检索结果-南通市图书馆

Non-invasive imaging of pathological scars using a portable handheld two-photon microscope

Chinese Medical Journal 2024年第3期137卷 329-337页

作者： Yang Han Yuxuan Sun Feili Yang Qingwu Liu Wenmin Fei wenzhuo qiu Junjie Wang Linshuang Li Xuejun Zhang Aimin Wang Yong Cui Graduate School Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China College of Engineering Peking UniversityBeijing 100871China School of Chemical Biology and Biotechnology State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Department of Dermatology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Future Technology Peking UniversityBeijing 100871China Beijing Transcend Vivoscope Biotech Beijing 100085China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230001China Institute of Dermatology Anhui Medical UniversityHefeiAnhui 230001China School of Electronics Peking UniversityBeijing 100871China

Background:Pathological scars are a disorder that can lead to various cosmetic,psychological,and functional problems,and no effective assessment methods are currently *** and treatment of pathological scars are based on cutaneous manifestations.A two-photon microscope(TPM)with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in *** study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar ***:Fifteen patients with pathological scars and three healthy controls were *** was performed using a portable handheld *** indexes were extracted from two dimensional(2D)and three dimensional(3D)perspectives,including collagen depth,dermo-epidermal junction(DEJ)contour ratio,thickness,orientation,and occupation(proportion of collagen fibers in the field of view)of *** depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D *** assessed index differences between scar and normal skin and changes before and after ***:Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen *** indexes were employed to distinguish between normal skin and scar *** significant differences were found in average depth(t=9.917,P<0.001),thickness(t=4.037,P<0.001),occupation(t=2.169,P<0.050),orientation of collagen(t=3.669,P<0.001),and the DEJ contour ratio(t=5.105,P<0.001).Conclusions:Use of portable handheld TPM can distinguish collagen from skin tissues;thus,it is more suitable for scar imaging than reflectance confocal ***,a TPM may be an auxiliary tool for scar treatment selection and assessing treatment efficacy.

关键词： Scars Two-photon microscope Two-photon excitation fluorescence Second harmonic generation microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

膨胀土生态治理研究进展

引用

岩土工程学报 2024年第S2期46卷 60-66,176页

作者：白玉霞常顺肖衡林李丽华何俊邱季周文卓邓永锋湖北工业大学土木建筑与环境学院河湖健康智慧感知与生态修复教育部重点实验室湖北武汉430068 东南大学交通学院江苏南京211189

膨胀土是一种遇水急剧膨胀变形、失水迅速收缩开裂的问题土,需对其进行治理以满足工程要求。对近年来新发展的膨胀土生态治理材料进行了归纳、总结,并根据其组分、特点分为地聚合物类、离子固化剂、有机高分子材料类、微生物与酶类和生... 详细信息

膨胀土是一种遇水急剧膨胀变形、失水迅速收缩开裂的问题土,需对其进行治理以满足工程要求。对近年来新发展的膨胀土生态治理材料进行了归纳、总结,并根据其组分、特点分为地聚合物类、离子固化剂、有机高分子材料类、微生物与酶类和生物胶类,并阐述了各类固化剂的材料特点、固化效果及作用机理,均符合新时代发展要求,可作为一种可持续的、环保的、多功能的技术大范围推广应用,最后从生态治理和推广应用角度探讨了目前需要克服的问题。

关键词：膨胀土生态治理固化效果改性机制研究进展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于离散元法的隧道穿越卵石地层稳定性研究

引用

土木工程与管理学报 2024年第4期41卷 76-82页

作者：杨治军胡金鑫邱成虎王文卓曾洋甘肃省交通规划勘察设计院股份有限公司甘肃兰州730030 长安大学公路学院陕西西安710064

为了研究卵石层构造参数对隧道围岩稳定性及地表沉降的影响规律,建立不同围岩(卵石层)参数条件下的离散元数值计算模型,并进行了不同试验工况的对比分析。结果表明:在卵石层不同构造参数条件下,隧道开挖引起的地表沉降曲线能与Peck公式... 详细信息

为了研究卵石层构造参数对隧道围岩稳定性及地表沉降的影响规律,建立不同围岩(卵石层)参数条件下的离散元数值计算模型,并进行了不同试验工况的对比分析。结果表明:在卵石层不同构造参数条件下,隧道开挖引起的地表沉降曲线能与Peck公式较好拟合;当“节理倾角”在30°~35°之间时,隧道顶部地表沉降峰值最大,沉降槽宽度系数最小;同时,“节理倾角”增加使得剪切变形区域由拱顶逐渐向两侧延伸,并形成贯通破裂面;破裂面与最大主应力作用方向的夹角接近45°,并将拱顶和拱腰附近的围岩切割成锥形松动体;此外,隧道开挖初期围岩(卵石层)受拉破坏区主要集中于拱圈附近,而破坏区范围随着卵石块体间摩擦角的增加逐渐减小;工程实际中可通过注浆措施提高拱圈围岩稳定性,对此类工程设计、施工具有理论指导意义。

关键词：卵石地层离散元围岩变形地表沉降

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

The pooled analysis of efficacy and safety profiles of bevacizumab in Chinese cancer patients

引用

The Chinese-German Journal of Clinical Oncology 2011年第11期10卷 621-625页

作者： Huijuan qiu wenzhuo He Guifang Guo Xuxian Chen Fang Wang Feifei Zhou Chenxi Yin Liangping Xia State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou 510060 China VIP Region Sun Yat-sen University Cancer Center Guangzhou 510060 China Tumor Center The Foshan First People＇s Hospital Foshan528000 China

Objective: The aim of this study was to investigate the efficacy and safety profiles of bevacizumab, the commonly used monoclonal antibody and its safety profiles were challenging, based on Chinese cancer patients. Methods: All the papers studied on Chinese cancer patients treated by bevacizumab were found in both databases of Chinese journal database for fulltext and PubMed were collected. The commonly used efficacy index such as disease control rate (CR + PR + SD) and response rate (CR + PR) were analyzed, and the bevacizumab related side effects were analyzed too. Results: (1) There were ten original papers contained total 199 patients who were the candidates to analyze the safety profiles, and 115 patients with colorectal cancer in five papers who were candidates to analyze the efficacy. (2) Nine in ten papers set the dose of bevacizumab in 2.5 mg/kg/week - 5 mg/kg/week, and the biweekly was the standard chemotherapy interval. (3) The disease control rate and response rate in Chinese colorectal cancer patients were 85% (95% CI: 79%-92%) and 61% (95% CI: 52%-70%), respectively. (4) The side effects related to bevacizumab were rare and most of them were grades 1-2, and only one case with grade 4 bleeding was recorded and only two cases with discontinuation of bevacizumab since hemoplysis. Also, the grades 3-4 side effects related cytotoxic agents were not common. Conclusion: This study summarized the data of Chinese cancer patients treated by bevacizumab-contained regimens, and it showed that the monoclonal antibody was effective and safe for Chinese patients as the West patients.

关键词： Chinese patient cancer bevacizumab efficacy side effects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The pooled analysis of single gemcitabine for non-small cell lung cancer patients with elderly age

引用

The Chinese-German Journal of Clinical Oncology 2010年第12期9卷 683-687页

作者： Fang Wang Liangping Xia Guifang Guo Huijuan qiu Feifei Zhou wenzhuo He State Key Laboratory of Oncology in South China Guangzhou 510060 China VIP Region Sun Yat-sen Universty Cancer Center Guangzhou 510060 China Tumor Center The First People＇s Hospital of Foshan Foshan 528000 China

Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II *** aim of this study was to summarize all those phase II studies with the hope to get a comprehensive understanding of gemcitabine ***:The PubMed database was used to search all the papers on NSCLC associated with gemcitabine used as single agent in the first line setting till to March 31st,*** the medians and their 95% CI of overall response rate (ORR),disease control rate (DCR),progression free survival (PFS),and overall survival (OS) were ***:*** were 7 papers including 410 patients with performance status (PS) ≤ 2 and advanced stage *** dose-intensities of gemcitabine were 843.75 mg/m 2 /week-1125 mg/m 2 /week in the 4-week schedule,and 666.7 mg/m 2 /week in the 3-week *** median age was 73.8 (95% CI was 72.44,75.16) years old;36.1% (95% CI:31.4%,40.7%) of patients with stage IIIB and 60.5% (95% CI:55.8%,65.2%) of patients with stage IV;35.9% (95% CI:31.2%,40.5%) patients were adenocarcinomas and 43.7% (95% CI:38.9%,48.5%) patients were squamous cell carcinomas (SCCs).*** ORR,DCR,PFS/TTP,and OS were 22.3% (95% CI:18.2%,26.5%),58.4% (95% CI:53.5%,63.4%),3.6 (95% CI:2.9,5.15) months and 6.68 (95% CI:5.4,8.11) months,***:Gemcitabine as single agent applied in this special population was effective and can be well tolerated under different doses and usage.

关键词： elderly non-small cell lung cancer (NSCLC) pooled-analysis gemcitabine first line setting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The efficacy of bevacizumab in Chinese patients with metastatic colorectal cancer and its effect in different line setting

引用

The Chinese-German Journal of Clinical Oncology 2014年第4期13卷 169-173页

作者： Chenxi Yin Chang Jiang Fangxin Liao Yuming Rong wenzhuo He Xiuyu Cai Guifang Guo Huijuan qiu Xuxian Chen Bei Zhang Liangping Xia State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center VIP Region Sun Yat-sen University Cancer Center Collaborative Innovation Center for Cancer Medicine

Objective: We aimed to evaluate the effect of bevacizumab in the palliative treatment of Chinese metastatic colorectal cancer(mCRC) and its efficacy in different lines. Methods: Patients of mCRC treated with bevacizumab or not at Sun Yat-sen University Cancer Center from 2005 to 2013 were recruited as the study group and control group. The endpoints were objective response rate(ORR), disease control rate(DCR), overall survival(OS) and progression free survival(PFS). The OS and PFS of first-, second- and third-line treatment groups were compared between study group and control group. Results: The median PFS of the study and the control group were 8.2 months(7.0–9.4 months), 5.7 months(4.7–6.6 months), P = 0.001; OS were 26 months(5.4–130.5 months), 18 months(16.6–19.4 months), P < 0.001, respectively. The ORR and DCR of first-, second- and third-line were 30.3%(20/66), 20%(6/30), 17.6%(3/17) and 97%(64/66), 86.7%(26/30), 100%(17/17). In the first-line chemotherapy group, the OS of the study group and the control group were 22.9(5.4–96.7) months and 18(16.6–19.4) months(P < 0.001); PFS were 9.4(8.4–10.4) months and 5.7(4.7–6.6) months(P < 0.001), respectively. While in the second- and third-line setting, only OS were statistically different, PFS had no significant difference. Conclusion: The combination of bevacizumab and chemotherapy had a promising short-term and long-term efficacy in Chinese mCRC patients than those without bevacizumab regimens, and the effect could be better reflected in the first-line treatment.

关键词： bevacizumab chemotherapy metastatic colorectal cancer efficacy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钢-聚氨酯组合剪力墙侧向刚度理论研究

引用

钢结构 2018年第12期33卷 43-47页

作者：王林张晓五殷文倬曹凯岳仇诗雨江苏科技大学土木工程与建筑学院江苏镇江212000

以杆系简化模型作为钢-聚氨酯组合剪力墙的理论分析基础,提取结构屈曲时钢板与聚氨酯两种材料的应力状态。通过建立平衡方程、变形协调方程以及物理方程,化简得到组合剪力墙侧向刚度的理论计算式。然后,利用ANSYS有限元软件建立8组单层... 详细信息

以杆系简化模型作为钢-聚氨酯组合剪力墙的理论分析基础,提取结构屈曲时钢板与聚氨酯两种材料的应力状态。通过建立平衡方程、变形协调方程以及物理方程,化简得到组合剪力墙侧向刚度的理论计算式。然后,利用ANSYS有限元软件建立8组单层单跨组合剪力墙模型,分析它们的侧向刚度,并与计算刚度进行对比,最终验证理论计算式的正确性。

关键词：简化模型应力状态侧向刚度计算式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长江口竹园排污区磷的转移动力学

引用

台湾海峡 1998年第3期17卷 255-261页

作者：陈希青邱巍巫志萍陈松廖文卓水电部上海勘测设计研究院科研所上海200434 国家海洋局第三海洋研究所厦门361005

模拟研究上海市污水排入长江口竹园排污区时，污水-海水混合过程中磷含量和形态的变化，及其在颗粒物-海水界面的转移动力学，提供动力学模式，测定转移的速率，进行容量校正，为上海市污水排海环境容量估算和水质控制提供动力学资料和... 详细信息

模拟研究上海市污水排入长江口竹园排污区时，污水-海水混合过程中磷含量和形态的变化，及其在颗粒物-海水界面的转移动力学，提供动力学模式，测定转移的速率，进行容量校正，为上海市污水排海环境容量估算和水质控制提供动力学资料和理论依据。

关键词：污水海水动力学长江口磷扩散排污区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

79家医院718例结直肠肿瘤经自然腔道取标本手术回顾性研究

引用

中华结直肠疾病电子杂志 2017年第6期6卷 469-477页

作者：关旭王贵玉周主青周海涛陈瑛罡汤庆超宋军民蔡建春鲍传庆张宏刘雁军熊治国吴淼宋纯郑阳春蒋嘉睿燕速汪泳胡清林马丹任柯熊德海张兴宏杨明睿白月奎符炜李蜀华张诗峰柳俊刚莫显伟宫红彦江波王铁张安平朱平付涛胡军红贾文焯秦长江苏琪王道荣吴万庆赵紫罡朱洪波金武勇靖昌庆李德钢刘文志刘志春庞黎明汤东王小强杨国山姚坤厚张学明赵磊钟晓刚周雷朱州白雪峰陈超武陈诗伟陈泽华戴凌付振保高峰高浩高磊龚剑锋姜勇介建政金伟森李德川李军蔺宏伟刘宝林刘春庆刘明孟建彬邱健饶贵安孙东辉孙学军邰建东王志刚谢光伟谢铭韦烨严俊阎立昆杨丰杨鹤鸣杨万军陈路川叶再生喻志革赵中海钟鸣朱玉萍傅传刚王锡山国家癌症中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科北京100021 中国NOSES联盟北京100021 同济大学附属东方医院胃肠肛肠外科上海200120

目的通过收集国内79家医院开展的结直肠肿瘤经自然腔道取标本手术(NOSES)病例,阐述NOSES术在结直肠肿瘤中的应用现状及其可行性。方法本研究最终共纳入718例结直肠肿瘤NOSES病例,收集资料包括患者术前一般资料、手术相关资料、术后病理... 详细信息

目的通过收集国内79家医院开展的结直肠肿瘤经自然腔道取标本手术(NOSES)病例,阐述NOSES术在结直肠肿瘤中的应用现状及其可行性。方法本研究最终共纳入718例结直肠肿瘤NOSES病例,收集资料包括患者术前一般资料、手术相关资料、术后病理资料以及随访资料。结果患者一般资料显示:患者平均年龄为59.4±10.8岁,患者平均BMI指数为22.9±6.3 kg/m2,直肠NOSES术患者占总数的72.3%,有3.5%的患者接受了术前新辅助治疗;术后病理资料显示,I^IV期患者分别占31.3%,26.8%,30.8%,0.8%;中分化腺癌比例占病例总数的62.1%,肿瘤最大直径平均为4.1±1.8 cm,淋巴结检出数目平均为13.4±3.5枚。本研究中76.2%的患者行腹腔镜直肠前切除术联合经自然腔道取标本手术;90.4%的患者采用经直肠取标本,经阴道取标本病例占9.6%;NOSES手术时间平均为210.5±39.4分钟,术中出血量平均为61.8±23.1 ml,术后排气时间平均为44.5±10.3小时,术后进食时间平均为64.9±14.6小时,术后住院时间为12.1±4.0天,并发症发生率为10.6%,术后肛门功能障碍者占总数的1.5%,未发现阴道功能障碍者。结论结直肠肿瘤NOSES术在我国广泛开展,且表现出巨大的推广潜力。同时,NOSES术符合肿瘤根治术要求,并具有良好的近期疗效,因此该技术是一种安全可靠的微创外科技术。

关键词：结直肠肿瘤经自然腔道取标本手术腹腔镜手术微创外科

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：