Sympathetic activity in breast cancer and metastasis:partners in crime

作     者：Francisco Conceição Daniela M.Sousa Joana Paredes Meriem Lamghari Francisco Conceição;Daniela M.Sousa;Joana Paredes;Meriem Lamghari

作者机构：I 3S-Instituto de Investigação e Inovação em SaúdeUniversidade do Porto4200-135 PortoPortugal INEB-Instituto Nacional de Engenharia BiomédicaUniversidade do Porto4200-135 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel SalazarUniversidade do Porto4050-313 PortoPortugal IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto4200-135 PortoPortugal FMUP-Faculdade de Medicina da Universidade do Porto4200-319 PortoPortugal 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2021年第9卷第1期

页      面：26-36页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financed by FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and Portuguese funds through FCT/ MCTES in the framework of the project “Sprout OC” (POCI-01-0145-FEDER-030158, PTDC/MED-PAT/30158/2017) a recipient of the Ph.D.fellowship SFRH/BD/ 128771/2017 a recipient of the postdoctoral fellowship SFRH/BPD/115341/ 2016 

主　　题：breast metastasis invasion 

摘      要：The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of *** cancer cells are characterized by a strong tropism to the bone *** engraftment and colonization of bone,breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic“metastatic vicious cycle.The sympathetic nervous system has emerged in recent years as an important modulator of breast cancer progression and metastasis,potentiating and accelerating the onset of the vicious cycle and leading to extensive bone ***,sympathetic neurotransmitters and their cognate receptors have been shown to promote several hallmarks of breast cancer,such as proliferation,angiogenesis,immune escape,and invasion of the extracellular *** this review,we assembled the current knowledge concerning the complex interactions that take place in the tumor microenvironment,with a special emphasis on sympathetic modulation of breast cancer cells and stromal ***,the differential action of epinephrine and norepinephrine,through eitherα-orβ-adrenergic receptors,on breast cancer progression prompts careful consideration when designing new therapeutic *** addition,the contribution of sympathetic innervation to the formation of bone metastatic foci is *** particular,we address the remarkable ability of adrenergic signaling to condition the native bone remodeling process and modulate the bone vasculature,driving breast cancer cell engraftment in the bone ***,clinical perspectives and developments on the use ofβ-adrenergic receptor inhibitors for breast cancer management and treatment are discussed.