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Use of Interspecific Hybrids in the Texas A&M University Cotton Improvement Laboratory

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棉花学报 2008年第S1期20卷 91-页

作者： HAGUE Steve smith C wayne Department of Soil and Crop Sciences Texas A&M University College Station

Integrating alleles from Gossypium species into *** is important for the enhancement of genetic variability and for creating polymorphism useful in molecular mapping *** collaborative efforts,several species including... 详细信息

关键词： Use of Interspecific Hybrids in the Texas A&M University Cotton Improvement Laboratory

Informatic analysis reveals Legionella as a source of novel natural products

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Synthetic and Systems Biotechnology 2016年第2期1卷 130-136页

作者： Chad w.Johnston Jonathan Plumb Xiang Li Sergio Grinstein Nathan A.Magarvey The Michael G.DeGroote Institute for Infectious Disease Research Department of Biochemistry and Biomedical SciencesMcMaster UniversityHamiltonONCanada L8N 3Z5 Department of Chemistry and Chemical Biology McMaster UniversityHamiltonONCanada L8N 3Z5 Cell Biology Program Hospital for Sick ChildrenTorontoOntarioCanada M5G 1X8

Microbial natural products are a crucial source of bioactive molecules and unique chemical *** their importance,rediscovery of known natural products from established productive microbes has led to declining interest,even while emergent genomic data suggest that the majority of microbial natural products remain to be ***,new sources of microbial natural products must be defined in order to provide chemical scaffolds for the next generation of small molecules for therapeutic,agricultural,and industrial *** this work,we use specialized bioinformatic programs,genetic knockouts,and comparative metabolomics to define the genus Legionella as a new source of novel natural *** show that Legionella *** a diverse collection of biosynthetic gene clusters for the production of polyketide and nonribosomal peptide natural *** confirm this bioinformatic survey,we create targeted mutants of *** and use comparative metabolomics to identify a novel polyketide *** spectroscopic techniques,we show that this polyketide possesses a new chemical scaffold,and firmly demonstrate that this unexplored genus is a source for novel natural products.

关键词： Natural products Legionella Polyketides PRISM

The Global Boundary Stratotype Section and Point （GSSP） for the base of the Cenomanian Stage, Mont Risou, Hautes-Alpes, France

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Episodes 2004年第1期27卷 21-32页

作者： w.J.Kennedy A.S.Gale J.A.Lees M.Caron OxfordUniversityMuseumofNaturalHistory ParksRoadOxfordOXI3PWU.K. DepartmentofPalaeontology TheNaturalHistoryMuseumCromwellRoadLondonSW75BPU.K.andSchoolofEarthandEnvironmentalSciencesUniversityofGreenwichChathamMaritimeCampusChathamKentME44AWU.K. ResearchSchoolofGeologicalandGeophysicalSciences BirkbeckCollegeandUniversityCollegeLondonGowerStreetLondonWCIE6BTU.K. InstitutdeGeologie UniversitedeFribourgCH-1700FribourgSwitzerland.

Following the unanimous recommendation of the International Commission on Stratigraphy, the Global boundary Stratotype Section and Point (GSSP) for the base of the Cenomanian Stage is defined at a level 36 metres below the top of the Marnes Bleues Formation, a level that corresponds to the the first appearance of the planktonic foraminiferan Rotalipora globotruncanoides Sigal, 1948, on the south side of Mont Risou, east of Rosans, Haute-Alpes, France, where it can be placed in the context of a series of secondary marker levels based on nannofossils, planktonic foraminifera, ammonites,and an ornate δ^13C curve.

关键词：地层学地层分界线层型地质构造

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模糊控制在钢缆拖动系统中的应用

西安交通大学学报 1998年第11期32卷 27-30页

作者：迟钦河 LePori,w 西安交通大学美国A＆M大学

建立了钢缆拖动系统的数学模型，并在此基础上生成了对该系统运动控制的模糊控制算法．计算机对误差信号进行计算，输出控制信号操纵滚动圆盘，使机具沿着预定的路径运动．实验结果证明，该模糊控制算法具有较好的控制精度和响应速度．

关键词：模糊控制机动车钢缆拖动系统农机具农用车

Magnetic imaging-assisted colonoscopy vs conventional colonoscopy: A randomized controlled trial

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world Journal of Gastroenterology 2014年第36期20卷 13178-13184页

作者： Christopher w Teshima Sergio Zepeda-Gómez Suliman H AlShankiti Gurpal S Sandha Division of Gastroenterology University of Alberta Edmonton Alberta T6G 2X8 Canada

AIM: To compare magnetic imaging-assisted colonoscopy (MIC) with conventional colonoscopy (CC).

关键词： Colonoscopy Conscious sedation Magnetic endoscope imaging Pain measurement Randomized controlled trial

Physical activity and chronic back conditions:A population-based pooled study of 60,134 adults

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Journal of Sport and Health Science 2019年第4期8卷 386-393页

作者： Hosam Alzahrani Debra Shirley Sonia w.M.Cheng Martin Mackey Emmanuel Stamatakis Discipline of Physiotherapy Faculty of Health SciencesThe University of SydneySydneyNSW 2006Australia Physiotherapy Department College of Applied Medical ScienceTaif UniversityTaif21974Saudi Arabia Charles Perkins Centre Prevention Research CollaborationSchool of Public HealthThe University of SydneySydneyNSW 2006Australia

Background:Little is known about the association between different types of physical activity(PA)and chronic back conditions(CBCs)at the population *** investigated the association between levels of total and type-specific PA participation and ***'.The sample comprised 60,134 adults aged>16 years who participated in the Health Survey for England and Scottish Health Survey from 1994 to *** logistic regression models,adjusted for potential confbunders,were used to examine the association between total and type-specific PA volume(walking,domestic activity,sport/exercise,cycling,football/rugby,running/jogging,manual work,and housework)and the prevalence of ***'.we found an inverse association between total PA volume and prevalence of *** with inactive participants,the fully adjusted odds ratio(OR)for very active participants(≥15 metabolic equivalent h/week)was 0.77(95%confidence interval(CI):0.69—0.85).Participants reporting≥300 min/week of moderate-intensity activity and≥75 min/week of vigorous-intensity activity had 24%(95%CI:6%—39%)and 21%(95%C1:11%—30%)lower odds of CBCs,*** odds of CBCs were observed for participation in high-level manual domestic activity(OR=1.22;95%CI:1.00-1.48).Sport/exercise was associated with CBCs in a less consistent manner(e.g.,OR=1.18(95%CI:1.06—1.32)for low levels and OR=0.82(95%CI:0.72—0.93)for high levels of sport/exercise).Conclusion'.PA volume is inversely associated with the prevalence of CBCs.

关键词： Activity Chronic low back pain Chronic musculoskeletal conditions Epidemiology Exercise

ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling

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Neural Regeneration Research 2022年第11期17卷 2472-2483页

作者： Nadia McMillan Gregory w.Kirschen Sanket Desai Emma Xia Stella E.Tsirka Adan Aguirre Program in Neuroscience and Medical Scientist Training Program Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Pharmacological Sciences Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Neurology Beth Israel Deaconess Medical Center/Harvard Medical SchoolBostonMAUSA Department of Gynecology and Obstetrics Johns Hopkins HospitalBaltimoreMDUSA

The mechanisms that regulate neural stem cell(NSC)lineage progression and maintain NSCs within diffe rent domains of the adult neural stem cell niche,the subventricular zone are not well *** NSCs are arranged at the apical ventricular wall,while mitotically activated NSCs are found in the basal,vascular region of the subventricular ***,we found that ADAM 10(a disintegrin and metalloproteinase 10)is essential in NSC association with the ventricular wall,and via this adhesion to the apical domain,ADAM10 regulates the switch from quiescent and undiffe rentiated NSC to an actively prolife rative and differentiating cell *** of JAMC(junctional adhesion molecule C)by ADAM 10 increases Rap1 GAP *** molecular machinery promotes NSC transit from the apical to the basal compartment and subsequent lineage *** the molecular mechanisms responsible for regulating the proper positioning of NSCs within the subventricular zone niche and lineage progression of NSCs could provide new targets for drug development to enhance the regenerative prope rties of neural tissue.

关键词： ADAM10 adhesion junctional adhesion molecule C neural stem cells neurogenesis olfactory bulb Rap1Gap sub-ventricular zone

Cirrhotic portal hypertension: From pathophysiology to novel therapeutics

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world Journal of Gastroenterology 2020年第40期26卷 6111-6140页

作者： Lakmie S Gunarathne Harinda Rajapaksha Nicholas Shackel Peter w Angus Chandana B Herath Department of Medicine Melbourne Medical SchoolThe University of MelbourneHeidelbergVIC 3084Australia School of Molecular Science College of ScienceHealth and EngineeringLa Trobe UniversityBundooraVIC 3086Australia ANZAC Research Institute ConcordNSW 2139Australia Department of Gastroenterology Austin HealthHeidelbergVIC 3084Australia South western Sydney Clinical School Faculty of MedicineUniversity of New South WalesIngham Institute for Applied Medical Research1 Campbell StreetLiverpoolNSW 2170Australia

Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin Ⅱ type receptor 1 blockers, which target the components of the classical renin angiotensin system(RAS), are expected to reduce intrahepatic vascular tone by reducing extracellular matrix deposition and vasoactivity of contractile cells and thereby improve portal hypertension. However, these drugs have been shown to produce significant offtarget effects such as systemic hypotension and renal failure. Therefore, the current pharmacological mainstay in clinical practice to prevent variceal bleeding and improving patient survival by reducing portal pressure is non-selective-blockers(NSBBs). These NSBBs work by reducing cardiac output and splanchnic vasodilatation but most patients do not achieve an optimal therapeutic response and a significant proportion of patients are unable to tolerate these *** statins, used alone or in combination with NSBBs, have been shown to improve portal pressure and overall mortality in cirrhotic patients, further randomized clinical trials are warranted involving larger patient populations with clear clinical end points. On the other hand, recent findings from studies that have investigated the potential use of the blockers of the components of the alternate RAS provided compelling evidence that could lead to the development of drugs targeting the splanchnic vascular bed to inhibit splanchnic vasodilatation in portal hypertension. This rev

关键词： Portal hypertension Cirrhosis Intrahepatic vascular resistance Hyperdynamic circulatory state Splanchnic vasodilatation Portal blood flow Non-selective betablockers Alternate renin angiotensin system

Evaluation of Breeding Substrates for Cocoa Pollinator, <i>Forcipomyia</i>spp. and Subsequent Implications for Yield in a Tropical Cocoa Production System

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American Journal of Plant Sciences 2013年第2期4卷 204-211页

作者： Michael Adjaloo Ben Kwaku Branoh Banful william Oduro Department of Horticulture Faculty of Agri- culture College of Agriculture and Natural Resources KNUST Kumasi Ghana Department of wildlife and Range Management Faculty of Renewable Natural Resources College of Agriculture and Natural Resources KNUST Kumasi Ghana Technology Consultancy Centre College of Engineering KNUST Kumasi Ghana

A comparative study was carried out to determine the most suitable substrate for breeding of midges (Forcipomyia spp.) and the implications for pollination and yield in a typical cocoa production system in the forest ecological zone of Ghana. For the field experiment, the typically available substrates in cocoa farms which were used as the treatments under cocoa trees were: 1) rotten cocoa leaf litter;2) rotten cocoa pod husks;and 3) rotten banana pseudostem. The untreated cocoa trees served as control. The experiment was set up in a randomized complete block design with three replications. For the laboratory experiment, the design was completely randomized design with four replications. The objective was to determine which substrate best supported breeding of the midges. The rotten banana pseudostem substrate recorded the highest population (7680) of Forcipomyia spp. after 56 days of observation. The cocoa pod husk and cocoa leaf litter recorded populations of 5226 and 1920, respectively. Similar observations were recorded in the level of pollination of the cocoa trees treated with rotten banana pseudostem (95.78%), cocoa pod husks (89.05%) and cocoa leaf litter (68.42%). Application of all substrates to the cocoa tree resulted in a 77% mean reduction in flower abortion as compared to the control. Fruit abortion, on the other hand, was significantly greater in trees treated with rotten banana pseudostem (73.7%) and rotten cocoa pod husks (71.3%) than in trees treated with rotten cocoa leaf litter (54.3%). Application of banana substrate explained 88% of the variation in cherelle production (fruit set) whereas cocoa pod husks and cocoa leaf litter accounted for 71% and 94%, respectively, of the variation in cherelle production. The study concluded that although cocoa leaf litter resulted in average increases in midges population and subsequently not too high levels of pollination, there was a significantly higher number of set fruits retained which implied high coco

关键词： Breeding Cocoa Pollinator Substrates Yield