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Science China(Information Sciences) 2021年第7期64卷 230-232页

作者： Xiujuan LEI wenxiang zhang School of Computer Science Shaanxi Normal University

Dear editor,Genetic diseases have seriously threatened human health;however, identifying candidate disease genes is expected to contribute to understanding complex genetic diseases. Several machine learning algorithms... 详细信息

关键词： Information Systems and Communication Service

Integration of peripheral circadian clock and energy metabolism in metabolic tissues

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Journal of Molecular Cell Biology 2020年第7期12卷 481-485页

作者： Yanchen zhang wenxiang zhang Chang Liu State Key Laboratory of Natural Medicines and School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China

The mammalian circadian clock precisely controls various physiological processes,including energy metabolism,to help the body adapt to the diurnal light–dark cycles induced by the earth *** the clock and metabolism are tightly coupled and interacted,the molecular mechanism through which these two pathways are integrated remains largely *** the past 10 years,we have been focusing on this important scientific question and innovatively proposed three integration modes,including the‘parallel connection’mode orchestrated by nuclear factors.

关键词： energy precisely metabolism

Highly dispersed metal incorporated hexagonal mesoporous silicates for catalytic cyclohexanone oxidation to adipic acid

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2542-2548页

作者： Wenjuan Yan wenxiang zhang Qi Xia Shuaishuai Wang Shuxia zhang Jian Shen Xin Jin State Key Laboratory of Heavy Oil Processing Center for Chemical Engineering Experimental TeachingChina University of PetroleumQingdao 266580China College of Environment and Resources Xiangtan UniversityXiangtan 411105China

Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and *** use of nitric acid as an oxidant in the industrial production of adipic acid poses significant carbon footprint to the *** adipic acid synthesis methods using a heterogeneous catalyst with H2O2 as oxidant and water as solvent have potential advantages of low catalyst cost,easy synthesis and recovery,cleanness and environmental *** this work,hexagonal mesoporous silicate materials were synthesized by a sol–gel method and evaluated for cyclohexanol/cyclohexanone oxidation to adipic *** physical and chemical properties of Fe-HMS were characterized by XRD,HR-TEM,BET and UV–*** experimental results showed that Fe-HMS materials show pore sizes ranging from 2–3 nm.W-and Mo-based polyoxometalates were also evaluated and compared to the Fe-based HMS *** improve the adipic acid yield,the influence of the transition metal as well as the effect of metal loading,reaction temperature and catalyst amount on the catalytic performances of Fe-HMS have been investigated in *** Si/Fe atomic ratio=100,Fe-HMS catalyst shows the highest activity,with a cyclohexanone conversion of 92.3%and adipic acid selectivity of 29.4%.The reaction pathway of cyclohexanone oxidation was further proposed based on experimental data.

关键词： Oxidation Adipic acid Hexagonal mesoporous silicates hydrogen peroxide

Multiple types of disease-associated RNAs identification for disease prognosis and therapy using heterogeneous graph learning

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Science China(Information Sciences) 2024年第8期67卷 341-342页

作者： wenxiang zhang Hang WEI Wenjing zhang Hao WU Bin LIU School of Computer Science and Technology Beijing Institute of Technology School of Computer Science and Technology Xidian University Department of Teaching and Research Shenzhen University General Hospital Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical Engineering Shenzhen University Medical School Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology

Identifying disease-associated RNAs is crucial in revealing the pathogenic mechanisms of diseases [1], and biologists have made notable progress in this field [2]. However, more effective computational methods are needed to provide reference disease-associated RNAs, reducing the manpower and material resources required for biological experiments.

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Evidence for pore-filling gas hydrates in the sediments through morphology observation

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Chinese Journal of Chemical Engineering 2019年第9期27卷 2081-2088页

作者： wenxiang zhang Shuanshi Fan Yanhong Wang Xuemei Lang Kai Guo Jianbiao Chen Key Lab of Enhanced Heat Transfer and Energy Conservation Ministry of Education School of Chemistry and Chemical Engineering South China University of Technology

To provide an evidence of natural gas hydrate occurrence state,a series of experiments on multiple growth and dissociation of 90.0%methane/10.0%propane hydrates at 1.3 MPa and 270.15 K were carried out in two sediments for morphology observation via a visible *** gas hydrate crystals were observed to form and grow on the surface of sediments at the initial *** the thermal decomposition,gas and liquid products had an unceasingly impact on the sediments,then gas/liquid–solid migration occurred,and a large number of cavitation *** the later growth and dissociation experiments,the gas hydrate particles were in suspension or supporting states in the interstitial pore space between the sediment particles,indicating that the gas hydrate displayed a pore-filling *** analyzing the distribution of gas hydrates and bubbles,it was found that the amount of gas hydrates distributed in the sediments was improved with multiple growth-dissociation cycle *** migration enhanced the sediment movement,which led to the appearance of the increasing quantity of gas bubbles in the sediments during *** affected the growth of the gas hydrates and the migration of sediment grains,which also restricted the accumulation of gas bubbles in the *** to the Raman analysis,the results showed that sII hydrates were formed for CH4 and C3H8 gas mixtures in different sediments and solutions with hydration number of 5.84–*** Salt restricted the access of gas into the hydrate cages.

关键词： Gas hydrate Sediments Growth Dissociation Pore-filling

Rational design of new in situ reduction of Ni(II)catalytic system for low-cost and large-scale preparation of porous aromatic frameworks

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Carbon Energy 2024年第5期6卷 105-113页

作者： Shanshan Wang Yue Wu wenxiang zhang Hao Ren Guangshan Zhu Heping Ma School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchunChina College of Chemistry Northeast Normal UniversityChangchunChina

Porous aromatic framework 1(PAF-1)is an extremely representative nanoporous organic framework owing to its high stability and exceptionally high surface ***,the synthesis of PAF-1 is catalyzed by the Ni(COD)2/COD/bpy system,suffering from great instability and high ***,we developed an in situ reduction of the Ni(II)catalytic system to synthesize PAF-1 in low cost and high *** active Ni(0)species produced from the NiCl_(2)/bpy/NaI/Mg catalyst system can effectively catalyze homocoupling of tetrakis(4-bromophenyl)methane at the room temperature to form PAF-1 with high Brunauer-Emmett-Teller(BET)-specific surface area up to 4948 m^(2) g^(−1)(Langmuir surface area,6785 m2 g−1).The possible halogen exchange and dehalogenation coupling mechanisms for this new catalytic process in PAF's synthesis are discussed in *** efficiency and universality of this innovative catalyst system have also been demonstrated in other PAFs'*** work provides a cheap,facile,and efficient method for scalable synthesis of PAFs and explores their application for high-pressure storage of Xe and Kr.

关键词： adsorption carbon material nickel catalysis porous aromatic framework porous organic polymer

Molecular fossil and paleovegetation records of paleosol S4 and adjacent loess layers in the Luochuan loess section, NW China

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Science China Earth Sciences 2008年第3期51卷 321-330页

作者： zhang HuCai YANG MingSheng zhang wenxiang LEI GuoLiang CHANG FengQin PU Yang FAN HongFang Key Laboratory of Western China’s Environmental Systems Ministry of EducationCollege of Earth and Environment SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Lake and Environment Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China

Using gas chromatography-mass spectrometry (GC-MS) technique, a series of biomarkers were identi- fied, including n-alkanes, n-alkane-2-ones, isoprenoid etc. from the loess-paleosol samples collected from the S4 and adjacent L5, L4 of the Luochuan loess section, Northwestern China. Based on these data, especially n-alkanes and high-resolution magnetic susceptibility and grain size data, the pa- leoenvironment and paleovegetation history during S4 was reconstructed. The CPI (Carbon Predomi- nance Index) and correlation between n-alkanes and magnetic susceptibility and grain size data dem- onstrated that the molecular fossils in paleosol and loess layers can reflect the vegetation condition during the loess-paleosol formation, if the allochthonous organic inputs could be excluded reasonably. The ACL (average chain length) index is correlated well with paleomagnetic susceptibility and grain size variations, displaying their good synchrony with warm and humid climate. However, it relatively lagged behind the paleomagnetic susceptibility and the grain size variations when the climate began to deteriorate. During the formation period of paleosol, the n-alkanes was dominated by C31 homologue, indicating that the primary organic input originated from herbs. Our study also demonstrated that the herbs were more flourish than wood plants in Loess Plateau, especially in the Luochuan area during the warm and humid phase, and there was no typical forest vegetation developed in the studied period.

关键词： paleoenvironment Paleosol S4 Luochuan loess section biomarker paleovegetation

Ionic Covalent Organic Framework:What Does the Unique Ionic Site Bring to Us?

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Chemical Research in Chinese Universities 2022年第2期38卷 296-309页

作者： FU Yu LI Yinhui zhang wenxiang LUO Chen JIANG Lingchang MA Heping School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049P.R.China Petrochemical Research Institute PetroChinaBeijing 102200P.R.China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing 314001P.R.China

Ionic covalent organic frameworks featuring both crystallinity and charged sites have arose tremendous attention from scientific community. The adjustable textural structures, well-defined channels and abundant charged sites of ionic COFs facilitate great potential in diverse aspects, such as separation, ion conduction, sensing, catalysis and energy storage. In this review, we first introduced the design and construction of ionic covalent organic frameworks(COFs), and classified them according to the types of charged sites. We focused on the various applications of ionic COFs in diverse fields. The structure-function relationship was also explored in detail. Finally, the opportunities and challenges of ionic COFs were summarized to provide guidance for better design and application of ionic COFs.

关键词： Ionic covalent organic framework Design and construction Various application Structure-function relationship

黄萎病菌诱导下陆地棉酵母双杂交文库的构建及GhMAPKKK2互作蛋白的筛选

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核农学报 2025年第1期39卷 68-76页

作者：程贯富张文祥郭新悦张国帅吕晓迪代培红雷建峰李月新疆农业大学生命科学学院新疆乌鲁木齐830052 新疆农业大学农学院新疆乌鲁木齐830052

为了探究棉花响应黄萎病菌侵染的分子机制并筛选GhMAPKKK2的互作蛋白,以陆地棉XLZ35为材料,基于Gateway克隆技术构建了棉花黄萎病菌诱导的陆地棉酵母双杂交文库,其中初级文库和次级文库的库容分别为1.2×10^(7)和2.0×10^(7)CFU,插入片... 详细信息

为了探究棉花响应黄萎病菌侵染的分子机制并筛选GhMAPKKK2的互作蛋白,以陆地棉XLZ35为材料,基于Gateway克隆技术构建了棉花黄萎病菌诱导的陆地棉酵母双杂交文库,其中初级文库和次级文库的库容分别为1.2×10^(7)和2.0×10^(7)CFU,插入片段重组率均为100%且平均长度大于1000 bp。次级文库质粒浓度为953 ng·μL^(-1),符合构建酵母文库的标准,可用于酵母双杂交筛选互作蛋白。构建了pGBKT7-GhMAPKKK2表达载体,并验证了该载体对酵母细胞无毒性且不存在自激活活性。以GhMAPKKK2为诱饵蛋白,利用酵母文库初步筛选,获得81个阳性互作蛋白,经测序对比选取6个候选蛋白,通过酵母双杂交及双分子荧光互补试验(BiFC)验证,明确了候选蛋白GhFLA与GhMAPKKK2存在互作关系。本研究结果为解析GhMAPKKK2调控棉花抗黄萎病反应分子机制及调控网络提供了重要参考。

关键词：棉花黄萎病菌酵母双杂交互作蛋白 GhMAPKKK2

Geochemical fractionation of rare earth elements in lacustrine deposits from Qaidam Basin

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Science China Earth Sciences 2009年第11期52卷 1703-1713页

作者： zhang HuCai zhang wenxiang CHANG FengQin YANG LunQing LEI GuoLiang YANG MingSheng PU Yang LEI YangBin Key Laboratory of Western China’s Environments MOECollege of Earth Sciences and EnvironmentsLanzhou UniversityLanzhou 730000China State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Boyang Lake MOESchool of Environmental and Chemical EngineeringNanchang UniversityNanchang 330031China

Based on the concentration and distribution pattern analysis of the rare earth elements (REEs) at the Shell Bar section from Qaidam Basin, we studied the geochemical fractionations of REE in paleolake deposits and their paleo-environmental significance. Our results show that the REE concentration in AS (acid soluble) and AR (acid residual) fractions are 20.9 μg/g and 95.4 μg/g (except element Y) individually, showing a strong REE differentiation between AS and AR fractions. However, the two types of fractions (AS & AR) have similar REE distribution patterns, which are slightly rich in light earth rare elements (LREEs), with slightly right-tilting and negative Eu anomaly. The LREE of AR is richer than that of AS. There were no significant correlations between the REE in AS, AR and other proxies. It indicated that the lacustrine deposition had different material sources and experienced varying geochemical procedures. Correlation analysis between the REE and the content of fine grain-size (<4 μm) of the sediments, Rb/Sr ratio and Mn concentration showed high correlation coefficients. Our results demonstrated that the REE in acid soluble and residual fractions bear different environmental significances, which are strongly dependent on local environment. The REE of acid soluble fraction is closely related to the paleoclimatic changes in the lake catchment and the evolutionary processes of lake itself. Our results suggest that δCe and (La/Yb)n could be used as proxies of the reduction-oxidation conditions and furthermore the temperature change and the lake level fluctuations. Using these proxies, we reconstructed the paleoclimate and water level fluctuation history during the high lake level period lasting between 43.5 and 22.4 cal. ka BP.

关键词： Shell Bar section rare earth elements (REE) fractionation paleoclimate Qaidam Basin