利用基因敲出鼠模型研究Gab2连接蛋白在造血调控中的作用

作     者：张毅 Ernesto Diaz-Flores Geqiang Li zhengqi Wang Zizhen Kang Eleonora Haviernikova Sara Rowe Cheng-Kui Qu William Tse Kevin M.Shannon Kevin D.Bunting 

作者单位：军事医学科学院基础医学研究所二室 Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Reserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA Department of MedicineDivision of Hematoloy/OncologyCase Western Beserve UniversityClevelandOHUSA 

会议名称：《第11次中国实验血液学会议》

会议日期：2007年

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

关 键 词：Gab2连接蛋白 造血调控 基因敲除 动物模型 

摘      要：正Gab2作为细胞信号通路中一重要的连接蛋白,主要是通过一些细胞因子刺激酪氨酸磷酸化参与信号通路的调节作用。已有文献报道显示, Gab2可激活 PI-3K 和 MAPK 信号通路,调节造血细胞的迁移。利用 Gab2基因敲除鼠模型研究其生物学功能,结果表明 Gab2的缺失可导致严重的过敏反应;且可改变肥大细胞的发育。另