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Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan Zi-Jie Li Zi-Yi Lin Shu-Qin Ji william Ka Fai tse Zhi-Qiang Meng Chang Liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

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Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

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Genes & Diseases 2024年第1期11卷 413-429页

作者： Dongsheng Zhang Wenjuan Tang Haitao Niu william tse Hai-Bin Ruan Helmut Dolznig Thomas Knosel Friedrich Karl-Heinz Madeleine Themanns Jiang Wang Mingquan Song Lee Denson Lukas Kenner Richard Moriggl Yi Zheng Xiaonan Han Division of Hematology and Oncology Division of Cancer BiologyDepartment of MedicineMetroHealth Medical Center(MHMC)Case Western Reserve University(CWRU)School of MedicineClevelandOH 44109USA Cancer Genomics and Epigenomics Program Case Comprehensive Cancer CenterCase Western Reserve University(CWRU)ClevelandOH 44106USA Division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical Center(CCHMC)CincinnatiOH 45229USA Children’s Hospital of Fudan University Shanghai 201102China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Laboratory Animal Science(ILAS) Chinese Academy of Medical Science(CAMS)and Peking Union Medical College(PUMC)Beijing 100006China Department of Integrative Biology and Physiology University of Minnesota Medical SchoolMinneapolisMI 55455USA Institute of Medical Genetics Medical University of ViennaVienna 1040Austria Institute of Pathology Ludwig-Maximilians-University MunichMunich 80539Germany Institute of Biochemistry II University Hospital JenaJena 07743Germany Laboratory Animal Pathology University of Veterinary Medicine ViennaVienna 1210Austria Department of Pathology University of CincinnatiCincinnatiOH 45221USA Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266005China Department of Pathology Medical University of ViennaVienna 1040Austria Ludwig Boltzmann Institute for Cancer Research Vienna 1090Austria Medical University of Vienna Vienna 1040Austria Institute of Animal Breeding and Genetics University of Veterinary Medicine ViennaVienna 1210Austria Division of Experimental Hematology CCHMCCincinnatiOH 45229USA

CDC42 controls intestinal epithelial(IEC)stem cell(IESC)*** aberrant CDC42 initiates intestinal inflammation or neoplasia is *** utilized models of inflam-matory bowel diseases(IBD),colorectal cancer,aging,and IESC injury to determine the loss of intestinal Cdc42 upon inflammation and *** specimens were collected to determine the levels of CDC42 in IBD or colorectal ***42 floxed mice were crossed with Villin-Cre,Villin-CreERT2 and/or Lgr5-eGFP-IRES-CreERT2,or Bmi1-CreERT2 mice to generate Cdc42 deficient ***,colitis,aging,and intestinal organoid were used to evaluate CDC42 upon mucosal inflammation,IESC/progenitor regenerative capacity,and IEC *** studies revealed that increased CDC42 in colorectal cancer correlated with lower survival;in contrast,lower levels of CDC42 were found in the inflamed IBD *** Cdc42 depletion significantly reduced Lgr5+IEsCs,increased progenitors'hyperplasia,and induced mucosal inflammation,which led to crypt *** Cdc42 depletion markedly enhanced irra-diation-or chemical-induced *** or inhibition of Cdc42 reduced colonic Lgr5+IESC *** conclusion,depletion of Cdc42 reduces the IESC regeneration and IEC repair,leading to prolonged mucosal *** monogenic loss of Cdc42 in-duces mucosal inflammation,which could result in intestinal neoplasia in the context of aging.

关键词： Cell divisioncycle 42(CDC42) Colitis Colorectal cancer(CRC) Inflammatory bowel diseases(IBD) Intestinal epithelial cell(IEC) Intestinal epithelial stem cell(IESC) Irradiation

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Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma

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Chinese Journal of Cancer Research 2013年第2期25卷 128-129页

作者： Alexander Chi Sijin Wen Nam P. Nguyen Geraldine Jacobson Scot Remick william tse Zhongxing Liao Department of Radiation Oncology West Virginia University Department of Biostatistics West Virginia University Department of Radiation Oncology University of Arizona Mary Babb Randolph Cancer Center Department of Hematology Oncology West Virginia University Department of Radiation Oncology the University of Texas MD Anderson Cancer Center

Although declining in the US due to restrictions of asbestos exposure, malignant pleura/mesothelioma （MPP） remains a very serious thoracic malignancy that is rising in incidence worldwide （1）. Trirnodality therapy with chemotherapy and radiotherapy combined with extrapleural pneumonectomy （EPP） has gained acceptance given the acceptable mortality rate （〈5%） and long term survival reported in patients with epithelial histology, negative margins, and no extrapleural lymph node involvement after trimodalitv treatment （2）.

关键词： Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma

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AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression

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Journal of Cancer Metastasis and Treatment 2019年第3期4卷 20-31页

作者： Jino Park Jae Yeon Hwang Alexandra Thore Soojin Kim Tomiteru Togano Shotaro Hagiwara Juw Won Park william tse James Graham Brown Cancer Center University of Louisville School of MedicineLouisvilleKY 40202USA Division of Blood and Bone Marrow Transplantation Department of MedicineUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Computer Science and Computer Engineering University of LouisvilleLouisvilleKY 40292USA Division of Haematology National Center for Global Health and MedicineTokyo 162-8655Japan Division of Haematology Tokyo Women’s Medical UniversityTokyo 162-8666Japan

Aim: To investigate whether AF1q, overexpressed in metastatic cells compared with the primary tumor cells, plays a pivotal role in breast cancer metastasis. Methods: To investigate whether AF1q has a responsibility in the acquisition of a metastatic phenotype, we performed RNA-sequencing (RNA-Seq) to identify the gene signature and applied the Metacore direct interactions network building algorithm with the top 40 amplicons of RNA-Seq. Results: Most genes were directly linked with intercellular adhesion molecule-1 (ICAM-1). Likewise, we identified that ICAM-1 expression is attenuated in metastatic cells compared to primary tumor cells. Moreover, overexpression of AF1q attenuated ICAM-1 expression, whereas suppression of AF1q elicited the opposite effect. AF1q had an effect on ICAM-1 promoter region and regulated its transcription. Decreased ICAM-1 expression ;affected the attachment of T cells to a breast cancer cell monolayer. We confirmed the finding by performing the analysis on Burkitt's lymphoma. Conclusion: Attenuation of ICAM-1 by AF1q on tumor cells disadvantages host anti-tumor defenses through the trafficking of lymphocytes, which affects tumor progression and metastasis.

关键词： MLLT11 AF1q intercellular adhesion molecule-1 breast cancer metastasis RNA-sequencing

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利用基因敲出鼠模型研究Gab2连接蛋白在造血调控中的作用

利用基因敲出鼠模型研究Gab2连接蛋白在造血调控中的作用

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第11次中国实验血液学会议

作者：张毅 Ernesto Diaz-Flores Geqiang Li zhengqi Wang Zizhen Kang Eleonora Haviernikova Sara Rowe Cheng-Kui Qu william tse Kevin M.Shannon Kevin D.Bunting 军事医学科学院基础医学研究所二室 Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Reserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of Medicine Division of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA

＜正＞Gab2作为细胞信号通路中一重要的连接蛋白,主要是通过一些细胞因子刺激酪氨酸磷酸化参与信号通路的调节作用。已有文献报道显示, Gab2可激活 PI-3K 和 MAPK 信号通路,调节造血细胞的迁移。利用 Gab2基因敲除鼠模型研究其生物学功... 详细信息

＜正＞Gab2作为细胞信号通路中一重要的连接蛋白,主要是通过一些细胞因子刺激酪氨酸磷酸化参与信号通路的调节作用。已有文献报道显示, Gab2可激活 PI-3K 和 MAPK 信号通路,调节造血细胞的迁移。利用 Gab2基因敲除鼠模型研究其生物学功能,结果表明 Gab2的缺失可导致严重的过敏反应;且可改变肥大细胞的发育。另

关键词： Gab2连接蛋白造血调控基因敲除动物模型

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Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

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World Journal of Gastroenterology 2006年第18期12卷 2923-2927页

作者： william Ng Wai-Man Wong Wai-Hong Chen Hung-Fat tse Pui-Yin Lee Kam-Chuen Lai Sheung-Wai Li Matthew Ng Kwok-Fai Lam Xi Cheng Chu-Pak Lau Division of Cardiology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Gastroenterology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Rehabilitation Medicine University Department of Medicine Queen Mary Hospital Hong Kong SAR China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong SAR China

AIM： The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding （UGIB） with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS： A total of 991 patients with coronary artery disease （CAD） on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. RESULTS： UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension （OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009）, history of peptic ulceration （OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039）, tertiary education （OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039） and higher lean body mass （P = 0.016） were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. CONCLUSION： The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy.

关键词： Coronary artery disease, Aspidn Gastrointestinal bleeding

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Meta-analysis of T-wave indices for risk stratification in myocardial infarction

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Journal of Geriatric Cardiology 2017年第12期14卷 776-779页

作者： Gary tse Cheuk Wai Wong Meng-Qi GONG Lei MENG Konstantinos P Letsas Guang-Ping LI Paula Whittaker Aishwarya Bhardwaj Abhishek C Sawant william KK Wu Sunny Hei Wong Jayaprakash Shenthar Lap Ah tse Martin CS Wong Adrian Baranchuk Gan-Xin YAN Tong LIU Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Second Department of Cardiology Laboratory of Cardiac Electrophysiology 'Evangelismos' General Hospital of Athens Athens Greece Division of Population Health Health Services Research and Primary Care School of Health Sciences University of Manchester United Kingdom Division of Cardiology Department of Internal Medicine State University of New York at Buffalo USA Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China Electrophysiology Unit Sri Jayadeva Institute of Cardiovascular Sciences and Research B G Road 9th Block Jayanagar Bangalore India JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong China Division of Cardiology Kingston General Hospital Queen 's University Kingston Ontario Canada Lankenau Institute for Medical Research and Lankenau Medical Center Wynnewood Pennsylvania USA Beijing Anzhen Hospital Capital Medical University Beijing China

Ventricular tachy-arrhythmias are the commonest cause of sudden cardiac death in patients with ischemie heart dis- ease. It is estimated that up to 20% patients with acute myocardial infarction suffer from these *** i... 详细信息

关键词： Myocardial infarction Repolarization Sudden death Tpeak-Tend Tpeak-Tend/QT

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Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome： an updated systematic review and meta-analysis

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Journal of Geriatric Cardiology 2017年第10期14卷 639-643页

作者： Ahmed Bayoumy Meng-Qi GONG Ka Hou Christien Li Sunny Hei Wong william KK Wu Guang-Ping LI George Bazoukis Konstantinos P Letsas Wing Tak Wong Yun-Long XIA Tong LIU Gary tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Faculty of Medicine University of Amsterdam The Netherlands Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospitalof Tianjin Medical University Tianjin China Faculty of Medicine Newcastle University United Kingdom Department of Anaesthesia and Intensive Care Faculty of Medicine Chinese University of Hong Kong Hong Kong China Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece School of Life Sciences Chinese University of Hong Kong Hong Kong China Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian China

Brugada syndrome （BrS） is primary electrical disorder characterized by ST segment elevation with right bundle branch block morphology in patients with apparent structurally normal hearts, It predisposes affected individuals to ventricular tachycardia/fibrillation （VT/VF） and sudden cardiac death （SCD）.A number of studies have identified risk factors that are associated with a more malignant course of disease. These include male gender, syncope, a spontaneous type 1 ECG pattern, family history of SCD, family history of Brugada syndrome,

关键词： Brugada syndrome Risk stratification Spontaneous type 1 Sudden cardiac death Ventricular arrhythmia

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A meta-analysis of soluble suppression of tumorigenicity 2 （sST2） and clinical outcomes in pulmonary hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 766-771页

作者： King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG william KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Department of Cardiology Qilu Hospital Shandong University Jinan China Research Center of Ion Channelopathy Institute of Cardiology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan China JC School of Public Health and Primary Care The Chinese University ofHong Kong Hong Kong China State Key Laboratory of Digestive Disease LKS Institute of Health Sciences Chinese University ofHong Kong Hong Kong China

Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.

关键词： Mortality Poor outcomes Pulmonary hypertension Soluble suppression of tumorigenicity 2 SST2

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Impact of exercise on neuro-cognitive function and hippocampal plasticity in early psychosis—a preliminary data analysis

Impact of exercise on neuro-cognitive function and hippocamp...

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中华医学会精神病学分会第九次全国学术会议

作者： LIN Jing-xia,~1 May Mei-Ling Lam,~1 Kit-Wa Chan,~1 Wing-Chung Chang,~1 Glen Joe,~2 Gloria Hoi-Yan Wong,~1 Cindy Pui-Yu Chiu,~1 Pek-Lan Khong,~3 william G Honer,Wayne Su,~4 Cecilia Lai-Wan Chan,~5 Kwok-Fai So,~6 Michael tse~2 and Eric Yu-Hai Chen~1 1 Department of Psychiatry,the University of Hong Kong 2 Institute of Human Performance,the University of Hong Kong 3 Department of Diagnostic Radiology,the University of Hong Kong 4 Department of Psychiatry,University of British Columbia,Vancouver,Canada 5 Department of Social Work and Social Administration,the University of Hong Kong 6 Department of Anatomy,the University of Hong Kong

Objectives Hippocampal volume is lower in schizophrenic patients than in normal *** present study aimed to investigate whether physical exercise would increase hippocampal volume in patients with early psychosis,and whether this effect would be related to improved neuro-cognitive functions. Methods A total of 60 female psychosis patients aged 18-55 years old with less than 5 years illness duration were

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