Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

作     者：Elisabet A.Rank Ryan Sentosa Danielle J.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister Jochen Kraft Rainer ALeitgeb Wolfgang Drexler Elisabet A.Rank;Ryan Sentosa;Danielle J.Harper;Matthias Salas;Anna Gaugutz;Dana Seyringer;Stefan Nevlacsil;Alejandro Maese-Novo;Moritz Eggeling;Paul Muellner;Rainer Hainberger;Martin Sagmeister;Jochen Kraft;Rainer A.Leitgeb;Wolfgang Drexler

作者机构：Center for Medical Physics and Biomedical EngineeringMedical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for MicrotechnologyVorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbHGieffinggasse 41210 ViennaAustria ams AGTobelbader Strasse 308141 PremstaettenAustria 

出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)

年 卷 期：2021年第10卷第1期

页      面：71-85页

核心收录：

学科分类：070207[理学-光学] 1002[医学-临床医学] 07[理学] 08[工学] 100212[医学-眼科学] 0803[工学-光学工程] 0702[理学-物理学] 10[医学] 

基　　金：The authors thank Rene Werkmeister for data acquisition and permission to use the data from the commercial benchmark system and EXALOS AG for the booster amplifier.E.A.R.greatly acknowledges fruitful discussions with Fabian Placzek.This work was carried out in the framework of project COHESION No.848588 funded by the Austrian Research Promotion Agency(FFG).This research has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No.688173(OCTCHIP).DJ.H.gratefully acknowledges financial support from the European Research Council(ERC)(No.640396 OPTIMALZ) 

主　　题：waveguide arrayed optical 

摘      要：In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.