The efficacy of bevacizumab in Chinese patients with metastatic colorectal cancer and its effect in different line setting

作     者：Chenxi Yin Chang Jiang Fangxin Liao Yuming Rong Wenzhuo He Xiuyu Cai Guifang Guo Huijuan Qiu Xuxian Chen Bei Zhang Liangping Xia 

作者机构：State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center VIP Region Sun Yat-sen University Cancer Center Collaborative Innovation Center for Cancer Medicine 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2014年第13卷第4期

页      面：169-173页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by grants from the National Natural Science Foundation of China(No.81272641 81071872) 

主　　题：bevacizumab chemotherapy metastatic colorectal cancer efficacy 

摘      要：Objective: We aimed to evaluate the effect of bevacizumab in the palliative treatment of Chinese metastatic colorectal cancer(mCRC) and its efficacy in different lines. Methods: Patients of mCRC treated with bevacizumab or not at Sun Yat-sen University Cancer Center from 2005 to 2013 were recruited as the study group and control group. The endpoints were objective response rate(ORR), disease control rate(DCR), overall survival(OS) and progression free survival(PFS). The OS and PFS of first-, second- and third-line treatment groups were compared between study group and control group. Results: The median PFS of the study and the control group were 8.2 months(7.0–9.4 months), 5.7 months(4.7–6.6 months), P = 0.001; OS were 26 months(5.4–130.5 months), 18 months(16.6–19.4 months), P 0.001, respectively. The ORR and DCR of first-, second- and third-line were 30.3%(20/66), 20%(6/30), 17.6%(3/17) and 97%(64/66), 86.7%(26/30), 100%(17/17). In the first-line chemotherapy group, the OS of the study group and the control group were 22.9(5.4–96.7) months and 18(16.6–19.4) months(P 0.001); PFS were 9.4(8.4–10.4) months and 5.7(4.7–6.6) months(P 0.001), respectively. While in the second- and third-line setting, only OS were statistically different, PFS had no significant difference. Conclusion: The combination of bevacizumab and chemotherapy had a promising short-term and long-term efficacy in Chinese mCRC patients than those without bevacizumab regimens, and the effect could be better reflected in the first-line treatment.