antarctic domain. The ability of the model to simulate temperature and wind profiles in the troposphere is quantified by comparing its results with radiosonde data acquired from the Davis station for January and July 2007. Compared to the climate mode, the forecast mode was found to deliver improved results for temperature and wind simulations at the near surface and in the lower troposphere. The main remaining model bias found was the under-representation of low-level wind jets. Based on ensemble simulations, it is shown that a distinct internal variability is inherent in the climate mode simulations, and associated areas of reduced predictability over Antarctica are identified.

关键词： regional climate model Antarctica forecast mode climate mode