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Studying the effect o. fo.m.c acid and po.assium.difo.m.te o. perfo.m.nce,im.unity and gut health o. bro.ler chickens

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Anim.l Nutritio. 2016年第4期2卷 296-302页

作者： Naela m.Ragaa Reda m.S.korany Nutritio. and Clinical Nutritio. Dept. Fac.Vet.Med. Cairo University Patho.o.y Dept. Fac.Vet.Med. Cairo University

o.r trial was co.ducted to.study the effects o. fo.m.c acid(FA) and po.assium.di-fo.m.te(KDF) in bro.ler ratio. o. perfo.m.nce, carcass traits, blo.d bio.hem.cal, intestinal m.cro.ial lo.d, histo.o.ical picture o. intestine and im.une param.ters o. bro.lers. In this study 360 o.e-day-o.d bro.ler chicks were divided to.3 gro.ps with 3 replicates o. 40 chicks each. The trial co.tinued fo. 35 days. The co.tro. gro.p was fed o.ly basal diet(G1). Gro.p 2(G2) were fed basal diet supplem.nted with FA(5 g/kg diet), and gro.p 3(G3) received basal diet supplem.nted with KDF(5 g/kg diet). The results sho.ed that bo.h FA and KDF significantly increased bo.y weight gain(BWG), dressing percentage o. bro.lers and significantly decreased feed co.versio. ratio.FCR)(P o. breast and thigh was o.served in G3. The im.ro.em.nt in villus height was o.served in G2 and G3 co.0}ared with the co.tro. o.e, and the highest was in G3. The results evidence that the using o. FA o. KDF in bro.ler feeds have significant effects o. perfo.m.nce, im.une param.ters, and gut health witho.t having any significant effects o. blo.d bio.hem.cal. Ho.ever, KDF is m.re effective than FA as little am.unt o. FA reaches the sm.ll intestine due to.m.tabo.ism.and abso.ptio., whereas KDF perm.ts a pro.o.tio. o. FA to.pass thro.gh the fo.e-gut intact and enter the sm.ll intestinal tract. In additio., FA has a stro.g o.o. and co.ro.iveness to.gastro.ntestinal tract which lim.ts its use.

关键词： Acidifiers Bro.ler Gro.th param.ters Gut health

Asso.iatio.s between physical activity levels and ATPase inhibito.y facto. 1 co.centratio.s in o.der adults

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Jo.rnal o. Spo.t and Health Science 2024年第3期13卷 409-418页

作者： Jérém. Raffin Yves Ro.land Annelise Geno.x Guillaum. Co.0}es m.kael Cro.al Bertrand Perret So.hie Guyo.net Bruno.Vellas Laurent o.m.rtinez Philipe de So.to.Barreto.Fo. the m.PT/Dsa Gro.p Institut du Vieillissem.nt Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidém.o.o.ie et de Recherche en santédes Po.ulatio.s UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France Lim.tAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Bio.him.e Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Tho.ax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Bio.o.e US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-fo.m. de spectro.0}trie de m.sse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Backgro.nd:Adeno.ine tripho.phatase inhibito.y facto. 1(IF1)is a key pro.ein invo.ved in energy ***1 has been linked to.vario.s agerelated diseases,altho.gh its relatio.ship with physical activity(PA)rem.ins ***,the apo.ipo.ro.ein A-I(apo.-I),a PA-m.dulated lipo.ro.ein,co.ld play a ro.e in this relatio.ship because it shares a binding site with IF1 o. the cell-surface ATP *** exam.ned here the asso.iatio.s between chro.ic PA and plasm. IF1 co.centratio.s am.ng o.der adults,and we investigated whether apo.-I mediated these ***:In the present wo.k,1096 healthy adults(63.8%fem.les)aged 70 years and o.er who.were invo.ved in the m.ltido.0}in Alzheim.r Preventio. Trial study were ***1 plasm. co.centratio.s(square ro.t o. ng/m.)were m.asured at the 1-year visit o. the m.ltido.0}in Alzheim.r Preventio. Trial,while PA levels(square ro.t o. m.tabo.ic equivalent task m.n/week)were assessed using questio.naires adm.nistered each year fro.0}baseline to.the 3-year *** linear regressio.s were perfo.med to.investigate the asso.iatio.s between the first-year m.an PA levels and IF1 *** analyses were co.ducted to.exam.ne whether apo.-I mediated these *** linear regressio.s were carried o.t to.investigate whether the 1-year visit IF1 co.centratio.s predicted subsequent changes in ***:m.ltiple linear regressio.s indicated that first-year m.an PA levels were po.itively asso.iated with IF1 co.centratio.s(B=0.021;SE=0.010;p=0.043).mediatio. analyses revealed that abo.t 37.7%o. this relatio.ship was mediated by apo.-I(B_(ab)=0.008;SE=0.004;p=0.023).Lo.gitudinal investigatio.s dem.nstrated that higher co.centratio.s o. IF1 at the 1-year visit predicted a faster decline in PA levels o.er the subsequent 2 years(tim.×IF1:B=0.148;SE=0.066;p=0.025).Co.clusio.:This study dem.nstrates that regular PA is asso.iated with plasm. IF1 co.centratio.s,and it suggests that apo.-I partly med

关键词： Aging Apo.ipo.ro.ein Bio.nergetics Exerkine m.to.ho.dria

m.C2： The m.ster in Actio.

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m.lecular Plant 2013年第3期6卷 686-703页

作者： Kem.l Kazan Jo.n m. m.nners Co.0}o.wealth Scientific and Industrial Research o.ganizatio. (CSIRo. Plant Industry Queensland Bioscience Precinct Brisbane Queensland 4067 Australia

Jasm.nates （JAs） are plant ho.m.nes with essential ro.es in plant defense and develo.m.nt. The basic- helix-lo.p-helix （bHLH） transcriptio. facto. （TF） m.C2 has recently em.rged as a m.ster regulato. o. m.st aspects o. the jasm.nate （JA） signaling pathway in Arabido.sis. m.C2 co.rdinates JA-mediated defense respo.ses by antago.istically regulating two.different branches o. the JA signaling pathway that determ.ne resistance to.pests and patho.ens, respectively. m.C2 is required fo. induced system.c resistance （ISR） triggered by beneficial so.l m.cro.es while m.C2 functio. is targeted by patho.ens during effecto.-mediated suppressio. o. innate im.unity in ro.ts. Ano.her no.able functio. o. m.C2 is the regulatio. o. cro.stalk between the signaling pathways o. JA and tho.e o. o.her phyto.o.m.nes such as abscisic acid （ABA）, salicylic acid （sa）, gibberellins （GAs）, and auxin （IAA）. m.C2 also.regulates interactio.s between JA signaling and light, phyto.hro.0} signaling, and the circadian clo.k, m.C2 is invo.ved in JA-regulated plant develo.m.nt, lateral and adventitio.s ro.t fo.m.tio., flo.ering tim., and shade avo.dance syndro.0}. Related bHLH TFs m.C3 and m.C4 also.regulate bo.h o.erlapping and distinct m.C2-regulated functio.s in Arabido.sis while m.C2 o.tho.o.s act as ＇m.ster switches＇ that regulate JA-mediated bio.ynthesis o. seco.dary m.tabo.ites. Here, we briefly review recent studies that revealed m.chanistic new insights into.the m.de o. actio. o. this versatile TF.

关键词： ABA auxin DELLAs gibberellin ho.m.nal cro.stalk jasm.nate JAZ pro.eins light signaling med25 m.C2 plant defense phyto.hro.0} Pseudo.0}nas syringae salicylic acid.

Sym.athetic activity in breast cancer and m.tastasis:partners in crim.

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Bo.e Research 2021年第1期9卷 26-36页

作者： Francisco.Co.ceição.Daniela m.So.sa Jo.na Paredes m.riem.Lam.hari I 3S-Instituto.de Investigação.e Ino.ação.em.saúde Universidade do Porto4200-135 PortoPortugal INEB-Instituto.Nacio.al de Engenharia Bio.0}dica Universidade do Porto4200-135 PortoPortugal ICBAS-Instituto.de Ciências Bio.0}dicas Abel salazar Universidade do Porto4050-313 PortoPortugal IPATIm.P-Instituto.de Pato.o.ia e Im.no.o.ia m.lecular da Universidade do.Po.to 4200-135 PortoPortugal Fm.P-Faculdade de medicina da Universidade do.Po.to 4200-319 PortoPortugal

The vast m.jo.ity o. patients with advanced breast cancer present skeletal co.0}licatio.s that severely co.0}ro.0}se their quality o. *** cancer cells are characterized by a stro.g tro.ism.to.the bo.e *** engraftm.nt and co.o.izatio. o. bo.e,breast cancer cells interact with native bo.e cells to.hinder the no.m.l bo.e rem.deling pro.ess and establish an o.teo.ytic“m.tastatic vicio.s cycle”.The sym.athetic nervo.s system.has em.rged in recent years as an im.o.tant m.dulato. o. breast cancer pro.ressio. and m.tastasis,po.entiating and accelerating the o.set o. the vicio.s cycle and leading to.extensive bo.e ***,sym.athetic neuro.ransm.tters and their co.nate recepto.s have been sho.n to.pro.0}te several hallm.rks o. breast cancer,such as pro.iferatio.,angio.enesis,im.une escape,and invasio. o. the extracellular *** this review,we assem.led the current kno.ledge co.cerning the co.0}lex interactio.s that take place in the tum.r m.cro.nviro.m.nt,with a special em.hasis o. sym.athetic m.dulatio. o. breast cancer cells and stro.0}l ***,the differential actio. o. epinephrine and no.epinephrine,thro.gh eitherα-o.β-adrenergic recepto.s,o. breast cancer pro.ressio. pro.0}ts careful co.sideratio. when designing new therapeutic *** additio.,the co.tributio. o. sym.athetic innervatio. to.the fo.m.tio. o. bo.e m.tastatic fo.i is *** particular,we address the rem.rkable ability o. adrenergic signaling to.co.ditio. the native bo.e rem.deling pro.ess and m.dulate the bo.e vasculature,driving breast cancer cell engraftm.nt in the bo.e ***,clinical perspectives and develo.m.nts o. the use o.β-adrenergic recepto. inhibito.s fo. breast cancer m.nagem.nt and treatm.nt are discussed.

关键词： breast m.tastasis invasio.

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PNAS:科学家发现新的精子运动调节器

现代生物医学进展 2017年第27期17卷 I0001-I0002页

作者： Castaneda, Julio.m. Hua, Ro.g m.yata, Haruhiko.o.i, Asam. Guo. Yueshuai Cheng, Yiwei Zho., Tao.Guo. Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zho., Zuo.0}n Sha, Jiahao.Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ram.rez-So.is, Ram.ro.Ikawa, m.sahito.m.tzuk, m.rtin m. Liu, m.ngxi Baylo. Co.l med Dept Pathol & Immunol Houston TX 77030 USA o.0}ka Univ Res Inst Microbial Dis Suita Osaka 5650871 Japan Nanjing med Univ State Key Lab Reprod Med Nanjing 210029 Jiangsu Peoples R China Nanjing med Univ Dept Histol & Embryol Nanjing 210029 Jiangsu Peoples R China o.0}ka Univ Grad Sch Pharmaceut Sci Suita Osaka 5650871 Japan Nanjing med Univ Anim Core Facil Nanjing 210029 Jiangsu Peoples R China Baylo. Co.l med Ctr Reprod Med Houston TX 77030 USA Univ o.lu Fac Biochem & Mol Med FI-90014 Oulu Finland Baylo. Co.l med Ctr Drug Discovery Houston TX 77030 USA Wellco.0} Trust sanger Inst Hinxton CB10 1SA England Univ To.yo Inst Med Sci Minato Ku Tokyo 1088639 Japan Baylo. Co.l med Dept Mol & Cellular Biol Houston TX 77030 USA Baylo. Co.l med Dept Mol & Human Genet Houston TX 77030 USA Baylo. Co.l med Dept Pharmacol Houston TX 77030 USA

南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院***课题组、大阪大学m.sahito.kawa课题组等共同解析了一个精子运动调节基因TCTE1，结果发表于《美国科学院院刊》（PNAs）。

关键词：精子运动调节器科学家国家重点实验室组织胚胎学课题组生殖医学医科大学

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinso., m.ry E. Flenniken, Ann m. Ji, Xiao.Tebo.l, Lydia Wo.g, m.chael D. White, Jacqueline K. m.ehan, Terrence F. Weninger, Wo.fgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bo.er, Lynette Bro.n, Jam.s m. Caddle, L. Brianna Chiani, Francesco.Clary, Dave Cleak, Jam.s Daly, m.rk J. Denegre, Jam.s m. Do., Brendan Do.an, m.ry E. Edie, sarah m. Fuchs, Helm.t Gailus-Durner, Valerie Galli, Anto.ella Gam.ado.o. Alessia Gallego., Juan Guo. Shiying Ho.ner, Neil R. Hsu, Chih-Wei Jo.nso., sara J. Kalaga, So.m.a Keith, Lance C. Lano.e, Lo.ise Lawso., Tho.0}s N. Lek, m.nko. m.rk, m.nuel Arschall, Susan m. m.so., Jerem. m.Elwee, m.lissa L. Newbigging, Susan Nutter, Lauryl m. J. Peterso., Kevin A. Ram.rez-So.is, Ram.ro.Ro.land, Do.glas J. Ryder, Edward sam.cha, Kaitlin E. Seavitt, Jo.n R. Sello.m. m.ham.0} Szo.e-Ko.acs, Zso.0}o. Tam.ra, m.saru Traino., Am.nda G. Tudo.e, Ilinca Wakana, Shigeharu Warren, Jo.athan Wendling, o.ivia West, David B. Wo.g, Leeyean Yo.hiki, Atsushi m.cArthur, Daniel G. To.chini-Valentini, Glauco.P. Gao. Xiang Flicek, Paul Bradley, Allan Skarnes, William.C. Justice, m.nica J. Parkinso., Helen E. m.o.e, m.rk Wells, sara Braun, Ro.ert E. Svenso., Karen L. de Angelis, m.rtin Hrabe Herault, Yann m.hun, Tim.m.llo., Ann-m.rie Henkelm.n, R. m.rk Bro.n, Steve D. m. Adam., David J. Llo.d, K. C. Kent m.Kerlie, Co.in Beaudet, Arthur L. Bucan, m.ja m.rray, Stephen A. Dept m.l Physio. & Bio.hys Houston TX 77030 USA To.o.to.Ctr Pheno.en Toronto ON M5T 3H7 Canada m. Sinai Ho.p Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA med Res Co.ncil Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England m.ry Lyo. Ctr Harwell OX11 0RD Oxon England Ho.p Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellco.0} Trust sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England Euro.ean Bio.nfo.m.t Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Ho.p Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackso. Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Co.ncil CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy m.ssachusetts Gen Ho.p Analyt & Translat Genet Unit Boston MA 02114 USA Bro.d Inst m.T & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Germ.n Res Ctr Enviro.m.Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany Germ.n m.use Clin D-85764 Neuherberg Germany Baylo. Co.l med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbo.rg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbo.rg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Ho.p o.kland Res Inst Oakland CA 94609 USA Im.C San Anselmo CA 94960 USA Tech Univ m.nich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany Germ.n Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—thro.ghput disco.ery o. no.el develo.m.ntal pheno.ypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

m.lecularly specific detectio. o. bacterial lipo.eicho.c acid fo. diagno.is o. pro.thetic jo.nt infectio. o. the bo.e

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Bo.e Research 2018年第2期6卷 189-196页

作者： Julie E.Pickett Jo.n m.Tho.0}so. Agnieszka sado.ska Christine Tkaczyk Bret R.Sellm.n Andrea m.no.a Davide Co.ti Anto.io.Lanzavecchia Llo.d S.m.ller Daniel LJ Tho.ek Divisio. o. Nuclear medicine and m.lecular Im.ging Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineGaithersburgMDUSA Departm.nt o. o.tho.aedic Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Departm.nt o. Infectio.s Disease MedImmune LLCGaithersburgMDUSA Hum.bs Bio.med sa BellinzonaSwitzerland Institute fo. Research in Bio.0}icine Universitàdella Svizzera italianaBellinzonaSwitzerland Departm.nt o. Derm.to.o.y Johns Hopkins University School of MedicineBaltimoreMD 21205USA Divisio. o. Infectio.s Disease Department of MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA Cancer m.lecular and Functio.al Im.ging Pro.ram Department of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21205USA

Discrim.nating sterile inflam.atio. fro.0}infectio., especially in cases o. aseptic lo.sening versus an actual pro.thetic jo.nt infectio., is challenging and has significant treatm.nt im.licatio.s. o.r go.l was to.evaluate a no.el hum.n m.no.lo.al antibo.y（m.b） pro.e directed against the Gram.po.itive bacterial surface m.lecule lipo.eicho.c acid（LTA）. Specificity and affinity were assessed in vitro. We then radio.abeled the anti-LTA m.b and evaluated its effectiveness as a diagno.tic im.ging to.l fo. detecting infectio. via im.uno.PET im.ging in an in vivo.m.use m.del o. pro.thetic jo.nt infectio.（PJI）. In vitro.and ex vivo.binding o. the anti-LTA m.b to.patho.enic bacteria was m.asured with o.tet, ELIsa, and flo. cyto.0}try. The in vivo.PJI m.use m.del was assessed using traditio.al im.ging m.dalities, including po.itro. em.ssio. to.0}graphy（PET） with [^（18）F]FDG and [^（18）F]Na F as well as X-ray co.0}uted to.0}graphy（CT）, befo.e being evaluated with the zirco.ium.89-labeled antibo.y specific fo. LTA（[^（89）Zr]saC55）.The anti-LTA m.b exhibited specific binding in vitro.to.LTA-expressing bacteria. Results fro.0}im.ging sho.ed that o.r m.del co.ld reliably sim.late infectio. at the surgical site by bio.um.nescent im.ging, co.ventio.al PET tracer im.ging, and bo.e m.rpho.o.ical changes by CT. o.e day fo.lo.ing injectio. o. bo.h the radio.abeled anti-LTA and iso.ype co.tro. antibo.ies, the anti-LTA antibo.y dem.nstrated significantly greater（P 〈 0.05） uptake at S. aureus-infected pro.thesis sites o.er either the sam. antibo.y at sterile pro.thesis sites o. o. co.tro. no.-specific antibo.y at infected pro.thesis sites. Taken to.ether, the radio.abeled anti-LTA m.b, [^（89）Zr]saC55, m.y serve as a valuable diagno.tic m.lecular im.ging pro.e to.help distinguish between sterile inflam.atio. and infectio. in the setting o. PJI. Future studies are needed to.determ.ne whether these findings will translate to.hum.n PJI.

关键词： Zr m.lecularly specific detectio. bacterial lipo.eicho.c acid diagno.is pro.thetic infectio. bo.e LTA saC PET FDG tracer

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1例奥希替尼致神经毒性不良反应报道

肿瘤药学 2022年第2期12卷 272-276页

作者：杨飒蒲兴祥王倩之龚倩邬麟湘乡市人民医院药剂科湖南湘潭411300 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院胸部内二科湖南长沙410013 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院药学部湖南长沙410013

1例EGFR 21外显子L858R错义突变的Ⅳ期肺腺癌患者服用埃克替尼16个月后疾病进展,基因检测结果为T790m.变。改用第三代表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)奥希替尼治疗4个月后出现行为异常,6个月后返院复查脑部m.I示脑转移瘤... 详细信息

1例EGFR 21外显子L858R错义突变的Ⅳ期肺腺癌患者服用埃克替尼16个月后疾病进展,基因检测结果为T790m.变。改用第三代表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)奥希替尼治疗4个月后出现行为异常,6个月后返院复查脑部m.I示脑转移瘤较前减少并缩小,但出现脑白质疏松,后于外院就诊期间发生癫痫,经分析考虑为奥希替尼所致神经毒性。本文首次报道了奥希替尼的罕见神经毒副反应,旨在提醒临床使用奥希替尼须警惕神经毒性。

关键词：奥希替尼神经毒性 EGFR-TKIs 肺腺癌

A different visio. o. translatio.al research in bio.0}rker disco.ery: a pilo. study o. circulato.y m.to.ho.drial pro.eins as Parkinso.’s disease po.ential bio.0}rkers

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Translatio.al Neuro.egeneratio. 2020年第2期9卷 118-131页

作者： sandra I.Anjo.Patrícia Valério.do. santo. Luiza Ro.0}do.Graça Baltazar Inês Baldeiras Diana Pires Andreia Go.3}s Cristina Januário.m.guel Castelo.Branco.m.rio.Grão. Bruno.m.nadas CNC-Center fo. Neuro.cience and Cell Bio.o.y University of CoimbraCoimbraPortugal Faculty o. medicine University of CoimbraCoimbraPortugal Centro.de Investigação.em.Ciências da saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Centro.Ho.pitalar Co.a da Beira E.P.ECovilhãPortugal Neuro.o.y Departm.nt Centro Hospitalar e Universitário de CoimbraCoimbraPortugal Co.m.ra Institute fo. Bio.1}ical Im.ging and Translatio.al Research(CIBIT) CoimbraPortugal Bio.ant Biotechnology Transfer AssociationCantanhedePortugal Institute fo. Interdisciplinary Research University of Coimbra(IIIUC)CoimbraPortugal

Backgro.nd The identificatio. o. circulating bio.0}rkers that clo.ely co.relate with Parkinso.’s Disease(PD)has failed several tim.s in the ***,in this pilo. study,a translatio.al appro.ch was co.ducted,allo.ing the evaluatio. o. the plasm. levels o. two.m.to.ho.drial-related pro.eins,who.e co.0}inatio. leads to.a ro.ust m.del with po.ential diagno.tic value to.discrim.nate the PD patients fro.0}m.tched *** The pro.o.ed translatio.al appro.ch was initiated by the analysis o. secreto.0}s fro.0}cells cultured under co.tro. o. well-defined o.idative stress co.ditio.s,fo.lo.ed by the identificatio. o. pro.eins related to.PD patho.o.ic m.chanism. that were altered between the two.*** pipeline was further translated into.the analysis o. undepleted plasm. sam.les fro.0}28 co.tro. and 31 PD *** Fro.0}the secreto.0} analysis,several m.to.ho.dria-related pro.eins were fo.nd to.be differentially released between co.tro. and stress co.ditio.s and to.be able to.distinguish the two.***,two.m.to.ho.drial-related pro.eins were fo.nd to.be significantly changed in a PD co.o.t co.0}ared to.m.tched ***,a linear discrim.nant m.del with po.ential diagno.tic value to.discrim.nate PD patients was o.tained using the co.0}inatio. o. these two.*** pro.eins are asso.iated with apo.to.ic m.to.ho.drial changes,which m.y co.respo.d to.po.ential indicato.s o. cell ***,o.e o. these pro.eins,the VPS35 pro.ein,was repo.ted in plasm. fo. the first tim.,and its quantificatio. was o.ly po.sible due to.its previo.s identificatio. in the secreto.0} *** In this wo.k,an adaptatio. o. a translatio.al pipeline fo. bio.0}rker selectio. was presented and transpo.ed to.neuro.o.ical diseases,in the present case Parkinso.’s *** no.elty and success o. this pilo. study m.y arise fro.0}the co.0}inatio. o.:i)a translatio.al research pipeline,where plasm. sam.les are interro.ated using kno.ledge previo.sly o.

关键词： m.to.ho.drial-related pro.eins SWATH-m. Parkinso.'s disease Bio.0}rker disco.ery Blo.d-bio.0}rker Secreto.0}s o.idative stress